New Antibiotic-Coated nail aims to stop bone infections after severe leg breaks
NCT ID NCT05421741
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether coating a metal rod (intramedullary nail) with antibiotics (vancomycin and gentamicin) can prevent deep infections in people with severe open tibia fractures. About 484 adults with Gustilo Type II or III open tibia fractures will be randomly assigned to receive either the antibiotic-coated nail or a standard nail. The main goal is to see how many develop a deep surgical site infection within 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
antibiotic-coated intramedullary nail (vancomycin and gentamicin mixed with bone cement)
What this could lead to
If it works, this could provide a simple way to prevent serious bone infections after open tibia fractures, reducing the need for additional surgeries and antibiotics.
What could go wrong
This is a single trial with 484 participants, and the antibiotic coating may not reduce infections significantly. There is also a risk of allergic reactions or antibiotic resistance.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for OSTEOMYELITIS TIBIA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Atrium Health Cabarrus
RECRUITINGConcord, North Carolina, 28025, United States
Contact
Contact
Contact
Contact
-
Atrium Health Carolinas Medical Center
RECRUITINGCharlotte, North Carolina, 28203, United States
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
Contact
-
Atrium Health Navicent
RECRUITINGMacon, Georgia, 31201, United States
Contact
Contact
-
Atrium Health Wake Forest Baptist
RECRUITINGWinston-Salem, North Carolina, 27157, United States
Contact
Contact
-
Carilion Clinic
NOT_YET_RECRUITINGRoanoke, Virginia, 24016, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Florida Orthopaedic Institute
RECRUITINGTemple Terrace, Florida, 33637, United States
Contact
Contact
-
Penn State Milton S. Hershey Medical Center
RECRUITINGHershey, Pennsylvania, 17033, United States
Contact Email: •••••@•••••
Contact Email: •••••@•••••
-
San Antonio Military Medical Center
RECRUITINGSan Antonio, Texas, 78234, United States
Contact
Contact
-
University of Florida Gainesville
RECRUITINGGainesville, Florida, 32607, United States
Contact
Contact
-
University of Kentucky
RECRUITINGLexington, Kentucky, 40536, United States
Contact
Contact
-
University of North Carolina Chapel Hill
RECRUITINGChapel Hill, North Carolina, 27546, United States
Contact
Contact
-
University of Texas Houston
RECRUITINGHouston, Texas, 77030, United States
Contact
Contact
-
Valley Health System
RECRUITINGWinchester, Virginia, 22601, United States
Contact Email: •••••@•••••
Contact Email: •••••@•••••
-
Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
Contact
Contact