New painkiller aims to prevent gut woes after brain surgery

NCT ID NCT07650812

Not yet recruiting Symptom relief Sponsor: Beijing Tiantan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a drug called oliceridine can reduce stomach and bowel problems after brain surgery. About 176 adults having brain tumor removal will receive either oliceridine or a standard opioid during surgery. The goal is to see if oliceridine lowers the risk of nausea, vomiting, and constipation, which can be dangerous after neurosurgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

oliceridine

What this could lead to

If it works, this could offer a way to reduce nausea, vomiting, and constipation after brain surgery, potentially lowering the risk of bleeding.

What could go wrong

This is a small, early-stage trial that hasn't started yet. The benefit over standard opioids is unproven, and oliceridine may still cause side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTROINTESTINAL DYSFUNCTION