New hand transplant protocol aims to cut lifelong drug risks
NCT ID NCT01459107
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This Phase 2 trial at Johns Hopkins University will transplant donated hands onto 30 people who have lost one or both hands or arms. The key innovation is a bone marrow cell therapy designed to allow the body to accept the new hand with just one low-dose anti-rejection drug, instead of the usual three-drug cocktail. The goal is to restore function and appearance while reducing the long-term risks of infection, cancer, and other side effects from standard immunosuppression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
deceased donor hand transplantation combined with bone marrow cell therapy and single-drug immunosuppression
What this could lead to
If successful, this could make hand transplants safer and more widely available by reducing the need for strong, lifelong anti-rejection drugs.
What could go wrong
This is an early Phase 2 trial with only 30 participants. The new immunosuppression approach may still cause rejection, infection, or other side effects, and results may not apply to everyone.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-••••
Locations
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Johns Hopkins University School of Medicine
RECRUITINGBaltimore, Maryland, 21287, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Contact Phone: •••-•••-••••