Wake Forest University Health Sciences

This study looks at whether adding the diabetes drug metformin to standard cancer therapy can help people with advanced soft tissue sarcoma that has spread. About 50 adults who have not yet started treatment for their advanced sarcoma will take metformin along with their usual me…

This study looks at how well different treatments work for central centrifugal cicatricial alopecia (CCCA), a condition that causes permanent hair loss in African American women. Researchers will take photos of participants' scalps before and after treatment to compare results. T…

This pilot study is for adults with type 2 diabetes who have trouble affording healthy food. Participants will receive culturally appropriate food bundles and easy-to-read recipes and cooking guides. Researchers will track changes in cooking habits, nutrition knowledge, diabetes …

This study compares using telehealth visits and home blood pressure monitoring to standard in-person clinic visits for managing chronic high blood pressure during pregnancy. Pregnant women aged 18-45 with chronic hypertension can join. The goal is to see if remote care is safe an…

This study tests whether adding omeprazole (a common heartburn drug) to standard chemotherapy can help men with a hard-to-treat type of prostate cancer. About 50 men whose cancer has stopped responding to hormone therapy and a previous chemo drug will receive omeprazole along wit…

This study tests a high dose of the chemotherapy drug methotrexate given through a vein in people with breast cancer that has spread to the lining of the brain and spinal cord. The goal is to see if this treatment helps patients live longer than 12 weeks. The trial is for adults …

This study tests a coordinated weight loss program for parents and children. About 90 families will join a program that helps with healthy eating, physical activity, and positive communication. The goal is to see if working together as a family leads to better weight loss results…

This study tests a procedure called Round Spermatid Injection (ROSI) for couples where the male partner cannot make mature sperm. Doctors will collect immature sperm cells from the testicles and inject them into eggs to see if they can create a pregnancy. The study involves 50 co…

This study compares two radiation schedules for people with head and neck cancer who start treatment more than six weeks after surgery. One group gets radiation six days a week (accelerated), the other gets the standard five days a week. The goal is to see if the faster schedule …

This early study tests whether injecting a person's own muscle fibers into the shoulder muscle can improve strength and function after rotator cuff repair. Twenty adults aged 40-80 with small tears will receive the injection during surgery. The main goal is to check safety, but r…

This study looks at whether giving the drug Durvalumab within two weeks of finishing chemotherapy and radiation is safe and practical for people with stage III lung cancer that cannot be removed by surgery. About 28 participants will receive the drug early and be monitored for si…

This study tests a new, flexible hearing aid that sticks to the skin like a patch. It uses tiny vibrating actuators to send sound through the skull to the inner ear, bypassing damaged outer or middle ear parts. The trial includes 200 children and adults with conductive hearing lo…

This study looks at whether taking vitamin D during chemotherapy can help shrink tumors more effectively in people with triple negative breast cancer who are low in vitamin D. About 50 participants will receive standard chemotherapy plus vitamin D supplements, and researchers wil…

This study looks at whether a pharmacist can help adults aged 75 and older who take 6 or more medications reduce their pill burden safely. The goal is to cut down on falls, hospital visits, and improve quality of life. Participants will have their medicines reviewed and possibly …

This early-stage trial tests a vaginal implant made from a woman's own cells for those born without a vagina (Mullerian duct anomaly). Ten participants will receive the implant and be monitored for safety and quality of life. The goal is to see if this approach can create a funct…

This study looks at two medicines, levetiracetam and lacosamide, to see which one is better at preventing seizures in people who have had a traumatic brain injury. The researchers are also checking which drug causes fewer side effects like agitation or behavior changes. The study…

This study tests two ways of giving financial rewards to encourage people with opioid or cocaine use disorder to stay abstinent. 600 adults will use a smartphone app that tracks drug tests and adjusts payments based on their success. The goal is to find the best incentive design …

This study tests whether a surgical method called frozen-section directed excision, already used in dermatology, can reduce the chance of leftover abnormal tissue after surgery for high-grade vulvar dysplasia compared to the standard wide local excision. About 112 adults with con…

This study looks at which food assistance programs work best for people with uncontrolled high blood pressure who also struggle to get enough food. About 224 adults will try different levels of support, like help getting healthy foods, to see if it improves their diet, medication…

This study looks at whether lung cancer patients who are less healthy (Performance Status 2) can be treated with the same chemo/immunotherapy as healthier patients (Performance Status 0-1). The goal is to see if the treatment works just as well and is safe for them. About 105 adu…

This study tests whether a personalized dialysis schedule (incremental hemodialysis) is safer and improves quality of life compared to standard dialysis for people with end-stage kidney disease. About 350 patients and 140 caregivers will take part, with patients randomly assigned…

This study compares two different smartphone apps designed to help people living with HIV quit smoking. All participants will also receive nicotine patches and gum. The goal is to see which app works better at helping people stay smoke-free over 6 months.

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce these health risks. About 200 adults from a North Carolina HIV clinic will take part. T…

This study compares ACL reconstruction with and without a functional brace in 96 athletes aged 14-39 who want to return to sports. The main goal is to see if bracing improves psychological readiness and reduces fear of re-injury. Results will help clarify whether bracing is truly…

This study tests whether a monthly pill called risedronate can prevent bone and muscle loss in people who have had sleeve gastrectomy weight-loss surgery. 200 participants will take either risedronate or a placebo for 6 months and be followed for 1 year. Risedronate is already FD…

This study tests whether the drug cetuximab can shrink tumors in people with head and neck cancer that has spread or come back, after they have already tried immunotherapy. About 38 adults will receive cetuximab alone. The main goal is to see how many patients' tumors shrink or d…

This study is for people with advanced head and neck cancer that has spread and cannot be treated with surgery or radiation. It tests a weekly combination of two chemotherapy drugs (carboplatin and paclitaxel) plus an immunotherapy drug (pembrolizumab) in patients who cannot take…

This study is for people with pancreatic cancer that is either borderline resectable or locally advanced, meaning it is hard to remove with surgery. Researchers want to see if giving two standard chemotherapy regimens one after the other (Gemcitabine-Abraxane followed by mFOLFIRI…

This study tests ways to prevent bone loss in older adults who are losing weight. It combines exercise, a bone-strengthening drug (alendronate), and calorie restriction. The goal is to find the best strategy to keep bones healthy while shedding pounds. About 900 participants will…

This study is testing whether injections of a person's own muscle cells can help repair the anal sphincter muscle and improve bowel control. Researchers will enroll 10 adults with long-term fecal incontinence who haven't been helped by standard treatments. The goal is to see if t…

This study tests a new DNA-based method (Next Generation Sequencing) to detect bacteria in urine from women with suspected urinary tract infections (UTIs) but low bacteria counts on standard cultures. Researchers will compare the DNA results to symptom improvement after targeted …

This study aims to find multiple myeloma at its earliest, precancerous stage (MGUS) in people at higher risk, such as Black adults and close relatives of patients with plasma cell disorders. Participants will provide a blood sample to check for abnormal proteins. The goal is to c…

This study offers free mobile low-dose CT scans to people aged 40-54 who have smoked heavily (30 pack-years or more) and live in North or South Carolina. The goal is to see if screening at a younger age can find lung cancer earlier, when it's easier to treat. About 1,160 particip…

This study aims to validate a computer algorithm that predicts whether a person has COPD, a serious lung disease. Many people with COPD are not diagnosed until the disease is advanced, while others are wrongly told they have it. The researchers will test the tool on 500 adults ag…

This study is testing a software tool called Belle.ai that uses artificial intelligence to help doctors diagnose common skin diseases. About 400 people visiting a dermatology clinic will have three photos taken of their skin condition. The AI will then suggest possible diagnoses,…

This study tests a program called Walk On! to see if it helps older adults prevent falls. Researchers want to know if joining group walking sessions twice a week for 12 weeks can reduce falls and improve confidence. The study involves 192 older adults who have trouble moving or f…

This study combines peer navigation (trained community members) with a mobile health app to help gay, bisexual, and transgender individuals in rural Appalachia access HIV, STI, and hepatitis C testing and prevention services. About 141 participants will be assigned to either the …

This study tests whether rinsing with virgin coconut oil can prevent severe mouth sores in children and young adults (ages 7-26) receiving high-dose chemotherapy before a bone marrow transplant. Participants will either use standard mouth rinses or add coconut oil rinses to their…

This study tests an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) designed for young women aged 18-39 with overweight or obesity who may become pregnant within two years. Participants will either join online group classes for 12 months or receive sta…

This study tests whether a nail coated with antibiotics can prevent deep infections in people with severe open fractures of the shinbone. About 484 adults will be randomly assigned to get either the antibiotic-coated nail or the standard nail. The main goal is to see if the speci…

This study tests whether a daily low-dose aspirin can prevent dangerous blood clots in people with advanced germ cell cancer (including testicular cancer) who are receiving standard chemotherapy. About 35 participants at high risk for clots will take aspirin alongside their chemo…

This study tests whether placing a calcium sulfate antibiotic depot inside the bone during surgery can prevent infections after severe open tibia fractures. About 497 adults with type II or III open fractures will be randomly assigned to receive either the depot plus standard car…

This study tests whether starting cholesterol-lowering treatment in the emergency department can prevent future heart problems. About 130 adults aged 40-75 who are at risk for heart disease but not yet on treatment will receive guideline-based care right in the ER. The goal is to…

This study is testing a program called COACH that teaches youth football coaches safer practice planning to reduce head impacts and concussions. About 880 young athletes will participate, and researchers will measure head impacts and brain health before and after the season. The …

This study compares two surgical methods for treating severe heel fractures. One group will receive standard surgery, while the other will have an additional procedure that fuses the subtalar joint. The goal is to see if this extra step helps people return to work and daily activ…

This study looks at whether injecting Xeomin® into the arm can improve walking in adults who have had a stroke. Twenty people with arm and leg stiffness will be tested before and 4-6 weeks after the injection using simple walking tests. The goal is to see if treating arm spastici…

This study tests whether virtual reality (VR) can reduce phantom limb pain in people who have lost an arm. About 20 adults with phantom limb pain will use VR experiences to see if it lowers their pain and improves quality of life. The goal is to find a drug-free way to manage thi…

This study compares two diets—a low-carb (ketogenic) diet and a low-fat diet—in 120 adults with mild memory issues. Participants follow their assigned diet for 16 weeks, then return to normal eating. Researchers check thinking skills, brain blood flow, and spinal fluid markers. T…

This study compares two different virtual, non-drug programs for adults with migraines. Both involve 8 weekly online sessions and extra learning materials. The goal is to see which program better reduces migraine-related disability and improves daily life. Participants can contin…

This study tests whether freezing certain nerves during surgery to fix broken ribs can provide better pain relief than surgery alone. About 80 adults with multiple rib fractures will be randomly assigned to receive either standard surgery or surgery plus nerve freezing. The main …

This study compares two treatments—microneedling and dermabrasion—to see which improves the look of facial scars from surgery. About 30 adults with scars on the upper face will be treated and followed for 6 months. The goal is to find the best way to make scars less noticeable.…

This study tests whether giving IV lidocaine during paraesophageal hernia surgery can improve pain control and recovery compared to standard care. About 50 adults undergoing elective laparoscopic hernia repair will receive either lidocaine or a placebo. Researchers will measure p…

This study is testing whether a non-invasive, drug-free device that uses low-frequency magnetic fields can safely reduce pelvic pain and urinary symptoms in women with Interstitial Cystitis/Bladder Pain Syndrome. About 75 female adults will use the device at home and report their…

This study tests if a new sticky device (K-LOCK) can hold surgical drains in place better than the usual stitches. The goal is to see if it improves patient comfort and reduces problems like pain or the drain falling out early. About 140 adults having surgery will take part.

This study tests whether a 24-week collaborative care program, where a care manager works with patients and their neurologist, can improve emotional well-being and quality of life for 60 adults with epilepsy who also have anxiety or depression. Participants are randomly assigned …

This study looks at whether physical therapy treatments like pulsed wound irrigation and electrical stimulation can help heal pressure sores (bedsores) in people with spinal cord injuries. About 40 adults in rehab will get one of three wound care approaches. The goal is to see wh…

This study tests whether taking a supplement called fisetin can help reduce fatigue in older adults who have survived cancer. Researchers will measure changes in fatigue levels using a standard questionnaire. The study aims to enroll 60 participants.

This study looks at different ways to close the skin after a cesarean section (C-section) to find which method leads to a better-looking scar and fewer wound problems. Researchers will take photos of scars and have doctors rate them. The study involves 52 women having scheduled C…

This study is testing whether oxytocin, given as a nasal spray and through an IV, can reduce pain caused by heat on the skin. Researchers will measure how much pain 24 healthy adults feel after receiving the drug. The goal is to see if oxytocin works as a pain reliever and if fac…

This study compares two pain relief approaches for people undergoing robotic kidney surgery (nephrectomy) for kidney cancer. One group gets a combination of drugs called R.E.C.K, and the other gets a more expensive drug called Exparel. The goal is to see which provides better pai…

This study looks at whether a telehealth program can help caregivers of people with cancer who are having a major surgery and chemotherapy. The goal is to reduce their stress, depression, and money worries, and help them feel more in control. About 50 caregivers will take part, a…

This small study tests a red LED cap in 5 women with central centrifugal cicatricial alopecia (CCCA), a scarring hair loss that mainly affects middle-aged Black women. The cap uses light therapy to reduce inflammation and may help ease scalp symptoms, slow hair loss, and possibly…

This study tests a way for orthopaedic surgeons to screen for depression in patients recovering from broken bones and offer medication treatment. About 100 adults who score at least mild depression after surgery can join. The goal is to see if antidepressant medication helps impr…

This study looks at whether a yoga program is practical and helpful for people with functional dyspepsia or gastroparesis, conditions that cause nausea and vomiting. Ten adults will try the yoga sessions and report how they feel. The goal is to see if yoga can be a useful tool to…

This study is creating and testing a speech therapy program for people who feel a constant lump in their throat (globus pharyngeus). Ten adults with this sensation will try the new treatment. The goal is to see if the program can reduce throat discomfort and improve quality of li…

This study tests whether using a virtual reality headset during a bone marrow biopsy can lower pain and anxiety. About 160 adults with blood cancers will be randomly assigned to use VR or standard care. Researchers will compare pain scores right after the procedure and the next d…

This study tests whether regular supportive phone calls (collaborative care) can improve quality of life for adults with posttraumatic epilepsy who also have anxiety or depression. About 40 participants will either receive these calls plus usual neurology care or just usual care …

This study is testing a device called Cereset Research to see if it can help people who feel stressed, anxious, or have trouble sleeping. The device measures heart rate and blood pressure to see how the body's stress system changes. About 200 adults with these symptoms will take …

This study looks at two different ways to surgically fix certain types of breaks in the thigh bone just above the knee. The goal is to find out which method helps people get back to work and everyday activities sooner. About 144 adults with these fractures will be randomly assign…

This study is testing whether a low-dose medication called clonidine, usually used for high blood pressure, can help veterans with PTSD feel better during the day and sleep more soundly at night. About 32 veterans with PTSD will take clonidine for 6 weeks, and researchers will tr…

This study compares two different remote support programs to see which one helps women feel better after surgery for suspected gynecological cancer. About 160 women will participate, and researchers will measure pain, mood, and sleep. The goal is to find better ways to improve re…

This study tests whether a custom 3D-printed mouth splint can help burn patients who have difficulty opening their mouths due to scarring (microstomia). Ten participants will use the splint and be measured for changes in mouth opening and function. The goal is to improve daily ac…

This study tests whether giving magnesium through an IV can safely and quickly slow down a rapid heart rate in people with atrial fibrillation or atrial flutter. About 153 adults with a heart rate of 120 bpm or higher will receive either a low dose (2g), a higher dose (4g) of mag…

This study looks at whether a mobile app called Mighty Pro can help young women (ages 18-45) with breast cancer feel less distressed. About 120 participants will use the app for 26 weeks to track their feelings and communicate with their care team. The goal is to see if using the…

This study looks at whether teaching cancer patients about taste changes from chemotherapy and how to manage them can reduce symptoms and help them eat better. About 400 adults starting chemotherapy will be split into two groups: one gets usual care, the other gets extra educatio…

This study tests whether a tailored physical activity program can help lymphoma and breast cancer patients maintain their exercise ability, heart function, memory, and quality of life during cancer treatment. About 110 adults aged 18-85 with certain lymphomas or breast cancers wi…

This study tests a program to help children who were seriously hurt and their caregivers deal with post-traumatic stress and depression. About 24 child-caregiver pairs will take part. The program uses screening tools and support to reduce emotional distress after events like burn…

This study tests whether a 12-week high-velocity resistance training program is safe and doable for older adults with advanced chronic kidney disease. Researchers will compare the exercise group to a group that attends weekly healthy lifestyle sessions. The goal is to see if this…

This study compares two types of catheters for women who need help emptying their bladder. 17 women will test both catheters and report which one works faster and feels better. The goal is to find a more comfortable and efficient option for daily use.

This study tests a brief group therapy program (Dialectical Behavior Therapy - Skills Training) to help cancer patients who smoke cut down or quit. Sixteen adults with cancer who smoke daily will try the 8-session program. The main goal is to see if the program is practical and a…

This early-stage study tests whether giving inhaled nitric oxide (a gas) to people having emergency clot removal for a stroke is safe. About 36 adults will receive different doses to find the highest safe amount. The goal is to see if this approach can be used in future studies t…

This study looks at whether a structured exercise routine (30 minutes, 5 days a week) can help children and young adults aged 2–25 with newly diagnosed cancer maintain physical function and improve quality of life during chemotherapy. Participants are randomly assigned to either …

This study is testing different ways to give weekly feedback to help people lose weight. Researchers want to see which type of message helps participants stay on track with their goals. About 300 adults with a BMI of 25 or higher will take part. The study uses a smartphone app an…

This study looks at whether telehealth can help primary care doctors better care for children with very rare and complex health conditions that require multiple specialists. The goal is to reduce the number of hospital visits and appointments, making life easier for both the chil…

This study looks at 88 women having vaginal surgery for pelvic organ prolapse. Half will take oral senna and half will use a bisacodyl suppository after surgery. The goal is to see which approach leads to a faster first bowel movement and higher patient satisfaction.

This study tests whether adding magnesium to the usual migraine drug prochlorperazine helps people feel less pain within 30 minutes. About 100 adults with migraines will take part in the emergency department. Researchers will compare pain scores before and after treatment to see …

This study tests whether using just one Perclose device to close the large blood-vessel entry point after TAVR works as well as the usual two devices. About 300 adults having TAVR through the leg will be randomly assigned to one or two devices. The main goals are to see how quick…

This study is testing a combined treatment for adults with serious leg injuries. The treatment pairs a custom-made, energy-storing ankle brace with a high-intensity physical therapy program. Researchers want to see if this approach helps people walk better, climb stairs more easi…

This study is testing whether an online pain coping skills program helps cancer survivors manage persistent pain better than standard care alone. Researchers will enroll 456 adult cancer survivors who have pain that started or worsened after cancer diagnosis or treatment. Partici…

This study looks at how chronic marijuana use changes brain inflammation and thinking skills in people with HIV. Researchers will use brain scans and blood tests to measure brain health in 220 adults, comparing those who use marijuana regularly with those who do not. The goal is …

This study asks 300 adolescents and young adults who have or had cancer to fill out surveys about what they were taught regarding exercise, sexual health, fertility, money issues, relationships, and clinical trials. The goal is to find gaps in education so hospitals can better su…

This study gathers health information from 2,000 people receiving stem cell transplants for blood cancers or immune disorders. The goal is to track survival and complications to help improve future treatments and hospital operations. No experimental therapies are given; participa…

This study follows 200 people with pelvic or hip socket fractures to understand how they recover over time. Researchers track when patients return to work and daily activities, and measure changes in physical function, mood, and pain. The goal is to learn what recovery looks like…

This study looks at how myotonic dystrophy types 1 and 2 affect the brain. About 100 adults aged 30-65 will have MRI scans, thinking and movement tests, and blood draws. The goal is to find brain changes linked to memory and thinking problems, which could help design better treat…

This study looks at whether older adults (age 50+) with advanced ovarian or endometrial cancer are willing and able to complete physical and cognitive tests before and after their standard cancer treatment. Researchers want to see how many people sign up, start the tests, and fin…

This study looks at whether a nurse-led support program helps new mothers and their babies in five rural North Carolina counties get better care after childbirth. About 1,300 women will either receive the extra nurse support or standard care. The goal is to see if the program red…

This study looks at whether simulation training for doctors, nurses, and midwives can reduce the number of cervical exams women receive during labor and make exam results more consistent. Over 1,100 healthcare providers and patients will take part. The goal is to improve care by …

This study looks at whether a special education and mentorship program, called COACH-APP, can help advanced practice providers (like nurse practitioners and physician assistants) feel more confident about taking part in cancer research. About 97 providers from community cancer ce…

This study looks at whether a wearable activity tracker can be used to collect heart rate data from people with pancreatic or breast cancer who are undergoing treatment. The goal is to see if patients find the device easy to use and if they will wear it consistently for 14 days. …

This study aims to find out if younger women (45 and under) with non-metastatic breast cancer experience more pain from pegfilgrastim (a drug that helps white blood cell recovery during chemotherapy) compared to older women. About 115 women will report their pain levels and have …

This study collects blood and tissue samples from 20,000 people with suspected solid tumors. The samples are stored in a central bank for researchers to use in future studies. The goal is to help scientists better understand cancer and develop new treatments. Participation involv…

This study looks at how very low nicotine cigarettes change heart rate and heart rate variability in people who smoke daily or occasionally. About 49 adults aged 21 and older who have smoked at least once in the past month will participate. Researchers compare the effects of low-…

This study is testing a blood test called liquid biopsy to see if it can find bits of tumor DNA in people with sarcoma (a type of bone or soft tissue cancer). Researchers will collect blood samples from 300 participants before, during, and after treatment to see how well the test…

This study looks at two ways to help families who struggle to get enough food while their child is in the hospital: delivering meals or giving grocery gift cards. Researchers want to find out which method works best for these families. About 30 caregivers of hospitalized children…

This study looks at how oxytocin, a natural hormone given as a shot, affects the part of your nervous system that helps you rest and digest. Researchers will measure tiny changes in pupil size to see the effect. The study includes healthy adults and people with chronic knee pain …

This study aims to create a computer program that can predict how easy or hard it will be to place a breathing tube by analyzing photos of a patient's face. Researchers will take pictures from three angles and use them to develop a more accurate, consistent method than current ma…

This study looks at how salt in the diet affects blood pressure in young adults who were born prematurely. Researchers will measure blood pressure changes on high- and low-salt diets, and test if a drug called allopurinol can reduce salt sensitivity. About 120 participants, both …

This study is for people with blood cancers who are getting a stem cell transplant from a donor. Researchers want to learn how a person's genes and the amount of a drug called cyclophosphamide in their body affect the risk of graft-versus-host disease (GVHD), a common complicatio…

This study looks at whether patients who talk to an EMS doctor on the phone are less likely to refuse going to the hospital by ambulance. About 250 adults who want to refuse transport will be included. The goal is to see if a doctor's guidance can improve patient decisions and re…

This study compares different outreach methods to encourage lung cancer screening in people at high risk. About 27,000 participants aged 50-77 who smoke or recently quit will use a digital tool called mPATH-Lung. The goal is to see which approach works best, especially for racial…

This study looks at how a gene called APOL1 affects kidney transplant success. People of African ancestry are more likely to have certain versions of this gene that can cause kidney disease. Researchers will test DNA from 5,000 kidney donors and recipients to learn how these gene…

This study looks at how a person's genetic makeup influences side effects and how well they respond to a common treatment for acute myeloid leukemia (AML). About 50 newly diagnosed adults will receive azacitidine and venetoclax, and researchers will track severe side effects and …

This study looks at whether providing financial navigation services can reduce the money-related stress (financial toxicity) that often comes with cancer treatment. About 120 adults aged 18-64 with newly diagnosed acute myeloid leukemia (AML) who are starting intensive chemothera…

This study aims to measure normal pressures in the brain's veins in people who do not have Idiopathic Intracranial Hypertension (IIH). Researchers will record these pressures during a routine angiogram in 10 participants. The goal is to establish a baseline of normal values, whic…

This study collects bone marrow samples from 70 people with blood cancer to grow 3D organoids—tiny lab-made models of the cancer. Researchers will test different chemotherapy combinations on these organoids to see which kills the most cancer cells. The goal is to learn if this ap…

This study looks at adults aged 65 and older receiving chemotherapy for any type of cancer. Researchers will use a frailty index to create personalized care plans and track how well participants handle treatment. The goal is to see if this approach improves resilience and reduces…

This study looks at whether giving older adults (65+) an antidepressant called duloxetine when they leave the hospital after a broken leg can prevent depression. Researchers will track how many people agree to take the medicine and how their mood changes over a year. The goal is …

This study looks at whether people with chest pain who are at moderate risk for a heart attack can be safely evaluated as outpatients instead of being admitted to the hospital. About 500 adults will be randomly assigned to either rapid outpatient testing or standard hospital care…

This study looks at how a common breast cancer drug called an aromatase inhibitor changes the bacteria in your gut. Researchers want to see if these changes affect estrogen levels in the body. About 25 women starting this drug will provide stool and blood samples over 12 weeks.

This study works with families of children with cancer to design a program called CERCA. The goal is to identify and address non-medical needs like housing, food, or transportation. Researchers will interview caregivers and clinic staff to understand current challenges and build …

This study is for older adults with advanced colorectal cancer who are about to start chemotherapy. It aims to see if having low muscle mass at the start of treatment leads to more severe side effects. Researchers will track side effects and survival for at least a year. The goal…

This study looks at how well the immune system works in children who have finished cancer treatment. It aims to restart routine vaccines earlier than usual—just 3 months after therapy ends—and compares giving a single booster shot versus a full series of vaccines. The goal is to …

This study looks at whether a special genetic test (microarray PGx) can find more useful information than the standard single-gene test for cancer patients. The goal is to help doctors choose the right drug and dose, especially for people with gastrointestinal cancers. About 120 …

This study looks at whether oxytocin, a natural hormone, can change how nerves send pain signals after mild heat. Sixty healthy adults will receive either oxytocin or a placebo through an IV. Researchers will measure nerve activity and pain ratings when light and firm pressure is…

This study aims to identify early signs of Alzheimer's disease by tracking memory, brain scans, and blood sugar levels in 850 adults over time. Participants include those with normal cognition or mild impairment, and some with prediabetes. The goal is to better understand how met…

This study looks at how belly pressure changes during a heart procedure called pulsed field ablation for atrial fibrillation. Researchers will compare pressure levels when patients receive sedation versus general anesthesia. About 50 adults having this standard heart treatment wi…

This study listens to cancer survivors to understand how they experience and talk about fatigue. Researchers will interview 80 survivors and their doctors to create a visual poster that helps patients describe their fatigue better. The goal is to improve communication and help pe…

This study looks at whether community paramedics in rural counties can reach smokers who are not yet ready to quit and help them stop. About 800 adult smokers who are not planning to quit soon will receive text-message support. The goal is to see if this approach gets more people…

This study looks at whether PET scans and blood tests can predict how a person's memory and thinking might change after radiation therapy for a type of brain tumor called high-grade glioma. About 16 adults who are getting chemoradiation will have two PET scans, cognitive tests, a…

This study looks at whether giving first-year medical students a wearable device (like a smartwatch) and personalized wellness coaching can help them handle stress better. Researchers will track heart rate, sleep, and stress levels over time. The goal is to see if these tools can…

This study looks at how chronic stress changes brain and immune function in people with HIV who use stimulants. Researchers will test whether a positive affect intervention can reduce stimulant use and depressed mood. The goal is to better understand these processes to develop im…

This study looks at why people with a CALR gene mutation and a type of blood cancer called MPN have a lower risk of dangerous blood clots compared to those with a JAK2 mutation. Researchers will measure certain immune markers and inflammatory proteins in blood samples from 35 adu…

This study looks at whether removing stomach contents before taking heart images during surgery improves picture quality. About 200 adults having heart surgery with a special ultrasound probe will be enrolled. Researchers will compare images taken before and after stomach suction…

This study is following 2000 adults with newly diagnosed breast, colorectal, lung, melanoma, or lymphoma cancer who are receiving chemotherapy or immunotherapy. Researchers will track whether patients who use cannabis or cannabinoids report fewer or less severe symptoms like pain…

This study looks at how a non-invasive brain stimulation technique called TMS affects brain activity in people who drink heavily and those who don't. Researchers will use MEG brain scans to measure these effects in 10 participants. The goal is to gather information that could hel…

This study looks at whether regular MRI scans of the brain after radiation therapy can find cancer that has spread to the brain before it causes symptoms. It involves 60 adults with stage III non-squamous lung cancer. The goal is to see if early detection can reduce the number of…

This study aims to find better ways to help people with atopic dermatitis (eczema) use their topical medication as prescribed. About 30 adults and children over age 9 will be divided into groups: one gets standard care, another gets a demonstration, and a third uses a mobile app.…

This study surveys surgeons and advanced practice providers to see how often they prescribe blood clot prevention medication after abdominal or pelvic cancer surgery. The goal is to understand current practices and improve adherence to guidelines. About 500 participants from canc…

This study will check 300 firefighters in Charlotte, NC, for early signs of blood cancers. Researchers want to see if job-related chemical exposures increase the risk of pre-cancerous conditions like clonal hematopoiesis and monoclonal gammopathy. Participants must be 40-49 years…

This study aims to understand cancer-related fatigue in 20 adults with non-small cell lung cancer who are receiving immunotherapy. Researchers will conduct interviews and use questionnaires to learn about fatigue patterns, daily impacts, and patients' views on physical activity. …

This study explores why many pancreatic cancer patients develop severe muscle wasting, known as cachexia. Researchers will collect blood samples from 100 patients to look for genetic differences that may be linked to this condition. The goal is to better understand the causes and…

This study observes 600 children under 10 years old to find better ways to remove breathing tubes after surgery when IV anesthesia is used. Researchers will track how often removal is successful and if any breathing problems occur. The goal is to improve safety and outcomes for y…

This study aims to identify frailty and pre-frailty in people with HIV who are 50 years or older. Researchers will measure physical performance and quality of life to better understand the challenges of healthy aging in this group. No treatments or medications are being tested; t…

This study looks at how certain natural chemicals in the body, like angiotensin-(1-7), uric acid, and klotho, are linked to high blood pressure and damage to the heart, kidneys, and blood vessels in children. Researchers will follow 125 children aged 7-18 with newly diagnosed hig…

This study looks at whether offering different types of food assistance to pregnant women who struggle to afford enough food can work in a real-world clinic setting. About 60 pregnant women in their first trimester will be enrolled and followed for 6 months. The goal is to see if…

This study is looking at whether chemotherapy given before surgery can improve physical fitness and thinking skills in older adults with advanced ovarian or endometrial cancer. Researchers will measure changes in frailty (physical weakness) and cognitive function after 3-4 rounds…

This study looks at how many opioid pain pills people actually take after surgery for bladder, kidney, or prostate cancer. About 684 adults will report their opioid use for 30 days after leaving the hospital. The study also tests whether a simple pamphlet helps people safely disp…

This study aims to develop better tools to measure how myotonic dystrophy (DM) progresses. Researchers will use advanced MRI scans to measure muscle size and fat content in the legs of 75 adults with DM1 or DM2. The goal is to create a precise, objective way to track muscle chang…