PAIN MANAGEMENT

This study tests whether a new, long-acting painkiller (liposomal bupivacaine) combined with a standard painkiller can reduce pain for up to 72 hours after hemorrhoid surgery. About 156 adults aged 18–64 having elective hemorrhoid surgery will take part. The goal is to see if thi…

This study tests a new way to manage pain after lung surgery (VATS). It combines two numbing medicines given as a nerve block. The goal is to see if it reduces pain and the need for extra painkillers. About 134 adults having lung surgery will take part.

This study looks at whether the BETY exercise program, which combines physical exercises with emotional and social support, can improve pain and quality of life in people with knee osteoarthritis who have already received a joint injection. About 60 adults with moderate knee oste…

This study looks at whether giving sedation before spinal anesthesia, guided by ultrasound, can lower the chance of back pain after surgery. Spinal anesthesia is common for lower body surgeries, but some people develop back pain afterward. Researchers will compare standard method…

This study tests whether a pain plan that limits opioids can help adults who get hip replacement surgery use fewer opioids while still controlling pain well. About 120 people having anterior hip replacement will be randomly assigned to either the limited-opioid plan or a standard…

This study compares two types of pain blocks (M-Tapa and TAP) given before hernia surgery to see which one controls pain better and makes patients more satisfied. About 60 adults having elective open inguinal hernia repair will receive one of the two blocks and then report their …

This study tests whether a special ultrasound-guided nerve block (called Quadro-Iliac Plane block) can reduce pain and the need for strong painkillers after hip replacement surgery. About 100 adults having a first hip replacement will be randomly assigned to get either the nerve …

This study compares two methods of patient-controlled pain relief after surgery. One method gives a steady dose of pain medicine, while the other adjusts the dose over time to match changing pain levels. The goal is to see which method reduces the total amount of opioids needed, …

This study looks at whether a supervised program of moderate aerobic and resistance exercise is safe and helpful for breast cancer survivors who have ongoing pain. Ten women who finished cancer treatment at least six months ago will take part. The goal is to see if exercise can r…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can safely ease severe pain in people with advanced cancer that doesn't respond to opioids. Fifteen adults with advanced cancer and persistent pain will receive the treatment and …

This study tests two different methods of patient-controlled pain pumps after surgery. The goal is to see if a smarter pump that adjusts medicine based on pain levels can reduce the total amount of opioids needed and improve pain control. About 1170 adults having various surgerie…

This study tests if a special numbing injection (parasternal plane block) can better control pain during heart surgery in children aged 6 months to 7 years. The goal is to reduce the need for strong pain medicines and help children recover faster. Sixty children having planned he…

This study tests a mobile app designed to help cancer survivors manage pain and other symptoms after finishing treatment. Researchers want to see if the app is easy to use and helpful. About 25 adults who have completed cancer treatment and still have pain will try the app for a …

This study is testing an app called PancreasPlus that helps people with pancreatic cancer track symptoms, weight, and appointments from home, and stay in touch with their care team. About 185 adults with pancreatic cancer will use the app for 3 months. The goal is to see if the a…

This study looks at two different nerve blocks—rectus sheath block and caudal epidural block—to see which one controls pain better after a minimally invasive hernia surgery in children aged 1 to 8. The goal is to reduce pain and the need for strong painkillers, which can have sid…

This study tests whether a long-acting painkiller (liposomal bupivacaine) plus a standard painkiller works better than the standard painkiller alone for pain after lung surgery. About 100 adults having lung surgery will be enrolled. The goal is to see if the combination reduces t…

This study tests whether adding ketamine to a standard nerve block (called a retroclavicular block) can better control pain during and after upper arm surgery. About 80 adults having arm surgery will receive either the standard block or one with ketamine added. Researchers will m…

This study compares standard pain relief (IV drugs plus wound numbing) to a combination of two nerve blocks (BAP and TAP) in 140 adults having minimally invasive left-sided colorectal surgery. The goal is to see if the nerve blocks lower pain intensity and reduce the need for opi…

This study tests whether a special nerve block given before gallbladder surgery can lower the amount of pain medicine and anesthesia needed during the operation. It also looks at whether it helps with pain and nausea after surgery. The trial will include 64 adults having their ga…

This study tests two types of nerve blocks—anterior iliopsoas space block and PENG block—to see which helps hip surgery patients get into position for spinal anesthesia with less pain. About 90 adults having hip fracture repair will be enrolled. The main goal is to measure how ea…

This study in Ukraine compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to relieve pain caused by nerve growths (neuromas) after combat injuries. About 50 adults with moderate to severe pain will be randomly assigned to one t…

This study looks at whether adding a small amount of ketamine to usual pain medicine (like morphine) can better relieve severe pain from sickle cell disease in children and young adults ages 5 to 20. About 120 participants will be randomly assigned to receive either standard pain…

This study tests whether watching a calming nature video through a virtual reality (VR) headset can reduce pain and anxiety during a first-trimester abortion. About 72 adults will either get usual care or usual care plus the VR headset. Researchers will measure pain and anxiety s…

This study tests if a continuous infusion of nefopam, a non-opioid painkiller, can lower the amount of opioids needed and improve pain control after pancreatoduodenectomy (a complex pancreatic surgery). About 93 adults having this surgery will be randomly assigned to receive nefo…

This study looks at whether a 16-week supervised aerobic exercise program, combined with a session on pain education, can help women aged 18 to 48 who have migraines. Researchers will measure changes in headache-related disability, pain sensitivity, and quality of life. The goal …

This study tests a new pain medicine called suzetrigine in 210 adults having hip replacement surgery. Half will get the drug and half a placebo for 7 days, starting before surgery. The main goal is to see if it lowers the amount of opioids needed in the first 48 hours after surge…

This study looks at whether a special nerve block, called transversalis fascia plane block, can help control pain and reduce the need for strong painkillers after kidney donation surgery. About 50 living kidney donors will take part. Half will get the nerve block plus standard an…

This study compares two types of nerve blocks to manage pain after heart surgery through the breastbone. About 50 adults will receive either one block or a combination of two blocks. The goal is to find which method provides better pain relief and reduces the need for strong pain…

This study tests whether personalized lifestyle coaching can reduce chronic muscle and joint pain in people aged 60 and older. About 268 participants will either receive four coaching sessions or continue their usual care. Researchers will measure pain levels, sleep, stress, and …

This study tests whether listening to a short mindfulness audio while waiting for an orthopedic appointment can reduce pain. About 400 adults will be randomly assigned to either the mindfulness exercise or a standard injury management talk. The goal is to see if this simple, no-d…

This study looks at two ways to manage pain during battery replacement surgery for deep brain stimulators in people with Parkinson's disease. One method uses general anesthesia (you are fully asleep), and the other uses regional anesthesia (you are awake but numb). The goal is to…

This study tests whether teaching transplant patients a simple breathing exercise can lower their pain and improve how well they feel after surgery. Sixty adults having their first transplant will be split into two groups: one will do the breathing exercise every hour, and the ot…

This study tests whether a robotic baby seal named PARO can reduce pain and anxiety in children aged 1 to 7 during a common but stressful procedure: placing an IV line. About 120 children across five hospitals will either get standard care alone or standard care plus the robot. R…

This study tests if heat wraps can reduce knee pain in people with osteoarthritis. About 80 adults with moderate knee pain will wear the wraps for 8 hours a day over 7 days. The main goal is to see if pain decreases after 3 days of use.

This study tests whether a combination of two pain medicines given through an IV (tramadol and paracetamol) works better and has fewer side effects than a standard shot of pethidine for women in early labor. About 140 pregnant women with a single baby at full term will take part.…

This study tests whether playing pop or rock music during a colonoscopy can lower the pain people feel. About 1,042 adults will be randomly assigned to have music or not during their procedure. Afterward, they will rate their pain on a 0–10 scale. If music helps, it could be a si…

This study looks at whether combining pain education with therapeutic exercise can reduce pain and improve quality of life in women with endometriosis. Researchers will track how well participants stick with the program and measure changes in pain, negative thoughts about pain, a…

This study compares breathing exercises to local anesthesia for pain during joint injections. About 136 adults getting ultrasound-guided joint injections will be randomly assigned to receive either numbing medicine or breathing instructions. The goal is to see if the breathing me…

This study tests which combination of pain medicines works best after rotator cuff repair. 130 adults who need shoulder surgery will receive different pain regimens. The goal is to see which approach reduces the need for strong narcotic painkillers while still controlling pain ef…

This study looks at whether a specific nerve block can reduce pain after kidney transplant surgery. 50 adults will receive either the nerve block or standard care. The goal is to lower pain and the need for strong painkillers, helping patients recover faster.

This study tests whether a numbing injection (nerve block) given before facial fracture surgery can lower the amount of strong painkillers (opioids) needed after the operation. About 70 adults with broken jaw or midface bones will be randomly assigned to receive either the numbin…

This study compares two pain relief methods used during robotic kidney surgery: a cheaper mix of drugs called R.E.C.K and a more expensive option called Exparel. About 170 adults having robotic kidney removal will be randomly assigned to one of the two treatments. Researchers wil…

This study compares two methods of pain relief for people having lung surgery with small incisions (VATS). One group gets a single nerve block, the other gets that block plus a continuous infusion through a small tube. The goal is to see if the combination leads to better recover…

This study tests whether adding a common anti-inflammatory drug (dexamethasone) to a standard numbing medicine (bupivacaine) can improve pain control during upper limb vascular surgery. About 80 adults having arm surgery will receive the injection near their collarbone. The goal …

This study tests whether giving ketamine during laparoscopic gastric sleeve surgery can lower the chance and severity of shoulder pain afterward. About 50 adults having this weight-loss procedure will be randomly assigned to receive ketamine or not as part of their anesthesia. Re…

This study tests whether adding a short course of the steroid methylprednisolone to standard pain treatment can lower pain and reduce the need for opioids after ACL repair surgery. About 90 people aged 13 to 50 having ACL repair will participate. The goal is to improve pain contr…

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat-related chest injuries. About 50 adults in Ukraine will be randomly assigned to one of the two treatments. The goal is to see…

This study tests a quick-dissolving tablet placed under the tongue (sublingual sufentanil) to relieve moderate to severe pain from a single injury in the emergency room. About 300 adults with arm or leg injuries will receive either the new tablet or standard pain treatment. The g…

This study compares two common steroids, dexamethasone and methylprednisolone, to see which works better at reducing swelling and pain after surgery for a broken jaw. About 72 adults aged 18 to 40 with a recent jaw fracture will receive one of the two drugs. The goal is to help d…

This study compares two common treatments for De Quervain's tenosynovitis, a painful thumb tendon condition: wearing a static hand-wrist splint versus doing specific exercises. Researchers will track pain, hand function, and satisfaction in 40 adults over several weeks. The goal …

This study tests if taking melatonin before a planned C-section can lower pain and the need for extra pain medicine afterward. Sixty women aged 18-40 will receive different doses of melatonin 30 minutes before surgery and be monitored for 24 hours. The goal is to find the best do…

This study compares two ways of numbing the arm for hand or forearm surgery in 60 obese patients. The goal is to see which method works faster and provides better pain relief after surgery. Participants will receive an ultrasound-guided nerve block and report their pain and satis…

This study looks at whether a low dose of ketorolac, an NSAID painkiller, can safely reduce the need for opiates in critically ill ICU patients. Opiates are effective but can lead to dependence after leaving the hospital. The trial will enroll 30 adults in the ICU who are in pain…

This study compares two hands-on treatments—kinesiotaping (a special tape) and peloidotherapy (mud packs)—plus home exercises, against exercises alone for people with mild-to-moderate carpal tunnel syndrome. 90 adults will be randomly assigned to one of three groups. The goal is …

This study watches 254 adults after planned surgery to see what factors affect how much pain medicine they need. Researchers will track pain levels and medication use in the recovery room, without changing any care. The goal is to find patterns that help doctors personalize pain …

This study aims to understand what sensations people feel when their spinal cord is stimulated. Ten adults with chronic pain who already have a spinal cord stimulator will take part. Researchers will adjust the stimulation and ask participants to describe what they feel, helping …

This study looks at how patients experience pain checks after planned surgery. Researchers want to know if these checks feel supportive or stressful, and how that affects trust in nurses and willingness to report pain. About 300 adults having elective general surgery will fill ou…

This study looks at how a gentle electrical current applied to specific acupoints (like those used in acupuncture) affects the way the brain handles pain signals. Researchers will measure brain activity in 35 healthy adults before and after the stimulation. The goal is to underst…

This study looks at how pain and the ability to walk change in the days after a limb amputation. Researchers will review medical records of 150 adults who had an amputation. The goal is to find patterns that could help improve pain management and rehabilitation in the future.

This study looks at how metamizole (Optalgin®), a painkiller, changes the levels of blood thinners (apixaban or rivaroxaban) in cancer patients. Researchers will measure drug levels at different times when patients take metamizole and when they don't. The goal is to understand th…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and how different types of moderate exercise—strength training versus aerobic exercise—affect their pain. Participants will complete three sessions: baseline tests, a …

This study aims to understand how common chronic pain and a condition called central sensitization are in adults with autism spectrum disorder (ASD) who do not have an intellectual disability. Researchers will enroll 100 adults with ASD and have them complete questionnaires about…