Beijing Tiantan Hospital

This study tests whether two drugs, isosorbide mononitrate and butylphthalide, can lower the risk of disability after a lacunar stroke—a type of small stroke deep in the brain. About 3,156 adults who had a stroke within the past week will take one or both drugs or a placebo for u…

This study tests whether adding a steroid medication (dexamethasone palmitate) to standard shingles treatment can better reduce pain and prevent long-term nerve pain called postherpetic neuralgia. About 558 adults with severe shingles pain will receive the drug by injection or st…

This study tests whether adding a drug called Tolecilimab to standard cholesterol-lowering therapy can lower a type of fat in the blood called lipoprotein(a) and reduce the risk of another stroke within 90 days. The trial includes 242 adults aged 35-80 who recently had a stroke o…

This study tests whether the drug anakinra can reduce brain damage in people who have had a severe stroke and undergone a procedure to reopen a blocked artery. About 159 adults aged 18-80 will receive either standard care or anakinra at different doses. The goal is to see if anak…

This study looks at whether raising blood pressure soon after surgery or coiling for a ruptured brain aneurysm can improve recovery in people with subarachnoid hemorrhage. About 750 adults aged 18-75 will have their blood pressure kept at a higher or lower target for 72 hours, th…

This study tests a new medicine called ongericimab, given as an injection, to see if it can lower bad cholesterol and prevent future strokes, heart attacks, or heart-related death in people who recently had a stroke. The trial will include about 4,810 adults who have a stroke wit…

This study tests whether the drug cilostazol can prevent delayed brain injury (called delayed cerebral ischemia) in people who have had a bleeding aneurysm. About 316 adults aged 18-80 who had surgery to fix the aneurysm will be randomly assigned to receive either cilostazol or a…

This study tests whether adding the blood thinner tirofiban after standard stroke treatment helps people recover better from a severe stroke caused by plaque buildup in a large artery. About 564 adults in China will receive either tirofiban or usual care after a clot-removal proc…

This study tests whether the antibiotic minocycline can help people recover better after a stroke caused by a blood clot. About 934 adults who receive clot-busting medicine will be given either minocycline or a placebo. The goal is to see if minocycline reduces disability and imp…

This study tests whether a Chinese medicine called Naoxuekang Dropping Pills can help prevent future strokes, heart attacks, or blood clots in people who recently had a brain bleed caused by high blood pressure. About 1,950 adults will take either the pill or a placebo for 90 day…

This study tests whether a drug called ulinastatin can lower the risk of stroke after brain tumor removal. About 1,370 people having brain tumor surgery will receive either the drug or a placebo before and after their operation. The goal is to see if the drug's anti-inflammatory …

This study tests a traditional Chinese medicine called Jiedu Huayu to see if it can lower the chance of another brain bleed or stroke in people with cerebral amyloid angiopathy (CAA). About 436 adults who recently had a small brain bleed will take either the herbal prescription o…

This study tests a new approach for people with a serious type of brain bleed (lobar hemorrhage). It combines a precise, image-guided surgery to drain the blood with a clot-busting drug called tenecteplase. The goal is to see if this combo helps more people regain the ability to …

This study tests whether adjusting blood pressure based on each patient's brain blood flow (collateral circulation) after a stroke procedure can improve recovery. About 544 adults who had a major stroke and successful treatment will be randomly assigned to either a personalized b…

This study tests whether sending people with a suspected major stroke directly to the angiography suite (a special X-ray room) for treatment is better than the usual approach of doing a CT or MRI scan first. About 568 adults with severe stroke symptoms within 6 hours of onset wil…

This study tests whether a procedure to remove blood clots from the brain (endovascular therapy) helps people with severe stroke recover enough to walk independently. It involves 308 adults aged 18-80 who have a large stroke in the back part of the brain and can be treated within…

This study tests whether levetiracetam, a seizure medication, can prevent seizures in adults after brain tumor surgery. About 558 participants will receive either the drug or a placebo starting one hour before surgery and continuing for three months afterward. The goal is to see …

This study tests two methods—scalp nerve blocks and a sedative drug called dexmedetomidine—to see if they can reduce the need for strong opioid painkillers and prevent confusion after brain tumor surgery. About 2000 adults having elective brain surgery will be randomly assigned t…

This study tests whether adding tizanidine to the standard drug pregabalin can better relieve pain in people with fibromyalgia. Fibromyalgia causes widespread pain, fatigue, and emotional distress, and current treatments often provide only modest relief. The trial will enroll 164…

This study tests whether giving a stellate ganglion block (a nerve injection) before surgery can improve sleep quality and brain recovery in 25 adults with prolonged disorders of consciousness after brain injury. Participants will have their sleep, brain oxygen levels, and consci…

This study will test a new type of rehabilitation robot for people who have had a stroke and have trouble moving one arm. The robot uses a non-invasive brain-computer interface and mirror therapy, where the patient moves their healthy arm and the robot helps move the affected arm…

This study tests whether a new version of the anti-inflammatory drug dexamethasone, called dexamethasone palmitate, can better prevent moderate-to-severe pain after surgery compared to the standard form. About 446 adults aged 18-65 having various surgeries will receive the drug b…

This study tests a combination of pain medicines and local numbing to improve pain control after brain tumor surgery. The goal is to reduce the need for strong opioids, which can cause side effects and complications. About 2,000 adults having planned brain surgery will take part.…

This study compares a new 'one-stop' emergency stroke unit that combines CT and DSA scans in one room to the usual step-by-step imaging process. The goal is to see if faster diagnosis and treatment helps more people recover independently within 90 days after a severe stroke. Abou…

This study tests a new approach for people with severe insomnia that hasn't improved with standard treatments. Participants receive a mild anesthetic to help them sleep, while researchers monitor brain activity to see if it produces natural sleep patterns. The goal is to improve …

This study looks at people with a brain condition called arteriovenous malformation (AVM) that affects the left side of the brain, which normally controls language. Surprisingly, these patients often have normal language skills because their right brain takes over. Researchers wi…

This study looks at whether using multiple brain monitoring tools together can help predict strokes in people having heart surgery. About 369 high-risk patients will be watched during their operation. The goal is to catch early warning signs and improve brain protection during su…