New hope for breast cancer patients with brain lining spread: High-Dose methotrexate trial underway
NCT ID NCT02422641
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a high dose of the chemotherapy drug methotrexate given through a vein in people with breast cancer that has spread to the lining of the brain. The goal is to see if it helps them live longer. The trial includes adults with triple-negative, HER2-positive, or hormone-resistant breast cancer who have this specific type of brain involvement.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Comprehensive Cancer Center at Wake Forest University (CCCWFU)
RECRUITINGWinston-Salem, North Carolina, 27157, United States
Contact Email: •••••@•••••
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Sidney Kimmel Comprehensive Cancer Center
RECRUITINGBaltimore, Maryland, 21287, United States
Contact Email: •••••@•••••
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Siteman Cancer Center- Washington University School of Medicine in St. Louis
ACTIVE_NOT_RECRUITINGSt Louis, Missouri, 63130, United States