PAIN MANAGEMENT

This study tests whether using the soundBrilliance app—which combines enhanced music, natural visuals, and spoken guidance—can help people aged 13 and older manage anxiety, depression, and stress. Over 12 weeks, participants use the app at least 4 days per week and report their m…

This study compares two types of nerve blocks—coeliac plexus block and splanchnic nerve block—to see which one reduces pain better in adults with upper abdominal cancer. Forty-four participants will receive one of the procedures and be monitored for pain, opioid use, and quality …

This study compares two ultrasound-guided nerve blocks—recto-intercostal fascial plane block (RIFPB) and transversus abdominis plane block (TAPB)—for pain control after laparoscopic gallbladder removal. 90 adults undergoing elective surgery will receive one of the two blocks. The…

This study tests two different methods of patient-controlled pain pumps to see which one reduces opioid use and improves pain relief after surgery. About 1170 adults having various surgeries will be randomly assigned to one of two pump settings. The goal is to find a smarter way …

This study tests whether giving the anti-inflammatory drug dexketoprofen through a vein can prevent or lessen the severe pain that often occurs when a nerve block wears off after shoulder surgery. About 66 adults having arthroscopic shoulder surgery will be randomly assigned to r…

This study tests whether watching a video that guides you to imagine acupuncture can reduce pain and the need for painkillers after spinal surgery. 120 adults will either watch the imagery video or an education video daily for a week after surgery. Researchers will compare pain s…

This study tests suzetrigine, a new FDA-approved non-opioid pain medication, in 210 adults undergoing total hip replacement. Participants receive either suzetrigine or a placebo for seven days, starting before surgery. The goal is to see if suzetrigine reduces the amount of opioi…

This study compares two ultrasound-guided nerve block techniques—Quadro-iliac Plane Block and Transversus Abdominis Plane Block—for pain control after inguinal hernia repair. About 60 adults aged 18-65 will be enrolled to see which method provides better pain relief and recovery.…

This study tests whether adding a new nerve block (BiFeS) to the standard adductor canal block provides better pain relief after knee surgery for torn cartilage. About 135 adults aged 18-65 will be enrolled. Researchers will measure pain scores and morphine use in the first 24 ho…

This study tests if a special nerve block given before gallbladder surgery can lower the amount of painkillers and anesthesia needed during the operation. It also looks at whether it helps with pain and nausea after surgery. About 64 adults having gallbladder removal are being re…

This study tests whether a robotic baby seal named PARO can reduce pain and anxiety in children aged 1 to 7 during a common but stressful procedure: placing an IV line. About 120 children will either receive standard care alone or standard care plus the robot. Researchers will me…

This study is testing an app called PancreasPlus for people with pancreatic cancer. The app helps patients track symptoms, get information, and communicate with their care team from home. Researchers want to see if using the app improves quality of life, reduces anxiety, and cuts…

This study tests whether personalized health coaching can reduce chronic muscle and joint pain in people aged 60 and older. 268 participants will either receive four face-to-face coaching sessions focused on exercise, diet, stress, sleep, social support, and avoiding risky substa…

This study tests whether adding dexamethasone (a steroid) to a standard numbing medication (bupivacaine) in a nerve block can extend pain relief for people undergoing upper limb vascular surgery. Eighty adult patients will receive the block before surgery, and researchers will me…

This study is testing whether adding ketamine to a standard nerve block can reduce pain after upper arm surgery. About 80 adults having arm surgery will receive the nerve block with or without ketamine, and their pain levels will be measured. The goal is to see if ketamine improv…

This study tests whether using a virtual reality (VR) headset showing calming nature videos can reduce pain and anxiety during a first-trimester procedural abortion. Seventy-two adults will either receive usual care (pain medication and local anesthetic) or usual care plus the VR…

This study tests whether a nerve block called transversalis fascia plane block can reduce pain after kidney transplant surgery. Fifty adults will receive either the nerve block plus standard painkillers or standard painkillers alone. The goal is to see if the block lowers pain sc…

This study tests a 30-microgram sublingual sufentanil tablet for treating moderate to severe pain from a single injury in the emergency department. 300 adults with pain scores of 4 or higher on a 0-10 scale will receive either the tablet or standard pain treatment. The goal is to…

This study looks at whether a supervised aerobic exercise program, combined with a single session of pain education, can reduce migraine-related disability and improve sensory and muscle function. One hundred women with migraine will either exercise on a treadmill three times a w…

This study tests whether a pain management plan that limits opioids can help adults who need hip replacement surgery use fewer opioids while still controlling pain well. About 120 people having anterior total hip replacement will be randomly assigned to either the opioid-sparing …

This study looks at whether combining pain neuroscience education with therapeutic exercise can reduce pain, improve quality of life, and lower pain-related distress in women with endometriosis. About 32 adult women diagnosed with endometriosis will take part. Researchers will tr…

This study looks at two different methods for using a patient-controlled pain pump after surgery. The goal is to see if a new, time-based method can reduce the amount of opioids needed while still controlling pain effectively. About 450 adults having various surgeries will take p…

This study compares two common steroids, dexamethasone and methylprednisolone, to see which one better reduces swelling and pain after surgery for a broken lower jaw. About 72 adults aged 18 to 40 with a recent, isolated jaw fracture will receive one of the two drugs during surge…

This study tests whether listening to a brief mindfulness audio recording while waiting for an orthopedic appointment can help reduce pain. 400 adults will be randomly assigned to hear either a mindfulness practice or a standard pain management recording. The goal is to see if a …

This study tests whether a special nerve block called Quadro-Iliac Plane (QIP) block can reduce pain and the need for opioids after hip replacement surgery. 100 adults scheduled for hip replacement will be randomly assigned to receive either the QIP block with numbing medicine or…

This study tests whether the BETY exercise program, which combines physical exercises with pain management and emotional support, can help people with knee osteoarthritis who recently received injections. Sixty adults with knee osteoarthritis will be enrolled. The goal is to see …

This study tests whether a continuous infusion of nefopam, a non-opioid painkiller, can reduce opioid use and pain after pancreatoduodenectomy (a major pancreatic surgery). About 93 adults will be randomly assigned to receive nefopam, lidocaine, or standard epidural pain relief. …

This study compares two common conservative treatments for De Quervain's tenosynovitis, a painful thumb tendon condition: a static hand-wrist splint versus home-based exercise therapy. Forty adults with acute or subacute pain will be tracked for changes in pain, wrist function, a…

This study compares two treatments—kinesiotaping (a special tape) and peloidotherapy (mud therapy)—plus home exercises, against exercises alone for people with mild-to-moderate carpal tunnel syndrome. 90 adults will be randomly assigned to one of three groups. The goal is to see …

This study is testing a mobile health app designed to help cancer survivors manage pain and other symptoms after treatment. Twenty-five survivors who have finished cancer treatment but still have pain will use the app for one week, receiving helpful messages and completing daily …

This study compares two regional anesthesia techniques to manage pain in 50 adults undergoing heart surgery via a chest incision. One group receives an Erector Spinae Plane Block, while the other gets a combination of Superficial Parasternal Intercostal Plane Block and Serratus A…

This study tests whether playing pop or rock music during a colonoscopy can lower the pain people feel. About 1,042 adults having the procedure will be randomly assigned to either listen to music or not. Afterward, they will rate their pain on a 0–10 scale. If music helps, it cou…

This study tests two types of nerve blocks—anterior iliopsoas space block and PENG block—to see which helps patients with hip fractures get into position for spinal anesthesia more easily and with less pain. About 90 adults undergoing hip surgery will receive one of the blocks be…

This study is testing whether a low dose of ketamine, given alongside standard pain medicine, can better control severe pain from sickle cell disease in children and young adults aged 5 to 20. Participants will receive either ketamine or a placebo infusion, and researchers will m…

This study tests whether a long-lasting numbing drug (liposomal bupivacaine) combined with a standard numbing drug can improve pain control after lung surgery. About 134 adults having keyhole lung surgery will receive either the combination or standard care. The goal is to see if…

This study tests whether a long-acting numbing drug called liposomal bupivacaine, when added to a standard painkiller, provides better pain relief after video-assisted lung surgery. About 100 adults having lung surgery will receive either the combination or the standard drug alon…

This study tests whether a long-acting numbing drug called liposomal bupivacaine can control pain for up to 72 hours after hemorrhoid surgery better than standard numbing medicine. About 156 adults having hemorrhoid surgery will receive either the long-acting drug or regular bupi…

This study tests whether a numbing injection (nerve block) given before facial fracture surgery can lower the amount of opioids patients need after surgery. 70 adults with facial fractures will be randomly assigned to receive either the nerve block or a placebo. The goal is to se…

This study tests whether giving ketamine during laparoscopic gastric sleeve surgery can lower the chance and severity of shoulder pain after the operation. About 50 adults having the surgery will be split into two groups: one gets ketamine as part of anesthesia, the other does no…

This study in Ukraine compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by neuromas from combat injuries. Fifty adults with moderate to severe pain will be randomly assigned to one treatment. The go…

This study tests whether adding a special nerve block (BAP) to a standard abdominal wall block (TAP) can better control pain and reduce the need for strong painkillers after minimally invasive left-sided colorectal surgery. About 140 adults having elective laparoscopic surgery wi…

This study tests whether a nerve block called the transversalis fascia plane block can reduce pain and opioid use after hand-assisted laparoscopic donor nephrectomy. Fifty living kidney donors will be randomly assigned to receive either standard anesthesia alone or standard anest…

This study tests whether a nerve block called a parasternal plane block can better control pain during heart surgery in children aged 6 months to 7 years. The block is given after anesthesia and uses a numbing medicine (bupivacaine). Researchers will measure pain using a special …

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat injuries. About 50 adults in Ukraine will be randomly assigned to one treatment, and researchers will measure pain levels, op…

This study tests whether taking melatonin before a planned C-section can lower pain afterward. Sixty women will receive either 5 mg, 10 mg, or a placebo pill one hour before surgery. Researchers will track pain levels, how soon they need extra pain relief, and any side effects ov…

This phase 3 trial tests whether a combination of four drugs (R.E.C.K) controls pain after robotic kidney surgery as well as the more expensive drug Exparel. About 170 adults having robotic partial or total kidney removal will be randomly assigned to receive one of the two inject…

This study looks at which pain control method works best after rotator cuff repair surgery. Researchers will compare different combinations of pain medicines to see which reduces the need for strong narcotics like oxycodone. About 130 adults having shoulder surgery will take part…

This study tests whether controlled breathing exercises can control pain during joint injections as well as local anesthesia. 136 participants will be randomly assigned to either receive lidocaine (standard care) or practice 5-minute breathing cycles. The goal is to see if the br…

This study compares two types of nerve blocks—M-TAPA and TAP block—for pain relief after open inguinal hernia repair. Sixty adults undergoing elective surgery will receive one of the two blocks with the same numbing medicine. Researchers will measure pain scores and patient satis…

This study compares two ultrasound-guided methods (conventional vs. retroclavicular) for numbing the arm in 60 obese patients undergoing forearm or hand surgery. Both approaches use the same local anesthetics (bupivacaine and lidocaine). The goal is to see which technique is fast…

This study tests whether doing breathing exercises every hour after a transplant can reduce pain and improve how well patients recover. Sixty adults having their first transplant will be split into two groups: one will do the breathing exercises, the other will get usual care. Re…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help relieve severe pain in people with advanced cancer when opioids don't work. Fifteen participants will receive psilocybin capsules along with therapy sessions. The goal is to see if this approa…

This study tests whether a combination of two medicines given through an IV (tramadol and paracetamol) works better and causes fewer side effects than a standard shot of pethidine for managing pain during the first stage of labor. About 140 women in early labor will be randomly a…

This study looks at two types of anesthesia for replacing the battery of a deep brain stimulator in people with Parkinson's disease. Researchers want to see which method—general anesthesia or regional anesthesia with sedation—provides better pain control and patient satisfaction …

This study looks at whether a supervised program of moderate walking and strength training can safely reduce pain in breast cancer survivors who still have pain after treatment. Ten women who finished cancer therapy at least six months ago will participate. The goal is to see if …

This study tests whether giving sedation before ultrasound-guided spinal anesthesia can lower the chance of back pain after surgery. Spinal anesthesia is common for lower body surgeries, but some people develop discomfort or long-lasting back pain. The researchers will compare st…

This study tests whether adding a short course of the steroid methylprednisolone to standard pain treatment can lower pain and reduce the need for opioids after ACL repair. About 90 people aged 13 to 50 having ACL surgery will take part. The goal is to find a safer way to manage …

This study tests whether a low dose of ketorolac, an NSAID, can safely reduce pain and the need for opiates in critically ill ICU patients. Thirty adults with pain will receive either ketorolac or a placebo for up to three days. The main goal is to see if this approach is feasibl…

This study compares two types of nerve blocks—rectus sheath block and caudal epidural block—for pain relief in children aged 1 to 8 years undergoing hernia repair. Both blocks use the numbing medicine bupivacaine. Researchers will measure pain scores, nausea, and how quickly chil…

This study tests whether a special heat wrap can reduce knee pain in people with moderate osteoarthritis. About 80 adults aged 19 to 69 will wear the wrap for 8 hours a day over 7 days. Researchers will measure pain changes after 3 days using a simple pain scale.

This study compares two ways to manage pain after video-assisted lung surgery (VATS). One group gets a single nerve block, the other gets that plus a continuous nerve block with a numbing medicine. The goal is to see if the combination improves recovery quality in the first 24 ho…

This study is trying to figure out what counts as a meaningful improvement in pain after major orthopedic surgeries like hip, knee, shoulder, or spine procedures. Researchers will ask 300 adults to rate their pain and recovery before and after surgery. The goal is to set clear be…

This study watches 254 adults after elective surgery to see what factors—like age, type of surgery, or anesthesia—affect how much pain medicine they need in the recovery room. No new treatments are given; researchers just collect data from normal care. The goal is to help doctors…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and respond to moderate exercise. Participants will do strength and aerobic exercises while their pain tolerance and sensitivity are measured. The goal is to understan…

This study looks at how common central sensitization (a condition where the nervous system is overly sensitive to pain) is in adults with autism who do not have intellectual disabilities. Researchers will ask 100 participants to fill out a questionnaire about pain and sensitivity…

This study looks at how pain and the ability to walk change in the first days after a limb amputation. Researchers will review medical records of 150 adults to see how pain levels and recovery are linked to patient details and treatments. The goal is to find patterns that could h…

This study tests whether spinal cord stimulation can create artificial sensations, like tingling, and how changing stimulation settings affects those sensations. Ten adults with chronic pain who are already scheduled for spinal cord stimulation will participate. The goal is to be…

This study looks at how metamizole (Optalgin), a common painkiller, changes the levels of blood thinners (apixaban or rivaroxaban) in cancer patients. Researchers will measure drug concentrations at several time points in 30 adults. The goal is to understand if metamizole interfe…

This study tests whether transcutaneous electrical nerve stimulation (TENS) applied to specific acupoints can change how the brain processes pain signals. Thirty-five healthy adults will receive TENS on their hands while researchers measure brain activity using EEG. The goal is t…