Acupoint injection may ease gut troubles in ventilated patients

NCT ID NCT07692282

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This trial investigates whether injecting neostigmine into the Zusanli acupoint (ST36) can improve gastrointestinal function in patients on mechanical ventilation. The study compares this approach to acupoint stimulation alone or subcutaneous neostigmine injection. Participants are critically ill adults expected to need a breathing machine for at least 48 hours and who have not had a bowel movement for 48 hours or have high gastric residual volume. The main goal is to see if the treatment increases the rate of bowel movements and reduces stomach retention within 24 hours.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
neostigmine
What this could lead to
If effective, this approach could offer a simple, low-cost way to relieve gut problems in critically ill patients on breathing machines.
What could go wrong
This is a small, early-stage trial (90 participants) at a single center. The results may not apply broadly, and neostigmine can cause side effects like bradycardia or excessive salivation.

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