Speed saves limbs: trial tests 72-Hour flap surgery for crushed legs

NCT ID NCT06293469

Recruiting now Disease control Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares getting flap surgery within 72 hours of a severe leg injury versus waiting longer. The goal is to see if faster surgery reduces death, amputation, infections, and hospital stays. About 356 adults with open fractures or dislocations below the knee will take part.

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Conditions

The condition(s) this trial relates to.

bone fracture Leg Injuries tibia fracture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTREMITY FRACTURE LOWER EXTREMITY INJURIES LOWER OPEN DISLOCATION OF ANKLE OPEN TIBIA FRACTURE

Contacts and locations

Locations

John Hopkins Bayview Medical Center
RECRUITING

Baltimore, Maryland, 21224, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
R Adams Cowley Shock Trauma Center
RECRUITING

Baltimore, Maryland, 21201, United States
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
The Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States
UC Davis Medical Center
RECRUITING

Sacramento, California, 95817, United States
University of Maryland Capital Region Medical Center
RECRUITING

Largo, Maryland, 20774, United States
Vall d'Hebron University Hospital
RECRUITING

Barcelona, 08035, Spain
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States

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