Antidepressant venlafaxine put to the test against chronic back pain

NCT ID NCT07737158

Not yet recruiting Symptom relief Sponsor: Beijing Tiantan Hospital Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This trial tests whether the antidepressant venlafaxine can reduce pain and improve function in adults with chronic non-specific low back pain. Participants receive either venlafaxine (up to 225 mg daily) plus routine care, or routine care alone, for three months. The study measures changes in pain intensity and daily functioning to see if the drug offers meaningful relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: the antidepressant drug venlafaxine
What this could lead to: If it works, this could offer a new treatment option for chronic low back pain, potentially reducing reliance on opioids.
What could go wrong: This is a mid-sized trial, and venlafaxine may cause side effects like nausea or dizziness. It is not yet proven effective for pain, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SPECIFIC LOW BACK PAIN PAIN MANAGEMENT

Contacts and locations

Locations

Beijing Tiantan Hospital

Beijing, China, 100050, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.