New antibiotic cocktail aims to slash infection risk in severe bone breaks
NCT ID NCT04678154
First seen Jun 01, 2026 · Last updated Jun 23, 2026 · Updated 3 times
Summary
This study tests whether a new antibiotic protocol can prevent infections in people with severe open fractures (where the bone breaks through the skin). The experimental group gets antibiotics applied directly to the wound before closure, plus extended systemic antibiotics. The control group gets standard care. The goal is to see if the new approach lowers infection rates. The trial is currently recruiting 1,200 participants.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Atrium Health Carolinas Medical Center
RECRUITINGCharlotte, North Carolina, 28203, United States
Contact
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Atrium Health Wake Forest Baptist
RECRUITINGWinston-Salem, North Carolina, 27157, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Brown University/Rhode Island Hospital
RECRUITINGProvidence, Rhode Island, 02905, United States
Contact
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Dartmouth Hitchcock
RECRUITINGLebanon, New Hampshire, 03766, United States
Contact Email: •••••@•••••
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Emory University School of Medicine
RECRUITINGAtlanta, Georgia, 30303, United States
Contact
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Harvard/Mass General/Brigham Hospitals
RECRUITINGBoston, Massachusetts, 02115, United States
Contact Email: •••••@•••••
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Hennepin County Medical Center / Minneapolis
RECRUITINGMinneapolis, Minnesota, 55415, United States
Contact
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Indiana University School of Medicine - Methodist Hospital
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Indiana University/Eskenazi Health
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Inova Fairfax MEdical Campus
RECRUITINGFalls Church, Virginia, 22042, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Jamaica Hospital Medical Center
RECRUITINGJamaica, New York, 11418, United States
Contact
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LSU Health Sciences
RECRUITINGNew Orleans, Louisiana, 70112, United States
Contact Email: •••••@•••••
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METROHealth
RECRUITINGCleveland, Ohio, 44109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ohio State University Wexner Medical Center
RECRUITINGColumbus, Ohio, 43201, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Rhode Island Hospital/Brown University
RECRUITINGProvidence, Rhode Island, 02905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St Mary's University/Tenent Health
RECRUITINGWest Palm Beach, Florida, 33407, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Stanford University
RECRUITINGRedwood City, California, 94063, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Temple University
RECRUITINGPhiladelphia, Pennsylvania, 19140, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California at San Francisco
RECRUITINGSan Francisco, California, 94110, United States
Contact Email: •••••@•••••
Contact
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University of Colorado Anschutz Medical Campus
RECRUITINGAurora, Colorado, 80045, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kentucky
RECRUITINGLexington, Kentucky, 40506, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Maryland , MD Department of Orthopaedics
RECRUITINGBaltimore, Maryland, 21201, United States
Contact
Contact Email: •••••@•••••
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University of Mississippi Medical Center
RECRUITINGJackson, Mississippi, 39216, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of North Carolina at Chapel Hill
RECRUITINGChapel Hill, North Carolina, 27514, United States
Contact Email: •••••@•••••
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University of Oklahoma College of Medicine
RECRUITINGOklahoma City, Oklahoma, 73104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Texas Health Science Center - Houston
RECRUITINGHouston, Texas, 77030, United States
Contact
Contact Email: •••••@•••••
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University of Virginia
RECRUITINGCharlottesville, Virginia, 22903, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
Contact Email: •••••@•••••
Contact
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Virginia Commonwealth University Medical Center
RECRUITINGRichmond, Virginia, 23298, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Walter Reed Military Medical Center
RECRUITINGBethesda, Maryland, 20889, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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_University of California, San Francisco
RECRUITINGSan Francisco, California, 94110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vancomycin and Tobramycin applied directly to the wound before closure, plus at least 72 hours of systemic antibiotics
What this could lead to
If successful, this could reduce the risk of serious infections after severe open fractures, potentially improving recovery and reducing the need for additional surgeries.
What could go wrong
This is still a research study, and the new antibiotic protocol may not prove more effective than current standard care. There are also risks of antibiotic side effects or allergic reactions.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.