Beijing Tiantan Hospital

This study tests whether the clot-busting drug tenecteplase can help people who have a stroke caused by a blocked artery in the brain, even when treatment starts 24 to 72 hours after symptoms begin. About 330 adults with moderate to severe stroke will receive either tenecteplase …

This study compares two treatments for idiopathic intracranial hypertension (IIH), a condition where high pressure in the skull causes vision problems and headaches. Researchers will test if placing a small tube (stent) in a narrowed brain vein works better than standard medicati…

This study tests whether the antibiotic minocycline can improve recovery in people who have had a brain bleed (intracerebral hemorrhage). About 1,200 adults aged 18 to 80 will receive either minocycline or a placebo within 48 hours of their stroke. The goal is to see if the drug …

This study tests whether a drug called indobufen, combined with clopidogrel, is safer and more effective than the standard aspirin-plus-clopidogrel regimen for preventing strokes after a brain aneurysm is repaired. About 2,500 adults with unruptured brain aneurysms will take one …

This study tests whether a procedure to remove blood clots from medium-sized brain arteries, guided by advanced imaging, helps people recover better than standard medical care alone. It includes 568 adults who had a stroke within the last 24 hours. The goal is to see if this appr…

This study tests whether a surgical procedure on lymph vessels in the neck can help people with moderate-to-severe Alzheimer's disease. The surgery is designed to improve the brain's ability to drain waste. Researchers will compare the change in dementia symptoms over 12 months b…

This study tests whether the drug tenecteplase can help people who have had a stroke caused by a blockage in a medium-sized brain artery. Participants must be treated within 4.5 to 24 hours of symptoms starting. The goal is to see if the drug improves recovery and reduces disabil…

This study tests whether a computer-based decision-support system helps doctors manage cholesterol-lowering treatment (evolocumab) more effectively in people who recently had a stroke or mini-stroke. About 4000 participants in China will be followed for one year to see if more pa…

This study compares two surgical techniques for treating chronic subdural hematoma, a condition where blood collects between the brain and its outer covering. One method uses a small hole and a drain, while the other uses a tiny camera to see and remove the blood directly. The go…

This study tests whether a non-invasive ultrasound device can safely help clear blood clots in the brain after a hemorrhagic stroke. About 86 adults with small-to-medium sized brain bleeds will receive either standard care alone or standard care plus daily ultrasound sessions. Th…

This study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help people recover after a serious brain bleed (aneurysmal subarachnoid hemorrhage) and aneurysm clipping surgery. RIC uses a blood pressure cuff on the arm to create short, harmless …

This study tests a new drug-coated stent (NxiDIME) for people with severely narrowed brain arteries who have already had a stroke or mini-stroke. About 224 participants will be randomly assigned to get either the new stent or a similar approved stent. The goal is to see if the ne…

This study tests a laser treatment called MRgLITT for people with drug-resistant temporal lobe epilepsy. The goal is to see if it can stop or reduce seizures. About 120 adults will take part. The treatment uses heat from a laser to target the part of the brain causing seizures.

This early-stage study tests a new gene therapy (GA) for people with severe nerve pain that hasn't improved with standard treatments. The therapy involves injecting a gene into a brain area linked to pain, then taking a pill to activate it. The main goal is to check safety in jus…

This study tests whether giving a clot-busting drug called tenecteplase directly into the brain's arteries can help people recover better after a stroke caused by a medium-sized blockage. About 488 adults who have had a stroke within the last 24 hours will be randomly assigned to…

This study tests a new drug, Aleeto, to see if it helps people recover better after a moderate to severe stroke. About 192 adults who have had a stroke within the last 72 hours will receive either Aleeto or a placebo. The main goal is to measure changes in stroke-related disabili…

This study tests if a mild electrical stimulation on the ear (taVNS) can reduce dangerous brain swelling after a hemorrhagic stroke. 186 adults with a recent brain bleed will receive either real or fake stimulation. The main goal is to measure swelling reduction and check for sid…

This study tests whether a procedure to reopen a blocked artery in the back of the brain can help people who had a severe stroke 24 to 72 hours earlier. About 224 adults will be randomly assigned to get either the procedure or standard medical care. The goal is to see if more peo…

This study tests whether a WeChat-based intelligent management system can help people who have had a stroke or mini-stroke avoid another one. About 4,490 participants will either get usual care or use the app after leaving the hospital. After one year, researchers will check for …

This study is testing a new carotid artery stent system for people with narrowed neck arteries who are at high risk for the standard surgical procedure. It aims to see if placing this stent is safe and effective at preventing strokes and other complications. The study will enroll…

This study uses artificial intelligence to analyze facial expressions and speech patterns in people with Parkinson's disease and related conditions. The goal is to create a simple, non-invasive digital tool that can help doctors diagnose and track these diseases more accurately. …

This study tests whether the oral medication venlafaxine can prevent postherpetic neuralgia, a chronic pain condition that often follows shingles. Researchers will enroll 832 adults with active shingles and moderate to severe pain. The goal is to see if early treatment with venla…

This study tests whether improved oral hygiene combined with antibiotics can prevent pneumonia in people who have had a brain hemorrhage. About 440 adults with a small to medium-sized bleed will be randomly assigned to receive either standard care or enhanced mouth care plus anti…

This study tests whether a medicated patch (loxoprofen sodium) can safely reduce pain from shingles. About 750 adults with moderate to severe shingles pain will use the patch and report their pain levels. The goal is to find a topical option that works well with fewer side effect…

This study tests whether a single injection of dexamethasone palmitate before surgery can better prevent nausea and vomiting after minimally invasive procedures compared to standard care. About 588 adults aged 18-65 having laparoscopic or thoracoscopic surgery will take part. The…

This study compares two medications, pregabalin and mirogabalin, to see which works better for easing pain in people with fibromyalgia, a condition causing widespread pain and fatigue. About 674 adults with moderate to severe fibromyalgia who haven't tried these drugs before will…

This study tests a new way to give pain medicine after surgery. It compares a standard pump that gives a steady dose of opioids to a smart pump that adjusts the dose based on the patient's pain level. The goal is to see if the smart pump can lower the total amount of opioids need…

This study tests whether the antidepressant desvenlafaxine can safely reduce pain in people with shingles. Researchers will enroll 750 adults who have had a shingles rash for less than 90 days and are experiencing moderate to severe pain. The goal is to see if this medication off…

This study tests whether adding a newer pain medication called mirogabalin to standard shingles treatment provides better pain relief than standard treatment alone. The trial will enroll 750 adults with shingles rash for less than 30 days and moderate to severe pain. Mirogabalin …

This study tests whether a new, long-acting painkiller (liposomal bupivacaine) can provide better and longer pain relief after hemorrhoid surgery compared to the standard painkiller. About 156 adults having hemorrhoid surgery will receive one of the two painkillers injected into …

This study tests whether a longer-lasting steroid (dexamethasone palmitate) given before open surgery can better prevent nausea and vomiting than standard care. About 500 adults having spine, chest, or abdominal surgery will take part. The goal is to see if this drug reduces symp…

This study tests whether adding a long-acting numbing drug (liposomal bupivacaine) to the usual painkiller helps control pain better after laparoscopic (keyhole) surgery. About 190 adults having gallbladder, hernia, or appendix surgery will receive either the combination or the s…

This early-stage study tests the safety of a new drug, Aleeto, in 20 people with Multiple System Atrophy (MSA), a rare brain disease that affects movement and body functions. Participants will be randomly assigned to receive Aleeto or standard care, and researchers will monitor s…

This study looks at two different methods of giving pain medicine through a patient-controlled pump after surgery. The goal is to see if a new, time-based method can lower the amount of opioids needed, improve pain relief, and reduce side effects. About 450 adults having various …

This study tests whether injecting steroids into muscle trigger points can relieve chronic migraine pain as well as the standard nerve block injection. About 1,000 adults with long-term migraines will be randomly assigned to one of the two injection types and followed for two yea…

This study tests a non-invasive brain stimulation technique called iTBS to see if it can safely improve cognitive function in people with cerebral small vessel disease, a condition that damages small blood vessels in the brain and often leads to thinking and memory problems. Rese…

This study is for adults with fibromyalgia whose pain hasn't been helped enough by standard treatments. Researchers want to see if adding esketamine (a rapid-acting painkiller) to usual care can provide better and faster pain relief. About 92 participants will be randomly assigne…

This study tests whether injecting a low-dose painkiller (flurbiprofen) and a numbing drug (ropivacaine) into the scalp before brain surgery can reduce the need for strong opioid pain medicine afterward. About 216 adults having craniotomy will take part. The goal is to see if thi…

This study tests whether injecting a steroid into muscle trigger points (knots) works as well as injecting it directly into the knee joint for people with chronic knee osteoarthritis pain. About 1,000 adults aged 45 and older with knee pain will receive one of the two injections …

This study tests whether a long-acting painkiller (liposomal bupivacaine) plus a standard painkiller works better than the standard painkiller alone for pain after video-assisted lung surgery. About 100 adults having lung surgery will be randomly assigned to one of two groups. Th…

This study is testing whether a single low dose of esketamine can reduce symptoms of irritable bowel syndrome (IBS) in 552 adults aged 18-60 who also have anxiety or depression. Participants will receive the drug during a colonoscopy, and their IBS severity and quality of life wi…

This study is testing whether injecting a common anti-inflammatory medicine into muscle trigger points can relieve chronic headache pain as well as a standard nerve block injection. The trial will include 1036 adults aged 18-65 with cervicogenic headache (headache coming from the…

This study compares pregabalin alone versus pregabalin plus venlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The trial will enroll 750 adults with moder…

This study tests whether a longer-acting steroid (dexamethasone palmitate) given before brain surgery can better prevent nausea and vomiting afterward compared to standard treatment. About 500 adults having elective brain surgery will take part. The goal is to see if this drug re…

This study tests whether the muscle relaxant baclofen can safely reduce pain from shingles (herpes zoster). Researchers will enroll 750 adults with moderate to severe pain who have had a shingles rash for less than 90 days. Participants will take baclofen or a placebo, and pain l…

This study compares pregabalin alone versus pregabalin plus dexmedetomidine for treating fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The study will enroll 400 adul…

This study tests a new way to manage pain after lung surgery (VATS). It combines a long-lasting numbing medicine (liposomal bupivacaine) with a standard one, given as a nerve block. The goal is to see if it reduces the need for extra painkillers and improves comfort. About 134 ad…

This study tests two medications, pregabalin and a newer drug called crisugabalin, to see which works better for fibromyalgia pain. About 1,100 adults with moderate to severe fibromyalgia will take one of the drugs and report their pain levels. The goal is to find a more effectiv…

This study tests whether stimulating a nerve in the wrist can safely help improve thinking and memory in people who recently had a traumatic brain injury. Thirty adults aged 18-64 with moderate injuries will receive either real or sham stimulation. The goal is to see if this simp…

This study compares taking pregabalin alone versus pregabalin combined with desvenlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The study will involve 3…

This study compares two types of injections for chronic shoulder pain caused by osteoarthritis. About 1,000 adults aged 45 and older will receive either a trigger point injection or a standard joint injection. Researchers want to see if the simpler trigger point method works just…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can prevent or reduce headaches after a brain aneurysm repair procedure. About 440 adults who are scheduled for stent-assisted coiling will wear the device for 30 minutes twice a day, st…

This study tests whether adding a long-acting numbing medicine (liposomal bupivacaine) to a standard nerve block can better control pain after laparoscopic surgery for gynecologic cancers. About 110 adults aged 18-64 will receive either the combination or standard care. The goal …

This study compares the pain-relieving effects of pregabalin alone versus pregabalin combined with toludesvenlafaxine in people with fibromyalgia. Fibromyalgia causes widespread pain, fatigue, and mood issues, and current treatments often provide only modest relief. The study wil…

This study tests whether a long-acting numbing medicine (liposomal bupivacaine) combined with standard numbing medicine can provide better pain relief after laparoscopic surgery than standard care alone. About 318 adults having gallbladder, hernia, or appendix surgery will receiv…

This study tests whether adding crisugabalin, a newer pain medicine, to usual treatment provides better pain relief for people with shingles. About 750 adults with moderate to severe shingles pain will receive either standard care alone or standard care plus crisugabalin. The goa…

This study tests whether an oral medication called tulodsesvenlafaxine can safely reduce pain in people with shingles (herpes zoster). Shingles causes a painful rash and can lead to long-term nerve pain. The drug works by affecting brain chemicals that control pain. The trial wil…

This study compares two injection methods for treating chronic musculoskeletal pain, including hip arthritis and headaches. About 1,036 adults aged 45 and older will receive either a trigger point injection or a joint injection. Researchers will track pain scores and function ove…

This study tests whether a flurbiprofen patch can safely reduce pain from shingles (herpes zoster). The patch delivers pain relief directly to the skin, aiming to avoid side effects from oral painkillers. Researchers will enroll 750 adults with moderate to severe shingles pain to…

This study follows 2000 people in China with a rare brain aneurysm (vertebrobasilar dissecting aneurysm) that can cause strokes or bleeding. Researchers will compare three approaches: monitoring only, stenting with coils, or using a flow diverter. The goal is to learn which treat…

This study looks at whether people with insomnia need a different amount of the sedative ciprofol during a digestive endoscopy compared to people who sleep normally. About 840 adults aged 18-64 will take part. The goal is to help doctors give the right dose for safer and more com…

This study looks at whether people with insomnia need more or less anesthesia during a digestive endoscopy compared to people who sleep normally. Researchers will track the total amount of anesthetic used and watch for side effects. About 3,360 adults aged 18–64 will take part. T…

This study looks at whether people with insomnia need a different amount of the sedative rimazolen during a digestive endoscopy compared to people who sleep normally. Researchers will track the total sedative used and watch for side effects like breathing or heart problems. The g…

This study aims to find early markers of moyamoya disease—a rare condition that narrows brain arteries—in family members of affected patients. Researchers will use advanced MRI scans and lab tests on blood, urine, and saliva to spot risk before symptoms appear. About 700 people, …

This study will follow 10,000 people aged 12 and older who have primary headache disorders like migraine or tension-type headache, or medication-overuse headache. Researchers will collect data on genetics, brain scans, thinking skills, and daily life to better understand these co…

This study tests whether monitoring oxygen levels in the brain during carotid artery surgery can help doctors manage blood flow and reduce the risk of hidden strokes. About 560 adults having this surgery will be enrolled. The goal is to see if this monitoring approach lowers the …

This study looks at whether people with insomnia need more or less of the sedative etomidate during a digestive endoscopy (a scope procedure). Researchers will compare 840 adults—some with insomnia and some with normal sleep—to see if sleep problems affect sedation requirements. …

This study is observing about 10,000 adults who have had a stroke and received the clot-busting drug tenecteplase as part of their normal care. Researchers will track their recovery and any side effects for 90 days to see how well the drug works in real-world settings across many…