Could a mild zap to the brain help you find your words?
NCT ID NCT05386394
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase II trial tests whether a safe, non-invasive brain stimulation technique called tDCS, combined with language therapy, can improve word-finding in people with primary progressive aphasia (PPA). The study enrolls 180 adults aged 50–90 with certain types of PPA. Participants receive either real or sham tDCS during therapy sessions, and researchers measure changes in speaking accuracy right after treatment and again three months later.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
transcranial direct current stimulation (tDCS) — a gentle electrical current applied to the brain
What this could lead to
If it works, this could provide a safe, at-home-usable treatment to help people with primary progressive aphasia speak and name objects more accurately.
What could go wrong
This is a mid-stage trial with 180 participants, so results are not yet proven. The improvement may be small or not last long, and not everyone may benefit.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Baycrest Centre for Geriatric Care
RECRUITINGToronto, Ontario, M6A 2E1, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Johns Hopkins Hospital
RECRUITINGBaltimore, Maryland, 21287, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact