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Penis transplants could restore form and function for wounded warriors

NCT ID NCT02395497

Recruiting now Disease control Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study investigates penile transplantation as a way to replace a severely damaged or missing penis with a donor organ, aiming to restore appearance, sensation, and sexual function. It includes men aged 18-69 who have lost their penis due to trauma, surgery, or birth defects. The approach uses a special immune-suppressing drug regimen to reduce the risk of rejection and the need for long-term medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a combination of monoclonal antibody (humanized anti-CD52), tacrolimus, and penile allotransplantation
What this could lead to
If successful, this could offer a way to restore natural-looking and functional penises for men with severe injuries or congenital defects, improving their quality of life.
What could go wrong
This is an early-stage trial with only 60 participants, and the procedure carries risks of rejection, infection, and side effects from lifelong immunosuppression. It may not work for everyone.

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Conditions

The condition(s) this trial relates to.

46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency Amputation, Traumatic Congenital Abnormalities disorder of sexual differentiation indeterminate sex and/or pseudohermaphroditism injury penile agenesis penile cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMPUTATION AMPUTATION, TRAUMATIC AMPUTATION, TRAUMATIC/SURGERY CONGENITAL ANOMALY, MALE GENITALIA PENIS/INJURIES PENIS/SURGERY PENIS/TRANSPLANTATION UROLOGIC SURGICAL PROCEDURES, MALE WOUNDS AND INJURIES

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-••••

Locations

  • Johns Hopkins University School of Medicine

    RECRUITING

    Baltimore, Maryland, 21287, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact

    Contact

    Contact Phone: •••-•••-••••

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