Wake Forest University Health Sciences

This trial tests whether a structured physical rehabilitation and exercise program can help older adults (age 60+) who have been hospitalized for heart failure with preserved ejection fraction (HFpEF). Participants will receive a progressive, multi-domain rehab intervention after…

This study tests whether using just one Perclose device to close the artery after TAVR is as safe and effective as the usual two devices. Researchers will measure bleeding time and complications in 300 adults undergoing TAVR. The goal is to see if a simpler approach can reduce pr…

This study looks at ways to prevent bone loss when older adults lose weight. It will test if a combination of resistance exercise and a bone-strengthening drug (alendronate) can protect bone density. About 900 overweight or obese older adults with low bone mass will take part for…

This early-phase trial tests whether a lab-grown urethra made from a patient's own cells can safely repair urethral strictures (narrowing of the urine tube) in adult men. Ten participants will receive the engineered tissue, and researchers will monitor for side effects and improv…

This study tests a high dose of the chemotherapy drug methotrexate given through a vein in people with breast cancer that has spread to the lining of the brain. The goal is to see if it helps them live longer. The trial includes adults with triple-negative, HER2-positive, or horm…

This study enrolls 864 Black adults with uncontrolled high blood pressure to see if a home monitoring program with pharmacist and community health worker support works better than usual clinic care. Participants will either get a home BP monitor plus remote medication management …

This pilot study tests whether providing culturally appropriate food bundles and easy-to-read recipes can help adults with type 2 diabetes who face food insecurity. About 25 participants will receive food bundles and education, then complete surveys at 3 and 6 months. The goal is…

This study compares two surgeries for severe heel fractures: standard repair with plates and screws versus standard repair plus a subtalar joint fusion. The goal is to see which approach leads to better pain relief, function, and return to work. About 218 adults with severe heel …

This study tests whether a personalized, gradual start to dialysis is safer and improves quality of life compared to the standard fixed schedule. It involves 350 adults with end-stage kidney disease who recently started dialysis. Researchers will track hospital visits, overall he…

This study is testing whether providing information about local food resources, help from a community health worker, or medically-tailored meals can improve blood pressure and medication adherence in people with uncontrolled hypertension who also face food insecurity. About 224 p…

This study tests a coordinated weight loss program where parents and children work together to eat healthier, be more active, and support each other. About 90 families will join, with parents attending their own program while kids take part in a pediatric weight management clinic…

This study compares managing chronic high blood pressure during pregnancy using telehealth visits and home blood pressure monitoring versus standard in-person clinic visits. Pregnant women aged 18-45 with chronic hypertension can join. The goal is to see if this approach is safe …

This study compares two common seizure medications, levetiracetam and lacosamide, to see which works better at preventing early seizures after a traumatic brain injury. Researchers will also track side effects like agitation and sedation. The trial plans to enroll 600 adults with…

This study looks at whether taking vitamin D supplements during standard chemotherapy can help more tumors disappear in people with triple-negative breast cancer who are low in vitamin D. About 50 participants will receive vitamin D plus chemotherapy, and researchers will compare…

This study tests whether adding omeprazole (a common heartburn medicine) to standard chemotherapy can help control advanced prostate cancer that has stopped responding to other treatments. About 50 men with castration-resistant prostate cancer will receive either omeprazole plus …

The BEAT-AD study is testing whether a low-carb, high-fat ketogenic diet can improve thinking and memory in 120 adults with mild cognitive impairment, a precursor to Alzheimer's. Participants are randomly assigned to either a ketogenic diet or a low-fat diet for 16 weeks, with fo…

This study compares two surgical approaches for fixing certain types of fractures at the bottom of the thighbone (distal femur). One group gets a single implant (a plate or a rod), while the other gets two implants (a plate plus a rod or an extra plate). The goal is to see which …

This study looks at 250 African-American women with a type of scarring hair loss called CCCA. Researchers will compare how well different treatments—like steroid creams, steroid injections, an oral antibiotic, and minoxidil—work over 18 months. The goal is to see which approach b…

This study tests whether wearing a functional knee brace after ACL reconstruction helps athletes feel more ready to return to sports. 96 people aged 14-39 with a complete ACL tear who want to get back to sports will be enrolled. Half will wear a brace after surgery, half will not…

This study tests whether injecting a person's own muscle fibers into the shoulder muscle can safely improve strength and function after rotator cuff repair. Researchers take a small sample of chest muscle, break it into tiny fragments, and inject them into the torn muscle during …

This phase 2 trial is testing whether giving two different chemotherapy regimens one after the other can shrink pancreatic tumors that are borderline or locally advanced, making them easier to remove surgically. The study enrolls 64 adults with pancreatic adenocarcinoma. Particip…

This study looks at whether giving the immunotherapy drug durvalumab within two weeks of finishing chemotherapy and radiation is possible and helpful for people with stage III lung cancer that cannot be removed by surgery. About 28 participants will receive durvalumab early, and …

This phase 2 trial is testing the drug cetuximab by itself in people with head and neck cancer that has come back or spread. Participants have already tried immunotherapy (PD-1 inhibitors) and it stopped working or caused side effects. The study will measure how many patients see…

This study looks at whether non-small cell lung cancer patients who are less fit (performance status 2) can be treated just as effectively with a combination of chemotherapy and immunotherapy as those who are more fit (performance status 0-1). About 105 participants will receive …

This study is testing whether a custom energy-storing leg brace, combined with a high-intensity rehabilitation program, can improve walking, stair climbing, and daily function in people with lower leg injuries. About 370 adults who have been fitted with the brace will be followed…

This study looks at whether adding metformin, a common diabetes medicine, to standard cancer treatment can help people with advanced soft tissue sarcoma live longer. About 50 adults whose cancer has spread or cannot be removed will take metformin along with their usual therapy. T…

This early study tests whether injecting a person's own muscle fragments into the anal sphincter can repair muscle and improve bowel control. Ten adults with severe, long-term fecal incontinence who have not been helped by other treatments will receive the injection. The goal is …

This study tests whether starting cholesterol-lowering treatment in the emergency department can help prevent heart attacks and strokes in people at risk. About 130 adults aged 40-75 who are in the ER for possible heart issues will receive guideline-based care. The goal is to low…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce food insecurity and improve insulin resistance. About 200 adults with HIV from a clinic…

This study tests whether a monthly pill called risedronate can reduce bone and muscle loss after sleeve gastrectomy, a common weight-loss surgery. About 200 adults who have had the surgery will take either risedronate or a placebo for 6 months and be followed for a year. The goal…

This study tests whether paramedics in rural areas can help smokers who aren't ready to quit by offering a text-based program called Take a Break, along with nicotine lozenges. The program includes a two-week smoke-free challenge and coaching calls. Researchers will track how man…

This study tests whether giving financial incentives for negative drug tests can help people with opioid, cocaine, or methamphetamine use disorder stay abstinent. Six hundred participants use a smartphone app to submit saliva tests. Some receive escalating or de-escalating reward…

This study is testing a new, flexible hearing aid that sticks to the skin behind the ear or on the forehead. It is designed for people with conductive hearing loss, where sound doesn't travel properly to the inner ear. The trial will include 200 children and adults to see if the …

This study compares two radiotherapy schedules for people with head and neck cancer who begin radiation more than 6 weeks after surgery. One group gets standard treatment (5 days a week), the other gets an accelerated schedule (6 days a week). The goal is to see if the faster sch…

This study compares two smartphone apps designed to help people living with HIV quit smoking. Participants will use one of the apps for about six months and also receive nicotine patches and gum. The goal is to see which app works better at helping people stay smoke-free, using b…

This Phase 1 trial tests a lab-grown vaginal implant made from a patient's own cells for women with vaginal aplasia (born without a vagina). Ten participants will receive the implant to see if it is safe and can improve quality of life. The implant is designed to mimic natural va…

This study tests whether round spermatids (immature sperm cells) can be used in IVF to help men with a condition called non-obstructive azoospermia, where no mature sperm are present. Researchers will collect these cells from the testicles and inject them into eggs to see if they…

This study aims to detect multiple myeloma at its earliest stage, called MGUS, using a simple blood test. It will screen 1,665 Black adults and close relatives of people with plasma cell disorders. The goal is to reduce delayed diagnosis and improve outcomes by catching the disea…

This study uses mobile low-dose CT scans to screen for lung cancer in people aged 40-54 who have a heavy smoking history (30 pack-years or more). Participants in North and South Carolina will get up to three scans over time. The goal is to see if screening younger high-risk smoke…

This study tests whether next-generation sequencing (NGS), a DNA-based method, can detect bacteria in urine when standard lab cultures show very low or no growth. About 100 women with UTI symptoms but inconclusive standard tests will provide urine samples for NGS analysis. The go…

This study is testing a computer algorithm that uses health records to predict whether a person has COPD. Many people with COPD are not diagnosed until the disease is advanced, while others are wrongly told they have it. The goal is to see if the algorithm can correctly identify …

This study is testing a software tool called Belle.ai that uses artificial intelligence to help doctors diagnose common skin diseases. About 400 patients at dermatology clinics will have three photos taken of their skin condition. The AI will analyze the photos and suggest possib…

This study tests two community-based interventions to improve virus prevention behaviors: a crowdsourced campaign package and rapid response teams for contact tracing. Researchers will enroll 546 adults in North Carolina to see if these approaches increase participation and are s…

This study combines peer navigation (trained community members) with mobile health tools to help gay, bisexual, and transgender people in rural Appalachia access HIV, STI, and hepatitis C testing and prevention services. About 141 participants will be split into two groups: one g…

This study tests whether coating a metal rod (intramedullary nail) with antibiotics (vancomycin and gentamicin) can prevent deep infections in people with severe open tibia fractures. About 484 adults with Gustilo Type II or III open tibia fractures will be randomly assigned to r…

This trial tests whether a 12-week group walking program, called Walk On!, can help prevent falls in older adults who have trouble moving or feel socially isolated. Researchers will enroll 192 participants aged 60 and older at community sites. The program includes twice-weekly wa…

This trial tests whether sending text message reminders encourages more high-risk adults to complete a lung cancer screening CT scan. Researchers will enroll 27,000 people aged 50-77 who smoke or recently quit, focusing on minority and rural communities. The goal is to see if sim…

This study looks at whether giving the antidepressant duloxetine to adults aged 65 and older right after a broken leg can prevent depression. One hundred participants will take duloxetine daily for a year and be screened monthly for depressive symptoms. The main goal is to see if…

This study tests an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) designed for young women aged 18-39 with overweight or obesity who may become pregnant within two years. Participants will either join online group classes for 12 months or receive sta…

This study tests whether a daily low-dose aspirin can prevent dangerous blood clots in people with advanced germ cell tumors (including testicular cancer) who are receiving standard chemotherapy. About 35 participants will take aspirin alongside their chemo for 26 weeks. The goal…

This study tests if rinsing with virgin coconut oil can prevent severe mouth sores in children and young adults (ages 7-26) getting a bone marrow transplant. About 60 participants will either use standard mouth rinses or add coconut oil to their routine. Researchers will compare …

This study tests whether placing an antibiotic depot directly into the bone during surgery can prevent infections in people with severe open tibia fractures. About 497 adults with type II or III open fractures will be randomly assigned to get either the antibiotic depot plus stan…

This study tests a program called COACH that trains youth football coaches on safer practice planning to reduce head impacts and concussions. Researchers will track head impacts and cognitive changes in 880 players over a season. The goal is to see if the program is both practica…

This study tests whether freezing certain nerves (cryoablation) during surgery to fix broken ribs can help control pain better than surgery alone. About 80 adults with multiple broken ribs will be randomly assigned to receive either the standard surgery or surgery plus nerve free…

This small study tests if a non-invasive device that stimulates the brain during sleep can increase deep sleep in adults with depression. Researchers want to see if better deep sleep helps with memory, thinking, and mood. Participants wear a headband and activity tracker at home …

This study is testing whether a mobile app called Mighty Pro can help young women with breast cancer feel less distressed. The trial will include 120 women aged 18 to 45 who are patients at a specific cancer center. Participants will use the app for 26 weeks, and researchers will…

This study tests different types of weekly feedback to help people lose weight. 300 adults with overweight or obesity will receive feedback on their calorie intake, diet quality, or physical activity. The goal is to find which feedback works best for improving weight loss.

This study tests whether a virtual exercise and education program can help breast cancer patients maintain their fitness, heart health, and quality of life while undergoing chemotherapy. About 120 patients with stage I-III breast cancer will be enrolled. Participants will attend …

This study compares two non-drug, virtual programs for adults with migraine. Both involve 8 weekly group sessions and online learning. Researchers want to see if these programs can reduce migraine-related disability and improve mood. Participants can continue their usual medicati…

This pilot study tests whether a device called Cereset Research can help caregivers of people with dementia who feel stressed, anxious, or have trouble sleeping. The device plays tones that echo the brain's own rhythms, aiming to improve heart rate variability and reduce stress. …

This study is testing a short group therapy program based on Dialectical Behavior Therapy (DBT) to help cancer patients reduce or stop smoking. The program focuses on building skills in emotion regulation, distress tolerance, and mindfulness. The trial will enroll 16 participants…

This study tests whether a 24-week remote collaborative care program—involving care managers, a psychiatrist, and a psychologist—can improve quality of life for adults with posttraumatic epilepsy who also have anxiety or depression. About 56 participants will either receive this …

This study is testing a new group exercise program combined with remote activity monitoring for older adults with heart failure with preserved ejection fraction (HFpEF). The goal is to see if this approach can improve exercise habits, physical function, and quality of life. About…

This study looks at whether orthopaedic surgeons can safely screen for depression in patients recovering from a broken bone and offer treatment with common antidepressants like Prozac or Cymbalta. About 100 adults who score at least 5 on a depression questionnaire will be offered…

This study tests whether wearing a virtual reality (VR) headset during daily radiation therapy can help manage anxiety in people with prostate, breast, lung, or head and neck cancer. About 54 patients will use a Meta Quest 2 headset during their treatments, and researchers will t…

This study looks at whether teaching cancer patients about taste changes caused by chemotherapy and giving them self-management tools can help reduce those symptoms and maintain healthy eating. About 400 adults starting chemotherapy will be split into two groups: one gets standar…

This study is testing whether a low-frequency pulsed electromagnetic field (PEMF) device can safely reduce pelvic pain and urinary symptoms in women with Interstitial Cystitis/Bladder Pain Syndrome. About 75 female adults will use the device at home, and researchers will track th…

This study tests whether microneedling or dermabrasion works better for improving the look of early surgical scars on the face. Thirty adults with a vertical scar on the upper forehead will receive one of the two treatments. Researchers will measure scar appearance using standard…

This study tests a device called Cereset Research to see if it can improve how the body handles stress, anxiety, and insomnia. About 200 adults with these symptoms will use the device while researchers measure heart rate and blood pressure changes. The goal is to find a non-drug …

This early-phase trial tests whether inhaled nitric oxide is safe for people having emergency clot removal after a stroke. It includes 36 adults with severe strokes. The main goal is to find the highest safe dose without causing brain bleeding.

This study tests a telehealth program designed to help caregivers of people with cancer who are undergoing a special surgery and chemotherapy. The goal is to see if connecting caregivers with helpful resources online can reduce their stress, depression, and money worries. The stu…

This study looks at whether two physical therapy techniques—pulsed wound irrigation and electrical stimulation—can help heal pressure injuries (bedsores) in people with spinal cord injuries. Forty adults in rehab will receive one of three treatments: both techniques, irrigation a…

This study tests a counseling program for caregivers of children hospitalized for a traumatic injury like burns or a car accident. The goal is to reduce PTSD and depression in both the caregiver and child. 24 caregiver-child pairs will be randomly assigned to either the counselin…

This study tests whether a low dose of clonidine, a drug usually used for high blood pressure, can improve sleep and reduce PTSD symptoms in veterans. About 32 veterans with PTSD will take a flexible dose of clonidine nightly for 6 weeks. Researchers will track changes in sleep q…

This study tests whether wearing a virtual reality headset during a bone marrow biopsy can reduce pain and anxiety. 160 adults with blood cancers will be randomly assigned to either standard care or standard care plus a VR headset. The goal is to see if this simple, non-drug tool…

This study tests whether a tailored physical activity program can help lymphoma and breast cancer patients preserve their exercise ability, heart function, memory, and quality of life while undergoing cancer treatment. About 110 adults aged 18-85 with Hodgkin or non-Hodgkin lymph…

This study looks at different ways to close the skin after a C-section to find which method leads to the best-looking scar and fewer wound problems. About 52 women having scheduled C-sections will take part. Researchers will take photos of scars and have doctors rate them, and al…

This small pilot study tests whether a special red LED cap can improve symptoms and slow hair loss in women with central centrifugal cicatricial alopecia (CCCA), a scarring hair loss that mainly affects middle-aged Black women. Five women with confirmed CCCA will use the cap dail…

This study compares how fast urine flows through two different catheters designed for women who regularly use catheters to empty their bladder. Seventeen women will test both catheters during one visit, and answer questions about satisfaction a week later. The goal is to see if o…

This study tests whether a 24-week collaborative care program can improve quality of life for adults with epilepsy who also have anxiety or depression. The program includes regular check-in calls and expert recommendations from a psychiatrist and neurologist. Researchers will com…

This trial studies 88 women undergoing vaginal surgery for pelvic organ prolapse. Half will take senna pills and half will use bisacodyl suppositories after surgery. Researchers will measure how quickly each group has their first bowel movement and how satisfied they are with the…

This study compares a new stitchless drain holder (K-LOCK) to the usual stitch method in 140 plastic surgery patients. The goal is to see if the new device improves quality of life and reduces complications like pain or early drain loss. Participants will be randomly assigned to …

This study tests whether an internet-based pain coping skills program can help cancer survivors manage ongoing pain. About 456 adults who have completed cancer treatment or are on maintenance therapy will take part. Participants will either get the online program plus enhanced us…

This study tests whether giving magnesium along with the standard migraine drug prochlorperazine reduces pain more than the drug alone. About 100 adults with migraines in the emergency department will receive either the combination or a placebo. Researchers will measure pain chan…

This study is testing whether a structured exercise program called 'Just Move' can help children and young adults (ages 2–25) with newly diagnosed cancer maintain physical function and improve quality of life during chemotherapy. Participants will either follow a 30-minute exerci…

This phase 3 trial tests whether a combination of four drugs (R.E.C.K) controls pain after robotic kidney surgery as well as the more expensive drug Exparel. About 170 adults having robotic partial or total kidney removal will be randomly assigned to receive one of the two inject…

This study tests whether telehealth can help primary care doctors better manage children with complex medical conditions. About 900 children in North Carolina will either receive usual care or enhanced telehealth support. The goal is to reduce hospital visits and ease the burden …

This pilot study tests whether a 12-week high-velocity resistance training program is safe and doable for older adults with advanced chronic kidney disease. Thirty participants will either do the exercise program or join weekly healthy lifestyle sessions. The goal is to see if th…

This study tests whether a custom 3D-printed mouth splint can help burn patients who have developed microstomia (a tight, small mouth opening). Ten participants will use the splint and be measured for changes in mouth size and function using a special survey. The goal is to ease …

This study tests whether taking a fisetin supplement can lessen fatigue in older adults who have survived cancer. About 60 people who finished cancer treatment more than a year ago will take fisetin or a placebo. Researchers will measure changes in fatigue levels using a standard…

This study is creating and testing a new speech therapy program for people who feel a constant lump in their throat (globus pharyngeus). Ten adults will try the treatment to see if it reduces their throat discomfort and related anxiety. The goal is to develop a standard therapy t…

This study tests whether injecting Xeomin® into the upper arm can improve walking and quality of life in adults who have weakness on one side after a stroke. Twenty participants will be measured before and 4-6 weeks after the injection using walking tests and a sensor. The goal i…

This study tests whether virtual reality therapy can reduce phantom limb pain in people who have lost an arm. Twenty participants will either receive six sessions of VR therapy or just fill out surveys. The goal is to see if VR can lower pain and improve well-being.

This study tests whether giving magnesium through an IV can safely slow a rapid heart rate in people with atrial fibrillation or flutter. Researchers will compare two different doses of magnesium to a placebo. The goal is to see if magnesium helps control heart rate within the fi…

This study tests whether a 5-session online program teaching positive thinking skills can help people with HIV who use stimulants. Researchers want to see if it reduces stimulant use and depression by changing brain and immune function. 189 participants will be followed for 3 mon…

This study asks 3000 teens and young adults (ages 15-39) with cancer, along with their caregivers, to answer survey questions about body image, fertility, and financial stress. The goal is to create better tools to measure quality of life for future patients. Participants include…

This study looks at whether patients who talk to an EMS doctor on the phone are more likely to agree to go to the hospital by ambulance. About 250 adults who want to refuse transport will be studied. The goal is to see if a doctor's conversation can improve patient decisions and …

This study looks at how salt in the diet affects blood pressure in young adults who were born prematurely. Researchers will test whether the drug allopurinol can reduce salt sensitivity. 120 participants will follow high- and low-salt diets, and some will also take allopurinol to…

This study looks at whether simulation training for doctors, nurses, and midwives can reduce the number of cervical exams women receive during labor and make exam results more consistent. Over 1,100 healthcare providers and patients will take part. The goal is to improve care wit…

This study measures the normal blood pressure inside the brain's veins in 10 people who are already having a brain angiogram for other reasons. The goal is to create a baseline of healthy pressures, which can help doctors better understand and treat Idiopathic Intracranial Hypert…

This study is looking at whether younger women (45 and under) feel more pain from a drug called pegfilgrastim, which is given during chemotherapy for breast cancer, compared to older women. About 115 women will report their pain levels and have their blood counts checked. The goa…

This study looks at how to better support adults aged 65 and older during chemotherapy. Researchers will use a frailty score to create personalized care plans and track how well participants handle treatment. The goal is to see if this approach improves resilience and reduces hos…

This study looks at whether extra financial help (called financial navigation) can reduce money-related stress and improve quality of life for people being treated for acute myeloid leukemia (AML). About 120 adults aged 18-64 starting intensive chemotherapy will be split into two…

This study asks 300 adolescents and young adults (ages 15-39) who have or had cancer to fill out questionnaires. The goal is to find gaps in education about exercise, sexual health, fertility, finances, and more. No treatment is given—just a survey to help improve future care.

This study is collecting blood samples from 35 adults with a type of blood cancer called myeloproliferative neoplasm (MPN) who have a specific genetic mutation (CALR). Researchers want to understand why patients with a different mutation (JAK2) have a higher risk of dangerous blo…

This study is creating a program called CERCA to help families of children with cancer get their social needs met, like finding food, housing, or transportation. Researchers will work with families, doctors, and community groups to design the program and test if it is practical a…

This study looks at two ways to help families who struggle to get enough food while their child is in the hospital. Researchers will compare giving families free meal deliveries versus grocery gift cards. The goal is to find out which method works best to support these families d…

This study explores how transcranial magnetic stimulation (TMS) changes brain activity in people with and without heavy alcohol use. Researchers will use magnetoencephalography (MEG) to measure brain signals before and after TMS. The goal is to gather early data to support future…

This study looks at whether firefighters' exposure to hazardous chemicals leads to pre-cancerous changes in their blood. Researchers will collect blood samples from 300 firefighters aged 40-49 with at least 5 years on the job. The goal is to find early markers that might predict …

This study gathers basic health information from 2000 people receiving stem cell transplants for blood cancers or immune disorders. The goal is to track survival and complications to help doctors and researchers improve future treatments. Participants must be getting a standard t…

This study surveys 500 surgeons and advanced practice providers across the U.S. to see how often they prescribe blood thinners after cancer surgery to prevent dangerous blood clots. The goal is to understand current practices and find ways to improve care. No new treatments are b…

This study tests a mentorship and education program called COACH-APP for advanced practice providers (like nurse practitioners and physician assistants) who work in community cancer care. The goal is to see if the program increases their confidence in participating in clinical re…

This study tests whether a rapid outpatient evaluation within 72 hours of an emergency department visit is as safe and effective as hospitalization for people with chest pain at moderate risk of a heart attack. About 500 participants will be randomly assigned to either outpatient…

This study aims to develop a computer algorithm that uses three facial photographs to predict how difficult it will be to insert a breathing tube (intubation). Researchers will compare this automated method to traditional exams in 3,500 patients needing intubation. If accurate, t…

This study looks at how chronic marijuana use changes brain inflammation and thinking abilities in people with HIV. Researchers will use brain scans and blood tests to measure brain health in 220 adults. The goal is to understand the effects, not to test a new treatment.

This study is tracking 850 adults with normal cognition or early memory problems, some of whom have prediabetes. Researchers will monitor memory, brain scans, and spinal fluid over time to see how blood sugar issues might affect Alzheimer's risk. The goal is to better understand …

This study aims to understand frailty in people with HIV who are 50 or older. Researchers will screen participants for signs of weakness or low stamina, then offer a personalized activity plan with strength, balance, and walking goals. The study will track how well people stick w…

This study is testing whether PET scans and blood tests can predict memory and thinking problems that often occur after radiation treatment for high-grade glioma. Sixteen participants will have scans and cognitive tests before, during, and after radiation. The goal is to see if t…

This study looks at whether regular MRI scans of the brain after radiation therapy can find cancer that has spread to the brain before it causes symptoms. About 60 adults with stage III non-squamous lung cancer will get brain MRIs at set times. The goal is to see if this monitori…

This study follows 2,000 adults with newly diagnosed breast, colorectal, lung, melanoma, or lymphoma cancer who are receiving chemotherapy or immunotherapy. Researchers will track whether using cannabis or cannabinoids helps with symptoms like pain or nausea over time. No treatme…

This research study collects blood and tissue samples from 20,000 people with suspected solid tumors. The samples are stored in a repository for scientists to study later. The goal is to advance our understanding of cancer, not to test a new treatment.

This study looks at how belly pressure changes during a heart procedure called pulsed field ablation for atrial fibrillation. Researchers will use a special catheter to measure pressure in the abdomen while patients are under different types of anesthesia. The goal is to see if t…

This study looks at whether a personalized, step-by-step food assistance program can help pregnant women who struggle to afford enough food. About 60 pregnant women in their first trimester will receive different levels of support based on their needs. The goal is to see if this …

This study looks at whether oxytocin, a natural hormone, can change how nerves react to light touch and painful pressure after a small area of skin is heated. Sixty healthy adults will receive either oxytocin or a placebo through an IV, and a tiny needle will record nerve signals…

This study looks at whether a broad genetic test (microarray PGx) can find more drug-gene interactions than the standard single-gene test in 120 adults with cancer who are about to receive chemotherapy. The goal is to see if this extra information could help doctors adjust drug d…

This study is collecting genetic samples from 50 adults with newly diagnosed acute myeloid leukemia (AML) who are starting treatment with azacitidine and venetoclax. Researchers want to see if certain genetic variations are linked to severe side effects or how well the drugs work…

This study looks at how myotonic dystrophy types 1 and 2 affect the brain. About 100 adults aged 30-65 will have MRI scans, thinking and movement tests, and blood draws. Some will also have a spinal tap. The goal is to find brain changes that could be used as markers in future tr…

This study looks at how cancer survivors describe their fatigue, a common and often misunderstood symptom. Researchers will interview 80 survivors and their doctors to find common themes and language. The goal is to create a visual aid (like a Venn diagram) to help patients and p…

This study aims to understand cancer-related fatigue in people with non-small cell lung cancer who are receiving immunotherapy. Researchers will interview 20 patients about their fatigue, daily function, and views on physical activity. The goal is to learn how fatigue affects pat…

This study is looking for 75 adults with myotonic dystrophy (a muscle disease) and healthy volunteers to test new muscle imaging techniques. The goal is to find better ways to measure muscle changes over time, which could help future treatment studies. Participants will undergo M…

This study is looking for genetic differences that may explain why many people with pancreatic cancer develop severe muscle wasting (cachexia). Researchers will collect blood samples from 100 patients to analyze their DNA. The goal is to find markers that could lead to earlier de…

This study looks at how many opioid pain pills patients actually take after surgery for bladder, kidney, or prostate cancer. About 684 adults will report their opioid use 30 days after leaving the hospital. The study also tests whether a simple pamphlet helps people safely dispos…

This study looks at how well the immune system works in children who have finished cancer treatment. It aims to see if restarting vaccinations just 3 months after therapy is safe and effective. Researchers will compare giving a single booster shot versus a full series of vaccines…

This study is testing whether a blood test can find tiny bits of tumor DNA in people with sarcoma, a rare cancer of bone or soft tissue. Researchers will take blood samples before, during, and after treatment to see how well the test works. The goal is to learn if this liquid bio…

This study looks at whether low muscle mass (myopenia) is linked to severe side effects from chemotherapy in older adults with advanced colorectal cancer. Researchers will follow 300 newly diagnosed patients to track toxicities and survival. The goal is to better understand who m…

This study is looking at how a person's genes and the amount of the drug cyclophosphamide in their body affect the risk of graft-versus-host disease (GVHD) after a stem cell transplant. Researchers will study 120 transplant recipients and their donors. The goal is to find ways to…

This pilot study is testing whether wearable activity trackers, like fitness watches, can help monitor fatigue in people with pancreatic or breast cancer who are undergoing treatment. Researchers want to see if patients will use the device daily and find it easy to use. The study…

This study aims to understand why many people with atopic dermatitis (eczema) don't use their topical medication as prescribed, which can lead to worse symptoms and higher healthcare costs. About 30 adults and children with active dermatitis will be divided into groups to receive…

This study observes 600 children under 10 to find the best criteria for safely removing their breathing tubes after surgery using only IV anesthesia (no gas). Researchers will track how often removal is successful and if any problems like breathing trouble occur. The goal is to i…

This study looks at how oxytocin, a natural hormone, affects the part of your nervous system that controls rest and digestion. Researchers will give a single injection of oxytocin or a placebo to 38 people (some with knee arthritis, some healthy) and measure tiny changes in pupil…

This study is looking at children ages 7 to 18 who have been newly diagnosed with high blood pressure. Researchers want to understand how certain hormones in the body, like angiotensin-(1-7), may contribute to damage in the heart, kidneys, and blood vessels. Over two years, they …

This study follows 200 people who have broken their pelvis or hip socket to see how they recover over time. Researchers will track when patients return to work and daily activities, and measure changes in physical function, mood, and pain. The goal is to better understand the rec…

This study looks at whether emptying the stomach with a tube before taking heart ultrasound images during cardiac surgery makes those images clearer. About 200 adults having heart surgery will have their heart images rated before and after stomach suction. The goal is to find a s…

This study tests a program called NEST-Rural that provides extra nurse and social worker support to new mothers in five rural North Carolina counties. About 1,300 women will be randomly assigned to receive either the program or usual care. The goal is to see if the program leads …

This study looks at whether giving chemotherapy before surgery helps older adults (over 55) with advanced ovarian or endometrial cancer become fitter for their operation. Researchers will measure changes in frailty using a special score from medical records. The goal is to see if…

This early-phase study is testing whether cigarettes with very low nicotine content cause less strain on the heart compared to regular cigarettes. Researchers will measure heart rate and heart rate variability in 49 daily and non-daily smokers after smoking different types of res…