University Of Arizona

This phase 2 trial tests whether allopregnanolone, a natural hormone, can safely help repair the brain in people with early Alzheimer's disease. About 100 volunteers aged 55 to 80 will receive weekly infusions of the drug or a placebo for several months. Researchers will measure …

This study tests a culturally tailored medical nutrition therapy for African patients with type 2 diabetes. The program includes personalized meal plans, nutrition counseling, and group education. Researchers will measure blood sugar levels and diet adherence after 6 months, and …

This phase 2 trial tests a combination of two drugs, atezolizumab and cabozantinib, in 30 people with metastatic pancreatic cancer that has not responded to standard treatments. The goal is to see if the combination can shrink tumors or stop them from growing. Researchers will al…

This study tests whether a time-efficient breathing exercise program can help lower blood pressure in adults aged 50 and older who have moderate to severe sleep apnea but cannot or will not use a CPAP machine. Researchers will measure blood pressure changes over 36 weeks in 122 p…

This study tests a new software that combines MRI images with real-time ultrasound to guide prostate biopsies. The goal is to help doctors more accurately detect and locate aggressive prostate cancer early. About 100 men scheduled for a standard prostate biopsy will take part. Th…

This study tests whether metformin, a common diabetes drug, can prevent oral cancer in people with precancerous white or red patches in the mouth. About 34 participants will receive either metformin or a placebo for several months. Researchers will check if the patches shrink or …

This study tests whether a combination of two creams—calcipotriene (a vitamin D cream) and 5-fluorouracil (a chemotherapy cream)—can prevent skin cancer in organ transplant recipients. These patients are at high risk for skin cancer, especially from precancerous spots called acti…

This study looks at whether putting weight on your ankle soon after surgery for a broken ankle helps you recover faster and return to work sooner. About 150 adults with certain types of ankle fractures will be randomly assigned to start walking right away or wait several weeks. R…

This study tests a combination of two medicines (atomoxetine and oxybutynin) given at bedtime for 6 months to children aged 6-17 with Down syndrome and obstructive sleep apnea. The goal is to see if the treatment improves sleep quality and thinking skills. About 36 children will …

This study tests a 12-week coaching program for Hispanic cancer survivors and their caregivers. The program helps them set diet and exercise goals while managing symptoms like pain or fatigue. Researchers want to see if this leads to healthier eating and more physical activity, w…

This study tests a 3-month strength training program designed for Hispanic prostate cancer survivors and their caregivers. Participants exercise together in remote group classes to improve physical and mental health. The goal is to see if the program is practical and helpful for …

This study looks at whether having a psychiatric service dog makes prolonged exposure therapy work better for veterans with PTSD. About 216 veterans who already qualify for a service dog will be randomly assigned to get the dog right away or later. The goal is to see if the dog h…

This study looks at whether trained service dogs can help reduce PTSD symptoms in military veterans. 150 veterans who already qualified for a service dog are randomly assigned to receive one or to a waitlist. Researchers track their PTSD severity, depression, and overall well-bei…

This study tests whether adding two drugs (dexamethasone and dexmedetomidine) to a standard nerve block can extend pain relief after shoulder, foot, or ankle surgery. About 100 adults will be randomly assigned to get either the two-drug combo or dexamethasone alone. The goal is t…

This study looks at how many times a needle should be passed through a trigger point to best relieve myofascial pain. 300 adults with chronic muscle pain will be randomly assigned to receive 2, 10, or 20 needle passes during their injection. Researchers will measure pain relief, …

This study tests whether six weeks of daily breathing exercises against resistance can improve heart and lung function in people with pulmonary hypertension. Four participants will do 30 resisted breaths per day, five days a week. Researchers will measure changes in heart pressur…

This study tests whether daily exposure to green LED light can reduce chronic pain. 55 adults with conditions like fibromyalgia or nerve pain will use a green or white light device at home for 2 hours each day over 3 months. Researchers will measure changes in pain levels, medica…

This study tests whether specific voice therapy tasks can improve voice quality in 220 older adults with age-related voice changes (presbylarynx). Participants perform exercises like abdominal breathing, pushing tasks, and loud speaking. Researchers measure voice quality through …

This study looks at how the brain handles two different tasks: finding your way around and remembering daily events, like when you last took medicine. Researchers want to understand what parts of the brain are used for each task and how prior knowledge helps. The goal is to find …

This study tests whether green light can reduce pain by looking at brain activity in 30 healthy adults. Participants are exposed to green or white light for two hours while researchers measure pain pathways and brain waves. The goal is to understand how green light works, not to …

This study measures brain activity and chemical levels in people with epilepsy who already have electrodes implanted for medical reasons. Participants play simple computer games while their brain signals are recorded. The goal is to learn how the brain works during thinking and e…

This study looks at how different infant diets affect gut bacteria in healthy, full-term babies. Researchers are comparing a standard formula, a new formula designed to be more like breast milk (Enfamil NeuroPro), and breast milk itself. They will track changes in gut bacteria, g…

This study checks how long protection from a single HPV vaccine booster lasts in children who got the shot at age 9-11. Researchers will measure antibody levels in blood samples taken up to 6 years after the first dose. The goal is to understand if one booster provides lasting im…