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Common ICU procedure may briefly raise brain pressure — study investigates the risk

NCT ID NCT07704528

Knowledge-focused Sponsor: Beijing Tiantan Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This observational study looks at how inserting a central venous catheter into the neck affects pressure inside the skull in patients with acute brain injury. Researchers will monitor brain pressure, blood flow, and oxygen levels during and after the procedure in about 120 ICU patients. The goal is to understand the size and duration of any pressure changes, which could help make this routine procedure safer for brain-injured patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors understand the risks of a common ICU procedure and guide safer care for patients with acute brain injury.
What could go wrong
This is an observational study, not a treatment trial, so it will not directly improve outcomes. Results may not apply to all brain injury patients or hospital settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients (≥18 years) with acute brain injury (including traumatic brain injury, spontaneous intracerebral hemorrhage, large hemispheric infarction, and aneurysmal subarachnoid hemorrhage) who require invasive intracranial pressure monitoring and are scheduled for clinically indicated percutaneous internal jugular vein catheterization. Patients with ICP \>22 mmHg within 48 hours prior to the procedure, contraindications to jugular catheterization (e.g., severe coagulopathy, local neck pathology, bilateral catheters already in place), or who are pregnant/breastfeeding are excluded. The study population is recruited from two ICUs in China (Beijing Tiantan Hospital and Guiyang Second People's Hospital).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Admitted to the ICU with acute brain injury (including traumatic brain injury, spontaneous intracerebral hemorrhage, large hemispheric infarction, or aneurysmal subarachnoid hemorrhage) and ICU stay ≥ 24 hours * Invasive intracranial pressure (ICP) monitoring in place as part of clinical care * Scheduled to undergo percutaneous internal jugular vein catheterization (central venous catheter) as determined by the treating physician * Written informed consent obtained from the patient or legally authorized representative Exclusion Criteria: * Informed consent not obtained * Intracranial pressure (ICP) \> 22 mmHg within the past 48 hours * Any contraindication to internal jugular catheterization exists (severe coagulopathy with INR \> 1.5 or platelets \< 50×10⁹/L; neck infection, tumor, prior surgery or anatomical abnormality on either side; or bilateral jugular veins already catheterized) * Pregnancy or breastfeeding

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Conditions

The condition(s) this trial relates to.

acquired aneurysmal subarachnoid hemorrhage brain infarction Brain Injuries, Traumatic brain injury intracerebral hemorrhage intracranial hypertension subarachnoid hemorrhage traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute brain injury Aneurysmal subarachnoid hemorrhage (ASAH) Central venous catheter Intracerebral hemorrhage Intracranial hypertension Traumatic brain injury

Contacts and locations

Locations

  • Beijing Tiantan Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100070, China

  • The Second People's Hospital of Guiyang

    Guiyang, Guizhou, 550081, China

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