Can a pill reach the brain and fight tumors?
NCT ID NCT07751744
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This trial tests an oral drug called JBI-778 in people with brain metastases, leptomeningeal disease, or recurrent high-grade glioma. The drug is designed to block a protein that may help tumors grow. The study aims to find the safest dose and see if the drug can shrink tumors or improve survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- JBI-778, an oral drug that blocks a protein called PRMT5, which may help slow or shrink certain brain tumors.
- What this could lead to
- If it works, this could offer a new treatment option for people with brain metastases or aggressive brain tumors that have come back, potentially slowing the disease or shrinking tumors.
- What could go wrong
- This is an early-stage trial, so the drug may not work as hoped or may cause side effects. It is also a small study, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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