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Can a ventilator setting skew energy readings in the ICU?

NCT ID NCT07796698

Knowledge-focused Sponsor: Vastra Gotaland Region Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 01, 2026 · Last updated Sep 02, 2026 · Updated 1 time

Summary

In intensive care, indirect calorimetry measures oxygen use and carbon dioxide production to estimate energy needs for nutrition. This study tests whether changing positive end-expiratory pressure (PEEP), a common ventilator setting, alters those measurements. Twenty critically ill adults on breathing machines will have measurements taken at three PEEP levels: 8, 12, and 16 cmH2O. Researchers will compare oxygen consumption, carbon dioxide production, and resting energy expenditure across these levels to see if PEEP causes systematic changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Adjusting positive end-expiratory pressure (PEEP), a ventilator setting, to three levels during a single session
What this could lead to
If it works, this could help doctors interpret energy measurements more accurately in ventilated ICU patients, improving nutritional care.
What could go wrong
This is a small, early physiological study with 20 participants, so results may not apply broadly. Changing PEEP can affect heart and lung function, and the sequence stops if a patient deteriorates.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older. * Admitted to CIVA or NIVA at Sahlgrenska University Hospital. * Receiving invasive mechanical ventilation. * Expected intensive care stay longer than 72 hours. * Arterial catheter in place. * Clinical condition considered sufficiently stable by the responsible physician and research nurse to undergo the study-specific PEEP sequence. * PEEP levels of 8, 12, and 16 cmH2O considered clinically acceptable for the participant during the study measurement period. Exclusion Criteria: * Ongoing or planned continuous renal replacement therapy or intermittent hemodialysis (CRRT/iHD). * Extracorporeal membrane oxygenation (ECMO). * Fraction of inspired oxygen (FiO2) \>0.70. * Severe renal failure or rapidly increasing creatinine where metabolic measurements may be difficult to interpret. * Terminal illness or decision for end-of-life care. * Previous participation in the study during the same ICU admission. * Clinical instability or other condition judged by the responsible physician to make the PEEP measurement sequence unsafe or inappropriate.

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Conditions

The condition(s) this trial relates to.

Critical Illness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Indirect calorimetry Mechanical ventilation Positive end-expiratory pressure

How to take part

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  1. The official record

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