Brain hypoxia - ischemia

This program gives children with brain disorders like cerebral palsy or stroke access to umbilical cord blood infusions. The treatment uses donated cord blood cells to help repair brain damage. Kids up to age 26 with normal immune function may qualify. The goal is to improve symp…

After a cardiac arrest, some patients develop seizures that do not respond to standard treatment. This trial tests whether putting the brain into a deeper state of electrical silence — called burst suppression — can stop those seizures better than the usual approach of only suppr…

This study tests different lengths of body cooling in children who remain unconscious after a cardiac arrest outside the hospital. The goal is to see if longer cooling helps protect the brain and improve recovery. The trial will enroll 900 children and follow them for one year.

This early-phase study tests whether adding melatonin to standard cooling therapy can improve brain outcomes in newborns with hypoxic-ischemic encephalopathy (HIE), a condition caused by oxygen loss at birth. About 70 full-term infants will receive different doses of melatonin to…

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This study tests whether giving caffeine to newborns with hypoxic ischemic encephalopathy (HIE) can reduce death or long-term disability. HIE is a brain injury caused by lack of oxygen around birth. The trial will enroll 830 full-term infants and give them either caffeine or a pl…

This study tests whether cooling therapy (lowering body temperature for 72 hours) helps babies born with mild brain injury from oxygen loss, compared to standard care without cooling. Researchers will track 460 newborns' development at age 2 and monitor side effects. The goal is …

This study tests if carefully cooling the body of newborns who suffered brain injury from lack of oxygen at birth can improve their chances of survival and long-term brain development. The treatment, called therapeutic hypothermia, is already used in some hospitals. This trial wi…

This study tests a drug called RLS-0071 in newborns who have brain damage from lack of oxygen during birth. The babies also receive standard cooling therapy. The goal is to see if the drug is safe and may help reduce brain injury. About 70 babies will take part, and they will be …

This study tests whether a virtual version of the Abecedarian Approach, an early childhood education program, can help children ages 0-5 who had a brain injury from lack of oxygen (HIE) or were born very prematurely. Researchers will enroll 225 families and measure parent satisfa…

This study tests a drug called sovateltide in newborns with brain injury from lack of oxygen at birth (hypoxic-ischemic encephalopathy). The drug aims to help the brain repair itself. About 40 full-term babies will receive either sovateltide or a placebo, along with standard cool…

This study will test a portable, low-field MRI machine to see how well it detects brain injuries from lack of oxygen or blood flow in children. About 200 kids in intensive care will get both a portable and a standard MRI. The goal is to find out if the portable version is accurat…

This study tests whether a portable, low-field MRI machine can detect brain injuries in children who are on ECMO (a heart-lung bypass machine). The MRI is brought to the bedside, avoiding the need to move critically ill children. Researchers will scan children at several time poi…

This study tests whether a higher-than-usual dose of the seizure medicine levetiracetam can safely stop seizures in newborns. About 133 full-term infants with seizures will first receive a standard dose, and if seizures continue, they will be randomly assigned to get either a hig…

This study looks at giving hydrocortisone, a steroid, to newborns with brain injury from lack of oxygen who are being cooled and have low blood pressure. Researchers want to find the best dose for each baby by measuring steroid levels in the blood. The goal is to safely raise blo…

This study tests whether a wireless sensor placed on the forehead can accurately measure oxygen levels in the brains of infants in the neonatal intensive care unit (NICU). The wireless device is compared side-by-side with the standard wired monitor in 20 newborns with conditions …

This study is looking for biological markers (biomarkers) in blood, urine, spinal fluid, and other samples that could help predict who will have a stroke and how they will recover. Researchers will follow 7,000 people with and without ischemic cerebrovascular disease for up to 4 …

This study tests whether a video camera with artificial intelligence can track newborn brain health by analyzing their movements. About 200 babies in the NICU will be recorded continuously from admission to discharge. The AI's findings are kept from doctors for now, to see if the…

This study looks at how well hospitals manage severe oxygen deprivation (asphyxia) in newborns at or near full term. Researchers will review care given during labor and after birth to find where improvements can be made. The goal is to help doctors and nurses provide better, fast…

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study looks at how a newborn's brain and blood flow work together in the first minutes after birth. Researchers will place a small patch on the baby's scalp to measure brain activity and oxygen levels. The goal is to learn more about how babies adjust to life outside the wom…

This study looks at whether simple, non-invasive eye tests can help predict brain development in newborns with hypoxic-ischemic encephalopathy (HIE), a type of brain injury caused by lack of oxygen. Researchers will measure eye function using visual evoked potential (VEP) and ele…

Cerebral palsy (CP) is a brain injury that affects movement, but diagnosing it can take up to 2 years. This study follows 600 high-risk infants (premature, brain-injured, or with abnormal exams) across Irish hospitals. Researchers will use EEG sleep tests, protein markers, and co…

This study explores whether mild low-oxygen (hypoxic) conditioning, alone or combined with exercise, can improve blood vessel function in the brains of inactive adults aged 60-80. Researchers will measure changes in brain blood flow and other health markers in 64 participants. Th…

This study looks at how changes in brain blood flow affect breathing control during sleep in healthy adults. Researchers will expose participants to normal oxygen and low oxygen levels to see how the brain responds. The goal is to better understand sleep apnea and related conditi…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study looks at how different types of anesthesia change blood flow and oxygen use in the brains of children. Up to 1,000 kids having an MRI scan will be asked to join. The goal is to learn more, not to test a new treatment.

This study looks at how a 2-week, personalized therapy program helps children aged 4-12 with conditions like cerebral palsy, autism, or genetic disorders. Kids get about 2.5 hours of tailored therapy each day, focusing on skills like movement, attention, and communication. The go…

This study aims to uncover the molecular causes of secondary brain injury in patients who survive cardiac arrest. Researchers will analyze cerebrospinal fluid from 60 participants using advanced techniques to identify changes in genes, proteins, and other molecules. The goal is t…

This study looks at the genes of 300 infants who had brain injury around birth (neonatal encephalopathy) and their parents. Researchers want to find out if genetic differences explain why some babies have mild symptoms while others have severe long-term problems. The study does n…

This study collects blood, clots, and tissue from up to 1000 people having procedures for stroke or other blood vessel problems in the brain. Researchers will analyze these samples to find biological markers and understand inflammation. The goal is to learn more about how stroke …

This study tests a portable MRI machine to look for brain injury in patients who have had a cardiac arrest. Researchers will scan the brain multiple times over several days to see how injuries change. The goal is to make brain imaging available at hospitals without specialized sc…

This study tests a special microscope attachment called GLOW800 that helps surgeons see blood flow and tissues in real time during brain and reconstructive surgery. About 29 adults will take part, and surgeons will rate how well the tool works. The goal is to confirm the device i…

This study follows 700 patients who received ECMO after cardiac arrest to find out what predicts survival and good brain function. Researchers will also check if pre-primed ECMO machines work safely and how patients fare years later. The goal is to help doctors choose the right p…

This study looks at blood markers related to inflammation and clotting in people with brain oxygen deprivation from stroke or bleeding. Researchers will compare these markers between patients with brain hypoxia and those without. The goal is to see if these markers are linked to …

This early study is testing whether a robot can help doctors perform delicate brain blood vessel procedures, such as angiography, embolization, and thrombectomy. Ten patients scheduled for these standard procedures will have them done using a robotic system instead. The main goal…

This study follows 65 infants who had a stroke around birth, tracking their brain development and motor skills over two years. Researchers use MRI scans, brain stimulation, and movement tests to find markers of recovery. The goal is to understand how the brain heals, which could …

This study tests a new, non-invasive device that measures oxygen levels in the brains of newborns at risk for brain injury. Researchers will compare readings from babies receiving cooling therapy, those with brain injury not getting cooling, and healthy newborns. The goal is to s…

This study follows 60 infants at high risk for Cerebral Visual Impairment (CVI), a brain-based vision problem often missed until later childhood. Researchers will collect data from clinical exams, brain scans, and vision tests up to 24 months of age. The goal is to create a model…

This study watches 250 adults who are unconscious after a cardiac arrest to see if early brain tests can predict when they will wake up. Researchers use tools like EEG and ultrasound to monitor the brain. The goal is to find reliable signs of recovery, not to test a new treatment…

This study offers genome sequencing to 25 newborns diagnosed with HIE (a severe brain condition from lack of oxygen at birth) who are receiving cooling therapy. Researchers want to find out how often genetic changes cause or contribute to HIE. The goal is to help doctors decide w…

This study tests whether a simple clinical score can help doctors decide when to safely remove breathing tubes from brain-injured patients who are still unconscious. The trial will include 660 adults with acute brain injuries who have been on a ventilator for more than 48 hours. …

This study follows 130 patients with disorders of consciousness after stroke, traumatic brain injury, or oxygen deprivation. Researchers will use brain scans, electrical tests, and regular check-ups to find factors that might predict if and when patients regain consciousness. The…