Can a Custom-Made vaccine train the immune system to fight brain cancer?
NCT ID NCT07762716
First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This early-stage trial is testing a personalized cancer vaccine called BreakVax, designed from each patient's own tumor, in combination with standard chemotherapy and immunotherapy drugs. The goal is to see if this multi-pronged approach can safely and effectively boost the immune system's ability to attack glioblastoma, an aggressive brain cancer. The study involves adults with glioblastoma and will first check safety, then look at whether the treatment improves overall survival at 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A personalized peptide-based cancer immunotherapy (BreakVax) combined with ipilimumab, pembrolizumab, chemotherapy, losartan, and aspirin
- What this could lead to
- If successful, this approach could offer a new, personalized treatment option for glioblastoma, potentially improving survival by training the immune system to target each patient's unique tumor.
- What could go wrong
- This is an early-phase trial with only 10 participants, so results may not apply broadly. The combination therapy carries risks of immune-related side effects, and manufacturing the personalized vaccine may fail for some patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Miami Herbert Wertheim Cancer Institute
Miami, Florida, 33176, United States
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