A global effort to make moving critically ill patients safer

NCT ID NCT07805603

Knowledge-focused Sponsor: Medipol University Source: ClinicalTrials.gov ↗

First seen Sep 04, 2026 · Last updated Sep 04, 2026

Summary

This international study follows about 565 patients who need advanced breathing support, such as high-flow oxygen or a ventilator, while being transported within or between hospitals. Researchers will track what happens during these trips, including any equipment problems or interruptions in care. The goal is to learn which factors help keep respiratory support steady and safe from departure to arrival. The study does not assign any specific treatment; it observes routine clinical practice to gather real-world data.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: No specific intervention is assigned. The study observes patients who receive advanced respiratory support (high-flow nasal oxygen, noninvasive ventilation, or invasive mechanical ventilation) during transport, as part of routine care.
What this could lead to: If successful, this research could identify the factors that make patient transport safer, helping hospitals develop better protocols to prevent interruptions in breathing support during transfers.
What could go wrong: This is an observational study, so it cannot prove cause and effect. The findings may not apply to all hospitals or transport settings, and the study does not test any new treatment or device.

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Study facts

What this study's own registry entry says, in plain language.

Participants

About 565 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients of any age undergoing clinically indicated prehospital, interhospital, or intrahospital transport while receiving advanced respiratory support will be eligible for inclusion. Advanced respiratory support will include high-flow nasal oxygen (HFNO), noninvasive ventilation (NIV), including continuous or bilevel positive airway pressure, and invasive mechanical ventilation. Participants will be enrolled prospectively at participating international centers during routine clinical care. The indication for transport, respiratory-support modality, monitoring strategy, transport equipment, oxygen and electrical power sources, staffing configuration, and all therapeutic decisions will be determined by the treating clinical team according to local clinical practice and will not be assigned by the study protocol. The study population is intended to reflect real-world patients requiring advanced respiratory support during transport across emergency, critical care, and hospital settings.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients undergoing a clinically indicated prehospital, interhospital, or intrahospital transport. * Patients receiving advanced respiratory support at the beginning of the transport episode, including at least one of the following: High-flow nasal oxygen (HFNO); Noninvasive ventilation (NIV), including continuous positive airway pressure or bilevel positive airway pressure; Invasive mechanical ventilation. * Respiratory support and transport management determined by the treating clinical team according to routine clinical practice and local institutional protocols. * Availability of the minimum data required to document the transport episode, including respiratory-support modality and transport outcome. * Provision of informed consent by the patient or legally authorized representative when required by the applicable local ethics committee and national regulations, or inclusion under an approved waiver or alternative consent procedure where applicable. Exclusion Criteria: * Transport performed without HFNO, NIV, or invasive mechanical ventilation. * Transport in which respiratory-support modality or another therapeutic intervention is assigned specifically by the HERMES study protocol rather than by routine clinical care. * Transport episodes for which the minimum dataset required to determine the primary outcome cannot be obtained. * Withdrawal of consent when consent is required and withdrawal occurs before the participant's data can be included according to applicable regulations. * Transport episodes entered in error or duplicate records referring to the same transport event.

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Conditions

The condition(s) this trial relates to.

acute respiratory failure Critical Illness Dyspnea respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory failure Advanced respiratory support Cardiorespiratory failure Chronic respiratory failure Critical illness High-flow nasal oxygen therapy Mechanical ventilation Noninvasive ventilation Patient safety Patient safety during transport Patient transport Respiratory distress Respiratory insufficiency Transport of critically ill patients

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

4 sites in 4 countries. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

A global effort to make moving critically ill patients safer

What the study statuses mean