Oxygen-Enhanced MRI could sharpen radiotherapy for deadly brain cancers
NCT ID NCT07670455
First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times
Summary
This study tests whether oxygen-enhanced MRI (OE-MRI) can identify low-oxygen (hypoxic) regions in high-grade gliomas, the most common and aggressive adult brain cancers. Twenty-five patients will undergo OE-MRI scans before, during, and after standard radiotherapy. Researchers will then use computer models to see if targeting those hypoxic areas with higher radiation doses could improve tumor control. The study does not change actual treatment—it is purely imaging and planning.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Oxygen-enhanced MRI (OE-MRI)
- What this could lead to
- If successful, this imaging technique could help doctors target radiotherapy more precisely to low-oxygen tumor areas, potentially improving treatment for aggressive brain cancers.
- What could go wrong
- This is a small, early-stage imaging study (25 participants) that only models higher radiation doses—it does not test actual treatment changes. The technique may not reliably detect hypoxia or improve outcomes.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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