Could a common diabetes drug stop oral cancer before it starts?

NCT ID NCT05237960

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 31 times

Summary

This study tests whether metformin, a common diabetes drug, can prevent oral cancer in 34 people with precancerous white or red patches in the mouth. Participants take metformin to see if it can reverse or stop these patches from turning into cancer. The goal is to find a safe, low-cost way to stop oral cancer before it develops.

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Contacts and locations

Locations

  • British Columbia Cancer Agency

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Dalhousie University

    Halifax, Nova Scotia, B3H 4R2, Canada

  • Emory University Hospital/Winship Cancer Institute

    Atlanta, Georgia, 30322, United States

  • Louisiana State University

    Lafayette, Louisiana, 70503, United States

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • NYU College of Dentistry

    New York, New York, 10010, United States

  • UC San Diego Medical Center - Hillcrest

    San Diego, California, 92103, United States

  • University of Arizona Cancer Center-North Campus

    Tucson, Arizona, 85719, United States

  • University of Michigan Comprehensive Cancer Center

    Ann Arbor, Michigan, 48109, United States

  • University of Minnesota/Masonic Cancer Center

    Minneapolis, Minnesota, 55455, United States

Conditions

Explore the condition pages connected to this study.