PAIN MANAGEMENT

This study is testing an app called PancreasPlus for people with pancreatic cancer. The app helps patients track symptoms, weight, and appointments, and lets them message their care team. Researchers want to see if using the app improves quality of life, reduces anxiety, and cuts…

This study looks at whether a specific nerve block can reduce pain after kidney transplant surgery. 50 adults will receive either the nerve block or standard care. The goal is to lower pain and the need for strong painkillers, helping patients recover faster.

This study tests a new pain medicine called suzetrigine in 210 adults having hip replacement surgery. Half will get the drug and half a placebo for seven days, starting before surgery. The goal is to see if it lowers the amount of opioids needed for pain in the first 48 hours aft…

This study tests whether a numbing injection (nerve block) given before facial fracture surgery can lower the amount of strong painkillers (opioids) needed after the operation. About 70 adults with broken jaw or midface bones will be randomly assigned to receive either the numbin…

This study tests whether adding ketamine to a standard nerve block can provide better pain relief for people having upper arm surgery. About 80 adults will receive either the standard block or one with ketamine added. Researchers will measure pain levels using a 0-10 scale to see…

This study looks at two different methods of giving pain medicine through a patient-controlled pump after surgery. The goal is to see if a new, time-based method can lower the amount of opioids needed, improve pain relief, and reduce side effects. About 450 adults having various …

This study tests whether using a virtual reality (VR) headset showing a calming nature video can help reduce pain and anxiety during a first-trimester procedural abortion. About 72 adults will be randomly assigned to receive either standard care or standard care plus the VR heads…

This study looks at whether the BETY exercise program, which combines physical exercises with emotional and social support, can reduce pain and improve quality of life in people with knee osteoarthritis. Participants must have received a knee injection in the past month. The goal…

This study compares two pain relief methods used during robotic kidney surgery: a cheaper mix of drugs called R.E.C.K and a more expensive option called Exparel. About 170 adults having robotic kidney removal will be randomly assigned to one of the two treatments. Researchers wil…

This study tests whether listening to a short mindfulness audio while waiting for an orthopedic appointment can reduce pain. About 400 adults will be randomly assigned to either the mindfulness exercise or a standard injury management talk. The goal is to see if this simple, no-d…

This study tests two types of nerve blocks given before spinal anesthesia for hip surgery. The goal is to see which block makes it easier and less painful for patients to get into the right position for the spinal needle. About 90 adults having hip fracture repair will take part.…

This study tests whether personalized lifestyle coaching can help older adults manage long-term muscle and joint pain. 268 participants will work with a health coach to set goals, while a comparison group receives usual care. The goal is to reduce pain intensity and improve daily…

This study tests whether a continuous infusion of nefopam, a non-opioid painkiller, can reduce the need for opioids and improve pain control after pancreatoduodenectomy (a major pancreatic surgery). About 93 adults scheduled for this surgery will be randomly assigned to receive n…

This study tests whether a long-acting painkiller (liposomal bupivacaine) plus a standard painkiller works better than the standard painkiller alone for pain after video-assisted lung surgery. About 100 adults having lung surgery will be randomly assigned to one of two groups. Th…

This study looks at two ways to manage pain during battery replacement surgery for deep brain stimulators in people with Parkinson's disease. One method uses general anesthesia (you are fully asleep), and the other uses regional anesthesia (you are awake but numb). The goal is to…

This study tests whether a new ultrasound-guided nerve block (called Quadro-Iliac Plane block) can reduce pain and the need for strong painkillers after hip replacement surgery. About 100 adults having hip replacement will be randomly assigned to get either the real nerve block o…

This study tests a new way to give pain medicine after surgery. It compares a standard pump that gives a steady dose of opioids to a smart pump that adjusts the dose based on the patient's pain level. The goal is to see if the smart pump can lower the total amount of opioids need…

This study looks at whether a 16-week supervised aerobic exercise program, combined with a single session of pain education, can help women aged 18 to 48 who have migraines. Participants will be randomly assigned to either the exercise group or a control group that gets advice on…

This study tests two different numbing techniques to manage pain after heart surgery. 50 adults having open-heart surgery will receive either one nerve block or a combination of two others. The goal is to find which method provides better pain relief and reduces the need for stro…

This study tests whether teaching transplant patients a simple breathing exercise can lower their pain and improve how well they feel after surgery. Sixty adults having their first transplant will be split into two groups: one will do the breathing exercise every hour, and the ot…

This study tests whether a robotic baby seal named PARO can reduce pain and anxiety in children aged 1 to 7 during a common but stressful procedure: placing an IV line. About 120 children across five hospitals will either get standard care alone or standard care plus the robot. R…

This study tests whether a new, long-acting painkiller (liposomal bupivacaine) can provide better and longer pain relief after hemorrhoid surgery compared to the standard painkiller. About 156 adults having hemorrhoid surgery will receive one of the two painkillers injected into …

This study tests if heat wraps can reduce knee pain in people with osteoarthritis. About 80 adults with moderate knee pain will wear the wraps for 8 hours a day over 7 days. The main goal is to see if pain decreases after 3 days of use.

This study tests whether a combination of two pain medicines given through an IV (tramadol and paracetamol) works better and has fewer side effects than a standard shot of pethidine for women in early labor. About 140 pregnant women with a single baby at full term will take part.…

This study tests whether playing pop or rock music during a colonoscopy can lower the pain people feel. About 1,042 adults will be randomly assigned to have music or not during their procedure. Afterward, they will rate their pain on a 0–10 scale. If music helps, it could be a si…

This study compares two methods of pain relief for people having lung surgery with small incisions (VATS). One group gets a single nerve block, the other gets that block plus a continuous infusion through a small tube. The goal is to see if the combination leads to better recover…

This study tests whether adding a common anti-inflammatory drug (dexamethasone) to a standard numbing medicine (bupivacaine) can improve pain control during upper limb vascular surgery. About 80 adults having arm surgery will receive the injection near their collarbone. The goal …

This study tests whether giving ketamine during laparoscopic gastric sleeve surgery can lower the chance and severity of shoulder pain afterward. About 50 adults having this weight-loss procedure will be randomly assigned to receive ketamine or not as part of their anesthesia. Re…

This study tests whether adding a short course of the steroid methylprednisolone to standard pain treatment can lower pain and reduce the need for opioids after ACL repair surgery. About 90 people aged 13 to 50 having ACL repair will participate. The goal is to improve pain contr…

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat-related chest injuries. About 50 adults in Ukraine will be randomly assigned to one of the two treatments. The goal is to see…

This study tests whether a pain management plan that limits opioid use after hip replacement surgery can reduce how many opioids patients take while still controlling pain well. About 120 adults getting a hip replacement for osteoarthritis will be randomly assigned to either the …

This study looks at two different nerve blocks—rectus sheath block and caudal epidural block—to see which one provides better pain relief for children aged 1 to 8 after a minimally invasive hernia repair. The goal is to reduce pain and the need for strong painkillers, which can c…

This study tests a quick-dissolving tablet placed under the tongue (sublingual sufentanil) to relieve moderate to severe pain from a single injury in the emergency room. About 300 adults with arm or leg injuries will receive either the new tablet or standard pain treatment. The g…

This study tests a new way to manage pain after lung surgery (VATS). It combines a long-lasting numbing medicine (liposomal bupivacaine) with a standard one, given as a nerve block. The goal is to see if it reduces the need for extra painkillers and improves comfort. About 134 ad…

This study is testing whether adding a low dose of ketamine to standard pain medicine (like morphine) can better relieve severe pain from sickle cell disease in children and young adults ages 5 to 20. Participants will be randomly assigned to receive either standard care plus ket…

This study compares two common steroids, dexamethasone and methylprednisolone, to see which works better at reducing swelling and pain after surgery for a broken jaw. About 72 adults aged 18 to 40 with a recent jaw fracture will receive one of the two drugs. The goal is to help d…

This study compares two common treatments for De Quervain's tenosynovitis, a painful thumb tendon condition: wearing a static hand-wrist splint versus doing specific exercises. Researchers will track pain, hand function, and satisfaction in 40 adults over several weeks. The goal …

This study tests whether adding two targeted nerve blocks (one around the colon and one in the belly wall) to standard pain relief can lower pain and the need for strong painkillers after minimally invasive left-sided colon cancer surgery. About 140 adults having elective laparos…

This study tests if taking melatonin before a planned C-section can lower pain and the need for extra pain medicine afterward. Sixty women aged 18-40 will receive different doses of melatonin 30 minutes before surgery and be monitored for 24 hours. The goal is to find the best do…

This study looks at whether a special nerve block, called a transversalis fascia plane block, can help control pain and reduce the need for strong painkillers (opioids) after kidney donation surgery. About 50 living kidney donors will take part. Half will get the nerve block plus…

This study compares two ways of numbing the arm for hand or forearm surgery in 60 obese patients. The goal is to see which method works faster and provides better pain relief after surgery. Participants will receive an ultrasound-guided nerve block and report their pain and satis…

This study tests if a special numbing injection (parasternal plane block) can better control pain during heart surgery in children aged 6 months to 7 years. Sixty children will be randomly assigned to receive either the block plus standard care or standard care alone. The goal is…

This study compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by combat injuries in Ukraine. Fifty adults with moderate to severe pain from neuromas will be randomly assigned to one treatment. The go…

This study looks at whether giving sedation before using ultrasound to guide spinal anesthesia can lower the chance of back pain after surgery. Spinal anesthesia is common for lower body surgeries, but some people develop back pain afterward. The researchers will compare standard…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can safely help relieve severe pain that doesn't respond to opioids in people with advanced cancer. Fifteen adults with advanced cancer and persistent pain will receive psilocybin-assisted therapy. The…

This study compares breathing exercises to local anesthetic for pain control during joint injections. About 136 adults getting ultrasound-guided joint injections will be randomly assigned to either receive lidocaine (numbing medicine) or learn a 5-minute breathing technique. The …

This study compares two types of pain blocks (M-Tapa block and TAP block) for people having open inguinal hernia repair. About 60 adults will receive one of the blocks before surgery, and their pain scores and satisfaction will be measured 24 hours later. The goal is to see which…

This study looks at whether a low dose of ketorolac, an NSAID painkiller, can safely reduce the need for opiates in critically ill ICU patients. Opiates are effective but can lead to dependence after leaving the hospital. The trial will enroll 30 adults in the ICU who are in pain…

This study looks at whether combining pain education with therapeutic exercise can reduce pain, improve quality of life, and lower pain-related distress in women with endometriosis. Researchers will track how well participants stick with the program and any side effects like incr…

This study compares two hands-on treatments—kinesiotaping (a special tape) and peloidotherapy (mud packs)—plus home exercises, against exercises alone for people with mild-to-moderate carpal tunnel syndrome. 90 adults will be randomly assigned to one of three groups. The goal is …

This study is testing a mobile app designed to help cancer survivors manage pain and other symptoms after finishing treatment. About 25 adults who have completed cancer treatment and still have pain will use the app for several weeks. The goal is to see if the app is easy to use …

This study looks at whether a supervised exercise program with moderate aerobic and resistance training can safely reduce pain in breast cancer survivors who have ongoing pain. Ten women who finished treatment at least six months ago will take part. The goal is to see if the prog…

This study tests which combination of pain medications works best after rotator cuff repair surgery. Researchers want to see if a multimodal pain regimen can reduce the need for narcotics like oxycodone. About 130 adults having arthroscopic rotator cuff repair will participate. T…

This study tests whether a nerve block given before gallbladder surgery can lower the amount of pain medicine and anesthesia needed during the operation. It also looks at pain and nausea after surgery. The trial will include 64 adults having laparoscopic gallbladder removal.

This study looks at how a gentle electrical current applied to specific acupoints (like those used in acupuncture) affects the way the brain handles pain signals. Researchers will measure brain activity in 35 healthy adults before and after the stimulation. The goal is to underst…

This study watches 254 adults after elective surgery to see what factors affect how much pain medicine they need in the recovery room. No new treatments are given—just routine care. The goal is to find patterns that help doctors personalize pain management and improve recovery.

This study looks at how pain and the ability to walk change in the days after a limb amputation. Researchers will review medical records of 150 adults who had an amputation. The goal is to find patterns that could help improve pain management and rehabilitation in the future.

This study aims to understand what sensations can be created by stimulating the spinal cord in people who already have a spinal cord stimulator for chronic pain. Researchers will test how changing the stimulation strength affects what participants feel. The goal is to learn how t…

This study looks at how patients experience pain monitoring after planned surgery. Researchers want to understand if these checks feel supportive or stressful, and how that affects trust in nurses and willingness to report pain. About 300 adults having elective general surgery wi…

This study looks at how metamizole (Optalgin®), a painkiller, changes the levels of blood thinners (apixaban or rivaroxaban) in cancer patients. Researchers will measure drug levels at different times when patients take metamizole and when they don't. The goal is to understand th…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and how different types of moderate exercise—strength training versus aerobic exercise—affect their pain. Participants will complete three sessions: baseline tests, a …

This study aims to understand how common chronic pain and a condition called central sensitization are in adults with autism spectrum disorder (ASD) who do not have an intellectual disability. Researchers will enroll 100 adults with ASD and have them complete questionnaires about…