Johns Hopkins University

This study tests if a 2-month combination of four TB drugs can cure drug-susceptible tuberculosis in children under 10 as safely and effectively as the standard 4- to 6-month treatment. A shorter regimen could be easier for children to tolerate and complete, and reduce the burden…

This study tests the RSV vaccine Arexvy in 170 adults with weakened immune systems to see if one or two doses work better. Participants will receive three vaccine doses over a year and be monitored for side effects and immune response. The goal is to find the best way to protect …

This study aims to find the best way to encourage more Latino adults and their friends to get the COVID-19 vaccine. Researchers will compare two methods: teaching some people motivational interviewing skills versus simply providing vaccine information. The goal is to see which ap…

This early-stage study tests whether psilocybin, the active ingredient in magic mushrooms, can help people with cannabis use disorder cut back or stop using cannabis. Twelve adults will receive two psilocybin sessions with psychological support and be followed for 6 months. The g…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help adults with obesity and binge-eating disorder. About 105 participants will receive tirzepatide, a placebo, or another drug (lisdexamfetamine), plus guided self-help therapy. The main goals ar…

This study tests a 5-session program for Black women living with HIV who have experienced intimate partner violence in the past two years. The program teaches skills to find strength, improve communication, and overcome barriers to HIV care. Researchers will check if the program …

This early-stage trial tests whether giving two medicines—erythropoietin and melatonin—together is safe for very premature babies who have bleeding in the brain. About 60 infants will receive either the drug combo or a placebo, plus standard care. The goal is to see if this treat…

This study tests a program to help 800 adults in Africa control their high blood pressure. The program includes support for patients, healthcare providers, and the health system. The goal is to lower blood pressure and reduce the risk of heart disease, stroke, and kidney disease.

This study tests a device called a vestibular implant, which electrically stimulates the balance nerve to help people with severe, long-term dizziness and unsteadiness. Researchers will follow 15 adults (ages 22–90) for up to 4 years after implantation to see if it improves walki…

This study looks at whether a stepped-care digital health program can help adults with obesity maintain at least 5% weight loss for a year. Participants first lose weight through a 16-week diet and group counseling. Those who succeed are then randomly assigned to usual care, self…

This study tests whether a mobile app and electronic pillbox can help adolescents and young adults (ages 13-25) who have had a kidney or liver transplant take their anti-rejection medication on time. Participants use a smart pillbox that tracks when they take their pills, and if …

This study tests a digital health program called Corrie Lipids in about 1,000 adults with high LDL cholesterol and elevated heart disease risk. Participants use a smartphone app, get clinician coaching, and have their care streamlined to help them reach cholesterol goals. The goa…

This study tests whether eating more omega-3 fats (found in fish and certain oils) can improve health and quality of life for people with COPD. Researchers will provide food to 200 adults with moderate-to-severe COPD and track changes in breathing, flare-ups, and daily function. …

This study tests a brain implant system that records neural signals and stimulates the brain to help people with tetraplegia control assistive devices like robotic arms. Up to 5 participants with C4-C6 spinal cord injuries will be enrolled. The main goal is to see if the device i…

This study tests a program that helps adults with uncontrolled high blood pressure plus diabetes or kidney disease. Participants use a home blood pressure monitor that sends readings to a care team, including a community health worker and a pharmacist. The goal is to see if this …

This study tests a new approach to hand and arm transplantation for people who have lost a hand or arm due to injury. The goal is to help the body accept the new limb while reducing the need for strong, lifelong anti-rejection drugs that can cause serious side effects. Up to 30 p…

This study tests a program called PICU Up! that helps critically ill children start moving earlier while in the intensive care unit. The program combines gentle exercise, better sedation practices, and family involvement. Researchers want to see if this approach can reduce the ti…

This study looks at when to start Hepatitis C (HCV) medication for people without HCV who receive a kidney from an HCV-positive donor. One group starts the medicine before transplant and takes it for 2 weeks; the other starts after transplant and takes it for 12 weeks. The goal i…

This study tests a device that electrically stimulates the balance nerve to help people with severe, long-term dizziness and unsteadiness. Researchers will implant the device in up to 8 adults whose balance problems did not improve with therapy. The goal is to see if the implant …

This study tests a new device, a vestibular implant, in 15 older adults (ages 65-90) who have long-term balance problems and dizziness from inner ear damage. The implant electrically stimulates the balance nerve to help restore steadiness and clear vision during movement. Researc…

This early-stage study tests if giving a newborn a dose of their parent's nasal bacteria can safely increase the variety of germs in the baby's nose. The goal is to see if this can help prevent dangerous infections like staph. The study involves 175 premature babies in the NICU a…

This study compares two ways to treat Gram-negative bloodstream infections: staying on IV antibiotics versus switching to oral pills early. Researchers want to see if the oral option works just as well but causes fewer side effects. About 1,030 hospitalized adults will take part.

This study tests whether adding Dysport (a muscle-relaxing injection) to standard back bracing can slow or stop spine curvature in teens with scoliosis. About 90 adolescents aged 10-16 with moderate curves will receive either Dysport or a placebo, plus a brace. The goal is to see…

This study looks at ways to help adolescents and young adults with HIV get the virus under control. It helps them choose the best treatment, including long-acting shots, and removes barriers to getting that treatment. The goal is to help more young people achieve and maintain vir…

This study tests whether adding a person's own concentrated bone marrow cells to standard hip decompression surgery can prevent the hip ball from collapsing and delay or avoid the need for a hip replacement. It enrolls 192 adults with early-stage osteonecrosis (before collapse) a…

This study looks at whether giving patients IV fluids at home for four weeks after bladder cancer surgery can lower the chance of needing to go back to the hospital. About 130 adults having this surgery will be randomly assigned to either get the usual care or the usual care plus…

This early study tests if a drug called IMLYGIC, already used for some skin cancers, can safely treat bothersome skin tumors in adults with NF1. Ten participants will receive injections directly into their tumors over four cycles. The goal is to see if the treatment is feasible a…

This study tests a drug called mirdametinib in adults with NF1 who have at least 24 skin tumors (cutaneous neurofibromas). The goal is to find the safest dose and see if it can shrink the tumors. The trial involves 24 participants and is run at Johns Hopkins University.

This study compares doing flap surgery within 72 hours of a severe leg injury versus waiting longer. Flap surgery uses skin and muscle to cover open fractures and dislocations below the knee. The goal is to see if faster surgery reduces death, amputation, infections, and hospital…

This study tests a 6-month program that combines exercise training, problem-solving help, and community health worker support for 210 adults with type 2 diabetes, obesity, and early heart problems. Participants must have low income and live in Baltimore or Washington County, Mary…

This study compares two types of light used during bladder cancer surgery to see which better removes tumors and prevents return of the disease. About 200 adults with high-risk non-muscle invasive bladder cancer will be randomly assigned to standard white-light or enhanced blue-l…

This study tests if people with atrial fibrillation (AFib) can use a smartwatch to guide when they take blood thinners, instead of taking them every day. The goal is to see if this approach is as good at preventing strokes while causing fewer bleeding problems. About 5,350 adults…

This study compares two short-term crisis interventions for young people ages 12-24 who are at risk for suicide. The goal is to see which approach works better at reducing suicidal thoughts and attempts. The study will enroll 1,000 participants from emergency departments in five …

This study tests whether wearing a custom-made external skull prosthetic can prevent Sunken Flap Syndrome, a condition where the brain sinks after a large piece of skull is removed to relieve pressure. About 72 adults who had this surgery will either wear the prosthetic or receiv…

This study looks at whether children aged 1 to 17 with well-controlled atopic dermatitis (eczema) can safely reduce the dose or stop taking dupilumab, a medication that helps control the condition. Researchers will monitor 30 children who have been on dupilumab for at least a yea…

This study tests whether a drug that activates GLP-1 receptors can slow brain and eye damage in people with multiple sclerosis (MS). The drug is already used for diabetes and weight loss. About 120 adults with stable MS will receive either the drug or a placebo for 96 weeks. Rese…

This study tests whether the drug Isturisa can improve health in people with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. Researchers will measure changes in blood sugar, cholesterol, weight, bone density, and quality of life over…

This study tests whether providing healthy food and lifestyle coaching can help adults with high blood pressure and type 2 diabetes living in areas with few grocery stores. About 80 participants will be randomly assigned to receive either standard diet advice or extra coaching an…

This study tests whether offering small financial rewards and using video calls to watch people take their medicine can help more people finish their treatment for latent tuberculosis. About 399 adults in Baltimore who are starting treatment will be split into two groups: one get…

This study tests if the drug tesamorelin can help nerves regrow and muscles recover after a serious nerve injury in the arm. About 36 adults with a cut ulnar nerve at the wrist will either receive tesamorelin or no extra treatment after surgery. Researchers will check pinch stren…

This study tests whether an 8-week or 24-week pulmonary rehabilitation program (breathing exercises and physical training) can improve lung function and quality of life in adults who have recently started treatment for tuberculosis. About 690 participants will be randomly assigne…

This study looks at whether a special high-fat, low-carb diet (modified Atkins diet) can help children with new-onset absence epilepsy without using standard seizure medications. About 40 children aged 3-12 will either follow the diet or take medication, based on their family's c…

This study follows 80 pregnant women whose babies have a severe diaphragmatic hernia. Half receive a fetal surgery called FETO, which temporarily blocks the windpipe to help the lungs grow. The goal is to see if FETO improves survival to discharge and reduces health problems up t…

This study tests whether metformin, a common diabetes drug, can improve asthma control in overweight or obese adults whose asthma is not well-controlled by their current inhalers. About 100 participants will take metformin or a placebo for 24 weeks and have their asthma symptoms,…

This study tests a program called Full-SPARCS, where trained peers help people with HIV stay on their medication and in care after they leave prison in South Africa. About 400 participants will be assigned to either the peer program or standard care. The main goal is to see if th…

This study tests a new way to help adults in Baltimore quit smoking. Participants use a computer program with an avatar that guides them through quitting, plus they get support from a community health worker who can also help them schedule a lung cancer scan. The study will see i…

This early study tests a brain implant in 5 adults with severe paralysis (from spinal cord injury, ALS, or similar conditions). The goal is to see if the device is safe and can help users control assistive devices like computers or wheelchairs. The implant records brain signals a…

This study is testing a simple, non-invasive device called EsophaCap — a sponge in a capsule that you swallow. It collects cells from the food pipe and stomach to look for DNA changes that might signal early cancer or pre-cancer conditions like Barrett's esophagus. The goal is to…

This study tests whether a new ultra-high resolution CT scan is better than a standard CT at finding blocked arteries in the heart. About 140 adults with possible heart disease will get one scan that creates both types of images, so no extra radiation is needed. The goal is to se…

This early-stage trial tests a new robot called ProBot that helps doctors perform prostate biopsies with greater precision. The robot uses a special ultrasound probe and aims to reduce pain and improve accuracy when taking tissue samples. About 60 men aged 40-75 with high-risk fe…

This study tests whether a special camera with artificial intelligence can help more young people with diabetes get screened for diabetic retinopathy, an eye disease that can lead to blindness. The study will include 500 underserved youth with type 1, type 2, or cystic fibrosis-r…

This study tests whether adding testing for common sexually transmitted infections (STIs) to standard risk screening helps more young women in Uganda start and stay on PrEP, a daily pill that prevents HIV. About 5,560 women aged 15-39 will be randomly assigned to either standard …

This study tests a mobile van that offers HIV and STI testing to men who have sex with men (MSM) in Baltimore, recruited through online spaces. Participants get either a peer health navigator to help them start PrEP or HIV care, or just a referral. The goal is to see if the navig…

This study looks at how a one-time dose of two F/TAF tablets (a common HIV prevention pill) works in the body over 14 days. It involves 24 healthy volunteers to measure drug levels inside cells. The goal is to see if a higher single dose could be a simpler way to prevent HIV.

This study tests whether a 4-week course of the drug bedaquiline can prevent tuberculosis (TB) as well as the standard longer treatments. It includes 2,530 people living with HIV and close contacts of TB patients, who are at high risk. If successful, this shorter regimen could ma…

This study tests whether a relaxation technique called progressive muscle relaxation (PMR) — done with or without virtual reality (VR) — can help adult burn survivors manage ongoing symptoms like pain, itch, anxiety, sleep problems, and fatigue. About 34 participants will try bot…

This study tests a safe, painless brain stimulation technique called tDCS to see if it can improve language skills in people with primary progressive aphasia (PPA), a condition that slowly destroys the ability to speak and understand language. Researchers will compare real tDCS t…

This study tests if wearing special tape over the mouth at night can reduce snoring and improve sleep for people with mild sleep apnea. Researchers will have 100 adults and their bed partners try the tape at home and report on snoring, sleep quality, and how easy the tape is to u…

This study tests a digital program designed to help immigrant women who have faced violence and struggle with PTSD or depression. The program provides tools to reduce stress, improve safety, and build self-care habits. Researchers will enroll 676 women to see if the app-based app…

This study tests whether a low-dose, slow-release form of levetiracetam (AGB101) can reduce overactivity in a key memory region of the brain in healthy older adults. Overactivity in this area is linked to higher dementia risk. Sixty participants aged 50-80 will receive both the d…

This early-stage study at Johns Hopkins University is testing whether psilocybin, a psychedelic compound, is safe for people who had a stroke at least one year ago. The study will enroll 20 adults and closely monitor their blood pressure and any psychiatric changes. The goal is t…

This study looks at whether switching from ocrelizumab to ublituximab can help people with multiple sclerosis (MS) who experience a return of symptoms before their next dose. About 50 adults with relapsing MS who have been on ocrelizumab for at least a year and notice this 'weari…

This study tests if treating insomnia first helps breast cancer survivors lose more weight. 250 women who are overweight and have insomnia will get either sleep therapy or sleep education, followed by a weight loss program. The goal is to see if better sleep leads to greater weig…

This early-stage study tests whether giving both psilocybin and MDMA together is safe and can help reduce PTSD symptoms in 40 military veterans. Participants will be closely monitored for side effects and changes in PTSD severity. The goal is to gather initial safety data and see…

This study tests Scrambler Therapy, a non-invasive device that sends gentle electrical signals through the skin to retrain how the brain feels pain. It is for adults with chronic pancreatitis whose belly pain has not improved with standard treatments. About 40 participants will r…

This study tests a 8-10 week program for caregivers with physical or sensory disabilities who care for a loved one. The program includes help finding resources, personal self-care planning, emergency and end-of-life preparation, and peer support. The goal is to see if it reduces …

This study tests whether personalized, virtual music therapy sessions can boost memory, mood, and thinking skills in people with mild Alzheimer's or mild cognitive impairment. Sixty participants will receive two 30-minute music sessions per week for 8 weeks. Researchers will meas…

This study tests two types of talk therapy—cognitive behavioral therapy (CBT) and mindfulness-based therapy—to see which works better for treating insomnia and related depression in people who have had a mild to moderate traumatic brain injury (TBI) and also have post-traumatic s…

This study compares Scrambler Therapy, a non-drug treatment using mild electrical signals, to standard pain medications for reducing post-stroke pain. Researchers will enroll 100 adults who have had a stroke and still feel pain in affected areas. The goal is to see if Scrambler T…

This study will compare physical therapy done through video visits (telerehabilitation) with in-person clinic visits for people with chronic low back pain. Researchers will enroll 1000 adults in Maryland and Utah who have had low back pain for at least 3 months. The goal is to se…

This study tests whether a mild electrical current applied to the back of the brain (cerebellar tDCS) can enhance language therapy for people with aphasia after a stroke. About 60 adults who had a stroke at least 6 months ago and have trouble naming objects will receive either re…

This study compares two surgical techniques for bladder cancer: prostate capsule-sparing and nerve-sparing radical cystectomy. The goal is to see which approach better preserves erectile function and urinary control. 70 men with bladder cancer will be randomly assigned to one of …

This study looks at how women with bladder cancer cope, focusing on emotional distress and sexual health. About 80 participants will either receive standard care or extra educational support. They will fill out surveys about their mood and sexual function. The goal is to see if e…

This study tests a low-dose drug called AGB101 to see if it can reduce hallucinations and delusions in people with Parkinson's disease. About 30 adults aged 40-85 will take the drug and a placebo at different times for 6 weeks each. The goal is to improve psychotic symptoms witho…

This study aims to see if using mobile health technology to personalize OCD symptom tracking is acceptable and helpful for children aged 8-17 and their parents. Researchers will compare personalized cognitive-behavioral therapy (CBT) based on these assessments to standard CBT. Th…

This study tests whether a device called ScentCare, used with a companion app, can improve smell and well-being in adults aged 60+ with smell loss. Participants will use the device or solve Sudoku puzzles twice daily for 3 months. Smell function and quality of life will be measur…

This study tests whether the sleep medication trazodone can improve sleep and memory in people with early Alzheimer's disease and sleep problems. Researchers will measure changes in sleep quality and brain activity in 100 participants over several months. The goal is to see if be…

This study tests a digital toolkit (smartphone app) designed to help people with atrial fibrillation (AFib) learn about their condition, stick to treatments, and manage episodes. Researchers want to see if using the app improves quality of life and reduces AFib episodes. The stud…

This study tests if entering an MRI machine more slowly can reduce the dizziness and vertigo some people feel. Researchers will have 100 participants enter the scanner at different speeds—20 seconds, 1, 2, or 3 minutes—and report their symptoms. The goal is to find a simple way t…

This study looks at whether escitalopram, a common antidepressant, can make language therapy work better for people who have trouble speaking after a stroke. About 88 adults who had a stroke within the past three months will take the drug or a placebo while doing language exercis…

This study tests a program called CAPABLE Transplant to help people on the kidney transplant waitlist become active again. It focuses on solving barriers like frailty, depression, or lack of support. The study includes 43 adults and will see if the program improves waitlist statu…

This study tests whether a program called CAPABLE can be added to home-based primary care for older adults who feel lonely or isolated. The program helps people with daily tasks like bathing and cooking, and aims to improve quality of life for both patients and their caregivers. …

This study looks at whether cannabidiol (CBD) can reduce stress and withdrawal symptoms in people who smoke cigarettes. About 90 smokers will take CBD and then be exposed to stress. Researchers will measure mood, heart rate, and stress hormones to see if CBD helps. Some participa…

This study tests whether cannabidiol (CBD) can reduce anxiety, mood problems, and agitation in adults with autism spectrum disorder. Forty participants will receive CBD for six weeks and a placebo for six weeks, with a two-week break in between. Researchers will measure changes i…

This study tests whether a mobile health program (mPATH) can help low-income older adults who have trouble sleeping and are not very active. Participants will use a smartphone app to increase physical activity, and researchers will measure changes in memory and sleep quality. The…

This study tests whether a pain management plan without opioids works just as well as one with opioids after a laparoscopic tubal sterilization (getting your tubes tied). About 120 women having this surgery will be randomly assigned to one of two pain control plans. The goal is t…

This study compares two approaches to help teenagers reduce alcohol use: brief counseling alone versus brief counseling plus a smartphone app that teaches mindfulness. Researchers will enroll 1,500 teens aged 12-17 who get care at Johns Hopkins pediatric clinics. The goal is to s…

This study is testing whether a compound from cannabis called cannabidiol (CBD) can help people stop smoking tobacco. Fifty adults who smoke more than 10 cigarettes a day and want to quit will take oral CBD during practice quit attempts. The goal is to see if CBD increases short-…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can help people with ALS who feel depressed. Researchers will check if the treatment is practical and if it improves mood, quality of life, and hopelessness. The study involves 24 adults with ALS and m…

This study looks at whether adding a structured yoga program to usual care can reduce back pain and improve quality of life for teens with scoliosis. About 500 teens aged 10-20 who have not had surgery will take part. Researchers will compare pain, sleep, mood, and activity level…

This study looks at two ways to drain fluid from around the lungs in people with advanced cancer: using gravity or a vacuum bottle. The goal is to see which method causes less chest pain during drainage. About 200 adults will take part, and their pain levels will be tracked over …

This study tests whether the antidepressant vortioxetine can improve mood symptoms and thinking skills in people with early-stage behavioral variant frontotemporal dementia (bvFTD). About 50 participants will take the drug for 12 weeks and undergo brain scans and memory tests bef…

This study tests a self-administered rehabilitation tool that gently guides people to move their heads more to reduce motion sickness and improve balance. It is for adults with motion sickness, dizziness from inner ear problems, or after certain ear surgeries. The tool aims to he…

This study tests whether giving a single dose of methadone during laparoscopic or robotic hysterectomy can reduce the need for opioid painkillers after surgery. About 100 adults with a uterus having the procedure for benign reasons will be randomly assigned to receive either meth…

This study tests if scrambler therapy, a non-invasive nerve stimulation treatment, can reduce chronic pain in people with corticobasal syndrome (CBS). About 25 adults with CBS and moderate-to-severe pain will be randomly assigned to receive either scrambler therapy or standard TE…

This study tests a hearing care program for older adults with Alzheimer's or related dementias who also have hearing loss. The goal is to see if addressing hearing loss can reduce troubling symptoms like agitation and distress, and also ease the burden on caregivers. 300 people a…

This study looks at why some children develop obesity by examining brain activity, eating habits, and genetics. Researchers will follow 210 children aged 7-12 from an existing study, using lab tests and MRI scans to measure how the brain responds to food. The goal is to find earl…

This study looks at how people with opioid use disorder handle stress. Researchers will use tasks that test thinking and emotions to see if they match how resilient people say they are. The goal is to create a better way to measure resilience in this group.

This study looks at how THC (the active part of cannabis) changes people's desire to smoke cigarettes, their cravings, and physical reactions like heart rate and blood pressure. Researchers will give different doses of THC or a placebo to 100 adults who smoke both tobacco and can…

This study follows 1,500 people with heart failure who already have an implantable defibrillator (ICD). The goal is to learn which patients are at highest risk of sudden cardiac death by looking at heart structure, electrical signals, genetics, and blood markers. This information…

This study looks at how a commercially available ketone drink, Ketone-IQ, affects sleep and breathing in 20 healthy adults. Participants will take two different doses of the drink before bed at home. They will measure their ketone levels and wear a headband to track sleep pattern…

This study aims to find biological markers in the blood that may help identify Premenstrual Dysphoric Disorder (PMDD), a severe mood condition linked to the menstrual cycle. Researchers will collect blood samples and track mood changes in 500 women—some with PMDD and some without…

This study looks at why some people have memory and thinking problems after a stroke. Researchers want to see if damage to the brain's protective barrier, seen on an MRI right after the stroke, can help predict who will have cognitive decline over the next three years. The study …

This study looks at how using vaporized cannabis and drinking alcohol at the same time affects thinking, coordination, and driving skills. About 90 healthy adults will take part in seven sessions where they receive different combinations of cannabis (placebo, 5 mg, or 25 mg THC) …

This observational study at Johns Hopkins University aims to understand how commercial kratom products affect healthy adults who use them regularly. Researchers will measure the immediate physical, mental, and emotional effects after a single dose, and then monitor what happens w…

This study tests a program that uses a patient portal to help older adults with mild cognitive impairment or dementia and their caregivers learn about and reduce potentially harmful medications. A pharmacist will work with them to align medicines with their personal goals. The st…

This study looks at whether sending text messages to first-time fathers, recruited through social media, can help them feel more confident and engaged during pregnancy and the first two months after birth. About 180 dads-to-be across the U.S. will receive texts and report on thei…

This study follows 50 people who have had a stroke and at least one risk factor like high blood pressure or diabetes. Researchers use repeated MRI scans over 15 months to watch how small blood vessel damage in the brain gets worse. The goal is to learn more about how this damage …

This study looks at how estrogen and hormonal birth control affect bone health in adolescent and young adult women with cystic fibrosis (CF). It has two parts: an observational study that follows participants for a year, and a small sub-study where volunteers use estrogen skin pa…

This study looks at whether a parenting program can help 4-5-year-olds in low-income areas do better in kindergarten. About 840 children and their families will take part. The program aims to improve children's social skills and behavior, and reduce school absences.

This study is creating a new tool to measure opioid cravings in people receiving treatment for opioid use disorder. Researchers will show participants opioid-related images and objects to trigger cravings, then interview them about their feelings and thoughts. The goal is to deve…

This study aims to find brain-based markers that can predict how well people with ADHD will respond to the medication methylphenidate. Thirty adults with ADHD will undergo brain scans and thinking tests after taking either the drug or a placebo. The goal is to improve future trea…

This study aims to see how many people visiting emergency departments in South Africa have HIV or are at high risk of getting it. Researchers will offer HIV tests to all patients and connect those who test positive to long-term care, while also referring those at risk to a preven…

This study uses a special MRI technique to measure the energy levels in the heart without any needles or tissue samples. Researchers want to see if heart failure is linked to lower energy production in the heart muscle. The study includes healthy volunteers and people with heart …

This study looks at whether listening to a steady beat (like a metronome) can improve walking in people with Parkinson's disease who have a deep brain stimulator (DBS). Ten participants will walk while the beat plays, and researchers will measure their step speed, stride length, …

This study aims to see if certain psychoactive substances can produce experiences similar to classic psychedelics. Fifty healthy volunteers aged 25-55 will receive up to 6 different drugs or a placebo in blinded sessions. Researchers will measure mystical-type effects using a sta…

This study tests whether a new digital tool and communication training can help doctors talk more effectively with parents about safe sleep practices for infants. About 350 parents and their babies will take part, with some doctors using the new tool and others providing standard…

This study looks at how the immune system of adults over age 75 responds to the annual flu shot. Researchers want to know if a common virus called CMV affects that response. About 1,025 healthy or frail older adults will join. Participants get the flu shot for free and provide bl…

This study looks at 1000 healthy people aged 25 to 35 to understand how their lungs and heart blood vessels are built and how well their lungs exchange gases. Researchers want to see if things like environment and general health are linked to lung structure and function. Particip…

This study looks at whether eating dinner earlier in the day can improve how the body burns fat and handles blood sugar. Researchers will compare early versus late dinner in 32 adults, including healthy-weight individuals and those with obesity and prediabetes. The goal is to und…

This study creates a registry for people under 26 with atopic dermatitis (eczema) who have used or will start systemic treatments. Researchers will collect data from medical records and surveys to see how well these treatments work and how they affect quality of life. The goal is…

This study compares group postpartum and well-child care to standard individual care for mothers and infants in Malawi. Researchers will measure effects on postpartum depression and infant immunization rates. About 1,125 mother-infant pairs will participate, with results expected…

This study looks at how the cerebellum, a part of the brain, influences alcohol cravings and the brain's reward system in people with alcohol use disorder (AUD). Researchers will compare 122 adults with AUD to healthy volunteers using brain scans and mild electrical stimulation. …

This study looks at how a brain area called the cerebellum helps with thinking, not just movement. Researchers will use mild brain stimulation in 50 healthy adults to see if it changes brain activity during tasks that involve predicting the next item in a sequence. The goal is to…

This study tests whether a drink containing ketones can change how healthy people breathe, especially during sleep. Twenty volunteers will try the drink and a placebo on separate days. The goal is to see if ketones might one day help with conditions like sleep apnea or high-altit…

This study is testing a new way to find early signs of pancreas cancer in people at high risk, such as those with a strong family history or certain gene mutations. Researchers will collect and analyze pancreatic juice during a routine endoscopy to look for cancer markers. The go…

This study is testing a web-based app that helps people waiting for a kidney or liver transplant share their story on social media to find a living donor. Researchers want to see if this approach brings in more potential donors and leads to more transplants. About 1,000 adults on…

This study is testing an artificial intelligence (AI) tool that helps emergency room doctors detect and manage acute kidney injury (AKI) earlier. Researchers will roll out the tool at three hospitals and track whether it improves care, such as catching kidney issues sooner and av…

This study tests a new imaging method called full-field optical coherence tomography (FFOCT) to see if it can quickly analyze small lung biopsy samples as accurately as standard lab tests. About 20 adults having a bronchoscopy for diagnosis or staging will participate. The goal i…

This study looks at whether a special CT scan can measure scarring in the heart muscle of people with atrial fibrillation (AF) before they have a procedure called ablation. The goal is to see if more scarring leads to worse outcomes, like the AF coming back or needing hospital vi…

This study looks at how your natural sleep type (night owl vs. early bird) affects blood sugar control in overweight young adults aged 18-23. Researchers will compare glucose tests and meals given at times that match or clash with each person's internal clock. No treatment is giv…

This early-stage lab study uses cells from 8 people with chronic sinusitis and nasal polyps to see how the drug mepolizumab affects inflammation and the health of the cells lining the nasal passages. Researchers want to understand if mepolizumab can reduce inflammation and help m…

This study follows 10,000 healthy adults for up to 20 years to find ways to detect cancer earlier. Participants provide blood samples and answer questions about lifestyle and medications. The goal is to identify changes in proteins, RNA, and DNA that appear before a cancer diagno…

This study looks at how the womb absorbs fluid during early pregnancy, which may affect fertility. Researchers will take small tissue samples from the womb lining of 140 women, some with endometriosis and some without. The goal is to understand differences in key proteins that co…

This study tests a new device that continuously measures pressure in the leg to detect a serious condition called compartment syndrome in patients on ECMO life support. Because these patients are sedated and can't report symptoms, the device may help doctors diagnose the problem …

This study looks at whether measuring how the airway opens during a sleep exam can predict if a nerve stimulator (Inspire) will work for people with obstructive sleep apnea who cannot use CPAP. About 60 adults with moderate to severe sleep apnea will take part. Researchers will s…

This study looks at how old, worn-out cells (senescent cells) might cause uterine fibroids—non-cancerous growths in the womb. Researchers will analyze tissue samples from 150 women with fibroids to map these cells and their signals. The goal is to better understand the disease, n…

This study aims to document how TRPV4 neuropathy changes over 6 years in people with a confirmed TRPV4 gene mutation. Researchers will track symptoms, nerve function, and disability using standard scales. Participants (ages 3–80) must visit Johns Hopkins annually. No treatment is…

This study from Johns Hopkins University aims to understand how commercial kratom extract products affect mood, thinking, and physical signs like heart rate and pupil size in adults who regularly use them. Researchers will also study how the body processes these products. The stu…

This study looks at how THC (the active part of cannabis) changes people's desire for e-cigarettes, their cravings, and physical reactions like heart rate. Researchers will give different doses of THC or a placebo to 100 adults who regularly use both e-cigarettes and cannabis. Th…

This study tests a program called Communities Care that aims to change harmful social norms linked to violence against women and girls in Somalia. About 3,500 adults and adolescents (age 10 and older) will take part in the program or be in a comparison group. Researchers will mea…

This study aims to see if doctors can change normal skin into the thicker, tougher skin found on palms and soles. Researchers will take a small skin sample, grow the cells in a lab, and inject them back into the skin. After some time, they will remove a tiny piece to check for ch…

This study looks at how heart failure may cause brain volume loss. Researchers will use MRI scans to measure brain structures in 100 adults with heart failure and compare them to people with normal heart function. The goal is to understand the link between heart health and brain …

This study looks at how well leg muscles produce energy in people aged 60 and older, both with and without HIV. Researchers want to see if muscle metabolism problems are linked to difficulty exercising. Participants will undergo muscle tests and walking assessments. The goal is t…

This study looks at whether a higher dose of aspirin can help people with COPD by reducing inflammation caused by blood platelets. Researchers will test two different doses in 48 former smokers with COPD to see which one works better. The goal is to find the right dose for a futu…

This study looks at why people with heart failure with preserved ejection fraction (HFpEF) have trouble exercising. Researchers will measure energy use in the heart and leg muscles using special scans. The goal is to understand the problem better, not to test a treatment. About 1…

This study follows 5,000 adults with pancreatic cysts to learn how these cysts behave over time. Researchers aim to create a better way to tell which cysts are harmless and which may turn into cancer. Participants provide medical records and samples, helping doctors improve early…

This study is testing whether very small doses of psilocybin (the active ingredient in magic mushrooms) are safe for healthy adults to take at home. Twenty healthy volunteers will receive different doses in a controlled lab setting, with their blood pressure, heart rate, and ment…

This study aims to understand how BCG treatment for non-muscle invasive bladder cancer affects patients' mood. About 42 adults receiving BCG therapy will provide blood and urine samples and fill out mood questionnaires and daily diaries. The goal is to see if changes in the body'…

This study aims to understand why some women develop Premenstrual Dysphoric Disorder (PMDD), a severe form of PMS. Researchers will measure brain-related hormones and proteins in the blood of 288 women with and without PMDD during their menstrual cycle. They will also test how a …

This study is creating a database of health information from people with achondroplasia, a bone growth condition. Researchers will collect data from medical records of up to 1,500 patients across several U.S. hospitals. The goal is to better understand growth patterns, surgeries,…