PRIMARY PROGRESSIVE APHASIA

This study tests whether mild electrical or sensory stimulation can improve short-term memory for words in people with primary progressive aphasia (PPA), a condition that slowly damages language areas of the brain. Twenty participants will receive real or fake stimulation while d…

This study tests a speech therapy program for bilingual Spanish-English or Spanish-Catalan speakers with primary progressive aphasia, a condition that slowly damages language abilities. Sixty participants will receive personalized script training via video sessions, while 30 othe…

This study tests a non-invasive brain stimulation technique called temporal interference stimulation (TIS) to see if it can improve cognitive function in people with mild cognitive impairment or early Alzheimer's disease. Sixty participants will receive either real TIS or a sham …

This study tests an educational support group program for people with progressive aphasia (a language disorder caused by Alzheimer's or other dementias) and their carepartners. The program includes group education, support sessions, and communication skills training. Researchers …

This study tests two types of speech therapy for adults with mild-to-moderate primary progressive aphasia, a condition that slowly impairs language. Researchers will compare the therapies in 200 participants to see which better improves communication and reduces caregiver burden.…

This Phase II trial tests whether a safe, non-invasive brain stimulation technique called tDCS, combined with language therapy, can improve word-finding in people with primary progressive aphasia (PPA). The study enrolls 180 adults aged 50–90 with certain types of PPA. Participan…

This study tests whether a gentle electrical current applied to specific brain areas can boost the effects of language therapy in people with logopenic variant primary progressive aphasia (lvPPA), a form of Alzheimer's that mainly affects language. Sixty participants will receive…

This study screens 360 adults with neurodegenerative disorders like ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will use medical history, physical exams, memory tests, movement analysis, MRI scans, and other tests to find common features and diff…

This study tests whether a non-invasive technique called repetitive Transcranial Magnetic Stimulation (rTMS) can improve memory and brain function in older adults with mild cognitive impairment or early Alzheimer's. Over 30 participants will receive both real and sham (placebo) s…

This study at Mayo Clinic looks at two different types of Progressive Apraxia of Speech, a condition that makes it hard to speak clearly. Researchers will use brain scans, speech assessments, and thinking tests in 47 adults to better tell these types apart. The goal is to improve…

This study follows 500 people with primary progressive aphasia, a condition that slowly damages the brain's language areas. Researchers will use brain scans and language tests to map how the disease progresses over time. The goal is to better understand the disease, not to test a…

This study is looking for 500 people with early dementia or mild cognitive impairment to help develop a way to predict how their disease will progress. Researchers will use blood tests and other models to better understand each person's outlook. The goal is to give patients and d…

This study uses advanced brain scans, including a special PET tracer called AV-1451, to track changes in the brains of 50 people with progressive apraxia of speech (a disorder that affects the ability to coordinate speech movements). Researchers at Mayo Clinic will compare these …