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Can a common sedative prevent ICU delirium?

NCT ID NCT07806188

Disease control Sponsor: Sohag University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

This study looks at whether dexmedetomidine, a sedative, reduces the chance of delirium in adults who need a breathing tube in the intensive care unit. Researchers will review records from about 412 patients, comparing those who received dexmedetomidine with those who got standard sedation. The main goal is to see how many patients develop delirium, a state of confusion that can complicate recovery. They will also track time on the ventilator, length of ICU stay, and survival.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine, a sedative drug
What this could lead to
If dexmedetomidine reduces delirium, it could become the preferred sedative for ventilated ICU patients, potentially shortening hospital stays and improving recovery.
What could go wrong
This is a retrospective study, so it can show association but not prove cause. Results may not apply to all ICU patients, and dexmedetomidine has risks like low blood pressure and slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 412 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

this retrospective observational trial was conducted in a 40-bed intensive care unit at sohag university hospital between January 2024, to ,march 2026. The Institutional Review Board granted approval for the trial protocol and informed consent was waived

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Consecutive adult patients aged 18 years or older who required invasive mechanical ventilation for more than 24 hours. Exclusion Criteria: * Neurological primary admission such as stroke or traumatic brain injury. * Active seizures or alcohol withdrawal at admission. * Prior dementia or severe cognitive impairment. * Mechanical ventilation \<24 hours. * Death within 48 hours of admission. * Missing essential sedation or delirium data.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mechanical ventilation

How to take part

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  1. The official record

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