The George Institute

This trial investigates whether two medications—colchicine (an anti-inflammatory) and deferoxamine (an iron chelator)—can prevent further brain injury after a hemorrhagic stroke. Up to 2,000 adults aged 18–80 with a spontaneous brain bleed will receive one of four treatments: sta…

This trial is testing several different treatments for stroke, including different doses of a clot-busting drug called tenecteplase and blood pressure management strategies. It aims to find which treatments or combinations work best to improve recovery and reduce disability. The …

This trial tests three different blood pressure management strategies in people who have had a stroke and received endovascular therapy (a procedure to remove a clot). The goal is to find the safest and most effective way to lower blood pressure after treatment to improve recover…

This study is for adults with chronic kidney disease (CKD) who are already receiving standard care. It tests different treatments, alone or in combination, to see which best slows kidney decline and prevents kidney failure. About 1,000 participants will be followed for over two y…

This study tests whether a steroid pill called fludrocortisone can reduce death and disability in people who have had a brain bleed from a burst aneurysm. The trial will enroll 524 critically ill adults who have had their aneurysm secured. Half will receive the drug, half a place…

This study tests whether a balanced electrolyte solution (Plasma-Lyte 148) helps people with moderate to severe diabetic ketoacidosis recover faster than standard saline. About 680 critically ill adults in the emergency department will be randomly assigned to one of the two fluid…

This study tests whether giving a single dose of a common antibiotic soon after a breathing tube is placed can prevent lung infections and improve survival in ICU patients with severe brain injuries. Researchers will enroll 3,300 adults on ventilators due to stroke, trauma, or la…

This study compares two forms of ketamine—Spravato (a nasal spray) and standard racemic ketamine (given as an infusion)—in 162 adults with treatment-resistant depression. Participants will be randomly assigned to one treatment and will complete questionnaires about mood, side eff…

This study tests whether two types of non-invasive brain stimulation—rTMS and tDCS—can improve symptoms of anorexia nervosa. Seventy participants in an inpatient setting will receive either active or sham (placebo) stimulation over 8 weeks. Researchers will measure changes in eat…