Could a vitamin d cream plus chemo cream stop skin cancer in transplant patients?

NCT ID NCT05699603

First seen Oct 31, 2025 · Last updated May 15, 2026 · Updated 27 times

Summary

This study tests whether a combination of two creams—calcipotriene (a form of vitamin D) and 5-fluorouracil (a chemotherapy cream)—can prevent skin cancer in organ transplant recipients. These patients have a high risk of developing skin cancer from precancerous spots called actinic keratosis. The study involves 56 kidney or lung transplant recipients who apply the creams to see if the treatment reduces these spots and lowers their cancer risk.

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Contacts and locations

Locations

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts, 02114, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • University of Arizona Cancer Center - Prevention Research Clinic

    Tucson, Arizona, 85719, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.