SPINAL CORD INJURIES

This study offers expanded access to a stem cell treatment for people with long-term spinal cord injuries. It uses the patient's own fat cells to try to restore nerve signals and feeling. The goal is to improve movement and quality of life, but it is not a cure and requires ongoi…

This study compares two osteoporosis medications—romosozumab followed by denosumab versus denosumab alone—in 40 adults with a spinal cord injury that happened less than six months ago. The goal is to see which approach better maintains bone density around the knee over two years.…

This early-phase study tests whether combining noninvasive spinal cord stimulation with a drug called buspirone can help people with severe spinal cord injury take steps overground. Fifteen participants who have been paralyzed for at least a year will undergo various training and…

This study tests a unique exercise program for people with high-level spinal cord injuries. Participants use a rowing machine that combines their own arm power with electrical stimulation to move their legs. The study also tests two methods to improve breathing during exercise: a…

This study tests a new approach called targeted plasticity therapy for people with spinal cord injuries who have arm weakness. It uses mild electrical pulses on the vagus nerve in the neck during rehab exercises to help the brain and spinal cord rewire. Twenty adults aged 18-64 w…

This study tests whether nerve transfer surgery can help people with complete spinal cord injuries regain hand and arm function. About 70 adults aged 18-65 who have been injured for at least 3 months but less than 36 months will take part. The surgery moves working nerves to rest…

This study aimed to test whether donated umbilical cord blood could help adults with stroke or spinal cord injury. It planned to measure changes in disability and track side effects. However, the trial was withdrawn before enrolling any participants, so no results are available.

This study tests if stem cells taken from a patient's own fat and injected into the spine can safely help improve movement and feeling after a spinal cord injury. About 40 adults with paralysis will receive the treatment. The goal is to see if this approach can restore some funct…

This study tests whether a personalized nutrition plan can help people with traumatic spinal cord injury avoid gaining excess body fat and becoming obese during the first year after injury. The trial involves 56 participants with spinal cord injuries between levels C1 and L2. Res…

This study tests a new way to use deep brain stimulation for people with severe, treatment-resistant chronic pain from stroke, spinal cord injury, or phantom limb. Instead of constant stimulation, the device delivers electrical pulses only when pain signals in the brain are high.…

This study tests whether electrical and magnetic stimulation can improve mobility and reduce muscle stiffness in people with chronic spinal cord injury. Ten participants, at least one year post-injury, will receive non-invasive stimulation and be assessed for movement, strength, …

This study tests a non-drug treatment called Hypnotic Cognitive Therapy for people with new spinal cord injuries who have pain. 88 participants will either receive 4 therapy sessions or 4 pain education sessions during their hospital rehab stay. The goal is to see if this approac…

This study tests a simple idea: temporarily numbing non-paralyzed arm muscles with over-the-counter cream while exercising paralyzed muscles. Researchers want to see if this helps improve strength, function, and sensation in people with spinal cord injury. About 30 adults with in…

This study tests whether a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) can reduce chronic neuropathic pain—pain from nerve damage that lasts over 6 months. About 32 adults with conditions like post-stroke pain, trigeminal neuralgia, or spinal…

This study tests whether a non-invasive device that sends a mild electrical current to the spine can improve walking when combined with treadmill training. 18 adults with incomplete spinal cord injury will receive either real or fake stimulation during 36 sessions. The goal is to…

This study tests whether adding a mild electrical stimulation to the spinal cord (TSCS) during exoskeleton training helps people with incomplete spinal cord injury walk better. Thirty adults within a year of injury will receive 24 training sessions. Researchers will measure chang…

This study tests a brief form of therapy called Brief Prolonged Exposure (Brief PE) to see if it can reduce posttraumatic stress in people who have had a spinal cord injury. About 200 adults in inpatient rehab will either get this therapy or standard care. The goal is to ease PTS…

This study tests whether a gentle electrical stimulation called TENS can reduce muscle spasticity and improve movement control in people with spinal cord injury. Forty adults with injuries between C5 and T12 will either receive TENS right away or after a two-month wait. Researche…

This study tests whether an 8-week online therapy program called acceptance and commitment therapy (ACT) can reduce depression and improve quality of life in people with spinal cord injuries. About 140 adults with mild to moderate depression will be randomly assigned to either th…

This study looks at whether short periods of breathing low-oxygen air can help people with chronic spinal cord injury walk better. Researchers will measure leg strength, reflexes, and walking endurance in 30 participants. The goal is to find a simple, drug-free way to improve mob…

This study was designed to create a self-management program for veterans with AIS D spinal cord injury, the mildest form. The goal was to improve their psychological well-being and quality of life. However, the study was withdrawn before any participants were enrolled, so no resu…

This study looks at whether using a powered exoskeleton (a wearable robot that helps you walk) can improve quality of life for people with spinal cord injury. About 18 participants will be trained to use the device, then randomly assigned to use it at home or during short clinic …

This study tests a method called conditioning open-label placebo (COLP) to help patients with spinal cord injury, multiple injuries, or burns use fewer opioids while still getting the same pain relief. About 66 adults in intensive rehab will receive the COLP approach alongside th…

This study aimed to test a new way of using electrical stimulation to help people with spinal cord injury control their bladder without cutting nerves. Researchers planned to test high-frequency stimulation in 5-10 people who already have a bladder control device. The study was w…

This study planned to see if a 6-month training program on a special rowing machine that uses electrical pulses to move the legs could improve fitness in adults with traumatic paraplegia. The main goal was to measure changes in oxygen use during exercise. However, the study was w…

This observational study looks at how the immune system responds to flu and COVID-19 vaccines in people with chronic spinal cord injuries compared to healthy individuals. Researchers will measure antibody levels and gene activity in blood samples to see if injury level or severit…

This study tests a new, affordable device that creates controlled slips while people walk. The goal is to understand balance in people with chronic incomplete spinal cord injuries. Ten participants who can walk without aids will be observed as they walk over the device. This rese…

This study looks at how spinal cord stimulation and different types of training (breathing, arm, or trunk exercises) affect lung and breathing muscle function in people with spinal cord injuries. About 36 adults with injuries at or above the T5 level will take part. The goal is t…

This study uses interviews and focus groups to understand how transcutaneous tibial nerve stimulation (TTNS) impacts the daily lives of people with neurogenic bladder due to spinal cord injury. Researchers will talk to 75 participants who have used TTNS for a year to learn about …

This study tests an online group program designed to help people with spinal cord injury (SCI) age in a healthier way. Researchers will enroll 180 adults who have had a traumatic SCI for at least 15 years or are over 45, and who use a wheelchair. The program focuses on improving …

This study asks up to 30 adults with spinal cord injury about their exercise habits and what they'd want in a physical activity program. Through surveys and interviews, researchers aim to learn what helps people start and keep exercising. The goal is to design better exercise pro…

This study follows 75 manual wheelchair users with spinal cord injuries over 3 to 5 years. Researchers use yearly MRIs and motion measurements to see when shoulder damage begins and which daily activities cause it. The goal is to find ways to prevent shoulder problems and keep wh…

This study looks at whether a powered wheelchair that can lift a child to a standing position helps them take part in more activities. It includes children aged 5 to 17 with conditions like cerebral palsy, spinal cord injuries, or genetic disorders who cannot walk. The goal is to…

This study tests a program called Skills on Wheels that teaches children who use manual wheelchairs how to move around safely and independently. The goal is to see if training improves their wheelchair skills, confidence, and social participation. Four children with conditions li…