Johns Hopkins University

This study tests whether a 2-month combination of four drugs can cure drug-susceptible tuberculosis (TB) in children under 10 as safely and effectively as the standard 4- to 6-month treatment. About 860 children will participate, including those with HIV. If successful, the short…

This study tests two ways to increase COVID-19 vaccination among Latino adults and their social networks. One group learns motivational interviewing skills to encourage their friends, while the other group just receives vaccine information. Researchers will compare how many peopl…

This study tests how well the RSV vaccine Arexvy works in 170 adults with weakened immune systems. Participants will receive up to 3 vaccine doses over a year and be monitored for side effects and immune response. The goal is to find out if one or two doses provide better protect…

This study compares two ways to treat Gram-negative bloodstream infections: staying on IV antibiotics versus switching to oral pills early. Researchers want to see if the oral option works just as well but causes fewer side effects. About 1,030 hospitalized adults will take part,…

This study tests whether adding Dysport (a muscle-relaxing injection) to standard back bracing can slow or improve spine curvature in teens with scoliosis. About 90 adolescents aged 10-16 with mild to moderate curves will be randomly assigned to receive either Dysport or a placeb…

This study compares two strategies for giving Hepatitis C medication to people without HCV who receive a kidney from an HCV-positive donor. One group starts the medicine before transplant and takes it for 2 weeks; the other starts after transplant and takes it for 12 weeks. The g…

This study tests if a simpler, two-drug HIV regimen (dolutegravir/lamivudine) works as well as the standard three-drug regimen for people who are newly starting HIV treatment and also being treated for tuberculosis. About 150 adults will take part. The goal is to see if the simpl…

This early study tests a brain implant that records and stimulates brain areas to help people with severe paralysis (from spinal cord injury, ALS, or stroke) control assistive devices like computers or wheelchairs. Only 5 adults will take part to check safety and whether they can…

This study tests a program called CAPABLE Transplant to help people with kidney failure who are on the transplant waitlist but not yet active. The program addresses barriers like frailty, depression, and lack of support. Researchers will see if it helps participants become active…

This study looks at whether children aged 1 to 17 with controlled atopic dermatitis (eczema) can safely take less dupilumab or stop it entirely. About 30 kids who have been on the drug for at least a year will be randomly assigned to reduce their dose or stop treatment. The goal …

This study tests whether providing healthy groceries and coaching on diet and weight management can lower blood pressure and blood sugar in adults with hypertension and type 2 diabetes who live in areas with limited access to healthy food. About 80 participants from Baltimore wil…

This study tests a 5-session program for Black women living with HIV who have experienced intimate partner violence in the past two years. The program teaches skills to find inner strength, build a safety net, improve communication, and overcome barriers to HIV care. Researchers …

This study compares two types of light used during bladder cancer surgery: standard white light and a special blue light that may help doctors see tumors more clearly. About 200 adults with high-risk non-muscle invasive bladder cancer will be randomly assigned to one of the two m…

This study tests a program called Full-SPARCS, where trained peers help people with HIV stay on their medication and in care after they leave prison in South Africa. About 400 participants will be assigned to either the program or standard care. The main goal is to see if the pro…

This study tests whether people with atrial fibrillation (AF) and low-to-moderate stroke risk can use a smartwatch to guide when they take blood thinners, instead of taking them every day. About 5,350 participants will either follow standard daily blood thinner use or take blood …

This study tests a new way to help people quit smoking using a computer program led by an avatar, plus support from a community health worker who can also help arrange lung cancer screening. About 30 adults aged 50 and older who smoke will try the program and be followed for 6 mo…

This study tests a drug called mirdametinib in adults with neurofibromatosis type 1 (NF1) who have skin tumors called cutaneous neurofibromas. The goal is to find a safe dose and see if the drug can shrink these tumors. About 24 people will take the drug daily or on a three-week-…

This study tests whether tesamorelin can help nerves regrow and muscles recover after a serious nerve injury in the arm. About 36 adults with a cut ulnar nerve will receive either tesamorelin or no extra treatment after surgery. Researchers will measure pinch strength, hand funct…

This study tests a device called a vestibular implant, which electrically stimulates the balance nerve to help people with severe, chronic dizziness and unsteadiness. Researchers will follow 15 adults (ages 22–90) for 4 years after implantation to see if it improves walking, post…

This study tests whether a mobile app and text message reminders can help teenagers and young adults (ages 13-25) take their daily anti-rejection medicine on time after a kidney or liver transplant. Participants use an electronic pillbox that tracks when they take their medicatio…

This early-stage trial tests whether giving two medicines—erythropoietin and melatonin—together is safe for very premature babies who have a serious brain bleed. About 60 infants will receive either the drug combo or a placebo, plus standard care. The goal is to see if this treat…

This study tests whether nurse-led treatment for drug-resistant tuberculosis (TB) in local clinics works as well as doctor-led care in hospitals. About 2,944 adults in South Africa will take part. The goal is to see if nurse-led care can achieve similar cure rates, be just as saf…

This study tests a device that electrically stimulates the inner ear's balance nerve to help people with severe, long-term dizziness and unsteadiness. Researchers will implant the device in up to 8 adults whose balance problems did not improve with standard therapy. The goal is t…

This study tests a program that helps people with uncontrolled high blood pressure plus diabetes or kidney disease. Participants use a home blood pressure monitor that sends readings to their care team. Community health workers and pharmacists provide extra support and medication…

This study tests whether giving newborns a nasal microbiome transplant from their parent can increase the diversity of bacteria in the baby's nose. The goal is to see if this can help prevent infections like Staphylococcus aureus. The study involves 175 premature babies in the NI…

This study compares getting flap surgery within 72 hours of a severe leg injury versus waiting longer. The goal is to see if faster surgery reduces death, amputation, infections, and hospital stays. About 356 adults with open fractures or dislocations below the knee will take par…

This study tests whether a modified Atkins diet (a type of ketogenic diet) can control absence seizures in children aged 3-12 who have just been diagnosed. Instead of starting seizure medication, some families will try the diet for 3 months. The study will compare seizure control…

This study tests whether a diet high in omega-3s (like fish oil) can improve health and quality of life for people with COPD. Researchers will provide food to 200 participants and track their symptoms and flare-ups over time. The goal is to see if changing what you eat can help m…

This study tests whether a 6-month program combining exercise training, problem-solving skills, and support from community health workers can improve fitness and heart health in 210 adults with type 2 diabetes, obesity, and early heart problems. Participants have low income and l…

This study tests a new approach to hand transplantation for people who have lost one or both hands, forearms, or arms. The goal is to help recipients regain hand function and appearance while reducing the need for lifelong, high-dose immune-suppressing drugs that can cause seriou…

This study tests whether adding a patient's own concentrated bone marrow cells to standard hip decompression surgery can prevent the hip ball from collapsing and delay or avoid the need for a hip replacement. It involves 192 adults with early-stage (pre-collapse) osteonecrosis of…

This study tests whether the drug Isturisa can improve blood sugar, cholesterol, blood pressure, weight, bone density, and quality of life in adults with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. Ten participants will take Istu…

This study tests ways to help adolescents and young adults with HIV achieve and maintain viral suppression, meaning the virus is at very low levels in the blood. Participants get personalized counseling to choose their preferred antiretroviral therapy, including a long-acting inj…

This study looks at whether having a surgeon directly refer osteoporosis patients to a bone health specialist after hip or knee replacement can reduce implant problems and fractures. About 2000 adults over 50 with confirmed osteoporosis will be observed for two years. The goal is…

This study looks at whether a stepped-care program using smart scales, activity trackers, and text messages can help adults with obesity maintain at least 5% weight loss for a year. Participants first lose weight through group counseling and meal replacements. Those who succeed a…

This study tests whether offering small financial rewards and using video calls to watch people take their medicine can help more people complete treatment for latent tuberculosis. About 399 adults in Baltimore who are starting treatment will be randomly assigned to get usual car…

This study tests whether giving adults with obesity and food insecurity free, healthy groceries or grocery vouchers, along with weight loss coaching, helps them lose more weight than coaching alone. About 300 adults will be assigned to one of three groups for 24 weeks. The goal i…

This early-stage study tests whether psilocybin, the active ingredient in magic mushrooms, can help people with cannabis use disorder cut back or stop using cannabis. Twelve adults will receive two psilocybin sessions with psychological support and be followed for 6 months. The g…

This study tests whether a program called PICU Up! helps critically ill children recover faster. The program combines gentle movement, better sedation management, and family involvement. About 1,440 children on breathing machines will take part across 10 U.S. hospitals. The goal …

This study tests a device that electrically stimulates the balance nerve to help older adults (ages 65-90) with chronic dizziness, unsteadiness, and blurry vision due to bilateral vestibular loss. The implant aims to improve walking, posture, and quality of life. Fifteen particip…

This study tests if sildenafil (the drug in Viagra) can improve walking ability in people with scleroderma who have mildly high blood pressure in their lungs. About 30 adults will receive either sildenafil or a placebo for 4 months. The main goal is to see if the drug helps them …

This study follows people who have received a hand or arm transplant to see how they are doing over the long term. Researchers will measure hand function, pain, quality of life, and mental health using surveys and physical tests. Participants must be at least 5 years post-transpl…

This study tests a program to help 800 adults in Africa better control their high blood pressure. The program includes support for patients, healthcare providers, and the health system. The goal is to lower blood pressure and reduce the risk of heart disease, stroke, and kidney d…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help adults with obesity and binge-eating disorder reduce binge episodes and lose weight. About 105 participants will receive tirzepatide, a placebo, or lisdexamfetamine (a current treatment), plu…

This study tests whether a drug originally used for diabetes can slow brain and eye damage in people with multiple sclerosis (MS). About 120 adults with stable MS will receive either the study drug or a placebo for 96 weeks. The main goal is to see if the drug reduces brain shrin…

This study looks at whether giving patients IV fluids at home for four weeks after bladder cancer surgery can lower the chance of needing to go back to the hospital. About 130 adults having this surgery will be randomly assigned to either get the usual care or the usual care plus…

This study tests a short, computer-based program to help people with HIV and alcohol use disorder avoid relapse. About 150 participants will receive two sessions designed to prevent a return to drinking. The goal is to see if this approach is practical and effective in reducing a…

This study tests a digital health program called Corrie Lipids in about 1,000 adults with high LDL cholesterol and heart disease risk. The program includes a smartphone app, doctor education, and better clinic workflows to help patients reach their cholesterol goals. Researchers …

This study tests whether metformin, a common diabetes medicine, can improve asthma control in overweight or obese adults whose asthma is not well managed by their current inhalers. About 100 participants will take metformin or a placebo for 24 weeks and have their asthma symptoms…

This study tests whether a structured pulmonary rehabilitation program (8 or 24 weeks) can improve lung function and reduce breathing problems after tuberculosis treatment. Researchers will enroll 690 adults with confirmed TB who have just started treatment. Participants will be …

This study tests a brain-computer system that lets people with tetraplegia (paralysis from the neck down) control assistive devices using only their thoughts. Five participants will have tiny electrode arrays placed in their brain to record signals and stimulate movement. The mai…

This study looks at whether wearing a custom-made prosthetic over the missing part of the skull can prevent 'Sunken Flap Syndrome'—a condition where the brain sinks and causes headaches, weakness, or even coma after life-saving skull removal surgery. About 72 adults who had this …

This study tests whether providing tailored meals and fresh food to Black mothers who had gestational diabetes can help them lose weight after childbirth and prevent type 2 diabetes. About 40 low-income women will receive either prepared meals or a mix of meals and fresh grocerie…

This study looks at a surgery called FETO, done while the baby is still in the womb, to treat a severe birth defect where the diaphragm muscle has a hole. The goal is to see if FETO helps more babies survive after birth and have fewer health problems compared to standard care. Ab…

This study tests if omalizumab, an allergy drug, can reduce serious breathing flare-ups in people with COPD who also have allergies. About 334 adults over 40 who smoke or used to smoke will receive the drug or a placebo for 12 months. The goal is to see if the drug helps control …

This study is testing a simple, non-invasive method to detect early signs of Barrett's esophagus, esophageal cancer, and stomach cancer. Participants swallow a capsule attached to a string, which collects cells from the esophagus and stomach. Researchers then analyze the DNA in t…

This study tests whether using a special camera with artificial intelligence (AI) during routine diabetes checkups can help more young people from underserved communities get screened for diabetic retinopathy, an eye disease that can lead to blindness. The study will include 500 …

This study tests a robot-assisted ultrasound biopsy to improve how doctors find prostate cancer. About 483 men with elevated PSA or abnormal exams will be enrolled. The robot aims to make biopsies more accurate and reduce missed cancers compared to standard freehand methods.

This study tests whether a new MRI contrast agent called Elucirem, given at half the usual dose, can detect heart scarring as well as the standard agent given at a higher dose. About 25 adults who previously had heart MRI scans will receive the new dye and have their images compa…

This early-stage study tests a new robot called ProBot that helps doctors perform prostate biopsies with greater precision. The robot uses a special ultrasound probe and aims to reduce pain and improve cancer detection. The trial will enroll 60 men aged 40-75 who are at higher ri…

This study tests whether a new ultra-high resolution CT scanner is better than a standard CT at finding blocked arteries in the heart. About 140 adults with suspected coronary heart disease will get one scan, and the images will be compared to the usual method (catheterization). …

This study tests two strategies for finding tuberculosis (TB) and starting preventive therapy in peri-urban Uganda. One approach screens people at a health facility, while the other sends mobile teams into neighborhoods thought to have the most undiagnosed TB. Researchers will co…

This study tests whether a 4-week course of the drug bedaquiline can prevent tuberculosis (TB) as well as the standard longer treatment. It involves 2,530 people living with HIV and close contacts of TB patients, who are at high risk. If successful, this shorter regimen could mak…

This study tests whether training people who inject drugs to become peer educators can increase HIV testing and prevention in their social circles. About 360 participants from syringe service programs in Maryland will be randomly assigned to either a peer-educator training or a c…

This study aims to help men who have sex with men (MSM) in Baltimore get tested for HIV and other sexually transmitted infections (STIs) via a mobile van, and then connect them to care. Participants will either receive help from a peer health navigator to get PrEP (HIV prevention…

This study looks at how a single dose of two F/TAF tablets (a common HIV prevention drug) works in the body over 14 days. It involves 24 healthy volunteers to measure drug levels inside cells. The goal is to see if this dosing approach could improve HIV prevention strategies.

This study tests whether adding an oral drug (tacrolimus) to a standard rectal anti-inflammatory (indomethacin) can prevent pancreatitis that sometimes occurs after a procedure called ERCP. About 4,874 adults undergoing ERCP will be randomly assigned to receive either the standar…

This study tests whether using a special walking analysis system and custom shoe inserts can reduce the chance of diabetic foot ulcers returning or leading to amputation. Researchers will follow 69 adults who have had a healed diabetic foot ulcer in the past. The goal is to see i…

This study tests whether adding testing for common sexually transmitted infections (like chlamydia and gonorrhea) to standard risk screening helps more women in Uganda start and continue taking PrEP, a daily pill that prevents HIV. About 4,500 HIV-negative women aged 15-39 will b…

This study tests a self-administered rehabilitation tool that guides users to gradually increase head movements. The goal is to reduce motion sickness and help with balance recovery after inner-ear problems or surgery. The study enrolls 48 adults with vestibular disorders or moti…

This study tests Scrambler Therapy, a non-invasive device that sends electrical signals through the skin to retrain how the brain feels pain. It is for adults with chronic pancreatitis whose abdominal pain has not been helped by standard treatments. Participants will receive 5-10…

This study tests whether a gentle electrical current applied to specific brain areas can enhance language therapy for people with logopenic variant primary progressive aphasia (lvPPA), a type of early-onset dementia that mainly affects language. Sixty participants will receive ei…

This study looks at whether escitalopram, a type of antidepressant, can make language therapy work better for people who have trouble speaking after a stroke. The trial includes 88 adults who had a stroke within the past three months. Participants will receive either escitalopram…

This study is testing a program called CAPABLE, which is added to regular home-based medical care for older adults who feel socially isolated or lonely. The goal is to see if this combined approach can improve daily function, reduce pain, and boost quality of life. About 450 home…

This study tests whether entering an MRI machine more slowly can prevent the dizziness and vertigo some people feel near strong magnets. Researchers will have 100 participants enter the scanner at different speeds—from the usual 20 seconds up to 3 minutes—and report any spinning …

This study tests whether using mobile health technology to personalize OCD symptom tracking makes cognitive-behavioral therapy (CBT) more effective for children and teens. Researchers will enroll 30 youth aged 8-17 with moderate OCD to compare personalized CBT with standard CBT. …

This early-stage study tests whether giving both psilocybin and MDMA together is safe and helpful for military veterans with PTSD. About 40 veterans will receive the drugs in a controlled setting and be monitored for side effects and changes in PTSD symptoms. The goal is to see i…

This study tests a new mental health program for preschool children from low-income families. About 160 parents and their children will take part through Head Start programs in Maryland. The program offers virtual sessions to help parents manage their child's behavior and emotion…

This study tests whether psilocybin therapy is practical and helpful for people with ALS who feel depressed. Researchers will enroll 24 adults with ALS and monitor mood, quality of life, and treatment adherence. The goal is to see if this approach can ease emotional distress, not…

This study tests whether emotional awareness and expression therapy (EAET) can help people with persistent pain after a serious orthopedic injury. Thirty adults will attend weekly therapy sessions and complete questionnaires and sensory tests before, after, and at follow-up. The …

This study compares two types of talk therapy—cognitive behavioral therapy and mindfulness—to see which works better for insomnia in people who have had a mild to moderate traumatic brain injury and also have post-traumatic stress symptoms. 360 participants will receive 6 therapy…

This study tests if treating insomnia first helps breast cancer survivors lose more weight. 250 women who are overweight and have insomnia will get either sleep therapy or sleep education, followed by a weight loss program. The goal is to see if better sleep leads to greater weig…

This study tests if a gentle brain stimulation technique called tDCS, combined with computer-based cognitive training, can improve memory and thinking in people who had a mild stroke. About 60 participants will receive either real tDCS or a sham (fake) version, plus cognitive tra…

This study tests whether a safe, non-invasive brain stimulation technique called tDCS can improve language skills in people with primary progressive aphasia (PPA), a condition that slowly damages the brain's language areas. Researchers will compare real tDCS to a sham (fake) vers…

This study tests a mobile health program (mPATH) designed to help low-income older adults who have trouble sleeping and are not very active. Participants will use a phone app to increase physical activity, with the goal of improving memory and sleep quality. The study involves 17…

This study tests whether a mild electrical current applied to the back of the brain (cerebellar tDCS) can boost language therapy for people who have trouble speaking after a stroke. About 60 adults with chronic aphasia will receive either real or fake stimulation during naming pr…

This study tests whether a low-dose, slow-release drug called AGB101 can reduce overactivity in a key memory region of the brain in healthy older adults aged 50 to 80. Over two weeks, each participant will receive both the drug and a placebo to compare effects. The goal is to see…

This study tests a special wellness program for adults with cystic fibrosis who feel very tired. About 80 people will either join the program or get their usual care. The goal is to see if the program helps improve fatigue, sleep, and daily activity.

This study compares telerehabilitation (physical therapy via video calls) with in-clinic physical therapy for 1000 adults with chronic low back pain. Participants will be randomly assigned to one of the two approaches for 8 weeks. The main goal is to see if video-based therapy re…

This study looks at whether a standardized anesthesia plan can reduce pain and shorten hospital stays for children and teens (14 and older) having LeFort jaw surgery. Researchers will compare a group that receives the new protocol to a group that had standard care in the past. Th…

This study tests a 8-10 week program for caregivers with disabilities who care for a loved one. The program offers help finding resources, self-care planning, emergency and end-of-life preparation, and peer support. The goal is to see if it can lower stress, burden, and depressio…

This study compares two language therapies for people with aphasia, a communication disorder caused by stroke. One therapy aims to stimulate the right side of the brain to improve storytelling and conversation, while the other focuses on word-finding. The goal is to see which app…

This study tests whether personalized virtual physical therapy (telerehabilitation) can reduce pain and disability in adults with chronic low back pain living in rural areas. About 434 participants will receive either tailored telehealth sessions or standard education. The goal i…

This study looks at whether a single high dose of psilocybin can help people who have both chronic low back pain and depression. About 40 adults will receive either psilocybin or a control drug, and researchers will track changes in mood, pain-related thoughts, and pain sensitivi…

This study compares Scrambler Therapy, a non-drug treatment using mild electrical signals, to standard pain medications for people who have ongoing pain after a stroke. Researchers aim to see if this therapy can reduce pain by at least half. The study will enroll 100 adults who h…

This study tests a hearing care program for older adults with Alzheimer's or related dementias who also have hearing loss. The goal is to see if addressing hearing loss can reduce troubling symptoms like agitation and distress, and ease the burden on caregivers. About 300 people …

This study tests whether the antidepressant vortioxetine can improve mood symptoms and thinking skills in people with early-stage frontotemporal dementia (bvFTD). About 50 participants will take the drug for 12 weeks and undergo brain scans and memory tests before and after treat…

This study tests a special belt that vibrates to give feedback, helping people with balance disorders (like dizziness or unsteady walking) improve their gait. Researchers at Johns Hopkins will enroll 90 adults aged 18-80. Participants wear the belt while walking, and their balanc…

This study tests whether AGB101 (a low-dose extended-release seizure medication) can reduce hallucinations and delusions in people with Parkinson's disease. About 30 adults aged 40-85 will take both the drug and a placebo at different times for 6 weeks each, with a break in betwe…

This study tests two short, proven treatments for suicidal teens and young adults (ages 12-24) in emergency rooms. One helps create a personal safety plan and follow-up calls; the other teaches skills to handle relationship problems that can trigger suicidal thoughts. Researchers…

This study tests if scrambler therapy (ST) can reduce nerve pain in people with corticobasal syndrome (CBS), a rare brain disease. About 25 adults with CBS and daily pain will receive either ST or standard TENS treatment. The goal is to see if ST lowers pain scores by at least a …

This study tests whether cannabidiol (CBD) can reduce anxiety, mood problems, and agitation in adults with autism spectrum disorder. Forty participants will receive CBD for six weeks and a placebo for six weeks, with a two-week break in between. Researchers will track changes in …

This study looks at two ways to drain fluid from around the lungs in people with advanced cancer: using gravity or a vacuum bottle. The goal is to see which method causes less chest pain during drainage. About 200 adults will be randomly assigned to one of the two methods, and th…

This study tests whether giving a single dose of methadone during laparoscopic or robotic hysterectomy can reduce the need for opioid painkillers after surgery. About 100 adults with benign uterine conditions like fibroids will be randomly assigned to receive either methadone or …

This study tests whether a natural hormone called pregnenolone can reverse the effects of cannabis intoxication. Twenty healthy adults who have used cannabis before will receive either pregnenolone or a placebo in random order. Researchers will measure changes in drug effects, th…

This study compares a mindfulness-based program (MBIT) to relaxation and support therapy for adults with Tourette syndrome or persistent tic disorders. Researchers want to see if mindfulness can reduce tic severity and improve daily life. About 150 participants will take part rem…

This study tests whether adding virtual reality (VR) to a simple relaxation technique called progressive muscle relaxation (PMR) can help burn survivors manage ongoing symptoms like pain, itch, anxiety, and trouble sleeping. About 34 adults who had a burn injury at least 6 months…

This study compares two approaches to help teenagers reduce alcohol use: brief counseling alone versus brief counseling plus a smartphone app that teaches mindfulness. About 1,500 teens aged 12-17 from pediatric primary care clinics will take part. Researchers will track drinking…

This study tests a special laser (1927-nm thulium) to see if it can safely improve the rough bumps and redness of keratosis pilaris, a common but harmless skin condition. About 25 adults with KP on both upper arms will receive the laser treatment. The goal is to find a better opt…

This study tests whether a device called ScentCare, used with a companion app, can improve smell and well-being in adults aged 60 and older who have lost their sense of smell. Participants will use the device or solve Sudoku puzzles twice daily for three months. Researchers will …

This study tests a digital program designed to help women who have experienced violence and struggle with PTSD or depression. The program provides tools to reduce stress, improve safety, and build self-care habits. Researchers will enroll 676 immigrant women to see if the app imp…

This small pilot study is testing whether a single dose of psilocybin, the active ingredient in magic mushrooms, given in a supportive setting, can safely reduce depression and improve quality of life in 20 people with mild cognitive impairment or early Alzheimer's disease. Resea…

This study tests if a procedure called middle meningeal artery embolization is safe and possible for people with hard-to-treat chronic migraines. Doctors will use a material called Onyx to block arteries in the brain, aiming to reduce migraine triggers. About 13 adults with bilat…

This study tests whether psilocybin, a psychedelic substance, is safe for people who had a stroke at least a year ago. Researchers will monitor blood pressure and other vital signs in 20 participants. The goal is to see if psilocybin can be used safely as part of therapy to help …

This study tests whether listening to Mozart or other age-appropriate music can lower the number of seizures or abnormal brain signals in children with epilepsy. Up to 10 children (ages 4–17) staying in a hospital epilepsy monitoring unit will participate. Researchers will measur…

This study looks at whether switching from ocrelizumab to ublituximab can reduce or delay the return of MS symptoms that some people experience before their next dose. About 50 adults with relapsing MS who have this 'wearing off' problem will be followed to see if the new drug he…

This study tests whether trazodone, a medication used for sleep, can improve both sleep and memory in people with early Alzheimer's disease. Researchers will give either trazodone or a placebo to 100 adults with mild memory problems and poor sleep. The goal is to see if better sl…

This study tests whether personalized, virtual music therapy sessions can help people with mild cognitive impairment or early Alzheimer's disease recall memories and feel better emotionally. Sixty participants will take part in 16 music therapy sessions over 8 weeks. Researchers …

This study looks at whether cannabidiol (CBD) can reduce stress and withdrawal symptoms in people who smoke cigarettes. Researchers will give CBD to 90 smokers and expose them to stress, measuring their mood, heart rate, and stress hormones. Some participants will be asked to sto…

This study tests whether vestibular therapy—exercises for the inner ear balance system—can reduce falls in people with Alzheimer's disease. About 100 older adults with mild to moderate Alzheimer's and balance problems will receive either the therapy or a control activity. Researc…

This early study tests whether a drug called IMLYGIC, injected directly into skin tumors, is safe and practical for adults with NF1 who have bothersome growths. Ten participants will receive up to four cycles of treatment. The goal is to see if the approach is tolerable and can b…

This study compares two types of bladder removal surgery in 70 men with bladder cancer. One method spares the prostate capsule, the other spares nerves. The goal is to see which approach better preserves erectile function and urinary control after surgery. Participants will compl…

This study tests whether injecting hyaluronic acid into shoulder muscles can reduce pain and improve movement in people who have had a stroke. About 68 adults with shoulder pain starting 3 to 180 months after a stroke will receive either the injection or a placebo. The goal is to…

This study tests whether wearing special tape over the mouth at night can reduce snoring and improve sleep for people with mild sleep apnea. About 100 adults who snore and have a bed partner will try the tape for a few weeks. Researchers will measure snoring, sleep quality, and h…

This study tests whether a pain plan without opioids works just as well as one with opioids after laparoscopic tubal sterilization (getting tubes tied). About 120 adults having this surgery will be randomly assigned to receive either opioid or non-opioid pain medicine. The goal i…

This study looks at how women with bladder cancer cope, focusing on emotional distress and sexual health. About 80 participants will either receive standard care or extra educational support. They will fill out surveys about their mood and sexual function, and researchers will tr…

This study tests whether oral cannabidiol (CBD), a well-tolerated compound from cannabis, can help people quit smoking tobacco. Researchers will give CBD to 50 adults who smoke over 10 cigarettes daily and are interested in quitting. The goal is to see if CBD increases short-term…

This study tests a digital toolkit for people with atrial fibrillation (AFib), a heart rhythm problem. The tool helps patients learn about treatment options, stick to healthy habits, and get guidance during AFib episodes. Researchers want to see if using the app improves quality …

This study looks at whether adding a structured yoga program to usual care can reduce back pain and improve quality of life for teens with scoliosis. About 500 participants aged 10-20 who are not having surgery will be randomly assigned to standard care or standard care plus yoga…

This study is testing a new imaging method called full-field optical coherence tomography (FFOCT) to see if it can quickly and accurately analyze small lung biopsy samples taken during a bronchoscopy. Researchers will compare FFOCT images to standard lab analysis. About 20 adults…

This early-phase lab study uses cells from people with chronic sinusitis and nasal polyps to see how the drug mepolizumab affects inflammation and the health of the nasal lining. Researchers want to learn if the drug can reduce inflammation and help maintain the barrier function …

This study follows 5,000 adults with pancreatic cysts to learn how these cysts behave over time. Researchers aim to create a better way to tell which cysts are harmless and which may turn into cancer. Participants provide medical records and samples to help improve diagnosis and …

This study aims to understand why the right side of the heart fails in people with heart failure and pulmonary hypertension. Researchers will measure heart function and test heart tissue samples from 50 adults to find the best ways to diagnose and treat this condition. The goal i…

This study tests a new electronic tool and communication training for doctors to improve conversations with parents about safe sleep for babies. The goal is to reduce the risk of sleep-related infant deaths, especially in communities with higher disparities. About 350 parents and…

This study tests whether a text-messaging program, promoted through social media, can help first-time fathers across the U.S. become more engaged during pregnancy and the first two months after birth. About 180 expectant dads will receive texts designed to support their role and …

This study from Johns Hopkins University aims to understand how commercial kratom extract products affect mood, thinking, and physical signs like heart rate and pupil size in adults who regularly use them. Researchers will also study how the body processes these products. The res…

This study is testing whether new MRI and CT scans can help doctors better predict who is at high risk for sudden cardiac death. Researchers will scan the hearts of 400 people with weak heart pumps who are getting a defibrillator. The goal is to find patterns that could save live…

This study uses a special MRI technique to measure the energy levels inside the heart without any needles or tissue samples. Researchers want to see if heart failure is linked to lower energy production in the heart muscle. The study includes healthy volunteers and people with di…

This study looks at how heart failure may cause changes in brain volume. Researchers will use MRI scans to measure brain structures in 100 adults with heart failure and compare them to people with normal heart function. The goal is to understand the link between heart health and …

This study aims to improve early cancer detection by following 10,000 healthy adults for up to 20 years. Researchers will collect data on lifestyle, medications, and blood samples to identify changes that happen before cancer is diagnosed. Participants must be 18 or older and und…

This study is for people with COPD who are former smokers. It tests two different doses of aspirin to see which one works better to reduce inflammation in the body. The goal is to find the right dose for a future larger study that will check if aspirin can improve breathing and r…

This study aims to see how many people visiting emergency departments in South Africa and Baltimore have HIV or are at high risk of getting it. Researchers will offer HIV tests to all patients and connect those who test positive or are eligible for PrEP (a daily pill that prevent…

This study looks at how a commercially available ketone drink (Ketone-IQ) affects sleep and breathing in 20 healthy adults aged 18-50. Participants take two different doses at home on separate nights and measure their ketone levels and sleep quality using a headband device. The g…

This study aims to see if doctors can change normal skin into the thicker, tougher skin found on palms and soles. Researchers will take a small skin sample, grow the cells in a lab, and inject them back into the skin. The goal is to measure changes in skin thickness and firmness.…

This study is testing a smartphone app designed to teach emergency room patients about hepatitis C (HCV). The app provides personalized information about liver health, barriers to care, and motivation to seek treatment. Researchers will enroll 308 HCV-positive patients from an ur…

This study looks at why some people have memory and thinking problems after a stroke. Researchers will check if damage to the brain's protective barrier (blood-brain barrier) at the time of stroke can help predict who might develop cognitive decline over the next three years. Abo…

This study looks at why some women get severe mood problems before their period (PMDD). Researchers will measure hormone levels and brain cell activity in 288 women—some with PMDD and some without. They will also test whether a low-dose antidepressant changes these measures. The …

This study looks at how a citrus compound called d-limonene, THC (the active part of cannabis), and their combination affect healthy adults. Researchers will measure drug effects, liking, and anxiety using simple rating scales. The goal is to understand these substances better, n…

This study looks at how different forms of cannabis edibles—like chocolates, gummies, and drinks—affect healthy adults. About 80 people will take part in multiple sessions where they consume these products and then complete thinking and coordination tests, have blood drawn, and r…

This study tests a new device that continuously measures pressure in the leg to detect a dangerous condition called compartment syndrome in patients on ECMO life support. Because these patients are sedated and can't report symptoms, the device may help doctors diagnose the proble…

This study looks at how THC (the main psychoactive ingredient in cannabis) influences cigarette smoking in people who use both tobacco and cannabis daily. Researchers will measure how much participants want to smoke, their cravings, heart rate, blood pressure, and thinking skills…

This study aims to develop a way to measure resilience in people with opioid use disorder. Researchers will compare how participants perform on thinking and emotion tasks with their own reports of resilience during stress. The goal is to better understand what helps some people c…

This study follows 1,500 people with heart failure who are getting a replacement implantable defibrillator (ICD) to prevent sudden cardiac death. Researchers will look at heart structure, electrical signals, genetics, and blood markers to better identify who is at highest risk. T…

This study looks at whether eating dinner earlier in the day helps people with obesity and prediabetes burn more fat and control blood sugar. Researchers will compare early versus late dinner times in 32 adults. The goal is to understand how meal timing affects metabolism.

This study looks at how using vaporized cannabis and drinking alcohol at the same time affects your thinking, coordination, and driving skills. Healthy adults aged 21 and older will take part in seven sessions where they receive different combinations of cannabis (placebo, 5 mg, …

This study will follow 4,000 adults aged 25-35 who do not have severe lung disease. Researchers will measure lung function over time to learn what keeps lungs healthy and how to spot early signs of chronic lung disease. The goal is to find ways to prevent lung problems before the…

This study looks at how the immune system of adults over age 75 responds to the annual flu shot. Researchers want to know if a common virus called CMV affects the vaccine's effectiveness. About 1,025 healthy or frail older adults will join, providing blood samples and symptom rep…

This study looks at how estrogen and other hormones affect bone development in teenage and young adult women with cystic fibrosis (CF). It has two parts: an observational study that tracks bone health in women using different types of birth control, and a small feasibility study …

This study looks at how nicotine pouches affect both cigarette smokers and people who rarely use nicotine. Researchers will measure nicotine levels in the blood and ask participants about their experiences. The goal is to understand the risks and appeal of these products for diff…

This study looks at whether a special drink (exogenous ketones) can affect breathing during sleep in 20 healthy adults. Participants will try the drink and a placebo on different days to compare results. The goal is to learn if ketones might help with breathing issues like sleep …

This study is testing an artificial intelligence (AI) tool that helps emergency room doctors spot and manage acute kidney injury (AKI) earlier. Researchers will introduce the tool at three hospitals and track whether it improves care, such as catching kidney problems sooner and a…

This study uses a special brain scan called MEG to learn why many people have trouble with attention, memory, and thinking after a minor stroke. Researchers will compare brain activity in stroke patients and healthy volunteers at 1, 6, and 12 months after the stroke. The goal is …

This early-stage study tests whether transferring a parent's nasal bacteria to a child can restore the child's nasal microbiome after they've been treated with antibiotics for a staph infection. The study involves children under 18 who have completed antibiotic treatment and are …

This study aims to find epigenetic markers in the blood that may be linked to premenstrual dysphoric disorder (PMDD). Researchers will compare women with and without PMDD by collecting blood samples and tracking mood changes during different phases of the menstrual cycle. The goa…

This study looks at how senescent (aging) cells might cause uterine fibroids. Researchers will analyze tissue samples from 150 women to map these cells and their signals. The goal is to better understand fibroid development, not to test a treatment.

This study aims to document how TRPV4 neuropathy changes over 6 years in people with a confirmed TRPV4 gene mutation. Researchers will track symptoms, function, and disability through annual visits at Johns Hopkins. No treatment is given—the goal is to better understand the disea…

This study looks at why people with a certain type of heart failure (HFpEF) get so tired when they exercise. Researchers will measure energy use in the heart and leg muscles using special scans. The goal is to understand the problem better, not to test a new treatment. About 130 …

This study is creating a detailed electronic registry of people with achondroplasia, a common form of dwarfism. Researchers will collect growth measurements and surgery records from up to 1,500 patients across several U.S. hospitals. The goal is to gather long-term data that can …

This study uses a special eye scan (OCT angiography) to take detailed pictures of blood vessels in the back of the eye. Researchers will follow 1,050 people with diabetic retinopathy, retinal vein occlusion, or high blood pressure, as well as healthy volunteers, to see how these …

This study looks at whether listening to a steady beat (like a metronome) can improve walking in people with Parkinson's disease who also have a brain implant (deep brain stimulation). Ten participants will walk while the beat plays, and researchers will measure their speed, stri…

This study is testing a special collar worn around the neck that continuously measures radiation exposure during radioactive iodine treatment for thyroid cancer and Graves' disease. The goal is to see if this device can help doctors give the right amount of radiation for each pat…

This study tests whether a parenting program helps 4-5-year-olds in public pre-K programs in low-income areas of Maryland become more ready for kindergarten. Researchers will measure children's social skills, behavior, and attendance, as well as parent involvement. The goal is to…

This study looks at whether group visits for new mothers and their babies, instead of individual check-ups, can improve health for both. About 1,125 women and their infants in Malawi will take part. Researchers will measure things like mom's mood, baby's vaccines, and how connect…

This study looks at how the cerebellum, a part of the brain, influences alcohol cravings and the brain's reward system in people with alcohol use disorder (AUD). Researchers will compare 122 adults with AUD to healthy volunteers using brain scans and a mild electrical stimulation…

This study explores whether BCG treatment for non-muscle invasive bladder cancer causes mood changes. About 42 adults will provide blood and urine samples and complete mood questionnaires and daily diaries. The goal is to understand how the body's immune response to BCG might aff…

This study creates a database of up to 400 people under 26 with atopic dermatitis (eczema) who have used or will start systemic treatments. Researchers will collect health information and samples to better understand how well these treatments work and to quickly notify participan…

This study looks at how your natural sleep pattern (chronotype) affects blood sugar control in overweight young adults aged 18-23. Researchers will compare glucose tolerance and insulin sensitivity when meals and tests are timed to match or mismatch your body clock. The goal is t…

This study looks at people with obstructive sleep apnea who are getting a nerve stimulator implant (Inspire) because they can't use a CPAP machine. Researchers want to see if measuring how the airway opens during a special sleep test can predict who will get the most benefit from…

This study looks at how a brain area called the cerebellum helps with thinking, not just movement. Researchers will use mild brain stimulation in 50 healthy adults while they perform tasks that involve predicting sequences. The goal is to see if the cerebellum is key for sequenci…

This study follows 235 adults who survived acute respiratory failure (ARF) and their family caregivers. Over 6 months, they complete surveys about their expectations, mood, and coping. The goal is to see if positive or negative expectations are linked to anxiety, depression, and …

This study looks at how THC (the active part of cannabis) changes people's desire for e-cigarettes and their body's reactions. Researchers will give different doses of THC or a placebo to 100 adults who regularly use both e-cigarettes and cannabis. They will measure things like h…

This study looks at how stress hormones and genes linked to Alzheimer's affect memory and thinking in older adults with mild memory problems. Researchers will measure stress responses and memory over two years to see if they can predict who might decline faster. The goal is to be…

This study is testing a web-based app that helps people waiting for a kidney or liver transplant share their story on social media to find a living donor. Researchers want to see if this approach leads to more potential donors coming forward and more transplants. The study involv…

This study gives healthy adults psilocybin (the active compound in magic mushrooms) and uses brain scans and language tasks to see how it changes thoughts and brain activity. Researchers aim to understand the drug's effects, not to treat any disease. About 30 volunteers aged 18–7…

This study aims to understand how methylphenidate, a common ADHD medication, changes brain activity and chemical levels in adults with ADHD. Thirty right-handed adults will receive a single dose of methylphenidate or a placebo and undergo brain scans. The goal is to find brain ma…

This study tests a program that uses a patient portal to help older adults with mild cognitive impairment or dementia, along with their care partners, talk to a pharmacist about stopping medications that may be harmful. The goal is to see if providing educational videos and messa…

This study aims to find out if certain psychoactive substances can cause experiences similar to classic psychedelics. Fifty healthy volunteers aged 25-55 will take up to 6 different substances or a placebo in a double-blind setup. Researchers will measure mystical-type effects us…

This study is testing whether very small, repeated doses of psilocybin (the active ingredient in magic mushrooms) are safe for healthy adults to take at home. Twenty participants will receive increasing doses and a placebo on different days in a lab, while researchers check their…

This study looks at how the lungs and heart work in 1000 healthy people aged 25 to 35. Researchers want to see if things like your body, environment, and general health affect your lung structure and function. Participants will take simple breathing tests to measure air movement,…

This study looks at how well leg muscles produce energy in people aged 60 and older, both with and without HIV. Researchers want to see if muscle energy problems are linked to tiredness and less ability to exercise. Participants will have muscle tests and walking assessments, but…

This study looks at 100 adults with atrial fibrillation who are scheduled for a heart procedure called ablation. Researchers want to see if a special CT scan can measure scarring in the heart muscle and whether more scarring leads to worse outcomes like the return of irregular he…

This study follows 50 people who have had a stroke and at least one risk factor like high blood pressure, high cholesterol, or diabetes. Researchers will use repeated MRI scans over about 15 months to watch how small vessel disease in the brain changes. The goal is to learn more …

This study watches 22 healthy adults who regularly use kratom. On day one, they take their usual dose under observation, and then stop for the next two days. Researchers measure physical, mental, and withdrawal symptoms to better understand kratom's effects and risks.

This study is creating a new tool to measure opioid cravings in people receiving treatment for opioid use disorder. Researchers will show participants opioid-related images and objects, then interview them about their feelings and thoughts. The goal is to develop a more accurate …

This study aims to find better ways to detect pancreas cancer early in people who are at high risk due to family history or certain gene mutations. Researchers will collect and analyze pancreatic juice and cyst fluid from 9,000 participants to look for markers that signal early c…

This study looks at 400 people with weak hearts who are getting a defibrillator (ICD) to prevent sudden cardiac death. Researchers want to see if detailed heart MRI scans can better predict who will actually have a dangerous heart rhythm, compared to current methods. The goal is …

This study looks at whether alerts in electronic health records can encourage doctors to follow clinical guidelines for bronchiolitis, a common lung infection in young children. About 8,000 children will be included, and their doctors will receive either no alert, a gentle remind…

This study aims to understand how COVID-19 infection and mRNA vaccines affect pregnant women, their newborns, and breastfeeding mothers. Researchers will collect blood, placenta, and breast milk samples from 300 participants to measure immune responses and check for signs of infl…

This study tests a program called Heart-to-Heart, where a community health worker helps heart patients with low income decide whether to join cardiac rehab. The goal is to see if the program is practical and if participants like it. About 50 adults from Johns Hopkins hospitals wi…

This study looks at why some children become overweight by examining their eating habits, brain activity, and family history. Researchers will measure how kids' brains respond to food and how well they control their eating. The goal is to find early warning signs so doctors can h…

This study looks at how the uterus absorbs fluid during early pregnancy, which may affect fertility. Researchers will compare tissue samples from women with and without endometriosis or infertility. The goal is to understand the role of certain proteins in this process. 140 healt…

This study tests a program called Communities Care, which works to change harmful social norms that lead to violence against women and girls. About 3,500 adults and teens (ages 10 and older) in Somalia will take part. Researchers will measure changes in experiences of violence, b…