New tool could help Brain-Injured patients breathe on their own sooner
NCT ID NCT04080440
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tests whether a simple clinical score can help doctors decide when to safely remove breathing tubes from brain-injured patients who are still unconscious. The trial will include 660 adults with acute brain injuries who have been on a ventilator for more than 48 hours. The goal is to reduce the number of patients who need to be re-intubated or die within five days of tube removal.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Extubation readiness clinical score (a procedure to guide decision-making)
What this could lead to
If successful, this could provide a simple, reliable tool to help doctors decide when to remove breathing tubes in brain-injured patients, potentially reducing complications and time on a ventilator.
What could go wrong
This is a single trial testing a clinical score, not a drug or device. The score may not improve outcomes in all patients, and results may not apply to other settings or patient groups.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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APHM
WITHDRAWNMarseille, France
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TERMINATEDBourg-en-Bresse, France
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TERMINATEDValence, France
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CHU
RECRUITINGAngers, France
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CHU
RECRUITINGBordeaux, France
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CHU
RECRUITINGBordeaux, France
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CHU
RECRUITINGCaen, France
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CHU
RECRUITINGClermont-Ferrand, France
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CHU
COMPLETEDGrenoble, France
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CHU
RECRUITINGLa Réunion, France
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CHU
RECRUITINGLille, France
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CHU
RECRUITINGMontpellier, France
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CHU
COMPLETEDNantes, France
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CHU
RECRUITINGNîmes, France
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CHU
RECRUITINGPoitiers, France
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CHU
RECRUITINGRennes, France
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CHU
COMPLETEDSaint-Etienne, France
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CHU
RECRUITINGToulouse, France
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Fondation Ophtalmologique Adolphe de Rothschild
RECRUITINGParis, France
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Hospices Civils de Lyon
RECRUITINGLyon, France
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Pasteur 2 Hospital - University Hospital
TERMINATEDNice, France