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Smart ventilation and targeted fluids may improve outcomes for severe burn victims

NCT ID NCT07689097

Disease control Sponsor: Ukrainian Society of Regional Anesthesia and Pain Therapy Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study looks at whether a specific type of breathing support (adaptive support ventilation) combined with carefully controlled fluid replacement can help adults with severe burns who need a breathing machine. The goal is to see if this approach improves oxygen levels, lung function, and overall recovery during the first few days in the intensive care unit. The findings could lead to better treatment guidelines for burn patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Adaptive Support Ventilation and targeted fluid resuscitation
What this could lead to
If successful, this approach could improve breathing and reduce complications in severely burned patients in the ICU.
What could go wrong
This is an early observational study with a small number of patients, so results may not apply to all burn cases. The combination may not improve outcomes over standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of adult patients admitted to the intensive care unit with severe burn injury requiring invasive mechanical ventilation during the acute phase of treatment. Patients will receive Adaptive Support Ventilation (ASV) and targeted fluid resuscitation as part of routine clinical care. The study will include patients with thermal, flame, scald, electrical, chemical, and combat-related burn injuries, including burns associated with drone and thermobaric attacks, when applicable. Clinical, respiratory, hemodynamic, and laboratory data will be collected prospectively during the first seven days of intensive care to evaluate respiratory function, fluid resuscitation, and early clinical outcomes.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older. * Hospital admission with severe burn injury involving ≥20% total body surface area (TBSA). * Requirement for invasive mechanical ventilation within 24 hours after admission to the intensive care unit. * Expected need for mechanical ventilation for at least 48 hours. * Treatment with Adaptive Support Ventilation (ASV) and targeted fluid resuscitation according to institutional protocols. * Written informed consent provided by the patient or legally authorized representative, in accordance with local regulations. Exclusion Criteria: * Age younger than 18 years. * Burn injury involving \<20% TBSA. * Mechanical ventilation initiated more than 24 hours after ICU admission. * Pregnancy. * Pre-existing chronic dependence on invasive mechanical ventilation. * Severe traumatic brain injury requiring a specific ventilation strategy. * Terminal illness with an expected survival of less than 24 hours. * Enrollment in another interventional clinical trial that may influence study outcomes. * Inability to obtain essential clinical data required for study analysis.

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Conditions

The condition(s) this trial relates to.

burn injury War-Related Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Burn Infusion fluid Mechanical ventilation War-related injuries

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Vinnitsya Regional Clinical Hospital n.a Pirogov

    Vinnytsia, 21000, Ukraine

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