One-Dose antibiotic could slash ventilator pneumonia deaths in brain injury patients

NCT ID NCT06819592

Recruiting now Prevention Sponsor: The George Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving a single dose of a common antibiotic soon after a breathing tube is placed can prevent lung infections and improve survival in ICU patients with severe brain injuries. Researchers will enroll 3,300 adults on ventilators due to stroke, trauma, or lack of oxygen. The goal is to see if early prevention of pneumonia leads to better recovery and lower death rates.

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Conditions

The condition(s) this trial relates to.

brain injury cerebral sinovenous thrombosis intellectual disability intracerebral hemorrhage ischemic stroke nervous system disorder perinatal asphyxia Respiratory Aspiration subarachnoid hemorrhage traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE BRAIN INJURY ALL-CAUSE MORTALITY DISABILITY, INTELLECTUAL INTENSIVE CARE MEDICINE NEUROLOGICAL DISORDER QUALITY OF LIFE VENTILATION, MECHANICAL

Contacts and locations

Locations

Fiona Stanley Hospital
NOT_YET_RECRUITING

Perth, Western Australia, 6150, Australia
Nepean Hospital
RECRUITING

Kingswood, New South Wales, 2747, Australia
Princess Alexandra Hospital
RECRUITING

Woolloongabba, Queensland, 4102, Australia
Royal Brisbane and Women's Hospital
RECRUITING

Herston, Queensland, 4006, Australia
Royal North Shore Hospital
RECRUITING

Sydney, New South Wales, 2000, Australia
St George Hospital
RECRUITING

Kogarah, New South Wales, 2217, Australia
The Alfred Hospital
NOT_YET_RECRUITING

Melbourne, Victoria, Australia
The George Institute
NOT_YET_RECRUITING

Randwick, New South Wales, 2031, Australia
Wellington Hospital
RECRUITING

Wellington, New Zealand

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