Could a mild zap to the brain help you find your words?

NCT ID NCT05386394

Recruiting now Symptom relief Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase II trial tests whether a safe, non-invasive brain stimulation technique called tDCS, combined with language therapy, can improve word-finding in people with primary progressive aphasia (PPA). The study enrolls 180 adults aged 50–90 with certain types of PPA. Participants receive either real or sham tDCS during therapy sessions, and researchers measure changes in speaking accuracy right after treatment and again three months later.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: transcranial direct current stimulation (tDCS) — a gentle electrical current applied to the brain
What this could lead to: If it works, this could provide a safe, at-home-usable treatment to help people with primary progressive aphasia speak and name objects more accurately.
What could go wrong: This is a mid-stage trial with 180 participants, so results are not yet proven. The improvement may be small or not last long, and not everyone may benefit.

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Conditions

The condition(s) this trial relates to.

logopenic progressive aphasia primary progressive aphasia progressive non-fluent aphasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOGOPENIC PROGRESSIVE APHASIA NON-FLUENT PRIMARY PROGRESSIVE APHASIA PRIMARY PROGRESSIVE APHASIA

Contacts and locations

Locations

Baycrest Centre for Geriatric Care
RECRUITING

Toronto, Ontario, M6A 2E1, Canada
Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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