ACUTE BRAIN INJURY

This phase II trial tests whether keeping fluid balance neutral (close to zero) is safe and feasible for adults with traumatic brain injury in the ICU. 88 participants will be randomly assigned to either a neutral fluid strategy or standard care for 5 days. The goal is to see if …

This study tests whether a portable, low-field MRI machine can detect brain injuries in children who are on ECMO (a heart-lung bypass machine). The MRI is brought to the bedside, avoiding the need to move critically ill children. Researchers will scan children at several time poi…

This study tests whether giving a single dose of a common antibiotic soon after a breathing tube is placed can prevent lung infections and improve survival in ICU patients with severe brain injuries. Researchers will enroll 3,300 adults on ventilators due to stroke, trauma, or la…

This study will track how often and how intensely patients with moderate to severe brain injury are moved or exercised while in intensive care units in Scandinavia. Researchers want to see if more movement is linked to better outcomes and safety. About 198 adults on breathing mac…

This study tracks 90 coma patients in intensive care to see if their body's natural daily rhythms (like sleep-wake cycles) return as they wake up. Researchers will measure behavior, eye movements, temperature, and urine biomarkers every few hours. The goal is to better understand…

This study watches 148 adults with acute brain injury who have a drain in their head. Researchers will check fluid from the brain to see if changes in a substance called lactate can signal an infection early. The goal is to learn more, not to test a new treatment.

This study explores whether using both lung and brain ultrasound can help doctors choose the best ventilator pressure for patients with acute respiratory distress syndrome (ARDS) and acute brain injury. About 30 critically ill adults on breathing machines will be enrolled. The go…

This study looks at 406 patients with acute brain injury who need a breathing machine. Doctors often struggle to know when it's safe to remove the tube, and many patients fail. The goal is to find clues that predict successful weaning, so patients can avoid unnecessary procedures…

This study tests whether a simple clinical score can help doctors decide when to safely remove breathing tubes from brain-injured patients who are still unconscious. The trial will include 660 adults with acute brain injuries who have been on a ventilator for more than 48 hours. …