The George Institute

This large international trial aims to find the best treatments to slow the progression of chronic kidney disease (CKD) and prevent kidney failure. It will test multiple medications or combinations in adults with CKD over two-year periods. The innovative 'platform' design allows …

This study is testing which of two common IV fluids helps adults with a severe diabetes complication called diabetic ketoacidosis (DKA) get better faster. It will compare a standard saline solution to a more balanced electrolyte solution. The main goal is to see which fluid helps…

This trial is testing if giving a low-cost steroid pill called fludrocortisone early after a severe brain bleed (aneurysmal subarachnoid hemorrhage) can help more people survive and live independently. It will involve 524 critically ill patients in intensive care, who will be ran…

This large trial is testing if a single dose of a common antibiotic, given soon after a brain-injured patient is put on a breathing machine, can prevent dangerous lung infections (pneumonia). The goal is to see if preventing these infections helps patients survive and recover bet…

This large global study is testing whether a daily pill called dapagliflozin can prevent severe kidney injury in 3000 critically ill patients admitted to intensive care. Patients are randomly assigned to receive either the active drug or a placebo pill for up to 30 days while in …

This study is testing whether two types of non-invasive brain stimulation can help reduce symptoms of anorexia nervosa. Researchers will compare two treatments—transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS)—against placebo t…