SPINAL CORD INJURIES

This study tests whether nerve transfer surgery can improve arm and hand function in people with complete spinal cord injuries who have no hand movement. Seventy participants will undergo surgery followed by 48 months of occupational therapy. The goal is to help them regain indep…

This study tests a device that reads brain signals and sends them to the spinal cord to help people with chronic spinal cord injury move their legs. Three participants will use the system during rehabilitation to see if it is safe and can improve walking. The goal is to create a …

This study tests whether a surgically implanted device that sends electrical pulses to the spinal cord can help people with spinal cord injury regain voluntary leg movement. Only 2 participants with specific injury levels and MRI evidence of spared nerve fibers will be enrolled. …

This early-phase study tests whether combining noninvasive spinal cord stimulation with the drug buspirone can help people with severe spinal cord injury take steps overground. Fifteen participants who have been paralyzed for at least a year will undergo various training and meas…

This study tests whether adding non-invasive ventilation (a breathing machine) or the drug Buspar to a special rowing exercise program can improve heart and lung fitness in people with high-level spinal cord injury. Seventy participants will exercise for 6 months while receiving …

This study tests if stem cells taken from a patient's own belly fat and injected into the spine can safely help restore movement and feeling after a spinal cord injury. About 40 adults with paralysis will receive the treatment. The goal is to see if this approach can improve func…

This study tested a stem cell treatment for people with long-term spinal cord injuries. It involved three patients who received their own fat-derived stem cells through an IV. The goal was to see if the treatment could safely restore nerve signals and improve sensation or movemen…

This phase 4 trial tests whether starting with romosozumab for 12 months and then switching to denosumab for another 12 months can better maintain bone density around the knee in people with recent spinal cord injury, compared to using denosumab alone. The study involves 40 adult…

This study planned to test whether donated umbilical cord blood could help adults with stroke or spinal cord injury. However, the trial was withdrawn before enrolling any participants, so no data or results are available.

This study tests a device called the RISES-T System, which uses mild electrical stimulation through the skin to help people with chronic spinal cord injury improve their mobility and reduce muscle stiffness. Ten participants will try different stimulation techniques while researc…

This study aimed to see if a simple mindfulness breathing exercise could improve health and quality of life in people with spinal cord injury. Participants would have done a 10-15 minute guided breathing session three times a week for a month. However, the trial was withdrawn bef…

This study tests a treatment called Hypnosis Enhanced Cognitive Therapy (HYPCT) for people with new spinal cord injuries who are in rehab. It compares HYPCT to standard pain education to see if it can lower pain intensity and prevent chronic pain. Participants will attend four se…

This study tests whether a non-invasive electrical stimulation applied to the back can boost the benefits of walking therapy for people with incomplete spinal cord injury. 18 adults with chronic spinal cord injury will receive either real or fake stimulation during their walking …

This study tests a new way to use deep brain stimulation for people with severe, treatment-resistant chronic pain from stroke, spinal cord injury, or phantom limb pain. Instead of constant stimulation, the device delivers electrical pulses only when the brain senses high pain sig…

This study looks at whether using a powered exoskeleton to walk can improve quality of life for people with spinal cord injury. Eighteen participants will either use the device at home or in a clinic over 24 months. Researchers will measure changes in well-being and compare costs…

This study tests whether brief periods of breathing low oxygen can improve leg strength and walking in people with chronic spinal cord injury. Thirty adults with incomplete spinal cord injury will inhale low oxygen for short sessions over time. Researchers will measure walking en…

This study tests whether repeated magnetic pulses (rTMS) aimed at the brain's motor area can safely reduce chronic nerve pain that hasn't responded to other treatments. About 32 adults with conditions like post-stroke pain, trigeminal neuralgia, or spinal cord injury will receive…

This study tests a device that stimulates the vagus nerve during arm rehabilitation exercises to see if it helps people with spinal cord injuries regain upper limb function. Twenty adults with chronic cervical spinal cord injury will receive either active or placebo stimulation d…

This early study tests a simple idea: temporarily numbing non-paralyzed arm muscles with an over-the-counter lidocaine cream while exercising paralyzed muscles. Researchers hope this will improve strength, function, and sensation in people with spinal cord injury. About 30 adults…

This study tests whether 8 weeks of acceptance and commitment therapy (ACT) delivered via Zoom can help reduce depression in people with spinal cord injuries. 140 participants with mild or worse depressive symptoms will be randomly assigned to either ACT or a wait-list that conti…

This study tests whether adding mild electrical stimulation to the spinal cord (TSCS) to exoskeleton training helps people with incomplete spinal cord injury walk better. 30 participants within a year of injury will receive 24 training sessions. Researchers will measure walking s…

This study tests whether a short form of talk therapy, called brief prolonged exposure therapy, can help prevent post-traumatic stress disorder (PTSD) in people who have had a spinal cord injury. The therapy involves three one-hour sessions during inpatient rehabilitation. Resear…

This study tests whether a gentle electrical current (TENS) applied to the lower back can reduce muscle stiffness and improve movement in people with spinal cord injuries. Forty adults with injuries between the neck and mid-back will either receive TENS for two months or wait two…

This study tests a method called conditioning open-label placebo (COLP) to help patients with spinal cord injury, multiple injuries, or burns use fewer opioids while still getting the same pain relief. About 66 adults in intensive rehab will receive a placebo alongside their regu…

This study planned to test whether training on a rowing machine that uses electrical stimulation to move the legs could improve fitness in adults with traumatic paraplegia. Participants would have trained for 6 months, but the trial was withdrawn before anyone enrolled, so no res…

This study tests a training program that teaches children with physical disabilities how to use their manual wheelchairs better. The goal is to help them move around on their own instead of relying on others, which can improve their confidence and social life. Four children aged …

This study follows 113 people who recently had a spinal cord injury to understand how feelings of injustice (like blaming others or feeling cheated) change over time and affect their mental health, pain, and quality of life. Researchers will interview some participants and use su…

This study tests a new, low-cost device that creates controlled slips while people with incomplete spinal cord injuries walk on it. The goal is to measure how their balance changes, both standing still and moving. Ten participants who can walk without aids will be observed to bet…

This study tests an 8-week online group program called Living Longer and Stronger with SCI, designed to help people with spinal cord injury improve their physical, mental, and social health as they age. Participants set health goals and make weekly action plans with support from …

This study asks 30 adults with spinal cord injury about their exercise habits and what they would want in a physical activity program. Researchers will use surveys and interviews to learn what helps people start and keep exercising. The goal is to design better exercise programs …

This study compares immune responses to flu and COVID-19 vaccines between people with chronic spinal cord injuries and healthy individuals. Researchers will analyze blood samples to see if gene activity and antibody levels differ between the groups. The goal is to understand why …

This study looks at whether non-invasive spinal cord stimulation, combined with breathing, arm, or trunk training, can improve lung and breathing muscle function in people with spinal cord injuries. 36 adults with injuries at or above the T5 level are participating. The goal is t…

This study aimed to create a self-management program to help veterans with AIS D spinal cord injury improve their well-being. It was designed for veterans who have some movement and sensation but often struggle with emotional and social challenges. However, the study was withdraw…

This study uses interviews and focus groups to understand how transcutaneous tibial nerve stimulation (TTNS) impacts quality of life and daily activities in 75 people with neurogenic bladder from spinal cord injuries. Researchers aim to identify key themes about bladder function …

This study aimed to test whether high-frequency electrical stimulation could improve bladder control in people with spinal cord injury who already have a special device implanted. Researchers planned to compare high-frequency versus low-frequency stimulation in 5 to 10 participan…

This study follows 75 manual wheelchair users with spinal cord injuries over 3 to 5 years to see when and why shoulder problems start. Researchers use yearly MRIs and motion tracking to link daily activities to shoulder damage. The goal is to find ways to prevent shoulder pain an…

This study looks at whether a power wheelchair that can lift a child from sitting to standing is practical for kids with conditions like cerebral palsy, spinal cord injuries, or genetic diseases. Only 4 children aged 5-17 are taking part. The goal is to see if the chair helps the…