Can a sugar pill curb the opioid crisis?

NCT ID NCT03906721

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This pilot study tests whether a technique called conditioning with open-label placebo (COLP) can help patients with spinal cord injuries, polytrauma, or burns reduce their opioid painkiller doses without losing pain relief. Participants receive a sugar pill and an essential oil scent alongside their usual oxycodone, with the goal of maintaining the same pain control while lowering opioid exposure. The study measures changes in opioid use and pain scores to see if this approach is worth further investigation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
A sugar pill (placebo) used with conditioning, alongside standard oxycodone and an essential oil scent
What this could lead to
If it works, this approach could help people with severe injuries get the same pain relief with lower opioid doses, reducing side effects and addiction risk.
What could go wrong
This is a small pilot study, so results may not apply broadly. The placebo effect can be unpredictable, and the approach may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for BURN INJURY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Spaulding Rehabilitation Hospital

    Charlestown, Massachusetts, 02129, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.