New coated nail could stop infections in severe leg breaks
NCT ID NCT05421741
First seen Oct 01, 2025 · Last updated May 14, 2026 · Updated 27 times
Summary
This study is for adults with a severe open break of the shin bone (tibia) who need surgery to fix it with a metal rod (nail). The researchers want to see if using a nail coated with antibiotics can prevent deep bone infections better than the standard uncoated nail. About 484 people will take part and be followed for one year to check for infections and bone healing.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Phone: •••-•••-•••• Email: •••••@•••••
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Atrium Health Cabarrus
RECRUITINGConcord, North Carolina, 28025, United States
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Atrium Health Carolinas Medical Center
RECRUITINGCharlotte, North Carolina, 28203, United States
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Atrium Health Navicent
RECRUITINGMacon, Georgia, 31201, United States
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Atrium Health Wake Forest Baptist
RECRUITINGWinston-Salem, North Carolina, 27157, United States
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Carilion Clinic
NOT_YET_RECRUITINGRoanoke, Virginia, 24016, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Florida Orthopaedic Institute
RECRUITINGTemple Terrace, Florida, 33637, United States
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Penn State Milton S. Hershey Medical Center
RECRUITINGHershey, Pennsylvania, 17033, United States
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San Antonio Military Medical Center
RECRUITINGSan Antonio, Texas, 78234, United States
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University of Florida Gainesville
RECRUITINGGainesville, Florida, 32607, United States
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University of Kentucky
RECRUITINGLexington, Kentucky, 40536, United States
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University of North Carolina Chapel Hill
RECRUITINGChapel Hill, North Carolina, 27546, United States
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University of Texas Houston
RECRUITINGHouston, Texas, 77030, United States
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Valley Health System
RECRUITINGWinchester, Virginia, 22601, United States
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
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Conditions
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