Extra oxygen during surgery may cut infection risk after bad breaks
NCT ID NCT01798810
First seen May 07, 2026 · Last updated Jun 23, 2026 · Updated 10 times
Summary
This study tested whether giving patients extra oxygen (80% FiO2) during surgery could reduce surgical site infections after severe tibial plateau or pilon fractures. Over 1,100 patients were randomly assigned to receive either supplemental oxygen or standard care. The main goal was to see if infection rates within 6 months were lower in the oxygen group.
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Banner University Medical Center/The CORE Institute
Phoenix, Arizona, 85023, United States
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University of Maryland R Adams Cowley Shock Trauma Center
Baltimore, Maryland, 21201, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Supplemental perioperative oxygen (80% FiO2 during surgery)
What this could lead to
If it works, this could provide a simple, low-cost way to lower infection rates after high-energy fracture surgery.
What could go wrong
This is a completed trial, but the intervention is a procedural change, not a drug. The benefit may be small or not apply to all fracture types.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.