New antibiotic cocktail aims to slash infection risk in severe bone breaks

NCT ID NCT04678154

Recruiting now Disease control Sponsor: Major Extremity Trauma Research Consortium Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study tests whether a new antibiotic protocol can prevent infections in people with severe open fractures (where the bone breaks through the skin). The experimental group gets antibiotics applied directly to the wound before closure, plus extended systemic antibiotics. The control group gets standard care. The goal is to see if the new approach lowers infection rates. The trial is currently recruiting 1,200 participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vancomycin and Tobramycin applied directly to the wound before closure, plus at least 72 hours of systemic antibiotics
What this could lead to: If successful, this could reduce the risk of serious infections after severe open fractures, potentially improving recovery and reducing the need for additional surgeries.
What could go wrong: This is still a research study, and the new antibiotic protocol may not prove more effective than current standard care. There are also risks of antibiotic side effects or allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

tibia fracture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST OPERATIVE SURGICAL SITE INFECTION

Contacts and locations

Locations

Atrium Health Carolinas Medical Center
RECRUITING

Charlotte, North Carolina, 28203, United States
Atrium Health Wake Forest Baptist
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Brown University/Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02905, United States
Dartmouth Hitchcock
RECRUITING

Lebanon, New Hampshire, 03766, United States
Emory University School of Medicine
RECRUITING

Atlanta, Georgia, 30303, United States
Harvard/Mass General/Brigham Hospitals
RECRUITING

Boston, Massachusetts, 02115, United States
Hennepin County Medical Center / Minneapolis
RECRUITING

Minneapolis, Minnesota, 55415, United States
Indiana University School of Medicine - Methodist Hospital
RECRUITING

Indianapolis, Indiana, 46202, United States
Indiana University/Eskenazi Health
RECRUITING

Indianapolis, Indiana, 46202, United States
Inova Fairfax MEdical Campus
RECRUITING

Falls Church, Virginia, 22042, United States
Jamaica Hospital Medical Center
RECRUITING

Jamaica, New York, 11418, United States
LSU Health Sciences
RECRUITING

New Orleans, Louisiana, 70112, United States
METROHealth
RECRUITING

Cleveland, Ohio, 44109, United States
Ohio State University Wexner Medical Center
RECRUITING

Columbus, Ohio, 43201, United States
Rhode Island Hospital/Brown University
RECRUITING

Providence, Rhode Island, 02905, United States
St Mary's University/Tenent Health
RECRUITING

West Palm Beach, Florida, 33407, United States
Stanford University
RECRUITING

Redwood City, California, 94063, United States
Temple University
RECRUITING

Philadelphia, Pennsylvania, 19140, United States
University of California at San Francisco
RECRUITING

San Francisco, California, 94110, United States
University of Colorado Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
University of Kentucky
RECRUITING

Lexington, Kentucky, 40506, United States
University of Maryland , MD Department of Orthopaedics
RECRUITING

Baltimore, Maryland, 21201, United States
University of Mississippi Medical Center
RECRUITING

Jackson, Mississippi, 39216, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of Oklahoma College of Medicine
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Texas Health Science Center - Houston
RECRUITING

Houston, Texas, 77030, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22903, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Virginia Commonwealth University Medical Center
RECRUITING

Richmond, Virginia, 23298, United States
Walter Reed Military Medical Center
RECRUITING

Bethesda, Maryland, 20889, United States
_University of California, San Francisco
RECRUITING

San Francisco, California, 94110, United States

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