Could controlled Low-Oxygen breathing prevent dangerous blood pressure swings in spinal injury?
NCT ID NCT05351827
First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 2 times
Summary
This study tests whether breathing a low-oxygen gas mixture (mild intermittent hypoxia) can help prevent blood pressure problems in people with spinal cord injuries. The 24 participants will have motor-incomplete injuries above the 12th thoracic vertebra and signs of autonomic dysfunction. Researchers will measure blood pressure changes during leg cuff inflation and position changes to see if the treatment works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- mild intermittent hypoxia (breathing low-oxygen air)
- What this could lead to
- If it works, this could offer a simple, drug-free way to prevent dangerous blood pressure swings in people with spinal cord injuries.
- What could go wrong
- This is a very small, early-stage trial with only 24 participants. The approach is experimental and may not work or be safe for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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John D. Dingell VA Medical Center, Detroit, MI
RECRUITINGDetroit, Michigan, 48201-1916, United States
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