New tool could help Brain-Injured patients breathe on their own sooner

NCT ID NCT04080440

Recruiting now Knowledge-focused Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether a simple clinical score can help doctors decide when to safely remove breathing tubes from brain-injured patients who are still unconscious. The trial will include 660 adults with acute brain injuries who have been on a ventilator for more than 48 hours. The goal is to reduce the number of patients who need to be re-intubated or die within five days of tube removal.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Extubation readiness clinical score (a procedure to guide decision-making)
What this could lead to: If successful, this could provide a simple, reliable tool to help doctors decide when to remove breathing tubes in brain-injured patients, potentially reducing complications and time on a ventilator.
What could go wrong: This is a single trial testing a clinical score, not a drug or device. The score may not improve outcomes in all patients, and results may not apply to other settings or patient groups.

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia Brain Injuries, Traumatic brain injury Coma Consciousness Disorders stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE BRAIN INJURY AIRWAY CONTROL ALTERED LEVEL OF CONSCIOUSNESS MECHANICAL VENTILATION MECHANICAL VENTILATOR WEANING

Contacts and locations

Locations

APHM
WITHDRAWN

Marseille, France
CH
TERMINATED

Bourg-en-Bresse, France
CH
TERMINATED

Valence, France
CHU
RECRUITING

Angers, France
CHU
RECRUITING

Bordeaux, France
CHU
RECRUITING

Bordeaux, France
CHU
RECRUITING

Caen, France
CHU
RECRUITING

Clermont-Ferrand, France
CHU
COMPLETED

Grenoble, France
CHU
RECRUITING

La Réunion, France
CHU
RECRUITING

Lille, France
CHU
RECRUITING

Montpellier, France
CHU
COMPLETED

Nantes, France
CHU
RECRUITING

Nîmes, France
CHU
RECRUITING

Poitiers, France
CHU
RECRUITING

Rennes, France
CHU
COMPLETED

Saint-Etienne, France
CHU
RECRUITING

Toulouse, France
Fondation Ophtalmologique Adolphe de Rothschild
RECRUITING

Paris, France
Hospices Civils de Lyon
RECRUITING

Lyon, France
Pasteur 2 Hospital - University Hospital
TERMINATED

Nice, France

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