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New study aims to solve ventilator dilemma for brain injury patients

NCT ID NCT06542107

Knowledge-focused Sponsor: Southeast University, China Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Sep 10, 2026 · Updated 4 times

Summary

This study looks at 406 patients with acute brain injury who need a breathing machine. Doctors often struggle to know when it's safe to remove the tube, and many patients fail. The goal is to find clues that predict successful weaning, so patients can avoid unnecessary procedures like tracheostomy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a practical tool that helps doctors decide when to safely remove a breathing tube in brain injury patients, potentially reducing complications.
What could go wrong
This is an observational study, not a treatment trial. It may not produce a reliable prediction tool, and results may not apply to all patients or hospitals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

605 people

The number who actually took part.

Started

Aug 2024

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All patients admitted to the ICU due to acute brain injury and treated with invasive mechanical ventilation

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * acute brain injury * age \>=18 years * invasive mechanical ventilation for at least 24 hours Exclusion Criteria: * tracheostomized before ICU admission * pregnant or lactation * with cervical spinal cord injury * decision to receive palliative care within 24 hours of ICU admission

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Conditions

The condition(s) this trial relates to.

brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute brain injury Ventilator lung

Contacts and locations

Locations

  • Department of Critical Care Medicine, Zhongda Hospital

    Nanjing, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.