Vitamin d cream plus chemo cream may shield transplant patients from skin cancer

NCT ID NCT05699603

Ongoing Prevention Sponsor: University of Arizona Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether a combination of two creams—calcipotriene (a vitamin D cream) and 5-fluorouracil (a chemotherapy cream)—can prevent skin cancer in organ transplant recipients. These patients are at high risk for skin cancer, especially from precancerous spots called actinic keratosis. The trial will treat 56 kidney or lung transplant recipients with multiple actinic keratoses and measure immune cell changes in the skin to see if the treatment reduces cancer risk.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: calcipotriene plus 5-fluorouracil cream
What this could lead to: If it works, this could offer a way to lower skin cancer risk in organ transplant recipients, who are especially vulnerable.
What could go wrong: This is a small, early-phase trial (56 people) with no control group, so results may not be conclusive. The treatment may not work as well in immunosuppressed patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

actinic keratosis skin cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACTINIC KERATOSIS

Contacts and locations

Locations

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
University of Arizona Cancer Center - Prevention Research Clinic

Tucson, Arizona, 85719, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

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