Burn

This pilot study tests a new way to make a custom pressure orthosis for burn scars using 3D scanning and printing. About 25 adults with healing hypertrophic burn scars will get the device. The main goal is to see if the manufacturing process works and the orthosis fits safely.

This study tests whether a gel made from umbilical cord stem cells can help heal severe burns faster and more safely. About 90 adults with burns covering less than 30% of their body will receive either a low-dose, high-dose, or placebo gel on their donor skin site. The main goal …

This study looks at whether giving less intravenous (IV) fluid to critically ill children with traumatic injuries leads to fewer complications. Currently, there is no standard for how much fluid these children should receive. The trial will enroll 250 children aged 6 months to 15…

This study tests whether a gel made from human umbilical cord stem cells and cow collagen can safely help third-degree burn wounds heal faster. About 108 adults with burns covering 1-5% of their body will receive the gel or a placebo. The main goal is to see how much and how quic…

This Phase 2 trial tests whether 4-aminopyridine, a drug already used for other conditions, can help second-degree burns heal faster. Researchers will give the drug or a placebo to 200 adults with fresh burns and track healing rate and scarring. The goal is to see if this safe, e…

This study compares two treatments to help blood clot in severely injured trauma patients who are bleeding heavily. One is a standard frozen blood product (cryoprecipitate) that takes time to thaw, and the other is a dry powder (fibrinogen concentrate) that can be given at the be…

This study tests whether adding a collagen scaffold called Miro3D to standard wound care helps acute and chronic wounds heal better than standard care alone. About 70 adults with soft tissue wounds or pressure ulcers will be randomly assigned to one of two groups. The main goal i…

This pilot study tests a device called Efferon LPS that filters the blood to remove toxins and inflammatory substances in adults with severe thermal burns. Fifteen participants will receive two filtering sessions, and their outcomes will be compared to a group of similar patients…

This study tests whether giving antibiotics before burn surgery lowers the chance of infections after the operation. About 506 adults with burns covering 5% to 40% of their body will take part. Half will get antibiotics before surgery, and half will get a placebo. The goal is to …

This study tests a device called Efferon LPS NEO that filters the blood of children with severe burns to remove harmful substances. The goal is to see if it reduces time in the ICU and improves recovery. Thirty children will receive the treatment and be compared to past cases.

This Phase 3 trial tests whether giving the steroid dexamethasone early after a severe burn can prevent major complications like lung or kidney failure and reduce death. About 478 adults with burns covering at least 20% of their body and on a breathing machine will receive either…

This study compares two medications applied to the wound bed before placing a skin graft in people with burns. The goal is to see if a low-cost drug called tranexamic acid works as well as the standard thrombin spray to prevent blood clots under the graft. About 62 adults with sm…

This early-stage trial tests whether tacrolimus ointment (Protopic) can prevent deep partial-thickness burns from worsening. Researchers believe the drug may calm the inflammation that often makes burns deeper. The study will enroll 18 adults aged 50 to 75 with burns on their han…

This study looks at whether two simple blood test results—the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio—can help predict which children with severe burns will develop acute respiratory distress syndrome (ARDS), a serious lung condition. Researchers will foll…

This study tests whether a short form of exposure therapy, given soon after a traumatic injury, can prevent posttraumatic stress disorder (PTSD). Researchers will enroll 300 injured adults admitted to Level I trauma centers. Half will receive the brief therapy plus standard care,…

This study tests whether playing an immersive virtual reality game during painful burn treatments (like dressing changes) can reduce pain and the need for opioid painkillers. Fifty adult burn patients will be randomly assigned to receive either standard care alone or standard car…

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This early study is testing a mineral-based spray called THERAVEX on 26 people with various wounds, including burns, pressure sores, and diabetic ulcers. The spray is used alongside standard wound care to see if it helps the skin heal better and faster. So far, it appears safe an…

This study tests whether a special laser can make burn scars look and feel better. Researchers will treat mature burn scars on the body and measure changes in scar height, texture, color, and flexibility. The study involves 6 adults in Winnipeg with scars that are 6-12 months old…

This study tests whether a drug called phenylephrine can control bleeding during burn surgery as well as the standard drug epinephrine, but without causing unwanted changes in heart rate or blood pressure. About 24 adults with burns needing skin grafts will take part. The goal is…

This early-phase trial tests whether disposable nitrous oxide (laughing gas) canisters can reduce pain and anxiety during burn dressing changes. Thirty adult burn patients will try both the gas and a placebo in random order. The goal is to see if this offers a safer alternative t…

This study tests a special gel dressing called Plurogel against standard burn dressings in people with partial thickness burns on the face or one limb. The goal is to see if Plurogel helps burns heal faster, reduces pain, and lowers the need for skin grafts. About 25 adults will …

This pilot study tests whether a gel called PluroGel®, used with standard dressings, can help burn injuries heal better and reduce the need for skin grafting. Twenty adults with similar burns on both arms or legs will have one limb treated with the gel and the other with standard…

This study looks at whether pulsed dye laser therapy can make burn scars less red, softer, flatter, and more flexible. Researchers will treat people with burn scars that are 1 to 6 months old and living in Winnipeg. The goal is to see if the laser helps scars heal better.

This study tests whether a soft robotic glove called Carbonhand can help people with hand weakness from injury or nerve conditions perform daily activities at home. Five participants will use the glove for six weeks while researchers measure arm activity, grip strength, and well-…

This study tests a cream containing FS2 (kynurenic acid) to see if it can reduce scarring in burn patients who need skin grafts. About 70 people aged 12 to 65 will apply the cream or a placebo to both the graft and donor sites for 90 days. The goal is to check safety and whether …

This study tests whether a 3D hologram can distract children aged 3 to 12 during painful burn dressing changes, reducing their pain, anxiety, and fear. About 70 children with second-degree burns covering less than 10% of their body will be randomly assigned to see a hologram or r…

This study tests whether giving fluoxetine (Prozac) immediately after a serious injury can prevent depression, PTSD, and reduce pain and opioid use. About 200 adults with fractures or other bodily trauma will receive either fluoxetine or a placebo during their hospital stay. The …

This study compares two sedation approaches—dormicum-ketamine versus dexmedetomidine—to see which better prevents emergence delirium (confusion and agitation) in children aged 3 to 16 with burns. Sixty kids undergoing burn dressing changes or minor procedures will be randomly ass…

This study tests whether adding blue light therapy to standard wound care helps donor sites (the area where healthy skin is taken for grafting) heal faster in burn patients. About 25 adults with deep burns will have two donor sites: one treated with standard care alone, the other…

This study tests a counseling program for caregivers of children hospitalized for a traumatic injury like burns or a car accident. The goal is to reduce PTSD and depression in both the caregiver and child. 24 caregiver-child pairs will be randomly assigned to either the counselin…

This study tests whether a single dose of ketamine given during surgery can help adults with serious orthopedic trauma recover better. Researchers want to see if it reduces pain, lowers the need for opioids, and improves symptoms of depression and PTSD. Ninety participants will b…

This study tests a new cream called MW-III on partial-thickness thermal burns (like from fire or hot liquids). It compares MW-III to a standard burn cream, Silvadene, to see which helps burns heal faster. About 60 adults with burns covering up to 25% of their body will take part.…

This study tests whether ketamine or fentanyl is better for pain relief in trauma patients with signs of shock. About 994 adults will receive one of the two drugs in the ambulance. Researchers will track survival at 24 hours and side effects like low oxygen or blood pressure.

This study tests whether a relaxation technique called progressive muscle relaxation (PMR) — done with or without virtual reality (VR) — can ease chronic symptoms like pain, itch, anxiety, and sleep problems in adult burn survivors. About 34 participants will try both VR-enhanced…

This study tests a telerehabilitation program that uses technology to help adults recovering from burns. Participants will do rehab exercises at home with remote guidance. The goal is to see if this approach improves joint range of motion and scar quality. The study enrolls 30 ad…

This study tests a single dose of a new drug called cP12 in 6 adults with thermal burns covering up to 10% of their body. The main goal is to check if the drug is safe and how the body processes it. Researchers will also monitor pain and burn healing for two weeks after treatment…

This study is checking how safe and effective a special dressing (3M V.A.C. Peel and Place) is when used with a standard wound vacuum therapy. About 90 adults with open wounds or surgical incisions will be treated and monitored. The goal is to see if the dressing helps wounds clo…

This study tests a new wound dressing called Field Shield for second-degree burns covering 5-30% of the body. About 40 people will join to see if it helps burns heal faster, with less pain and infection, compared to standard care. The dressing is changed and checked over 35 days.

This study tests a new two-sided pad (Debrisoft Duo) for cleaning wounds by removing dead tissue. About 104 adults with various wound types (like diabetic ulcers or burns) will be randomly assigned to the new pad or the current one-sided pad. The main goal is to see if the new pa…

This study tests if training with a wearable robot can improve walking in people who have long-term walking problems after a severe burn injury. Twenty adults who had burns on more than half of their legs and still had trouble walking 6 months later will receive 12 weeks of robot…

This study is testing a pad used to clean wounds, such as diabetic ulcers, leg ulcers, pressure sores, surgical wounds, and burns. The goal is to see if the pad safely removes debris and improves the wound bed right after use. About 184 adults with these types of wounds will take…

This study tests whether a continuous intravenous infusion of magnesium sulfate can reduce pain and the need for narcotic painkillers in critically ill trauma patients admitted to the intensive care unit. Researchers will compare magnesium to a placebo (normal saline) in 156 adul…

This study compares two sedatives, remimazolam and propofol, given during laser treatment for burn scars. The goal is to see which drug causes fewer breathing problems. About 136 adults will take part, each receiving both drugs in separate sessions. The results could help doctors…

This study compares a new powder dressing called Altrazeal to standard burn dressings in adults with partial thickness burns. The goal is to see if the new dressing reduces pain during changes and helps wounds heal faster. Sixty hospitalized patients will be randomly assigned to …

This study tests a new type of nerve block called LAM for pain after skin graft surgery. The block aims to numb the thigh where skin is taken, without weakening the leg muscles. Ten adults having skin graft surgery will receive the block, and researchers will map how much sensati…

This study tests whether wetting the skin can prevent dangerous rises in body temperature during exercise in hot conditions for burn survivors. Researchers will compare cooling methods in 40 adults, including those with and without burn injuries. The goal is to find a simple way …

This study tests whether a combination of famotidine (Pepcid) pills and cromolyn sodium lotion can reduce itching from burn scars. 44 adults with itchy burn scars will take either the active combo or a placebo (plus a standard antihistamine) for 6 months. The main goal is to see …

This study tests whether a chitosan-based gel (made from natural sources) helps children's burns heal faster and with less scarring than standard silver-based dressings. About 40 children aged 6 months to 17 years with mild to moderate burns will be randomly assigned to one of th…

This Phase 2 trial tests whether 4-aminopyridine, a drug already used for other conditions, can speed up healing of skin wounds. Researchers will give the drug or a placebo to 150 healthy adults and measure how quickly small biopsy wounds close. The goal is to see if this safe, e…

This study looks at how a serious burn injury changes the way cells produce energy. Researchers will collect blood, urine, and tissue samples from 125 children and adults admitted to the burn center. No new treatments are tested; the goal is simply to learn more about the body's …

This study looks at whether giving older trauma patients extra protein drinks (up to 3 times a day in the hospital and for 4 weeks after discharge) helps them regain muscle and function better than standard nutrition. Sixty adults aged 45 and older who can eat by mouth will be ra…

This study looks at records of 500 patients admitted to intensive care units in Colombia to find out what factors are linked to death after severe trauma. Researchers will compare trauma patients with other ICU patients using a discharge database. The goal is to better understand…

This study looks at how a simulated burn injury affects how quickly the body cools down after exercise in hot conditions. Researchers will compare the same person's recovery with and without a special material on the skin that mimics a burn. The goal is to understand if burn surv…

This study is looking at 327 adults with severe burns to understand why some develop invasive fungal infections while others do not. Researchers will collect blood and skin samples over several weeks to study the immune response. The goal is to uncover immune factors that could l…

This study looks back at medical records of 4 severely injured trauma patients who needed large blood transfusions. It compares two drugs that help blood clot—prothrombin complex concentrate and recombinant activated factor VIIa—to see which causes fewer dangerous blood clots and…

This study aims to see if updated criteria for activating trauma teams can reduce mistakes—either calling a team when not needed (over-triage) or missing a serious case (under-triage). Researchers will compare data from 5,000 trauma patients before and after the new rules were pu…

This study follows 350 adults with major injuries admitted to intensive care. Doctors will use a non-invasive bedside ultrasound to check blood flow in the kidneys and liver at several time points. The goal is to see if certain ultrasound patterns are linked to acute kidney injur…

This study looks at whether using a blood test (anti-Xa) to adjust the dose of a blood thinner (enoxaparin) works better than dosing based on weight alone for preventing dangerous blood clots in burn patients. About 25 adults with serious burns will be enrolled. The goal is to se…

This study looks at how glucose spreads in the body of adults with severe burns (covering at least 30% of their skin). Researchers will measure glucose levels after a small injection over the first four days. The goal is to see if this measurement can help guide fluid treatment i…

This study looks at how the antibiotic cefiderocol behaves in the bodies of people with severe burns. Researchers want to find the best dose to kill bacteria and prevent resistance. The study will enroll 12 adults with burns who have good kidney function.

This study will enroll 188 trauma patients in Iraq to see how well three scoring systems (EMTRAS, REMS, and GAP) predict who will die, need a breathing tube, or stay longer in the hospital. Researchers will calculate each patient's score upon arrival and track their outcomes. The…

This study compares two scoring systems (TTSS and TRISS) to see which better predicts outcomes like death or ICU admission in people with chest injuries. Researchers will assess 150 patients in the emergency room and track their hospital course. The goal is to find the most accur…

This study looks at whether storing blood for a long time before transfusion affects death rates and complications in severely injured trauma patients. Researchers will review records of 300 patients aged 18-75 who received large transfusions. The goal is to understand if blood s…

This study looks at how severe traumatic injury changes the bone marrow and gut, leading to long-term anemia and microbiome disruption. Researchers will collect bone marrow, blood, and stool samples from 275 adults with serious blunt trauma. The goal is to understand these intera…

This study compares Advanced Trauma Life Support (ATLS) training for doctors against usual care to see if it improves survival in adult trauma patients. Over 4,000 patients from hospitals in India will take part. The goal is to find out if this widely used training actually saves…

This study looks at how severe injuries change the way bone marrow stem cells work, especially in older adults. Researchers will collect bone marrow and blood samples from 400 trauma patients to understand why some develop long-term anemia and muscle loss. The goal is to learn mo…

This observational study tracks 200 adults with severe burns (over 30% of body surface) to see if giving albumin in the first 24 hours after injury improves outcomes. Researchers will measure death rates, kidney failure, and severe lung problems within 28 days. The goal is to gat…

This study is testing a Turkish version of the Burnt Hand Outcome Tool (BHOT) to see if it accurately measures recovery in adults with hand burns. About 100 participants will fill out questionnaires and have their hand function tested over six months. The goal is to provide a rel…

This study follows 30 adults with severe burns to see how their gut bacteria change over time. Researchers collect stool samples and measure inflammation and other health markers. The goal is to understand how these microbiome shifts relate to recovery, not to test a new treatmen…

This study tests two noninvasive imaging methods to assess burn wound severity and predict healing. Researchers will enroll 200 burn patients to see if these cameras can accurately determine which burns will heal on their own and which need surgery. The goal is to improve treatme…

This study follows 600 burn patients and 60 healthy people over two years to see how burns change the community of microbes on the skin and in the gut. Researchers will collect swabs, stool, and blood samples at several time points to map these changes. The goal is to better unde…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …