Antibiotic powder sprinkled in wounds may cut infection risk after severe leg fractures
NCT ID NCT02227446
First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time
Summary
This trial investigates whether placing vancomycin antibiotic powder directly into the wound during surgery can reduce deep surgical site infections in people with severe tibial plateau fractures. Participants are adults with high-energy fractures requiring plate and screw fixation. Half receive standard care plus vancomycin powder, and half receive standard care alone. The study tracks infections within six months after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- vancomycin antibiotic powder
- What this could lead to
- If it works, this could provide a simple, low-cost way to prevent serious infections after high-risk fracture surgery, reducing the need for additional operations and antibiotics.
- What could go wrong
- This is a single trial, and results may not apply to all fracture types or patients. Vancomycin powder could cause allergic reactions or contribute to antibiotic resistance, and it may not reduce infection rates as hoped.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
University of Maryland R Adams Cowley Shock Trauma Center
Baltimore, Maryland, 21201, United States
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