SPINAL CORD INJURIES

This study tests a new treatment using viruses (called phages) that specifically target E. coli bacteria in the urine of adults with spinal cord injury and neurogenic bladder. The goal is to see if the therapy is safe and can control bacteria without causing symptoms. Thirty part…

This study tests whether epidural stimulation can improve walking, standing, and bladder function in people with recent spinal cord injuries. Sixteen adults with injuries between T1 and T10 who cannot stand or walk and have bladder problems will receive the stimulation. The goal …

This study is testing a new spinal implant system (ARC-IM Lumbar) in 8 adults with chronic spinal cord injury who already have a spinal implant. The goal is to see if upgrading to this new system can improve walking, leg movement, and make it easier to use at home. Researchers wi…

This study tests a method to fine-tune epidural spinal cord stimulation in 100 adults with motor-complete paraplegia from a spinal cord injury between C6 and T10. The goal is to help them regain voluntary leg movement and improve autonomic functions like blood pressure control. P…

This study tests whether a non-invasive spinal stimulation device, combined with arm cycling exercise, can help improve blood pressure and heart rate control in people with chronic spinal cord injury (at or above T6). Sixteen adults will receive either real or sham stimulation du…

This study tests whether short, controlled sessions of mild low oxygen (mild intermittent hypoxia) can help prevent dangerous blood pressure swings in people with spinal cord injuries. The treatment aims to improve daily function and independence. The study will enroll 24 adults …

This study tests if an extra surgery called duroplasty can improve recovery after a severe neck spinal cord injury. Duroplasty opens the tough covering around the cord and adds a patch to give the swollen cord more space. About 222 adults will be randomly assigned to standard car…

This study tests a brain-computer interface (iBCI) that reads movement-related brain signals to let people with severe paralysis (from ALS, spinal cord injury, or brainstem stroke) control a tablet computer just by thinking. The goal is to restore fast, natural communication usin…

This study tests a device called the ARC-IM System, which is surgically implanted to help manage blood pressure instability in people with chronic spinal cord injury. The trial will enroll 60 adults who experience drops in blood pressure when sitting up. Participants will be rand…

This pilot study tests whether a home-based treatment called remote ischemic conditioning (RIC) can improve heart and blood vessel health in people with spinal cord injury (SCI). RIC involves briefly inflating a blood pressure cuff on the arm to restrict blood flow, then releasin…

This study is for adults aged 18–80 with chronic spinal cord injury who can already walk a little. It combines short periods of low oxygen, spinal cord stimulation, and walking practice to see if it can improve walking speed and endurance. The goal is to help people walk better, …

This study tests a device that reads brain signals and sends them to the spinal cord to help people with chronic spinal cord injury move their legs. Three participants will try the system to see if it is safe and can improve walking and leg control. The goal is to create a direct…

This early study tests a device that may help people with severe spinal cord injuries regain movement and feeling in their hands. Up to 7 adults with tetraplegia will use the Bidirectional Neural Bypass System, which connects brain signals to muscles and sends touch sensations ba…

This study tests whether electrical stimulation of the spinal cord can improve movement and brain-to-muscle signals in people with spinal cord injury. About 20 adults with complete or incomplete injuries will receive the stimulation and undergo rehabilitation. The goal is to see …

This study tests a brain implant called BrainGate2 for people with tetraplegia (paralysis of all four limbs) due to spinal cord injury, ALS, stroke, or similar conditions. The goal is to see if it is safe and if participants can use their thoughts to control a computer cursor or …

This study tests whether a noninvasive spinal cord stimulation device can improve bladder, bowel, and sexual function in people with spinal cord injury. About 60 veterans from Canada and Ukraine will receive either real or sham stimulation alongside standard rehab. The goal is to…

This study tests a new self-balancing exoskeleton that lets people with spinal cord injury walk hands-free. Ten adults with paralysis will train with the device to see if it is safe and helps them move around. The goal is to improve mobility and independence without needing surge…

This study tests whether combining a spinal cord stimulator, a wearable robot suit, and resistance training can help people with complete spinal cord injury walk on their own. Twenty adults with paralysis from the chest down will train for months. The goal is to improve walking s…

This study tests a fully implanted neuroprosthetic system designed to help people with cervical spinal cord injury regain hand, reach, and trunk function. About 30 participants with injuries at the C5-C7 level will use the device to perform daily tasks. The goal is to see if the …

This study tests two surgical procedures to reduce additional damage after a severe spinal cord injury. Ten adults with recent spinal cord injuries will receive either a spinal fluid sac expansion alone or combined with a nerve graft. The goal is to see if these approaches are sa…

This study tests whether starting leg cycling within the first week after a traumatic spinal cord injury can reduce complications like pneumonia and pressure sores, and improve long-term recovery. About 102 adults with recent spinal cord injuries will try sitting leg cycling earl…

This study tests an experimental drug called NVG-291 in 40 people with spinal cord injuries. The goal is to see if it can help repair damaged nerves and improve movement, strength, and hand function. Participants receive either the drug or a placebo, and researchers measure chang…

This study tests whether semaglutide, a common diabetes drug, works well for people with spinal cord injury (SCI) who also have type 2 diabetes. SCI increases the risk of diabetes, but standard treatments may not work the same. The study will measure how the drug affects blood su…

This early study tests the safety of implanting a spinal cord stimulator in people with neck-level spinal cord injuries who rely on ventilators to breathe. The goal is to see if the device can help them breathe more on their own. The study involves 12 adults who are at least one …

This study tests whether a combination of electrical spinal cord stimulation and breathing exercises can improve respiratory function in people with chronic spinal cord injury. Researchers will enroll 30 adults with neck-level injuries to measure changes in breathing strength and…

This early-stage study tests a single treatment of EG110A injections directly into the bladder muscle. It is for adults with a spinal cord injury who still have bladder leakage despite standard treatments. The main goal is to check safety and see if it reduces incontinence episod…

This study tests a new therapy that uses a brain-computer interface to control spinal stimulation, helping people with incomplete spinal cord injury improve their walking. The therapy is non-invasive and aims to boost leg strength, walking speed, and balance. The trial enrolls 12…

This study tests whether functional electrical stimulation (FES) therapy can improve arm, hand, and finger movement in people with spinal cord or peripheral nerve injuries. Researchers will use the MyndMove system to stimulate muscles while participants practice everyday tasks. T…

This study tests whether a 10-week online writing program, guided by a coach, can help adults with spinal cord injury process grief and improve emotional well-being. About 60 participants will write about their feelings and complete surveys on grief, stress, sleep, and mood. The …

This study tests a non-invasive spinal stimulation technique to help people with a recent spinal cord injury (within 30 days) manage blood pressure drops when sitting up. Participants will receive both real and sham stimulation during a sit-up test to see if it can prevent dizzin…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain in people with spinal cord injury. About 63 adults with spinal cord injury and chronic neuropathic pain will receive either real rT…

This study tests a powered knee-ankle-foot orthosis (KAFO) called Nomad in 36 people who have trouble walking due to conditions like stroke, spinal cord injury, or multiple sclerosis. Participants will use the device at home for three months to see if it improves mobility, balanc…

This study tests whether deep brain stimulation (DBS) can improve walking in people with spinal cord injury who still have some movement but cannot walk well on their own. Six adults aged 22 to 70 who have been injured for at least one year will receive DBS to a brain area called…

This study tests whether a mobile health system can help people with chronic conditions like spinal cord injury, cerebral palsy, spina bifida, or traumatic brain injury improve their wellness and self-management skills. About 160 participants aged 12 and older will use the system…

This study tests whether playing a virtual reality walking game can reduce nerve pain in adults with chronic spinal cord injury. Researchers will enroll 250 people who have had a spinal cord injury for at least a year and experience daily pain of at least 4 out of 10. Participant…

This study tests whether combining short bursts of low oxygen, spinal cord stimulation, and walking practice can improve walking for people with chronic spinal cord injury. About 60 adults with some remaining leg function will take part. The goal is to see if this approach speeds…

This small pilot study is testing whether adding a gentle electrical stimulation to the spinal cord (tSCS) can boost the benefits of robotic arm training for people with chronic tetraplegia (paralysis of arms and legs). Six to eight participants will first receive robotic trainin…

This study tests whether a special training program can change spinal reflexes to improve walking and reduce leg spasticity in people with chronic spinal cord injury. Researchers will enroll 25 adults who have had a spinal cord injury for at least one year and can walk at least 1…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce nerve pain in people with spinal cord injury. Researchers will apply high-frequency magnetic pulses to a brain area involved in pain processing. Sixty adults with spinal cord injury and at …

This study is testing whether a device that electrically stimulates the abdominal muscles can help people with chronic spinal cord injury complete their bowel routine faster. Fifteen adults with injuries above the T11 level will use the device at home and track their bowel manage…

This study tests whether gentle electrical stimulation on the lower back and stomach can reduce muscle spasms, pain, and improve strength in people with spinal cord injury. About 36 participants will attend sessions over 2-3 weeks. The goal is to find a noninvasive way to ease sy…

This study tests whether pairing brain stimulation with spinal cord stimulation can make hand exercises more effective for people with chronic cervical spinal cord injury. The idea is that synchronized stimulation strengthens nerve circuits, improving hand muscle responses. Up to…

This study tests whether playing a virtual reality walking game can help reduce nerve pain in adults with incomplete spinal cord injury. Researchers will measure changes in pain intensity and quality. The study aims to enroll 48 participants who have had persistent pain for at le…

This study tests a new method to dose repetitive transcranial magnetic stimulation (rTMS) for treating depression in people with spinal cord injury (SCI). Standard rTMS dosing relies on thumb movement, which many with SCI cannot do. The study will enroll 24 Veterans with SCI and …

This study tests a wheelchair with multiple gear ratios to see if it reduces shoulder strain and makes pushing easier. About 30 manual wheelchair users will try different gears on various surfaces. The goal is to improve comfort and independence for people with spinal cord injuri…

This study is testing a wearable robotic arm exoskeleton to help people with spinal cord injuries improve their arm and hand function. Nine participants will use the device for 45-minute sessions, 3-4 times a week for 12 weeks, alongside their usual care. Researchers will measure…

This study tests whether gentle electrical stimulation on the back can help people with chronic spinal cord injury maintain healthy blood pressure when they sit up. Participants will lie on a tilt table while their blood pressure is measured with and without stimulation. The goal…

This study tests a smartwatch system that gives real-time activity suggestions to people with spinal cord injury. About 196 adults who use wheelchairs will be split into two groups: one gets a standard web-based activity program, and the other gets that plus smartwatch coaching. …

This study tests whether combining body illusions (tricks that change how you perceive your body) with mild brain stimulation can reduce nerve pain and improve sensation in people with spinal cord injury. Researchers will enroll 30 adults with long-lasting neuropathic pain. The g…

This study tests whether a device that sends mild electrical pulses to the spinal cord (called epidural spinal stimulation) can improve arm, hand, and finger movement in people with cervical spinal cord injury. Twelve adults aged 22–65 will combine the stimulation with upper body…

This study tests whether a non-invasive spinal stimulation device (TSCS) is safe and can improve walking in children aged 3-16 with incomplete spinal cord injury. Twenty participants will receive either real or sham stimulation combined with eight weeks of gait training. The goal…

This study is testing a wearable robotic hand orthosis called MyHand-SCI to help people with C6-C7 spinal cord injury improve hand function. About 40 participants will use the device and rate its ease of use. The goal is to see if the device can assist with daily tasks like grasp…

This study tests a device called the Networked Neuroprosthesis for the upper extremity (NP-UE) in people with cervical spinal cord injury. The goal is to see if it safely helps improve the ability to pick up, move, and release objects. About 13 participants will be enrolled to me…

This study tests whether training the leg's reflexes can reduce nerve pain in people with spinal cord injury. Researchers will enroll 15 adults who have had a spinal cord injury for at least a year and have nerve pain in their lower leg. The study lasts about 6.5 months and invol…

This study tests if mild electrical stimulation to a nerve in the leg (TTNS) can help people with recent spinal cord injuries maintain bladder capacity and control. Researchers will enroll 120 adults with injuries at level T9 or above. The goal is to see if this non-invasive trea…

This study tests a non-invasive brain stimulation method called rTMS to treat depression in people with spinal cord injury (SCI). Fourteen adults with SCI and major depression will receive rTMS daily for four weeks. The goal is to see if the treatment is safe and helps reduce dep…

This study looks at whether special wound care treatments given by a physical therapist can help heal pressure sores (bedsores) in people with spinal cord injuries. The treatments include pulsed wound irrigation and electrical stimulation, used alone or together. The study will t…

This study tests whether a low-sugar diet and mild electrical pulses to the legs can prevent blood pressure from dropping too low after eating in people with chronic spinal cord injury. Researchers will measure blood pressure changes in the lab and at home over several days. The …

This study looks at a new method called 'telefitting' to fine-tune spinal cord stimulators in people with chronic back or leg pain. Fifteen adults who are already scheduled to get a spinal cord stimulator will try different stimulation settings (tonic, burst, and multistim) witho…

This study tests whether combining non-invasive spinal cord stimulation with walking rehabilitation can reduce muscle stiffness and improve leg strength and walking ability in people with incomplete spinal cord injury. Ten adults with stable, incomplete spinal cord injury who can…

This small study tests whether a device that gently stimulates a nerve in the ear (called auricular vagus nerve stimulation) is safe for people with chronic spinal cord injury. Sixteen participants will receive the stimulation and be monitored for side effects, as well as changes…

This study tests whether combining a powered exoskeleton (a robotic suit) with functional electrical stimulation (small muscle zaps) can improve walking speed in people with chronic spinal cord injury. About 34 participants with incomplete injuries will be randomly assigned to re…

This study tests whether adding a non-invasive spinal cord stimulation technique (TSCS) to standard rehabilitation can improve arm and hand function in people with a recent spinal cord injury. 18 adults with cervical-level injuries will receive either real or sham stimulation dur…

This study tests whether sildenafil (the drug in Viagra) can reduce urine leakage in people with spinal cord injuries. About 24 adults will take either sildenafil or a placebo for 4 weeks and track their daily bladder leaks. The goal is to see if this medication can improve bladd…

This early-stage study tests a new oral drug, EC5026, in 36 adults with spinal cord injury who have nerve pain. The main goal is to check safety and tolerability over 14 days, while also seeing if it reduces pain compared to a placebo. Participants take one pill daily and undergo…

This study tests whether combining non-invasive spinal cord stimulation with breathing exercises can improve lung function in 36 adults with chronic spinal cord injury. Participants will be split into three groups: breathing training alone, stimulation alone, or both together. Th…

This study uses advanced MRI scans to see how the brain and spinal cord change after a spinal cord injury. Researchers will study up to 225 people with recent or long-term injuries, as well as those with related conditions. The goal is to better understand nerve activity and dama…

This study looks at a part of the brain called the reticulospinal system, which helps control movement like walking and reaching. Researchers will use loud sounds and motion tracking to measure how this system works in healthy people and in those with spinal cord injuries. The go…

This study looks at why men with spinal cord injury have a higher risk of heart attacks and strokes. Researchers will test blood vessel function in 48 men with recent spinal cord injury and low testosterone. They aim to understand if low testosterone damages the cells lining bloo…

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders (like spinal cord injury, stroke, or multiple sclerosis) control assistive devices just by thinking about moving. Researchers will use EEG to read brain signals and comb…

This study tests whether short, repeated sessions of breathing low-oxygen air can improve breathing and other motor functions in people with chronic spinal cord injury. Researchers will also look for genetic markers that might predict who benefits most. About 62 adults with spina…

This study interviews 60 adults with spinal cord injuries and neurogenic bladder, plus their caregivers, to understand their experiences with different bladder washes (antibiotics, probiotics, or both). The goal is to learn what works best from the patient's perspective, not to t…

This study looks at how the body controls blood pressure after a spinal cord injury and whether spinal cord stimulation can improve that control. Researchers will also check heart rate and immune function. The goal is to understand these changes better, not to provide a treatment…

This early-stage study tests the safety of a brain implant (BrainGate system) in up to 3 people with severe paralysis or locked-in syndrome. The goal is to see if participants can use their thoughts to control a computer cursor or other assistive devices. The study focuses on saf…

This study aims to understand why some people develop nerve pain after a spinal cord injury. Researchers will use pain tests and body measurements to study how the nervous system changes. The study involves 300 participants, including people with spinal cord injuries and healthy …

This study looks at how the body controls blood pressure after a spinal cord injury and whether those changes can predict future medical issues. Researchers will monitor 18 adults with recent or long-term injuries using simple tests. The goal is to better understand risks, not to…

This study looks at how fast the bladder is filled during a test affects a condition called autonomic dysreflexia (sudden high blood pressure) in people with spinal cord injuries. Researchers will measure bladder volume, blood pressure, and heart rate at two different filling spe…

This study is checking if it's possible to give the drug gabapentin soon after a spinal cord injury to help nerves recover. It involves 42 adults with various types of spinal cord injuries. The main goal is to see if a larger, more definitive study can be done in the future.

This study looks at whether early, intensive arm and hand training can help the brain and nerves rewire after a cervical spinal cord injury. Researchers will measure changes in brain activity, nerve signals, and arm function in 44 participants. The goal is to understand how the n…

This study tests whether a noninvasive technique called transcutaneous spinal cord stimulation can improve arm and hand function in 30 adults with either a spinal cord injury or stroke. Participants will receive electrical stimulation through electrodes placed on the skin over th…

This study looks at whether the timing of a special walking therapy (body weight supported treadmill training) after a traumatic spinal cord injury affects how well people recover. Researchers will compare starting therapy within 60 days, 3 months, or 6 months after injury, and a…

This study looks at how spinal cord injury (SCI) may damage the cells lining blood vessels, increasing the risk of heart attacks and strokes. Researchers will measure blood vessel function in 40 adults with and without SCI. The goal is to understand the underlying causes so bette…

This study compares two wearable robotic leg exoskeletons to see how they affect walking and user experience in people with spinal cord injury. Six adults with motor-complete spinal cord injury (chest level T3-T11) will test both devices. The goal is to learn which design works b…

This study aims to understand how the autonomic nervous system (which controls things like blood pressure and sweating) works after a spinal cord injury. Researchers will test about 69 people with and without spinal cord injury using simple lab exercises and smartwatches that tra…

This study tests whether a custom smartphone app and e-coaching can help people with spinal cord injury stick to exercise guidelines. Researchers will first gather input from users and clinicians, then test the app's usability, and finally run a trial to see which combination of …

This study is testing a new, more detailed MRI sequence (3D FGAPSIR) to see if it can find spinal cord injuries that standard scans miss in people with multiple sclerosis. About 200 adults will get an extra 10-minute scan during their regular MRI. The goal is to improve detection…

This study tests a brain implant that reads signals from the brain to help people who have lost the ability to speak fluently communicate by simply trying to talk. Two adults with conditions like spinal cord injury or ALS will be enrolled. The goal is to understand how speech is …

This study looks at how breathing low oxygen for short periods (intermittent hypoxia) might help people with chronic spinal cord injury improve walking and muscle strength. Researchers want to understand the brain and nerve changes behind any recovery. The study involves 44 adult…

This study uses advanced MRI scans to see how the brain and spinal cord change after a spinal cord injury. Researchers will compare 450 people with spinal cord injuries to healthy volunteers to find patterns that predict recovery. The goal is to better understand these changes an…

This study aims to see if a specially designed education module helps people with spinal cord injuries learn about their increased risk for heart disease, obesity, and related conditions. Researchers will enroll 250 adults aged 18-70 with spinal cord injuries and measure their kn…

This study looks at how spinal cord injury changes the nerves and lining of the gut. Researchers will take small tissue samples from the colon of 40 people with spinal cord injury during a routine colonoscopy. The goal is to understand these gut changes and find new ways to treat…

This study tests whether six weeks of slow, resistive yoga breathing (Ujjayi) can improve breathing patterns, lung function, and sleep quality in 20 adults aged 18-60 with spinal cord injuries. Participants will practice the breathing technique at home and complete lab tests befo…

This study is testing a new rehabilitation program for people with spinal cord injury (SCI) that combines walking downhill on a treadmill with mild electrical stimulation to activate weak muscles. Researchers will also check blood and spinal fluid for biomarkers to decide whether…

This study follows 35 people with a recent spinal cord injury (within 6 weeks) for one year. Researchers will collect blood and stool samples and ask about bowel function to see how gut bacteria and body metabolism change over time. The goal is to understand the link between gut …

This study is testing the safety and feasibility of a new exoskeleton called TWIICE Rise for people with spinal cord injury. The study involves 15 participants and will take place in two phases, first in a clinic and later at home and in the community. The goal is to see if the d…

This study looks at how spinal cord stimulation combined with training changes the way nerves communicate in people with spinal cord injuries. Researchers will measure brain-to-muscle signals and reaction times in 120 participants to understand how these changes might improve mov…