WOUNDS AND INJURIES

This Phase 2 trial at Johns Hopkins University will transplant donated hands onto 30 people who have lost one or both hands or arms. The key innovation is a bone marrow cell therapy designed to allow the body to accept the new hand with just one low-dose anti-rejection drug, inst…

This study looks at whether giving less intravenous (IV) fluid to critically ill children with traumatic injuries leads to fewer complications. Currently, there is no standard for how much fluid these children should receive. The trial will enroll 250 children aged 6 months to 15…

This Phase 2 trial tests whether 4-aminopyridine, a drug already used for other conditions, can help second-degree burns heal faster. Researchers will give the drug or a placebo to 200 adults with fresh burns and track healing rate and scarring. The goal is to see if this safe, e…

This pilot study tests a new device called WounDx that gives surgeons information about a wound to help them decide when it's ready to be surgically closed. The study will enroll 40 people with large extremity wounds. The goal is to see if the device can be used smoothly in a hos…

This study tests whether a bedside ultrasound (called FAST) can safely reduce the number of CT scans in children who have suffered a blunt injury to the belly. About 4,300 children will be randomly assigned to get either the FAST exam or standard care without it. The goal is to s…

This study tests whether acupuncture can relieve symptoms of Gulf War Illness, a condition causing long-term health problems in veterans who served in the Gulf region. Two hundred veterans will be split into two groups: one gets acupuncture twice a week for six months, the other …

This study tests whether providing medically tailored meals and shakes for 12 days after orthopaedic trauma surgery can improve healing and reduce wound complications. Researchers will track metabolic markers and wound issues in 75 patients over one year. The goal is to see if be…

This study compares a new powder dressing called Altrazeal to standard burn dressings in adults with partial thickness burns. The goal is to see if the new dressing reduces pain during changes and helps wounds heal faster. Sixty hospitalized patients will be randomly assigned to …

This Phase 2 trial tests whether 4-aminopyridine, a drug already used for other conditions, can speed up healing of skin wounds. Researchers will give the drug or a placebo to 150 healthy adults and measure how quickly small biopsy wounds close. The goal is to see if this safe, e…

This study explores whether injecting special skin cells (fibroblasts) can change normal skin into the thicker skin found on palms and soles. Researchers will take a small skin sample, grow the cells in a lab, and inject them back into the skin. They will measure changes in cell …

This study aims to create a smart computer program that helps doctors better understand the sounds from a handheld device used to check blood flow in arteries. Many doctors lack formal training in using this device, which can lead to missed or wrong diagnoses. The study will coll…

This study compares Advanced Trauma Life Support (ATLS) training for doctors against usual care to see if it improves survival in adult trauma patients. Over 4,000 patients from hospitals in India will take part. The goal is to find out if this widely used training actually saves…