New hope for breast cancer patients with brain lining spread: High-Dose methotrexate trial underway

NCT ID NCT02422641

Recruiting now Disease control Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study tests a high dose of the chemotherapy drug methotrexate given through a vein in people with breast cancer that has spread to the lining of the brain. The goal is to see if it helps them live longer. The trial includes adults with triple-negative, HER2-positive, or hormone-resistant breast cancer who have this specific type of brain involvement.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm Meningeal Neoplasms neoplastic meningitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEPTOMENINGEAL DISEASE METASTATIC BREAST CANCER

Contacts and locations

Locations

Comprehensive Cancer Center at Wake Forest University (CCCWFU)
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Sidney Kimmel Comprehensive Cancer Center
RECRUITING

Baltimore, Maryland, 21287, United States
Siteman Cancer Center- Washington University School of Medicine in St. Louis
ACTIVE_NOT_RECRUITING

St Louis, Missouri, 63130, United States

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