Can keeping fluid levels neutral help brain injury patients?

NCT ID NCT07625995

Recruiting now Disease control Sponsor: Erasme University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial tests whether keeping fluid balance neutral (close to zero) is safe and feasible for adults with traumatic brain injury in the ICU. 88 participants will be randomly assigned to either a neutral fluid strategy or standard care for 5 days. The goal is to see if this approach can be achieved and whether it reduces complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Neutral fluid balance strategy (restricted fluids, diuretics, vasopressors)
What this could lead to: If successful, this could establish a safer way to manage fluids in brain injury patients, potentially reducing complications and improving recovery.
What could go wrong: This is an early phase II trial with only 88 participants, so results may not apply to all patients. The strategy may be difficult to achieve or could cause harm like low blood pressure or kidney issues.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic brain injury traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE BRAIN INJURY NEUROCRITICAL CARE SEVERE TRAUMATIC BRAIN INJURY TRAUMATIC BRAIN INJURY

Contacts and locations

Locations

Erasme University Hospital
RECRUITING

Brussels, 1070, Belgium
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Roma, 00168, Italy
IRCCS Ospedale Policlinico San Martino
RECRUITING

Genova, 16132, Italy

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