Beijing Tiantan Hospital

This study tests whether the antibiotic minocycline can improve recovery in people having an ischemic stroke. About 934 adults will receive either minocycline or a placebo, in addition to standard clot-busting medication. The goal is to see if minocycline leads to better function…

This study tests whether giving the drug milrinone directly into the brain's arteries, followed by a 72-hour IV drip, can prevent brain damage in people who develop artery spasms after a bleeding stroke from a burst aneurysm. The trial will enroll 306 adults across multiple hospi…

This study tests a traditional Chinese medicine called Jiedu Huayu oral prescription in 436 people who have had a brain bleed due to a condition called cerebral amyloid angiopathy. The goal is to see if the herbal treatment can lower the chance of having another stroke or blood v…

This early-phase trial is testing a new radioactive drug, [177Lu]Lu-DOTA-EB-RGD2, in 24 patients with recurrent high-grade glioma, a fast-growing brain cancer. The drug is designed to seek out and deliver radiation directly to tumor blood vessels. It can be given through a vein o…

This early-phase trial tests a single dose of a radioactive drug called [177Lu]Lu-XT771 in people with recurrent glioblastoma, an aggressive brain cancer. The drug is injected directly into the cavity left after tumor removal surgery, aiming to deliver radiation precisely to canc…

This study tests whether giving hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) soon after emergency clot removal can improve recovery in people with severe stroke. Researchers plan to enroll 420 adults aged 18–80 who had a large-vessel blockage stroke …

This study tests a surgical procedure called deep cervical lymphatic venous anastomosis (DC-LVA) in 376 people with moderate-to-severe Alzheimer's disease. The surgery connects lymph vessels in the neck to veins, aiming to improve drainage of waste from the brain. Researchers wil…

This study tests whether a procedure to reopen a major blocked artery in the brain can help people who had a severe stroke 24 to 72 hours earlier. About 224 participants will either get the procedure plus standard care or standard care alone. The goal is to see if the procedure i…

This study tests a clot-busting drug called tenecteplase, given directly into the brain artery, for people having a medium-sized stroke. About 488 adults will be randomly assigned to get the drug or standard care. The goal is to see if the drug helps more people recover with litt…

This study tests whether the antibiotic minocycline can help people recover better after a spontaneous brain bleed (intracerebral hemorrhage). About 1,200 adults who had a bleed within the last 48 hours will receive either minocycline or a placebo for a short time. The goal is to…

This study tests whether a non-invasive ultrasound device can safely help clear blood clots in the brain after a hemorrhagic stroke. About 86 adults with small-to-moderate brain bleeds will receive either standard care plus ultrasound or standard care alone. The main goal is to s…

This study is testing a new stent system to treat narrowed carotid arteries (the main arteries in your neck) in people who are at high risk for standard surgery. The goal is to see if the stent is safe and effective at preventing strokes, heart attacks, and death. About 212 parti…

This study tests whether the clot-busting drug tenecteplase can help people who have had a stroke caused by a medium-sized blood vessel blockage in the brain. About 600 participants will receive either tenecteplase or standard care within 4.5 to 24 hours of symptoms starting. The…

This study tests whether the clot-busting drug tenecteplase can help people who have had a stroke 24 to 72 hours earlier. Currently, such drugs are only given within a few hours. The trial will compare tenecteplase to standard care (blood thinners) in 330 adults with blocked brai…

This study tests if a drug called indobufen works better than aspirin at preventing strokes and blood clots after a brain aneurysm is fixed with a stent or coil. About 2,500 people with unruptured brain aneurysms will take either indobufen or aspirin, plus clopidogrel, for 6 mont…

This study tests whether a procedure to remove blood clots from medium-sized brain arteries, guided by advanced imaging, helps people recover better than standard medical care alone. It includes 568 adults who had a stroke within the past 24 hours. The goal is to see if more peop…

This study tests whether placing a small tube (stent) in a narrowed brain vein works better than standard medication for people with idiopathic intracranial hypertension (high pressure in the brain). About 74 adults with this condition and a narrowed vein will be randomly assigne…

This trial tests whether using a tiny camera (neuroendoscope) to guide the removal of a chronic subdural hematoma—a blood clot pressing on the brain—works better than the standard burr hole drainage. About 770 adults with symptoms like headache or weakness will be randomly assign…

This early-stage study tests the safety of a new gene therapy (GA) for people with severe nerve pain that hasn't improved with standard treatments. The therapy involves a one-time injection into a brain area that processes pain, combined with a pill to activate the treatment. Onl…

This study tests a minimally invasive laser treatment for people with drug-resistant temporal lobe epilepsy. The procedure uses heat from a laser to destroy the small part of the brain causing seizures. Researchers will track whether patients become seizure-free and how their mem…

This study tests a smart management system that uses a WeChat app and home devices like blood pressure monitors to help people who have had a stroke or mini-stroke avoid another one. About 4,490 participants will either get usual care or use the system after leaving the hospital.…

This study tests whether a device that gently stimulates a nerve in the ear can help people recovering from a brain bleed. The device is placed on the left ear and delivers mild electrical pulses for 30 minutes, twice a day, for 10 days. Researchers will measure brain swelling an…

This study tests whether a computer-based decision-support tool can help more people who have had a stroke or mini-stroke reach their LDL cholesterol goal of less than 1.8 mmol/L after one year of treatment with evolocumab. About 4,000 adults in China who recently had a non-cardi…

This study tests a new drug-coated stent (NxiDIME) for people with severely narrowed brain arteries that have already caused a mini-stroke or stroke. The goal is to see if it keeps the artery open better than an existing stent. About 224 adults will be randomly assigned to get ei…

This study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help people recover after surgery for a ruptured brain aneurysm. RIC involves using a blood pressure cuff on the leg to create brief, harmless blood flow interruptions, which may trigg…

This study tests whether monitoring the brain's oxygen levels during carotid artery surgery can help doctors manage blood pressure and reduce the risk of stroke. 560 adults scheduled for surgery will be randomly assigned to standard care or a strategy that uses a brain oxygen ind…

This early-phase trial tests a drug called Aleeto, a nerve repair protein made from stem cells, in 20 people with Multiple System Atrophy (MSA), a rare brain disease. The study checks if Aleeto is safe and might help with symptoms. Participants receive the drug via injection into…

This Phase 2 trial tests whether the drug Aleeto can improve neurological function in people who have had a moderate to severe ischemic stroke. About 192 participants will receive either Aleeto or a placebo by IV within 72 hours of their stroke. The main goal is to see if Aleeto …

This study is testing whether artificial intelligence can help diagnose Parkinson's disease by analyzing facial expressions and speech patterns. Researchers will record videos of 720 participants, including people with Parkinson's and similar conditions, as well as healthy volunt…

This study tests whether levetiracetam, a seizure medication, can prevent seizures in adults after brain tumor surgery. About 558 participants will receive either the drug or a placebo starting one hour before surgery and continuing for three months. The goal is to see if the dru…

This study tests whether the oral medication venlafaxine, typically used for depression, can prevent postherpetic neuralgia—a persistent nerve pain that often follows a shingles rash. Researchers will enroll 832 adults who have had a shingles rash for less than 30 days and are ex…

This study tests whether intensive oral hygiene combined with antibiotics can prevent pneumonia in people who have had a brain hemorrhage. About 440 adults with small to medium bleeds will be randomly assigned to receive either standard care or enhanced mouth care plus antibiotic…

This study compares two drugs, pregabalin and mirogabalin, to see which works better for fibromyalgia pain. About 674 adults with moderate to severe fibromyalgia who haven't tried these medications will take one of the drugs for several weeks. The main goal is to see how many peo…

This study tests whether pregabalin, a drug used for nerve pain, can ease symptoms of irritable bowel syndrome (IBS). About 258 adults with mild-to-moderate IBS will receive either pregabalin or standard IBS treatments for 12 weeks. Researchers will measure changes in IBS severit…

This study tests whether injecting a combination of a local anesthetic (ropivacaine) and a steroid (triamcinolone) into the incision site before laparoscopic surgery can reduce pain better than the anesthetic alone. The trial will enroll 150 adults undergoing gallbladder, appendi…

This study tests whether injecting a combination of a numbing drug (ropivacaine) and an anti-inflammatory steroid (diprospan) into the surgical cuts before lung surgery can reduce pain and the need for strong painkillers afterward. About 100 adults having keyhole lung surgery wil…

This study tests whether injecting a combination of a numbing drug (ropivacaine) and an anti-inflammatory steroid (diprospan) into the incision site before laparoscopic surgery can reduce pain better than the numbing drug alone. About 150 adults having gallbladder, appendix, or h…

This study tests whether placing a loxoprofen sodium patch on the skin where surgical cuts will be made can reduce pain after laparoscopic surgery. About 134 adults having gallbladder, appendix, or hernia surgery will take part. The goal is to see if this simple step lowers the n…

This study tests whether injecting a steroid (triamcinolone) plus a numbing drug (ropivacaine) into the incision site before lung surgery can reduce pain and the need for morphine afterward. About 100 adults having keyhole lung surgery will be randomly assigned to get either the …

This study tests two different methods of patient-controlled pain pumps to see which one reduces opioid use and improves pain relief after surgery. About 1170 adults having various surgeries will be randomly assigned to one of two pump settings. The goal is to find a smarter way …

This study looks at whether adding esketamine to standard fibromyalgia treatments can reduce pain more quickly and effectively. About 92 adults with fibromyalgia who haven't gotten enough relief from other treatments will take part. Researchers will compare pain levels between th…

This study looks at two different methods for using a patient-controlled pain pump after surgery. The goal is to see if a new, time-based method can reduce the amount of opioids needed while still controlling pain effectively. About 450 adults having various surgeries will take p…

This study tests whether adding a newer pain medication called mirogabalin to standard treatment provides better pain relief for people with shingles. About 750 adults with moderate to severe shingles pain will receive either standard care alone or standard care plus mirogabalin.…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can prevent headaches after a brain aneurysm procedure. About 440 adults will either get the real stimulation or a fake version. The goal is to find a safe, drug-free way to reduce pain …

This study tests whether a long-acting numbing drug (liposomal bupivacaine) combined with standard bupivacaine can provide better pain relief after laparoscopic surgery for gynecologic cancers. About 110 adults undergoing such surgery will receive either the combination or standa…

This study tests whether a long-acting numbing drug (liposomal bupivacaine) plus standard bupivacaine works better than standard bupivacaine alone for pain after laparoscopic surgery. About 190 adults having gallbladder, hernia, or appendix surgery will receive one of the two tre…

This study tests whether a long-acting numbing drug called liposomal bupivacaine, combined with standard bupivacaine, can provide better pain relief after laparoscopic surgery. About 318 adults having gallbladder, hernia, or appendix surgery will receive either the new combo or s…

This study tests whether a long-lasting numbing drug (liposomal bupivacaine) combined with a standard numbing drug can improve pain control after lung surgery. About 134 adults having keyhole lung surgery will receive either the combination or standard care. The goal is to see if…

This study tests whether a long-acting numbing drug called liposomal bupivacaine, when added to a standard painkiller, provides better pain relief after video-assisted lung surgery. About 100 adults having lung surgery will receive either the combination or the standard drug alon…

This study tests whether a long-acting numbing drug called liposomal bupivacaine can control pain for up to 72 hours after hemorrhoid surgery better than standard numbing medicine. About 156 adults having hemorrhoid surgery will receive either the long-acting drug or regular bupi…

This study tests if a gentle electrical pulse to the wrist nerve can safely help thinking and memory in people with recent traumatic brain injury. About 30 adults aged 18-64 with moderate injury will receive either real or sham stimulation. The goal is to see if this simple, non-…

This study compares two medications, pregabalin and a newer drug called crisugabalin, to see which works better for easing fibromyalgia pain. Over 1,100 adults with moderate to severe fibromyalgia will take one of the two drugs, and researchers will measure how many get at least …

This study tests whether a loxoprofen patch can safely reduce pain from shingles (herpes zoster). Researchers will compare standard treatment alone to standard treatment plus the patch in 750 adults with moderate to severe pain. The goal is to see if the patch provides better pai…

This study tests whether adding the muscle relaxant baclofen to standard shingles treatment can better reduce moderate to severe pain. Researchers will enroll 750 adults with shingles rash for less than 90 days. Participants will receive either baclofen plus usual care or usual c…

This study tests whether adding the antidepressant tulodesvenlafaxine to standard shingles treatment can better relieve pain. It includes 750 adults with moderate to severe shingles pain. The goal is to see if this drug reduces pain scores more than usual care alone.

This study tests whether a flurbiprofen patch can safely reduce pain in people with shingles (herpes zoster). About 750 adults with moderate to severe pain will either receive the patch plus standard treatments (antivirals, opioids) or standard treatments alone. The goal is to se…

This study tests whether the antidepressant desvenlafaxine can reduce pain from shingles (herpes zoster) better than standard treatments alone. Researchers will enroll 750 adults with moderate to severe pain and compare those taking desvenlafaxine plus usual care to those receivi…

This study tests whether a new oral medication called crisugabalin can provide better pain relief for people with shingles (herpes zoster) compared to standard treatments. The trial will enroll 750 adults with moderate to severe shingles pain. Participants will receive either cri…

This study compares two types of injections for people with chronic migraines or headaches. One targets trigger points in muscles, the other blocks a nerve in the neck. The goal is to see if the simpler trigger point injection works just as well. About 1,000 adults aged 18-65 wil…

This study tests whether injecting a common steroid into muscle trigger points can relieve long-term shoulder pain and certain headaches as well as injecting into the joint. About 1,000 adults aged 45 and older with shoulder arthritis will receive either a trigger point or joint …

This study tests whether injecting a steroid and numbing medicine into muscle trigger points can relieve knee osteoarthritis pain as well as injecting into the knee joint itself. About 1,000 adults with knee arthritis and at least one tender muscle spot will receive either a trig…

This study compares taking pregabalin alone versus pregabalin plus venlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The study will enroll 750 adults wit…

This study tests whether injecting a steroid and numbing medicine into muscle trigger points can relieve chronic cervicogenic headaches (headaches that start from the neck). Over 1,000 adults aged 18-65 with at least 3 months of headaches will receive either the trigger point inj…

This study compares two types of injections for hip osteoarthritis pain: one into the joint and one into nearby muscle trigger points. Over 1,000 adults with hip pain will be randomly assigned to one of the two groups and followed for two years. The goal is to see if the simpler …

This study tests whether adding a nasal spray drug called dexmedetomidine to the standard medication pregabalin can better relieve pain in people with fibromyalgia. The trial will enroll 400 adults with moderate to severe fibromyalgia who haven't found relief from non-drug treatm…

This study compares pregabalin alone versus pregabalin plus desvenlafaxine for treating fibromyalgia, a condition causing widespread pain and fatigue. Researchers will enroll 384 adults with moderate to severe pain that hasn't improved with non-drug treatments. The goal is to see…

This study tests whether injecting a low dose of two painkillers (flurbiprofen and ropivacaine) into the scalp before brain surgery can reduce pain and the need for strong opioids afterward. About 216 adults having a craniotomy will take part. The goal is to see if this local app…

This study compares pregabalin alone versus pregabalin plus toludesvenlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers will enroll 384 adults with moderate to severe pain that hasn't responded to non-drug treatments. The goal is to see if th…

This study tests whether a longer-acting form of the steroid dexamethasone can better prevent nausea and vomiting after open surgery. Researchers will give 500 adults either the standard dexamethasone or the new version (dexamethasone palmitate) right before surgery. The goal is …

This study tests whether a long-acting steroid called dexamethasone palmitate can better prevent nausea and vomiting after brain surgery compared to the standard steroid. About 500 adults having elective brain surgery will receive either the new drug or standard dexamethasone bef…

This study is testing whether a single low dose of esketamine, given during a colonoscopy, can reduce symptoms of irritable bowel syndrome (IBS) in adults who also have anxiety or depression. The trial plans to enroll 552 participants and will measure symptom severity and quality…

This study tests whether a non-invasive brain stimulation technique called iTBS can improve memory and thinking in people with cerebral small vessel disease, a common cause of cognitive decline. 58 adults aged 45-80 will receive either real or sham stimulation daily for 15 days. …

The CLUE study is a research project that follows 1,000 people with neuroinflammatory diseases like multiple sclerosis and neuromyelitis optica. Participants undergo detailed MRI and PET scans at the start and after one year to see how their brain, spinal cord, and optic nerves c…

This study is looking at families where someone has moyamoya disease, a rare condition that narrows brain arteries and raises stroke risk. Researchers want to find early warning signs in first-degree relatives using advanced MRI scans and biological samples like blood and saliva.…

This study is collecting information from 10,000 people aged 12 and older with common headache disorders like migraine and tension-type headaches. Researchers will track their symptoms, brain scans, genetics, and thinking abilities over time. The goal is to better understand thes…

This study will track 10,000 adults who receive tenecteplase for a stroke caused by a blood clot. Researchers want to see how well patients recover and if there are any safety issues when the drug is used in everyday hospital care. The goal is to improve stroke treatment across C…

This study tracks 2,000 people in China with a rare brain aneurysm called a vertebrobasilar dissecting aneurysm (VBDA). Doctors will use different treatments—observation, stenting, or flow diverters—and follow patients to see which works best. The goal is to create clear guidelin…

This study looks at whether people with insomnia need different amounts of anesthesia during a digestive endoscopy compared to those who sleep well. Researchers will track the total dose of anesthetic drugs used and watch for side effects. Over 3,300 adults aged 18–64 are being r…

This study compares how much etomidate (a sedative) is needed during digestive endoscopy between people with insomnia and those with normal sleep. Researchers will enroll 840 adults aged 18-64. The goal is to see if insomnia affects sedation requirements, which could help persona…

This observational study looks at whether people with insomnia need a different amount of the sedative rimazolen during a digestive endoscopy compared to those who sleep normally. Researchers will track 840 adults aged 18-64 to see if sleep problems affect sedation requirements a…

This study looks at whether people with insomnia need more or less of the sedative ciprofol during a digestive endoscopy. Researchers will compare 840 patients—some with insomnia and some with normal sleep—to see if sleep problems affect sedation requirements. The goal is to impr…