Can keeping fluid levels neutral help brain injury patients?
NCT ID NCT07625995
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial tests whether keeping fluid balance neutral (close to zero) is safe and feasible for adults with traumatic brain injury in the ICU. 88 participants will be randomly assigned to either a neutral fluid strategy or standard care for 5 days. The goal is to see if this approach can be achieved and whether it reduces complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Neutral fluid balance strategy (restricted fluids, diuretics, vasopressors)
What this could lead to
If successful, this could establish a safer way to manage fluids in brain injury patients, potentially reducing complications and improving recovery.
What could go wrong
This is an early phase II trial with only 88 participants, so results may not apply to all patients. The strategy may be difficult to achieve or could cause harm like low blood pressure or kidney issues.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Erasme University Hospital
RECRUITINGBrussels, 1070, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITINGRoma, 00168, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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IRCCS Ospedale Policlinico San Martino
RECRUITINGGenova, 16132, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••