Wake Forest University Health Sciences

This study tests whether injecting small pieces of a person's own chest muscle into the shoulder can help rebuild strength after rotator cuff repair. Twenty adults aged 40 to 80 with small tears will receive the injection during surgery. The main goal is to check safety, but rese…

This study tests whether adding metformin, a common diabetes medicine, to standard cancer therapy helps people with advanced soft tissue sarcoma live longer. About 50 adults whose cancer has spread or cannot be removed will receive metformin alongside their first-line treatment. …

This study tests whether giving two different chemotherapy combinations one after the other can shrink pancreatic tumors enough to allow successful surgery. About 64 adults with borderline resectable or locally advanced pancreatic cancer will receive gemcitabine plus nab-paclitax…

This study tests two ways of giving rewards to encourage people with opioid or cocaine use disorder to stay drug-free. 600 adults will use a smartphone app that tracks drug tests and offers incentives that either increase or decrease over time. The goal is to see which approach h…

This study looks for the best way to prevent bone loss when older adults lose weight. About 900 people with extra weight and low bone mass will try a combination of exercise, a bone-strengthening drug (alendronate), and a calorie-restricted diet. The goal is to keep bones strong …

This study tests whether adding omeprazole (a common heartburn drug) to chemotherapy (cabazitaxel or docetaxel) can help control advanced prostate cancer that has stopped responding to standard treatments. About 50 men with castration-resistant prostate cancer that progressed aft…

This study compares managing chronic high blood pressure during pregnancy using telehealth visits and home blood pressure monitoring versus standard in-person clinic visits. Pregnant women aged 18-45 with chronic hypertension can join. The goal is to see if this approach is safe,…

This study looks at whether people with advanced non-small cell lung cancer who are in poorer health (performance status 2) can benefit from the same first-line chemo/immunotherapy as those in better health. About 105 participants will be treated and followed to compare cancer pr…

This early-stage trial tests a vaginal implant made from a woman's own cells for those born without a vagina (Mullerian anomaly). Ten participants will receive the implant and be monitored for safety and quality of life improvements. The goal is to create a functional, natural-fe…

This study looks at two medicines, levetiracetam and lacosamide, to see which one is better at preventing seizures in people who have had a traumatic brain injury. Researchers will also check which drug causes fewer side effects like agitation or behavior changes. The study will …

This study tests a coordinated weight loss program for parents and children together. About 90 families will join, with parents and kids each following a structured program to improve eating, activity, and communication. The goal is to see if this team approach helps both lose we…

This study tests a weekly treatment of two chemotherapy drugs (carboplatin and paclitaxel) plus an immunotherapy drug (pembrolizumab) in 32 people with advanced head and neck cancer that has spread. It is for patients who cannot take the standard drug 5-fluorouracil. The goal is …

This study tests whether starting cholesterol-lowering care in the emergency department can reduce heart risks for adults aged 40-75 who are at risk for heart disease but not yet on treatment. About 130 participants will receive a guideline-based program to lower their cholestero…

This study tests a high dose of the chemotherapy drug methotrexate given through a vein in people with breast cancer that has spread to the lining of the brain or spinal cord. The goal is to see if this treatment can help patients live longer than 12 weeks. The trial enrolls adul…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a bilingual program that combines peer support and mobile health tools to help reduce these health risks. About 200 adults from a North Carolina HIV clinic will ta…

This study looks at whether taking vitamin D supplements during standard chemotherapy can help shrink tumors more effectively in people with triple negative breast cancer who are low in vitamin D. About 50 participants will either receive vitamin D plus chemotherapy or just chemo…

This study tests whether a monthly pill called risedronate can prevent bone and muscle loss that often happens after weight-loss surgery. About 200 adults who have had sleeve gastrectomy will take either risedronate or a placebo for 6 months and be followed for a year. Risedronat…

This study tests whether a personalized dialysis schedule works better than the usual one-size-fits-all approach for people with end-stage kidney disease. About 350 patients will be randomly assigned to either an individualized or standard dialysis plan. Researchers will track em…

This study looks at 224 adults with uncontrolled high blood pressure who also struggle with food insecurity. Researchers will test different food support programs to see which ones best help people take their medications and lower their blood pressure. The goal is to find the mos…

This study tests a procedure called Round Spermatid Injection (ROSI) for couples where the male partner cannot produce mature sperm. Doctors will collect immature cells from the testicles and inject them into eggs to try to create a pregnancy. The study will compare fertilization…

This study looks at whether a pharmacist-led review can safely reduce the number of medications taken by adults aged 75 and older who are on six or more drugs. The goal is to see if cutting back on unnecessary pills lowers falls, hospital visits, and improves quality of life. Par…

This study looks at how well different treatments work for central centrifugal cicatricial alopecia (CCCA), a condition that causes permanent hair loss in African American women. Researchers will take photos of participants' scalps before and after treatment to compare results. T…

This pilot study is for adults with type 2 diabetes who have trouble affording healthy food. Participants will receive culturally appropriate food bundles and easy-to-read recipes and cooking guides. Researchers will track changes in cooking habits, nutrition knowledge, diabetes …

This study compares two radiation schedules for people with head and neck cancer who start treatment more than six weeks after surgery. One group gets radiation six days a week (accelerated), the other gets the standard five days a week. The goal is to see if the faster schedule …

This study looks at whether giving the drug Durvalumab within two weeks of finishing chemotherapy and radiation is safe and practical for people with stage III lung cancer that cannot be removed by surgery. About 28 participants will receive the drug early and be monitored for si…

This study compares two different smartphone apps designed to help people living with HIV quit smoking. All participants will also receive nicotine patches and gum. The goal is to see which app works better at helping people stay smoke-free over 6 months.

This study tests whether the drug cetuximab can shrink tumors in people with head and neck cancer that has spread or come back, after they have already tried immunotherapy. About 38 adults will receive cetuximab alone. The main goal is to see how many patients' tumors shrink or d…

This study is testing whether injections of a person's own muscle cells can help repair the anal sphincter muscle and improve bowel control. Researchers will enroll 10 adults with long-term fecal incontinence who haven't been helped by standard treatments. The goal is to see if t…

This study tests a new DNA-based method (Next Generation Sequencing) to detect bacteria in urine from women with UTI symptoms whose standard urine culture shows very few bacteria. The goal is to see if this advanced technique can find hidden infections and guide better treatment.…

This study aims to find multiple myeloma at its earliest, precancerous stage (MGUS) in people at higher risk—Black adults and those with a family history of plasma cell disorders. By screening with a simple blood test, researchers hope to catch the disease before it causes seriou…

This study offers free mobile low-dose CT scans to people aged 40-54 who have smoked heavily (30 pack-years or more). The goal is to catch lung cancer earlier than current guidelines allow, potentially saving more lives. Participants will be screened up to three times over a few …

This study is testing a software tool called Belle.ai that uses artificial intelligence to help doctors diagnose common skin diseases. About 400 patients visiting a dermatology clinic will have three photos taken of their skin condition. The AI will then generate a list of possib…

This study aims to validate a computer algorithm that predicts whether a person has COPD, a serious lung disease. Many people with COPD are not diagnosed until the disease is advanced, while others are wrongly told they have it. The researchers will test the tool on 500 adults ag…

This study tests an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) designed for young women aged 18-39 with overweight or obesity who may become pregnant within two years. About 360 women will either join the online program or receive standard health …

This study combines peer navigation (trained community members who offer guidance) with a mobile health app to help gay, bisexual, and transgender people in rural Appalachia access HIV, STI, and HCV testing and prevention services. About 141 participants will be split into two gr…

This study tests whether rinsing with virgin coconut oil can prevent severe mouth sores (oral mucositis) in children and young adults aged 7-26 who are getting high-dose chemotherapy before a bone marrow transplant. Participants will either use standard mouth rinses or add coconu…

This study is for adults with a severe open break of the shin bone (tibia) who need surgery to fix it with a metal rod (nail). The researchers want to see if using a nail coated with antibiotics can prevent deep bone infections better than the standard uncoated nail. About 484 pe…

This study tests a program called Walk On! to see if it helps older adults prevent falls. Researchers want to know if joining group walking sessions twice a week for 12 weeks can reduce falls and improve confidence. The study involves 192 older adults who have trouble moving or f…

This study tests whether placing an antibiotic-coated material inside the bone during surgery can prevent infections after severe open fractures of the shinbone. About 497 adults with serious open fractures will be randomly assigned to get either the antibiotic depot plus standar…

This study tests whether a daily low-dose aspirin can prevent dangerous blood clots in people with advanced germ cell cancer (including testicular cancer) who are receiving standard chemotherapy. About 35 participants at high risk for clots will take aspirin alongside their chemo…

This study is testing a program called COACH that teaches youth football coaches safer practice planning to reduce head impacts and concussions. About 880 young athletes will participate, and researchers will measure head impacts and brain health before and after the season. The …

This study compares two pain relief methods used during robotic kidney surgery: a cheaper mix of drugs called R.E.C.K and a more expensive option called Exparel. About 170 adults having robotic kidney removal will be randomly assigned to one of the two treatments. Researchers wil…

This study tests whether telehealth can help primary care doctors better care for children with complex medical conditions, such as rare diseases affecting multiple organs. About 909 children under 18 who need care from four or more specialists or rely on medical devices like fee…

This study looks at whether wearing a functional knee brace after ACL reconstruction helps people feel more confident and ready to return to sports. About 96 people aged 14 to 39 who have a complete ACL tear and want to get back to sports will take part. Half will wear a brace af…

This study looks at whether a mobile app can help young women (ages 18-45) with breast cancer feel less distressed. About 120 participants will use the app for 26 weeks, and researchers will check if distress scores improve. The goal is to see if the app is a practical and helpfu…

This study compares two different supportive programs delivered remotely to help women recover after surgery for suspected gynecological cancer. The goal is to see which program works better for reducing pain, anxiety, depression, and sleep problems. About 160 women will take par…

This study tests whether oxytocin, given as a nasal spray or through an IV, can lower pain caused by heat on the skin. About 24 healthy adults will rate their pain after receiving the drug. Researchers also want to see if age, weight, or sex affect how well it works.

This study tests whether giving magnesium through an IV can safely lower a dangerously fast heart rate in people with atrial fibrillation or flutter. About 153 adults will receive either a low dose (2g), a higher dose (4g), or a placebo. The main goal is to see if magnesium helps…

This study is testing a new, noninvasive hearing aid that uses a small, flexible patch to send sound vibrations directly to the inner ear. It is designed for children and adults with conductive hearing loss, where sound doesn't travel properly through the outer or middle ear. Res…

This study tests a brief group therapy based on Dialectical Behavior Therapy (DBT) to help cancer patients reduce or stop smoking. Sixteen participants will attend eight video sessions and report their smoking habits. The goal is to see if the program is practical and acceptable …

This study tests a red LED light cap in 5 women with central centrifugal cicatricial alopecia (CCCA), a scarring hair loss that mainly affects middle-aged Black women. The cap is used daily for 10 minutes to see if it can calm scalp symptoms, slow hair loss, and help hair regrow …

This study tests whether a custom 3D-printed mouth splint can help burn patients who have developed a small mouth opening (microstomia). Ten participants will use the splint and be measured for changes in mouth size and function using a special survey. The goal is to ease symptom…

This study looks at whether people with chest pain who are at moderate risk for a heart attack can be safely evaluated as outpatients instead of being admitted to the hospital. About 502 adults with chest pain will be randomly assigned to either a rapid outpatient evaluation or s…

This study looks at two different bowel treatments—oral senna or a rectal suppository—to see which helps women have their first bowel movement sooner after vaginal surgery for pelvic organ prolapse. About 88 women will take part, and their satisfaction with the treatment will als…

This study tests whether using just one Perclose device to close the large blood-vessel entry point after TAVR works as well as the usual two-device method. About 300 adults getting TAVR through the leg will be randomly assigned to one or two devices. The main goals are to see ho…

This study tests whether a low-carbohydrate (ketogenic) diet or a low-fat diet can improve thinking and memory in people with mild cognitive impairment. About 120 volunteers will follow one of the two diets for 16 weeks, then return to their normal eating habits. Researchers will…

This study is testing whether using a virtual reality headset during a bone marrow biopsy can help lower pain and anxiety. About 160 adults with blood cancers will be randomly assigned to use the headset or receive standard care. The goal is to see if this simple, drug-free appro…

This study is testing a device called Cereset Research to see if it can help people who feel stressed, anxious, or have trouble sleeping. The device measures heart rate and blood pressure to guide relaxation. Researchers will track changes in heart rate variability and sleep qual…

This study tests whether wearing a virtual reality (VR) headset during radiation therapy can help reduce anxiety in people with prostate, breast, lung, or head and neck cancer. About 54 adults will try the VR device during their daily treatments. Researchers will check if the VR …

This study is testing whether a low-frequency pulsed electromagnetic field (PEMF) device can safely reduce pelvic pain and urinary symptoms in women with Interstitial Cystitis/Bladder Pain Syndrome. About 75 female adults will use the device at home and report their pain levels o…

This study compares two skin treatments—microneedling and dermabrasion—to see which works better for improving surgical scars on the face. About 30 adults with a vertical scar on the upper forehead will receive one of the treatments shortly after surgery. Researchers will measure…

This study tests whether adding magnesium to the usual migraine drug prochlorperazine provides faster pain relief for adults visiting the emergency department with a migraine. About 100 participants will receive either the combination or the drug alone, and their pain levels will…

This study tests if freezing certain nerves during surgery for broken ribs can reduce pain and the need for strong painkillers afterward. About 80 adults with multiple broken ribs will either get standard surgery or surgery plus nerve freezing. The goal is to see if the freezing …

This study looks at whether regular support calls from a care team can improve quality of life for adults with post-traumatic epilepsy who also have anxiety or depression. About 40 participants will either receive these calls plus usual care or just usual care for 24 weeks. The g…

This study is testing whether a low dose of clonidine, a drug usually used for high blood pressure, can help veterans with PTSD sleep better and feel less stressed. About 32 veterans will take the drug for 6 weeks while researchers track changes in sleep quality, PTSD symptoms, a…

This study looks at whether teaching cancer patients how to manage taste changes caused by chemotherapy can reduce symptoms and help them eat better. About 400 adults starting chemotherapy will either receive standard care or extra education and self-management tools. Researchers…

This study tests whether giving IV lidocaine during paraesophageal hernia surgery can improve pain control and recovery compared to standard care. About 50 adults undergoing elective laparoscopic repair will be randomly assigned to receive lidocaine or a placebo. Researchers will…

This study tests a telehealth program for caregivers of patients receiving a major cancer surgery called CS+HIPEC. Caregivers often face high stress and money worries. The program aims to connect them with helpful resources to reduce depression and improve their quality of life. …

This study compares two surgical methods for severe heel fractures. One group gets standard surgery, the other gets an extra procedure that fuses the subtalar joint. The goal is to see if the fusion helps people return to work and daily activities with less long-term pain. The st…

This study tests a 24-week collaborative care program for 60 adults with epilepsy who also have anxiety or depression. The program adds a care manager to usual neurology visits to support emotional well-being. The goal is to see if this approach improves quality of life more than…

This study is creating and testing a new speech therapy program for people who feel a constant lump in their throat (globus pharyngeus). Ten adults will try the therapy to see if it reduces that uncomfortable sensation. The goal is to develop a standard treatment that doctors can…

This study looks at whether special wound care treatments given by a physical therapist can help heal pressure sores (bedsores) in people with spinal cord injuries. The treatments include pulsed wound irrigation and electrical stimulation, used alone or together. The study will t…

This study tests whether a structured exercise routine (30 minutes, five days a week) helps children and young adults aged 2–25 with newly diagnosed cancer maintain physical function and emotional well-being during chemotherapy. Participants are randomly assigned to either an exe…

This study tests whether a tailored physical activity program can help preserve exercise capacity, heart function, memory, and quality of life in adults (ages 18-85) with Hodgkin or non-Hodgkin lymphoma or stage I-III breast cancer who are undergoing chemotherapy or other cardiot…

This study tests if a new sticky device (K-LOCK) can hold surgical drains in place better than the usual stitches. The goal is to see if it improves patient comfort and reduces problems like pain or the drain falling out early. About 140 adults having surgery will take part.

This study tests whether taking a supplement called fisetin can help reduce fatigue in older adults who have survived cancer. Researchers will measure changes in fatigue levels using a standard questionnaire. The study aims to enroll 60 participants.

This study looks at whether injecting Xeomin® into the arm can improve walking in adults who have had a stroke. Twenty people with arm and leg stiffness will be tested before and 4-6 weeks after the injection using simple walking tests. The goal is to see if treating arm spastici…

This study tests whether virtual reality (VR) can reduce phantom limb pain in people who have lost an arm. About 20 adults with phantom limb pain will use VR experiences to see if it lowers their pain and improves quality of life. The goal is to find a drug-free way to manage thi…

This study compares two different virtual, non-drug programs for adults with migraines. Both involve 8 weekly online sessions and extra learning materials. The goal is to see which program better reduces migraine-related disability and improves daily life. Participants can contin…

This study looks at different ways to close the skin after a cesarean section (C-section) to find which method leads to a better-looking scar and fewer wound problems. Researchers will take photos of scars and have doctors rate them. The study involves 52 women having scheduled C…

This study tests a way for orthopaedic surgeons to screen for depression in patients recovering from broken bones and offer medication treatment. About 100 adults who score at least mild depression after surgery can join. The goal is to see if antidepressant medication helps impr…

This study looks at whether a yoga program is practical and helpful for people with functional dyspepsia or gastroparesis, conditions that cause nausea and vomiting. Ten adults will try the yoga sessions and report how they feel. The goal is to see if yoga can be a useful tool to…

This study looks at two different ways to surgically fix certain types of breaks in the thigh bone just above the knee. The goal is to find out which method helps people get back to work and everyday activities sooner. About 144 adults with these fractures will be randomly assign…

This study tests a program to help children who were seriously hurt and their caregivers deal with post-traumatic stress and depression. About 24 child-caregiver pairs will take part. The program uses screening tools and support to reduce emotional distress after events like burn…

This study tests whether a 12-week high-velocity resistance training program is safe and doable for older adults with advanced chronic kidney disease. Researchers will compare the exercise group to a group that attends weekly healthy lifestyle sessions. The goal is to see if this…

This study compares two types of catheters for women who need help emptying their bladder. 17 women will test both catheters and report which one works faster and feels better. The goal is to find a more comfortable and efficient option for daily use.

This early-stage study tests whether giving inhaled nitric oxide (a gas) to people having emergency clot removal for a stroke is safe. About 36 adults will receive different doses to find the highest safe amount. The goal is to see if this approach can be used in future studies t…

This study is testing different ways to give weekly feedback to help people lose weight. Researchers want to see which type of message helps participants stay on track with their goals. About 300 adults with a BMI of 25 or higher will take part. The study uses a smartphone app an…

This study is testing a combined treatment for adults with serious leg injuries. The treatment pairs a custom-made, energy-storing ankle brace with a high-intensity physical therapy program. Researchers want to see if this approach helps people walk better, climb stairs more easi…

This study is testing whether an online pain coping skills program helps cancer survivors manage persistent pain better than standard care alone. Researchers will enroll 456 adult cancer survivors who have pain that started or worsened after cancer diagnosis or treatment. Partici…

This study aims to create a computer program that can predict how easy or difficult it will be to insert a breathing tube by analyzing digital photos of a patient's face from three angles. Researchers will enroll 3,500 people who need a breathing tube and compare the computer's p…

This study looks at how a person's genes might affect their risk of developing cancer cachexia, a severe muscle wasting condition common in pancreatic cancer. Researchers will collect blood samples from 100 adults with pancreatic cancer to find genetic markers linked to weight lo…

This study compares pain levels in younger (45 and under) versus older women receiving pegfilgrastim, a drug that helps boost white blood cells during chemotherapy for non-metastatic breast cancer. Researchers want to see if younger women report more frequent or intense pain. The…

This study tests a new way to help rural smokers who are not yet ready to quit. Paramedics will refer participants to a text-message program that encourages them to stop smoking. The goal is to see if this approach gets more people to engage and eventually quit.

This study looks at whether a special nurse team (NEST) can help new mothers and their babies in five rural North Carolina counties get better care after leaving the hospital. About 1,300 women will either get the NEST program or standard care. The goal is to see if the program r…

This study tracks 300 firefighters aged 40-49 with at least 5 years on the job to see if exposure to hazardous compounds increases early signs of blood cancers. Researchers will test for pre-cancerous conditions like clonal hematopoiesis and monoclonal gammopathy. The goal is to …

This study surveys surgeons and advanced practice providers to see how often they prescribe extended blood clot prevention after abdominal or pelvic cancer surgery. The goal is to understand current practices and improve guideline use. About 500 participants from the NCORP networ…

This study is following 2000 adults with newly diagnosed breast, colorectal, lung, melanoma, or lymphoma cancer who are receiving chemotherapy or immunotherapy. Researchers will track whether using cannabis or cannabinoids helps with symptoms like pain, nausea, or fatigue. No tre…

This study looks at how belly pressure changes during a heart procedure called pulsed field ablation, which treats atrial fibrillation. Researchers will compare pressure levels when patients receive general anesthesia versus sedation. About 50 adults having this standard heart tr…

This study looks at adults aged 65 and older who are starting chemotherapy. Researchers will measure their resilience and create personalized care plans to better support them. The goal is to learn what these patients need and improve their experience during treatment.

This study aims to measure normal pressures in the brain's veins in people who do not have Idiopathic Intracranial Hypertension (IIH). Ten participants already scheduled for a brain angiogram for other reasons will have additional pressure readings taken during their procedure. T…

This study tests a program called COACH-APP, which provides education and mentorship to advanced practice providers (like nurse practitioners and physician assistants) in community cancer clinics. The goal is to see if it helps them feel more confident and involved in clinical re…

This study looks at how myotonic dystrophy type 2 (DM2) affects the brain and thinking skills. About 100 adults with DM2, DM1, and healthy volunteers will get brain MRIs, thinking tests, and blood draws. The goal is to find brain changes that can be used to measure disease progre…

This study looks at whether older adults (age 50+) with advanced ovarian or endometrial cancer are willing and able to complete physical and cognitive tests before and after their standard cancer treatment. The goal is to understand how well these patients bounce back, or show re…

This study looks at how a non-invasive brain stimulation technique called TMS changes brain activity in people who drink heavily and those who don't. Researchers will use MEG brain scans to measure these effects in 10 volunteers. The goal is to gather information that could help …

This study aims to find early signs that predict memory loss and dementia in 850 older adults, including those with mild memory issues or prediabetes. Researchers will track thinking skills, brain scans, and spinal fluid markers over time. The goal is to better understand how pro…

This study follows 200 people who have broken their pelvis or hip socket to understand how they recover over time. Researchers will measure pain, physical function, and how soon patients can return to work or daily activities. The goal is to learn what recovery looks like for dif…

This study looks at how well the immune system works in children who have finished cancer treatment. It also tests restarting routine vaccines just 3 months after therapy ends, which is earlier than usual. Researchers will compare giving a single booster shot versus a full series…

This study looks at whether PET scans and blood tests can predict changes in memory and attention after radiation therapy for high-grade glioma. Researchers will follow 16 adults receiving chemoradiation, using brain scans, spinal taps, and cognitive tests. The goal is to better …

This study looks at whether older adults with advanced colorectal cancer who have low muscle mass are more likely to have severe side effects from chemotherapy. Researchers will follow 300 people starting treatment to track side effects and survival. The goal is to better underst…

This study looks at whether oxytocin, a natural hormone, can change how nerves send pain signals after a small area of skin is heated. Sixty healthy adults will receive either oxytocin or a placebo through an IV, and a tiny needle will record nerve activity before and after heat …

This study explores how a person's genetic makeup influences side effects and response to two common leukemia drugs (azacitidine and venetoclax). Researchers will enroll 50 adults newly diagnosed with acute myeloid leukemia (AML) and track side effects like infections and low blo…

This study looks at how chronic stress changes brain and immune function in people with HIV who use stimulants. Researchers will use brain scans and interviews to understand these changes, with the goal of finding better ways to treat depression and reduce stimulant use. The stud…

This study looks at whether a comprehensive genetic test (microarray PGx) can find more drug-gene interactions than the standard single-gene test in people with cancer. Researchers will enroll 120 adults with gastrointestinal cancer who are about to receive chemotherapy. The goal…

This study is developing a new MRI-based method to measure muscle changes in people with myotonic dystrophy, a condition that causes progressive muscle weakness. Researchers will scan the leg muscles of 75 adults (ages 18-65) with the disease and compare them to healthy volunteer…

This study looks at why people with a CALR gene mutation and a type of blood cancer called myeloproliferative neoplasm (MPN) have a lower risk of dangerous blood clots compared to those with a different mutation (JAK2). Researchers will collect blood samples from 35 adults with C…

This study looks at how chronic marijuana use impacts brain inflammation and thinking skills in people with HIV. Researchers will use brain scans and cognitive tests to compare marijuana users and non-users. The goal is to understand whether marijuana helps or harms brain health …

This study looks at how salt in the diet affects blood pressure in young adults who were born prematurely. Researchers will test whether a drug called allopurinol can reduce salt sensitivity. About 120 people born either before 34 weeks or after 36 weeks of pregnancy will partici…

This study tracks how a common breast cancer drug (aromatase inhibitor) changes the bacteria in your gut and how that might affect estrogen levels. Researchers will collect stool and blood samples from 25 participants before and after starting the medicine. The goal is to underst…

This study looks at how chemotherapy given before surgery affects frailty in adults over 55 with advanced ovarian or endometrial cancer. Researchers will track changes in an electronic frailty score and check for thinking problems. The goal is to see if chemo helps patients becom…

This study asks 300 adolescents and young adults (ages 15-39) who have or had cancer to fill out surveys about what they were taught regarding exercise, sexual health, fertility, finances, and other key topics. The goal is to find gaps in education so hospitals can better support…

This study gathers basic survival and complication information from 2000 people receiving stem cell transplants for blood cancers or immune diseases. The goal is to build a database for future research and to improve patient care. No new treatments are being tested; only standard…

This study looks at whether patients who talk to an EMS doctor over the phone are more likely to agree to go to the hospital by ambulance. About 250 adults who want to refuse transport will be included. The goal is to see if a doctor's advice can reduce the number of people who r…

This study aims to understand cancer-related fatigue in 20 adults with non-small cell lung cancer who are receiving immunotherapy. Researchers will conduct interviews and use questionnaires to learn about fatigue patterns, daily life impacts, and patients' views on physical activ…

This study aims to improve how we measure quality of life in adolescents and young adults (ages 15-39) with cancer. Researchers will ask 3,000 participants—including patients, survivors, and their caregivers—about topics like body image, fertility concerns, and financial stress. …

This study aims to identify frailty in people with HIV who are 50 years or older. Researchers will measure physical performance and quality of life to better understand the challenges of healthy aging in this group. No treatment or medication is given; the goal is simply to gathe…

This study looks at whether regular MRI brain scans after radiation therapy can find cancer that has spread to the brain before it causes symptoms. About 60 adults with stage III non-squamous lung cancer will get MRI scans at set times. The goal is to see if this monitoring reduc…

This study looks at how oxytocin, a natural hormone, affects the part of your nervous system that controls rest and digestion. Researchers will measure tiny changes in pupil size after an injection of oxytocin or a placebo. The study includes 38 adults with knee arthritis or heal…

This study is testing a blood test called liquid biopsy to see if it can find bits of tumor DNA in people with sarcoma (a type of bone or soft tissue cancer). Researchers will collect blood samples from 300 participants before, during, and after treatment to see how well the test…

This study looks at two ways to help families who struggle to get enough food while their child is in the hospital: delivering meals or giving grocery gift cards. Researchers want to find out which method works best for these families. About 30 caregivers of hospitalized children…

This study looks at whether simulation training for doctors, nurses, and midwives can reduce the number of cervical exams women receive during labor and make exam results more consistent. Over 1,100 healthcare providers and patients will take part. The goal is to improve care by …

This study looks at how certain natural chemicals in the body, like angiotensin-(1-7), affect high blood pressure and damage to the heart and kidneys in children. Researchers will follow 125 children with newly diagnosed high blood pressure and healthy kids for two years, collect…

This study looks at whether suctioning out stomach contents before taking heart ultrasound images during cardiac surgery makes those images clearer. About 200 adults having heart surgery with a special ultrasound probe will take part. Researchers will compare image quality before…

This study aims to understand why some people get graft-versus-host disease (GVHD) after a stem cell transplant for blood cancer, while others do not. Researchers will study genetics, drug levels, and immune cells in 120 transplant recipients and their donors. The goal is to find…

This study looks at whether a wearable activity tracker can be used to collect heart rate data from people with pancreatic or breast cancer who are undergoing treatment. The goal is to see if patients find the device easy to use and if they will wear it consistently for 14 days. …

This study collects blood and tissue samples from 20,000 people with suspected solid tumors. The samples are stored in a central bank for researchers to use in future studies. The goal is to help scientists better understand cancer and develop new treatments. Participation involv…

This study looks at how very low nicotine cigarettes change heart rate and heart rate variability in people who smoke daily or occasionally. About 49 adults aged 21 and older who have smoked at least once in the past month will participate. Researchers compare the effects of low-…

This study compares different outreach methods to encourage lung cancer screening in people at high risk. About 27,000 participants aged 50-77 who smoke or recently quit will use a digital tool called mPATH-Lung. The goal is to see which approach works best, especially for racial…

This study looks at how a gene called APOL1 affects kidney transplant success. People of African ancestry are more likely to have certain versions of this gene that can cause kidney disease. Researchers will test DNA from 5,000 kidney donors and recipients to learn how these gene…

This study looks at whether providing financial navigation services can reduce the money-related stress (financial toxicity) that often comes with cancer treatment. About 120 adults aged 18-64 with newly diagnosed acute myeloid leukemia (AML) who are starting intensive chemothera…

This study collects bone marrow samples from 70 people with blood cancer to grow 3D organoids—tiny lab-made models of the cancer. Researchers will test different chemotherapy combinations on these organoids to see which kills the most cancer cells. The goal is to learn if this ap…

This study looks at whether giving older adults (65+) an antidepressant called duloxetine when they leave the hospital after a broken leg can prevent depression. Researchers will track how many people agree to take the medicine and how their mood changes over a year. The goal is …

This study works with families of children with cancer to design a program called CERCA. The goal is to identify and address non-medical needs like housing, food, or transportation. Researchers will interview caregivers and clinic staff to understand current challenges and build …

This study listens to cancer survivors to understand how they experience and talk about fatigue. Researchers will interview 80 survivors and their doctors to create a visual poster that helps patients describe their fatigue better. The goal is to improve communication and help pe…

This study looks at whether giving first-year medical students a wearable device (like a smartwatch) and personalized wellness coaching can help them handle stress better. Researchers will track heart rate, sleep, and stress levels over time. The goal is to see if these tools can…

This study aims to find better ways to help people with atopic dermatitis (eczema) use their topical medication as prescribed. About 30 adults and children over age 9 will be divided into groups: one gets standard care, another gets a demonstration, and a third uses a mobile app.…

This study observes 600 children under 10 years old to find better ways to remove breathing tubes after surgery when IV anesthesia is used. Researchers will track how often removal is successful and if any breathing problems occur. The goal is to improve safety and outcomes for y…

This study looks at whether offering different types of food assistance to pregnant women who struggle to afford enough food can work in a real-world clinic setting. About 60 pregnant women in their first trimester will be enrolled and followed for 6 months. The goal is to see if…

This study looks at how many opioid pain pills people actually take after surgery for bladder, kidney, or prostate cancer. About 684 adults will report their opioid use for 30 days after leaving the hospital. The study also tests whether a simple pamphlet helps people safely disp…