Could a bone cement antibiotic stop infections after open leg fractures?

NCT ID NCT05766670

Recruiting now Prevention Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This study tests whether placing an antibiotic depot directly into the bone during surgery can prevent infections in people with severe open tibia fractures. About 497 adults with type II or III open fractures will be randomly assigned to get either the antibiotic depot plus standard care or standard care alone. The main goal is to see if the depot reduces deep surgical site infections within 12 months.

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Conditions

The condition(s) this trial relates to.

osteomyelitis tibia fracture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPEN TÍBIA FRACTURE OSTEOMYELITIS TIBIA TIBIAL FRACTURES

Contacts and locations

Locations

Atrium Health Cabarrus
RECRUITING

Concord, North Carolina, 28025, United States
Atrium Health Carolinas Medical Center
RECRUITING

Charlotte, North Carolina, 28204, United States
Atrium Health Navicent The Medical Center
RECRUITING

Macon, Georgia, 31201, United States
Atrium Health Wake Forest Baptist Medical Center
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Cedars-Sinai
RECRUITING

Los Angeles, California, 90048, United States
Louisiana State University Health Sciences Center
RECRUITING

New Orleans, Louisiana, 70112, United States
Pennsylvania State University
RECRUITING

Hershey, Pennsylvania, 17033, United States
University of Kentucky
NOT_YET_RECRUITING

Lexington, Kentucky, 40508, United States
Valley Health
RECRUITING

Winchester, Virginia, 22601, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States

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