Burn

This study compares two ways of using breathing machines in adults with severe burns (covering 20% or more of the body). One method, called Adaptive Support Ventilation (ASV), automatically adjusts the machine's settings to the patient's needs. The other is standard lung-protecti…

This study tests whether a new shelf-stable blood product (IFC) works faster than the standard cryoprecipitate to stop severe bleeding in trauma patients. About 320 adults with traumatic injuries and low fibrinogen levels will be enrolled. The goal is to see if IFC can be given m…

This early-phase study tests whether a special dye (methylene blue) activated by blue light can safely reduce bacteria in burn wounds. About 50 adults with partial- or full-thickness burns will receive either the light treatment or light alone during two dressing changes. The goa…

This study tests a blood-filtering device called Efferon LPS in 50 people with severe burns. The goal is to see if it can reduce dangerous inflammation and prevent organ failure. Participants will either receive standard care or standard care plus the blood filter. The study focu…

This study tests whether giving plasma (a part of blood) as soon as possible to adults with severe burns over at least 20% of their body can lower the chance of death or organ failure. About 750 patients will be randomly assigned to receive either early plasma or standard fluids.…

This early study is testing a new dressing made from sodium hyaluronate and carbomer hydrogel for first and shallow second-degree burns. The goal is to see if it helps the burn heal completely within 50 days and reduces itching. The study will involve 30 adults with burn wounds o…

This study looks at whether applying a patient's own skin cells (called a basal cell suspension) to surgical wounds can help them heal faster and with less scarring. Researchers will compare 500 people who get this extra treatment with 500 who get standard surgery alone. The goal…

This study is testing whether adding a cold atmospheric plasma device to standard wound care helps different types of wounds heal better. The device uses low-temperature plasma to kill bacteria and promote healing. Researchers will compare 500 patients who get plasma therapy plus…

This study tests whether a special placental tissue dressing (AmCoreMatrix Burn) helps second-degree burns heal faster than standard care. About 70 adults with burns covering 5-15% of their body will take part. The main goal is to see how quickly the burn skin fully closes.

This study tests whether a computer program called Burn Navigator™ can better guide fluid replacement in adults with severe burns (covering at least 20% of the body) compared to the standard Parkland formula. The software uses real-time patient data to recommend hourly fluid amou…

This study tests whether adding a patient's own fat tissue under a standard skin graft can improve healing and reduce scarring after severe burns or traumatic wounds. About 68 adults with deep skin loss will receive either the new fat-plus-skin graft or a traditional skin graft a…

This study tests whether using a person's own fat, combined with a skin graft, can improve tight scars from burns or injury better than standard skin grafting alone. Forty adults with scar contracture will receive either the new fat-plus-skin method or the usual full-thickness sk…

This Phase 3 trial will test whether a graft made from donated amniotic tissue can help heal chronic wounds like diabetic foot ulcers and venous leg ulcers better than standard care. About 600 adults with wounds that haven't healed in 4 weeks will take part. The study will measur…

This study tests an AI-powered imaging device called DeepView to see if it can accurately assess burn injuries on the hands, head, and feet. Researchers will collect images from people with burns in these areas to train and improve the AI system. The goal is to help doctors make …

This study tests a short, 4-session therapy for burn survivors and their caregivers to prevent posttraumatic stress disorder (PTSD). The therapy, called Promotion of Emotional Disclosure for Burns (PoED-B), helps patients and their loved ones communicate better about the traumati…

This study tests whether a higher dose of the blood thinner enoxaparin can better prevent dangerous blood clots in the legs or lungs of severely injured patients. About 540 adults in intensive care after trauma will receive either the standard or a double dose. The goal is to see…

This study tests whether adding a medication called 5-fluorouracil to a standard steroid treatment helps improve thick, raised burn scars more than the steroid alone. Both treatments are delivered through tiny holes made by a CO2 laser, which helps the medications reach deeper in…

This study tests whether wearing a special cast for one week can improve thick, itchy burn scars. Researchers will compare treated scars to untreated ones in 38 adult burn survivors. They will measure changes in scar thickness, redness, moisture, itching, and pain.

This study tests whether Frenkel exercises—slow, controlled movements to improve coordination—can help people with lower limb burns regain balance and improve their quality of life. Seventy adults aged 25 to 45 with second-degree thermal burns on their legs will be split into two…

This phase 2 trial tests whether ketamine-assisted psychotherapy (KAP) can safely ease PTSD and trauma symptoms in adults with severe burns covering more than 15% of their body. Twelve participants will receive two KAP sessions plus a preparatory talk therapy session. The main go…

This study tests a new treatment for burn scars on the chest, shoulders, and back. Doctors will take a small amount of fat from the patient's belly or thigh, process it into a liquid rich in healing cells, and inject it into the scar. The goal is to improve the scar's look, feel,…

This study tests whether using a virtual reality headset or a smartphone during burn dressing changes can lower pain and anxiety. 99 adults with second-degree burns will be randomly assigned to VR, smartphone, or standard care. Pain and anxiety are measured right after the dressi…

This study tests whether banana leaves can be used as a natural dressing for second-degree burns. About 30 adults with small burns will have their wounds covered with banana leaves, and their pain and healing will be compared to past patients. The goal is to see if this simple, l…

This study tests whether a special way of talking by nurses can help adults with burns feel less pain and worry during dressing changes. About 62 people will be split into two groups: one gets the special comfort talk, the other gets usual care. The goal is to see if simple, supp…

This study tests a new rehab program for adults with severe burns who are on breathing machines. The program uses brain stimulation, virtual reality, and special sedation to try to prevent muscle loss. Thirty patients will be split into two groups: one gets standard care, the oth…

This study tests whether listening to music with binaural beats (a type of sound that may influence brain activity) can help professional athletes who are afraid of getting hurt again after a musculoskeletal injury. Sixty-six athletes will listen to either binaural beat music, a …

This study tests whether a guided laughter exercise, called Laughie, can help people with second-degree burns feel less pain and anxiety during dressing changes. 88 adults will either watch and mimic a video of their own laughter before the procedure or receive standard care. The…

This study tests whether showing 3D hologram videos during burn dressing changes can reduce pain, anxiety, and fear in patients. 70 adults will be randomly assigned to either watch a hologram or receive standard care. The hologram projects interactive images into the air without …

This study looks at whether giving trauma patients personalized information and a voluntary digital follow-up visit (instead of only standard care) helps them have less disability, return to work more often, and feel better overall. About 256 adults admitted to a Norwegian trauma…

This study looks back at medical records of about 1,400 burn patients treated at a hospital near a border. Researchers want to see if foreign-national patients have different outcomes, such as death rates or need for intensive care, compared to Turkish citizens. No new treatments…

This pilot study tests whether a single 75mg dose of amitriptyline can reduce the release of microvesicle particles (tiny substances) from skin after a very small, controlled burn. Twenty healthy adults will receive either amitriptyline or a placebo, then a small heated rod creat…

This trial tests a software device called AI-TRiPS that uses real-time data from ambulances to predict the risk of death, bleeding, kidney injury, and need for blood transfusion in trauma patients. The tool displays these predictions to hospital trauma teams before the patient ar…

This study will check if an Arabic version of the Michigan Hand Outcomes Questionnaire works well for people who have had hand burns. About 100 adults with second-degree burns on their dominant hand will fill out the questionnaire twice, one week apart. Researchers will see if th…

This study follows 236 severely burned patients who received lab-grown skin grafts (CEA or CDEA) between 1985 and 2023 at Swiss burn centers. Researchers will measure scar quality, skin thickness, elasticity, and check for skin tumors. The goal is to understand long-term outcomes…

This study will train over 1,800 lay first responders—like taxi drivers and shopkeepers—in Cameroon to provide basic first aid and safe transport for injured people. Researchers will compare survival rates before and after the training program. The goal is to see if a data-driven…

This study looks at how different positions and positioning devices affect pressure on areas like the heels, tailbone, elbows, and back of the head in burn patients. Researchers will use a special pressure-sensing mat to find which setups create the least pressure. The goal is to…

This study will test a new program designed to help people who have been hospitalized for a physical injury. The program connects survivors with resources to meet their medical and social needs. Researchers will interview 25 participants and track which resources they use to see …

This observational study will use a non-invasive brain-computer interface and artificial intelligence to detect and record brain activity in terminally ill patients immediately after clinical death. Researchers aim to capture organized neurocognitive signals, such as gamma waves,…

This study looks at 400 severely injured patients treated by emergency medical teams in the Paris region. It aims to see if the time spent on scene before going to the hospital affects whether patients survive the first 24 hours. The goal is to find ways to improve emergency care…

This study follows 40 adults with serious burn injuries to collect blood, tissue samples, and medical record data. Researchers will look for patterns that could help predict who will develop sepsis or other complications. The goal is to build a computer-based 'digital twin' model…

This study follows 80 adults with serious burns to understand how their bodies respond to injury and treatment. Researchers collect blood and tissue samples and review medical records to find patterns that might predict sepsis and other complications. The goal is to build compute…

This study will analyze data from a pediatric trauma registry to understand injury patterns, outcomes, and what factors predict how severe an injury is. Researchers will look at records of 40 children under 18 who came to the hospital with a traumatic injury. The goal is to learn…

This study tests whether giving metoclopramide alone or with dexamethasone can speed up stomach emptying in trauma patients needing emergency surgery. Using bedside ultrasound, researchers will measure stomach contents to see which drug works better. The goal is to reduce the ris…

This study tests a new peer support program for adults recovering from serious injuries like car crashes, burns, or amputations. The program pairs survivors with trained peers who have been through similar experiences, offering support from hospital to home. The goal is to see if…

This study will use a special brain scanner to see how virtual reality (VR) affects pain in children aged 6-17 with burns. Four children will have their brain activity measured during burn dressing changes, both with and without VR. The goal is to find brain markers that show whe…