PAIN MANAGEMENT

This study tested three methods to reduce pain and fear in 166 children aged 5-9 during dental numbing injections: a device that cools and vibrates, gentle tapping near the injection site, and a thinner needle. Researchers measured pain scores, heart rate, and cooperation. The go…

This study tested whether Swedish massage with lavender or chamomile oils can help reduce pain, fear, and anxiety during labor. 90 pregnant women were split into three groups: one got massage with chamomile oil, one with lavender oil, and one with plain carrier oil. Researchers m…

This study compared two types of nerve blocks (supra-inguinal fascia iliaca block and lumbar erector spinae plane block) for pain relief in 84 adults undergoing hip fracture surgery. The goal was to see which block works better for positioning the patient for spinal anesthesia an…

This study tested whether a nerve block (PECS II) or local anesthesia works better for pain after breast cancer surgery, without using opioids. 124 women undergoing breast surgery were randomly assigned to receive one of the two methods. Researchers measured pain, nausea, and opi…

This study tested whether taking gabapentin along with oxcarbazepine works better than oxcarbazepine alone for trigeminal neuralgia, a condition causing severe facial pain. 44 adults were split into two groups and had their pain measured over 2 months. The goal was to see which a…

This study tested whether listening to music during a daily cleaning procedure can reduce pain in children aged 6 months to 15 years in a pediatric intensive care unit. Each child experienced the cleaning twice—once with music and once without—and pain was measured using a standa…

This study compared two ultrasound-guided nerve blocks—external oblique intercostal block and erector spinae plane block—for pain after laparoscopic gallbladder removal. Sixty adults received one of the blocks before surgery, and researchers measured their opioid use and pain sco…

This study tested whether wearing virtual reality goggles showing relaxing nature scenes and music during IUD insertion could reduce pain and anxiety. 70 women were randomly assigned to either VR or standard care. Researchers measured pain, anxiety, comfort, and vital signs. The …

This study tested whether a daily capsule combining etoricoxib and diacerein can reduce pain and improve function in adults with knee or hip osteoarthritis. Over 60 days, 123 participants took either the test combination or an active comparator (meloxicam plus diacerein). Researc…

This completed study tested a 7-week, peer-led program for adults with spinal cord injury and chronic pain. The program combined education about pain neuroscience with body-based tools like red light therapy, massage, and guided movement. Twelve participants attended group sessio…

This study tested whether a single dose of S-ketamine, given during surgery, could lower the amount of morphine patients needed for pain in the first 24 hours after laparoscopic gynecologic surgery. 53 relatively healthy adults took part. The goal was to see if S-ketamine could i…

This completed Phase 4 trial tested whether a turmeric extract (curcumin) can reduce pain after total laparoscopic hysterectomy. 126 participants took either liposomal curcumin or a placebo before and after surgery. The main goal was to measure pain levels 24 hours after the oper…

This study tested whether a custom-made acrylic palatal stent (like a mouth guard) can reduce pain and bleeding after gum graft surgery. 44 adults who needed a gum graft from the roof of their mouth either received the stent or standard care. The stent aims to protect the healing…

This study tested whether playing a xylophone during an IV insertion can help hospitalized children aged 3 to 6 feel less pain and fear. 64 children were randomly assigned to either play the toy with a nurse or receive standard care. Researchers measured pain, fear, and parent sa…

This study tested whether a gel (LAT gel) applied to cuts can numb them as well as the standard numbing shots (lidocaine) before getting stitches. 70 adults with simple cuts in the emergency department took part. The goal was to see if the gel causes less pain during application …

This study tested whether using a stress ball during active labor can reduce pain and improve comfort. 78 pregnant women were split into two groups: one used a stress ball during contractions, the other received standard care. Researchers measured pain, comfort, and self-efficacy…

This study compared two types of nerve blocks (serratus anterior plane block and serratus posterior superior intercostal plane block) for pain after video-assisted lung surgery. 60 adults aged 18-65 were enrolled. Researchers measured pain levels and patient satisfaction to see w…

This study tested whether a 15-minute talk with a clinical pharmacist helps people manage pain after getting a pacemaker. The pharmacist gave personalized advice on medications, side effects, and when to take pills. 60 adults who had pacemaker surgery took part. The study looked …

This study looked at whether adding a low-dose ketamine infusion to standard pain medication can help people who just had knee replacement surgery. One hundred adults were randomly assigned to get either standard pain relief alone or standard relief plus ketamine through a patien…

This study looked at 90 adults having knee replacement surgery to see which nerve block technique works better for pain control and getting patients moving sooner. One group got a fascia iliaca plane block, the other got a combination of adductor canal and IPACK blocks. Researche…

This study looked at 120 adults having gallbladder surgery to see if the position they are in when getting a nerve block (called an ESP block) affects pain after surgery. Patients were placed on their side, stomach, or sitting up during the block. The goal was to find which posit…

This study tested whether watching calming VR videos or squeezing a stress ball could reduce pain, anxiety, and improve satisfaction during insulin injections in older adults (65+) with type 2 diabetes. 90 participants were split into three groups: VR, stress ball, or usual care.…

This study compared two types of nerve blocks—serratus posterior superior intercostal plane block and thoracic paravertebral block—for pain relief after mastectomy. Sixty women received one of the blocks along with standard painkillers. Researchers measured pain scores and opioid…

This study looked at whether teaching elite volleyball players about the science of pain could help them manage chronic shoulder pain. Forty players took part, with some receiving six weeks of pain education in addition to their regular training. The results showed that those who…

This study tested whether wearing eye masks and earplugs at night for three nights could help prevent confusion (delirium) and reduce pain in children aged 6-12 in the pediatric intensive care unit (PICU). 74 children were randomly assigned to either wear the sleep aids or receiv…

This study tested whether letting women listen to their own chosen music during embryo transfer could lower anxiety and pain. 42 IVF patients were randomly assigned to either listen to music through noise-canceling headphones or receive standard care. Researchers measured anxiety…

This study tested whether applying scents (like lavender) during heel blood collection can reduce crying, pain, and stress in newborns. 120 healthy full-term babies were randomly assigned to receive a scent or not. Researchers measured crying time, heart rate, and a standard pain…

This study looked at 90 adults having shoulder surgery to compare two types of nerve blocks for pain relief. One block targets the shoulder area directly, while the other targets a nearby muscle. The goal was to see which method provides better pain control and reduces the need f…

This study tested two drug-free methods—deep breathing and virtual reality—to see which better reduces pain and anxiety during blood draws. 264 adults were randomly assigned to one of the two techniques or standard care. The goal is to find a simple, effective option for patients…

This study tested a nerve block called the high-thoracic erector spinae plane block to see if it could reduce pain and improve diaphragm function after posterior cervical spine surgery. 50 adults undergoing this surgery received either the block or standard care. The goal was to …

This study looked at whether showing cartoons or playing music during tooth extractions can lower pain and anxiety in children aged 6 to 12. Sixty kids were randomly assigned to watch cartoons, listen to music, or receive standard care. Researchers measured heart rate, oxygen lev…

This study compared two types of nerve blocks — the erector spinae plane block and the retrolaminar block — for controlling pain after major breast cancer surgery. Ninety women between 18 and 60 years old took part. Researchers measured pain scores and how much opioid painkiller …

This study looked at whether chewing gum (with or without sugar) can help children aged 7 to 12 feel less pain and fear during a blood draw. A total of 144 kids were randomly assigned to chew sugared gum, sugar-free gum, or no gum at all. Researchers measured pain, fear, and cryi…

This study tested whether a TENS device, which uses mild electrical pulses, can reduce pain during a prostate biopsy. 84 men were randomly assigned to receive TENS plus local anesthetic, a sham TENS device plus local anesthetic, or local anesthetic alone. Participants reported th…

This study looked at whether acupuncture can help manage pain for people visiting the emergency department with common painful conditions like back pain or abdominal pain. About 290 adults were split into two groups: one received acupuncture, the other got usual care. The goal wa…

This study tested whether a nerve block called the external oblique intercostal plane block could reduce the amount of opioid painkiller needed during laparoscopic gallbladder removal. 80 adults having elective surgery received the block before the procedure. Researchers measured…

This study tested whether breathing exercises and using a stress ball during dressing changes can reduce pain, anxiety, and improve comfort in burn patients. 210 adults with burns on 15% or less of their body took part. Researchers measured pain, anxiety, comfort, and vital signs…

This study tested two non-drug methods to reduce pain, fear, and anxiety in children aged 4 to 6 getting intramuscular injections in a pediatric emergency department. One method used a flat, bumpy plastic device called ShotBlocker pressed against the skin before the shot. The oth…

This study compared two types of pain-relief injections (posterior quadratus lumborum block and transversalis fascia plane block) in 54 children aged 1 to 7 years undergoing orchiopexy. Researchers measured how long it took for children to need their first painkiller after surger…

This study tested whether elastic therapeutic taping can reduce pain after open-heart surgery (CABG). 195 patients were randomly assigned to receive real tape, placebo tape, or another supportive treatment near the surgical site. Neither patients nor researchers knew who got whic…

This study looked at two methods to control pain after breast-conserving surgery: an ultrasound-guided nerve block (ESPB) and local wound infiltration (LWI). 66 adult women took part, and researchers measured how much morphine they needed in the first 24 hours after surgery. The …

This study tested whether a near-infrared LED device can reduce pain, speed up tooth movement, and lower the risk of root damage in people wearing braces. Sixteen Vietnamese patients aged 11 to 30 received either the real LED device or a sham device during their orthodontic treat…

This study tested whether Emotional Freedom Techniques (EFT), a simple tapping therapy, can help first-time mothers feel safer, less anxious, and experience less pain after a planned cesarean section. Sixty women were split into two groups: one received EFT in the first 24 hours …

This study tested a new 3-session mind-body pain management program called PACE CF for adults with cystic fibrosis (CF). The program was delivered via telehealth and aimed to help people cope with pain without medication. Researchers wanted to see if the program was acceptable an…

This study tested two common treatments for carpal tunnel syndrome: over-the-counter ibuprofen pills and a nerve exercise called neural mobilization. 123 adults with carpal tunnel took part. The goal was to see if these treatments reduce pain and improve hand and arm function bet…

This study tested a T-shirt printed with ceramic particles that claim to use body heat to emit far infrared radiation, potentially reducing inflammation and muscle pain. Fifty adults with chronic neck or lower back pain wore the shirt for 8 hours. Researchers measured changes in …

This study tested whether playing special music (solfeggio frequencies or Turkish classical tunes) during allergy skin tests could lower pain in children and anxiety in their parents. 120 children aged 2 to 17 took part. Parents reported their anxiety before and after the test, a…

This study tested whether listening to visualized meditation sessions for three days before a colonoscopy could help reduce anxiety, pain, and improve comfort. Seventy-two first-time colonoscopy patients participated. The meditation group listened to recordings twice daily before…

This study tested two simple distraction methods—blowing bubbles and a mental game with praise—to help children aged 7 to 12 feel less pain, fear, and anxiety during a blood draw. 207 children took part, and their pain and fear levels were measured before and after the procedure.…

This completed study tested whether an ultrasound-guided nerve block called RIFP can reduce pain and the need for rescue painkillers after laparoscopic gallbladder removal. 77 patients were enrolled. The block targets nerves in the upper abdomen to provide pain relief. The main g…

This study looked at whether adding a numbing injection into the wound and a steroid medication during a planned C-section could lower the number of women experiencing severe pain after surgery. The researchers compared pain scores before and after making this change in 100 women…

This study looked at whether giving children stickers during an IV insertion can lower their pain and anxiety. 72 children aged 5 to 10 took part. The idea is that stickers can distract kids and make the experience less scary.

This study looked at whether acupuncture can reduce pain and anxiety in men undergoing a prostate biopsy. 72 men were randomly assigned to receive either real acupuncture or a sham (fake) version before the procedure, in addition to standard numbing medicine. The main goal was to…

This study tested whether wearing virtual reality (VR) glasses during a leg artery procedure (angioplasty) can lower patients' pain and anxiety. 52 adults having elective angioplasty were randomly assigned to either use VR or standard care. Researchers measured pain and anxiety l…

This completed study looked at whether giving a spinal painkiller (morphine) before robotic hysterectomy helps reduce pain after surgery. Researchers reviewed records from 100 patients who had the procedure. The main goal was to see if this approach lowers pain scores, which coul…

This study is testing a new wearable device that uses focused ultrasound to stimulate nerves in the arms and legs. Researchers want to see if it's comfortable and easy to use in 15 healthy adults aged 20-40. Participants will complete nine sessions involving cold water and pressu…

This study looked at how patients view the routine pain checks they receive after planned surgery. Researchers surveyed and interviewed 312 adults to understand whether these checks feel supportive or stressful, and how that affects trust in nurses and willingness to report pain.…

This small study tested whether adding exercise (stationary biking) to standard sensory training could improve sensation and reduce pain after nerve injuries in the arm or hand. Seven adults who had a nerve injury between 2010 and 2025 took part. The goal was to see if this appro…

This study followed 294 knee replacement patients to see how often they experienced sudden, severe pain after their nerve block wore off. Researchers tracked pain levels, sleep quality, and patient satisfaction. The goal was to better understand this 'rebound pain' and improve pa…

This completed study with 120 adults undergoing brain surgery tested whether brain wave patterns and vital signs like blood pressure can show pain from skull pin fixation. Researchers compared three pain management methods: a scalp nerve block, IV opioids, and a local anesthetic …

This early-stage study tested a new drug called CG001419 in 72 healthy adults to see if it is safe and how the body processes it. The drug is being developed for pain relief. Participants took single or multiple doses, and some took it with food to check for effects. The study is…

This study looked back at the medical records of 134 adults with chronic cancer pain to see how well different pain management strategies worked. Researchers measured pain severity using a standard 0–10 scale and noted the types of pain and treatments used. Because it was a revie…

This study tested whether a 3D-printed model of pain biochemistry helps nursing students understand pain mechanisms and stay motivated. 90 students were split into two groups: one used the 3D model, the other used standard PowerPoint slides. Researchers measured knowledge and mot…

This study asked over 1,000 emergency doctors in Europe what they would prescribe for a patient with sudden belly pain. The patient's race was changed to see if it affected the doctor's choice to give morphine. The goal was to understand if racial bias plays a role in pain manage…

This study tested two different tablet forms of an experimental pain drug (LTG-001) in 14 healthy adults to see how well each is absorbed. Participants took single doses of each version, and researchers measured drug levels in the blood. The goal was to find which formulation wor…

This study looked at 52 adults having cosmetic breast surgery to see if things like self-esteem, anxiety, and personality traits affect how much pain they feel afterward. Before surgery, participants filled out questionnaires about their mental state and pain expectations. After …

This study looked at how two common steroids, methylprednisolone and dexamethasone, affect the time it takes for children to recover from muscle relaxants used during surgery. Sixty children aged 5 to 12 received one of the steroids or a placebo before their operation. The goal w…

This study tested whether a single 70-minute Pain Neuroscience Education session could improve pain knowledge and attitudes in 155 undergraduate physiotherapy students. The session covered pain neurophysiology, chronic pain mechanisms, and biopsychosocial factors. Students comple…

This study looked at whether specially trained anesthesia nurses can safely manage sedation for digestive endoscopy, with an anesthesiologist available if needed. Over 18,000 people took part to compare safety and satisfaction. The goal was to see if this nurse-led model could be…