Tibia fracture

This study tests whether a new antibiotic protocol can prevent infections in people with severe open fractures (where the bone breaks through the skin). The experimental group gets antibiotics applied directly to the wound before closure, plus extended systemic antibiotics. The c…

This study compares a standard metal rod (nail) used to fix shinbone fractures with a new 'micromotion' nail that allows a tiny amount of movement at the break. Researchers want to see if the new nail helps bones heal faster and with fewer problems. About 100 adults with stable s…

This study tests whether a negative pressure wound therapy (NPWT) device, placed over the surgical incision, can reduce infections and other wound complications compared to standard dressings in people with severe leg fractures. The trial will enroll 352 patients with high-risk t…

This study looks at whether giving less intravenous (IV) fluid to critically ill children with traumatic injuries leads to fewer complications. Currently, there is no standard for how much fluid these children should receive. The trial will enroll 250 children aged 6 months to 15…

This Phase 3 trial tests whether antibiotic cement beads or negative pressure wound therapy (a wound vac) works better for severe open tibia fractures. 312 adults with these injuries will be randomly assigned to one of the two treatments. Researchers will compare death, amputatio…

This study tests whether injecting N-acetylcysteine (NAC), an antioxidant, into the ankle right after a severe pilon fracture can keep cartilage cells alive and reduce the chance of developing post-traumatic arthritis. Thirty adults with closed high-energy pilon fractures will re…

This study follows 300 people who receive the IlluminOss device to treat broken bones from injury or disease. Researchers will track how well the device works, how safely it performs, and how patients recover over time. The goal is to gather real-world data on bone healing and re…

This study tests whether special crutch tips with sensors can help heal a specific type of shinbone fracture. Thirty people who had surgery for a broken tibia will use the smart crutches for up to 24 weeks. The crutches give real-time feedback to guide how much weight to put on t…

This study tests whether special crutch tips that measure how much weight you put on your leg can help a broken shinbone heal better. Thirty people who had surgery for a tibial fracture will use the smart tips for up to 24 weeks, following a personalized walking plan based on CT …

This study tests whether personalized weight-bearing instructions using smart crutch tips can help heal tibia fractures faster. Thirty adults who had surgery for a broken shinbone will use sensor-equipped crutch tips that give real-time feedback on how much weight they put on the…

This study is testing special screws that dissolve over time, used in foot and ankle surgeries for fractures, realignments, or joint fusions. The screws are meant to hold bones together while they heal, then safely absorb into the body. Researchers will follow 125 adults for 4 ye…

This study is testing a special 3D-printed cage called the TRUMATCH Graft Cage to help repair large bone defects in the arm or leg. Five adults with hard-to-heal breaks will receive the cage during surgery. Researchers will track healing, complications, and recovery time over thr…

This study compares two treatments to help blood clot in severely injured trauma patients who are bleeding heavily. One is a standard frozen blood product (cryoprecipitate) that takes time to thaw, and the other is a dry powder (fibrinogen concentrate) that can be given at the be…

This study compares two types of surgery for unstable ankle fractures in frail adults aged 60 and older. One group gets ankle fusion (joining the bones together), and the other gets open reduction and internal fixation (using plates and screws to hold the bones in place). A secon…

This study tests whether adding a collagen scaffold called Miro3D to standard wound care helps acute and chronic wounds heal better than standard care alone. About 70 adults with soft tissue wounds or pressure ulcers will be randomly assigned to one of two groups. The main goal i…

This study tests a new type of metal nail coated with a noble metal alloy to fix broken shin bones (tibia fractures). The goal is to see if it reduces the chance of infection compared to standard uncoated nails. About 500 adults with high-risk fractures will be followed for 12 mo…

This study compares getting flap surgery within 72 hours of a severe leg injury versus waiting longer. The goal is to see if faster surgery reduces death, amputation, infections, and hospital stays. About 356 adults with open fractures or dislocations below the knee will take par…

This study is testing whether eating almonds can help heal broken thigh and shin bones as effectively as vitamin D supplements, but with fewer side effects and lower cost. The trial will include 136 adults with these fractures, who will receive either almonds, vitamin D, or both,…

This study tests whether coating a metal rod (intramedullary nail) with antibiotics (vancomycin and gentamicin) can prevent deep infections in people with severe open tibia fractures. About 484 adults with Gustilo Type II or III open tibia fractures will be randomly assigned to r…

This study tests whether a short form of exposure therapy, given soon after a traumatic injury, can prevent posttraumatic stress disorder (PTSD). Researchers will enroll 300 injured adults admitted to Level I trauma centers. Half will receive the brief therapy plus standard care,…

This study tests whether placing an antibiotic depot directly into the bone during surgery can prevent infections in people with severe open tibia fractures. About 497 adults with type II or III open fractures will be randomly assigned to get either the antibiotic depot plus stan…

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This study tests whether a soft robotic glove called Carbonhand can help people with hand weakness from injury or nerve conditions perform daily activities at home. Five participants will use the glove for six weeks while researchers measure arm activity, grip strength, and well-…

This study looks at whether using a continuous passive motion (CPM) machine—a device that gently moves the leg—can help control pain and reduce the need for strong painkillers after surgery for certain leg fractures. About 100 adults who have had surgery for a broken hip socket, …

This study compares a nonopioid pain control plan to standard opioid pain medicine in 75 adults after surgery for a broken collarbone. The goal is to see if the nonopioid plan can control pain just as well while reducing opioid side effects and addiction risk. Participants are ra…

This study tests whether giving fluoxetine (Prozac) immediately after a serious injury can prevent depression, PTSD, and reduce pain and opioid use. About 200 adults with fractures or other bodily trauma will receive either fluoxetine or a placebo during their hospital stay. The …

This study tests a counseling program for caregivers of children hospitalized for a traumatic injury like burns or a car accident. The goal is to reduce PTSD and depression in both the caregiver and child. 24 caregiver-child pairs will be randomly assigned to either the counselin…

This study tests whether a single dose of ketamine given during surgery can help adults with serious orthopedic trauma recover better. Researchers want to see if it reduces pain, lowers the need for opioids, and improves symptoms of depression and PTSD. Ninety participants will b…

This study tests whether ketamine or fentanyl is better for pain relief in trauma patients with signs of shock. About 994 adults will receive one of the two drugs in the ambulance. Researchers will track survival at 24 hours and side effects like low oxygen or blood pressure.

This study looks at whether starting physical therapy soon after surgery for a specific knee fracture (tibial spine avulsion) helps people recover better than waiting longer. It includes 56 people aged 15-25 who had the surgery. Researchers will measure knee movement, muscle stre…

This study tests whether a nerve block (numbing medication injected near knee nerves) can control pain better than the usual method of numbing just the surgical cut. Researchers will compare pain scores and painkiller use in 38 adults recovering from surgery for a broken shinbone…

This study tests whether a 12-week course of a cetylated fatty acid supplement can improve bone healing after surgery for a broken femur or tibia. One hundred adults will receive either the supplement or a placebo, and healing will be tracked with X-rays and pain scores. The goal…

This study tests whether a continuous intravenous infusion of magnesium sulfate can reduce pain and the need for narcotic painkillers in critically ill trauma patients admitted to the intensive care unit. Researchers will compare magnesium to a placebo (normal saline) in 156 adul…

This study compares two types of physical therapy for people with a broken shinbone. One group will do low-weight exercises while wearing a blood flow restriction cuff on their leg. The other group will do the same exercises without the cuff. Researchers will measure muscle stren…

This Phase 2 trial tests whether 4-aminopyridine, a drug already used for other conditions, can speed up healing of skin wounds. Researchers will give the drug or a placebo to 150 healthy adults and measure how quickly small biopsy wounds close. The goal is to see if this safe, e…

This study looks at whether giving older trauma patients extra protein drinks (up to 3 times a day in the hospital and for 4 weeks after discharge) helps them regain muscle and function better than standard nutrition. Sixty adults aged 45 and older who can eat by mouth will be ra…

This study looks at records of 500 patients admitted to intensive care units in Colombia to find out what factors are linked to death after severe trauma. Researchers will compare trauma patients with other ICU patients using a discharge database. The goal is to better understand…

This study looks back at medical records of 4 severely injured trauma patients who needed large blood transfusions. It compares two drugs that help blood clot—prothrombin complex concentrate and recombinant activated factor VIIa—to see which causes fewer dangerous blood clots and…

This study aims to see if updated criteria for activating trauma teams can reduce mistakes—either calling a team when not needed (over-triage) or missing a serious case (under-triage). Researchers will compare data from 5,000 trauma patients before and after the new rules were pu…

This study follows 350 adults with major injuries admitted to intensive care. Doctors will use a non-invasive bedside ultrasound to check blood flow in the kidneys and liver at several time points. The goal is to see if certain ultrasound patterns are linked to acute kidney injur…

This study will enroll 188 trauma patients in Iraq to see how well three scoring systems (EMTRAS, REMS, and GAP) predict who will die, need a breathing tube, or stay longer in the hospital. Researchers will calculate each patient's score upon arrival and track their outcomes. The…

This study compares two scoring systems (TTSS and TRISS) to see which better predicts outcomes like death or ICU admission in people with chest injuries. Researchers will assess 150 patients in the emergency room and track their hospital course. The goal is to find the most accur…

This study looks at whether storing blood for a long time before transfusion affects death rates and complications in severely injured trauma patients. Researchers will review records of 300 patients aged 18-75 who received large transfusions. The goal is to understand if blood s…

This study looks at how severe traumatic injury changes the bone marrow and gut, leading to long-term anemia and microbiome disruption. Researchers will collect bone marrow, blood, and stool samples from 275 adults with serious blunt trauma. The goal is to understand these intera…

This study compares Advanced Trauma Life Support (ATLS) training for doctors against usual care to see if it improves survival in adult trauma patients. Over 4,000 patients from hospitals in India will take part. The goal is to find out if this widely used training actually saves…

This study looks at how severe injuries change the way bone marrow stem cells work, especially in older adults. Researchers will collect bone marrow and blood samples from 400 trauma patients to understand why some develop long-term anemia and muscle loss. The goal is to learn mo…

This study tests whether text messaging can help collect feedback from orthopedic patients about their recovery. Researchers will enroll up to 3,000 people with specific bone or spine injuries. The goal is to use this information to schedule clinic visits more efficiently, so pat…

This study compares two types of metal rods used to fix broken shin bones (tibia fractures). One rod allows tiny movements at the fracture site, while the other is standard. Researchers want to see which rod helps bones heal better and causes fewer problems. About 372 adults with…

This study tests a new computer tool that creates a 3D model of a broken shinbone to help surgeons plan where to place screws and plates before surgery. The tool uses the patient's own CT scan to simulate different repair options. About 40 adults with a lower leg fracture will ta…