INTENSIVE CARE MEDICINE

This study tests whether giving a single dose of a common antibiotic soon after a breathing tube is placed can prevent lung infections and improve survival in ICU patients with severe brain injuries. Researchers will enroll 3,300 adults on ventilators due to stroke, trauma, or la…

This study will track 1,000 adults admitted to the intensive care unit (ICU) in Colombia's Orinoco region to understand why some patients die. Researchers will look at factors like disease type and use a scoring tool called APACHE II to see how well it predicts death. The goal is…

This study is testing different treatments to reduce major complications and improve survival in 600 adults who need ECMO—a machine that does the work of the heart and lungs. Researchers will compare how well these treatments work in the first 28 days. The goal is to find safer, …

This study looks at how painkillers and sedatives are given to patients on ECMO, a life-support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals, then work with patients, families, and staff to design a safer sedat…

This study tests a new AI system called IntelliLung that suggests ventilator settings for ICU patients on breathing machines. Researchers will compare how often doctors' settings match the AI's recommendations. About 530 adults on ventilators will take part across multiple hospit…

This study tests a new stepping-in-place exercise test (F-IST) for people who are acutely ill, such as those in the ICU. Researchers want to see if this simple test is as accurate as the standard treadmill test for measuring fitness. Sixty adults who can walk (with or without hel…