New surgery could help paralyzed patients move again

NCT ID NCT04936620

Recruiting now Disease control Sponsor: St George's, University of London Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This study tests whether a surgical procedure called duroplasty can improve recovery after a severe spinal cord injury in the neck. The surgery involves opening the tough membrane around the cord and stitching in a patch to give the swollen cord more space. Researchers will compare standard surgery plus duroplasty to standard surgery alone in 222 adults, measuring changes in movement, sensation, and quality of life over a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Duroplasty (surgical procedure to expand the dura around the spinal cord)
What this could lead to: If it works, this could become a new standard surgical treatment to improve recovery after severe spinal cord injury.
What could go wrong: This is a mid-stage trial with 222 participants, so results are not yet proven. The surgery carries risks like infection or further injury, and it may not improve outcomes more than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

palsy spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SPINAL CORD INJURIES

Contacts and locations

Locations

12 de Octubre University Hospital
RECRUITING

Madrid, Spain
Aarhus University Hospital
RECRUITING

Aarhus, Denmark
Addenbrooke's Hospital
RECRUITING

Cambridge, United Kingdom
BG Unfallklinik Frankfurt am Main
RECRUITING

Frankfurt, Germany
Hadassah Medical Center
RECRUITING

Jerusalem, Israel
Hull Royal Infirmary
RECRUITING

Hull, United Kingdom
Kepler University Hospital
RECRUITING

Linz, Austria
Klinik und Poliklinik für Neurochirurgie Universitätsklinikum Frankfurt, 60596 FRANKFURT AM MAIN
RECRUITING

Frankfurt, Germany
Kuopio University Hospital
RECRUITING

Kuopio, Finland
Leeds General Infirmary
RECRUITING

Leeds, United Kingdom
Masaryk Hospital
RECRUITING

Ústí nad Labem, Czechia
Midlands Centre for Spinal Injuries,
ACTIVE_NOT_RECRUITING

Oswestry, United Kingdom
National Spinal Injuries Centre
ACTIVE_NOT_RECRUITING

Aylesbury, United Kingdom
North West Regional Spinal Injuries Centre
ACTIVE_NOT_RECRUITING

Southport, United Kingdom
Pinderfields Hospital
ACTIVE_NOT_RECRUITING

Wakefield, United Kingdom
Queen Elizabeth Hospital Birmingham
RECRUITING

Birmingham, United Kingdom
Queen Elizabeth University Hospital
RECRUITING

Glasgow, United Kingdom
Queen's Medical Centre
RECRUITING

Nottingham, United Kingdom
Royal Infirmary of Edinburgh
RECRUITING

Edinburgh, United Kingdom
Salford Royal
RECRUITING

Salford, United Kingdom
Shaare Zedek Medical Centre
RECRUITING

Jerusalem, Israel
Sheffield Teaching Hospitals NHS Foundation Trust
RECRUITING

Sheffield, United Kingdom
Skåne University Hospital
RECRUITING

Lund, Sweden
St George's Hospital
RECRUITING

London, United Kingdom
St Mary's Hospital
RECRUITING

London, United Kingdom
St Polten University Hospital
RECRUITING

Sankt Pölten, Austria
The London Spinal Cord Injury Centre
ACTIVE_NOT_RECRUITING

London, United Kingdom
The Royal London Hospital
RECRUITING

London, United Kingdom
The Walton Centre
RECRUITING

Liverpool, United Kingdom
UZ Leuven
RECRUITING

Leuven, Belgium
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, China
University Hospital Salzburg
RECRUITING

Salzburg, Austria
University Medical Centre Ljubljana
RECRUITING

Ljubljana, Slovenia
Universität Klinik für Neurochirurgie
RECRUITING

Innsbruck, Austria

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