Cancer drug repurposed to calm brain inflammation in autoimmune disease
NCT ID NCT07686042
First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time
Summary
This study tests whether a low dose of blinatumomab, a drug originally used for leukemia, can help people with severe autoimmune encephalitis or cerebellitis that hasn't responded to standard treatments. The drug targets and depletes certain immune cells (B cells) that are mistakenly attacking the brain. Participants receive two short cycles of the drug by IV, and researchers track changes in symptoms, daily function, and side effects over 48 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- blinatumomab
- What this could lead to
- If it works, this could offer a new treatment option for people with severe, treatment-resistant autoimmune brain inflammation.
- What could go wrong
- This is a small, early-phase study with only 12 participants and no placebo group, so results may not apply broadly. Blinatumomab can cause serious side effects like cytokine release syndrome or infections.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, 100070, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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